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ECCO IBD Curriculum

16.1. Understands the different types of evidence – clinical trial / cohort study / systematic review/ etc.
Small molecules and future treatment options5th Basic ECCO: EduCational COurse for Industry
Year: 2020
Authors: Geert D'Haens
Files: 1
Stricturing Crohn's Disease e-Coursee-Course
Year: 2016
Authors: Ren Mao, Jessica de Bruyn and Gianluca Pellino, Florian Rieder

This course is designed for gastroenterologists, surgeons, paediatricians, pathologists and other interdisciplinary medical experts interested in Inflammatory Bowel Disease(s) (IBD). One major aim of this e-learning activity is to increase competence and knowledge with regard to the prediction, diagnosis and management of stricturing Crohn's Disease (CD) patients and to harmonise diagnostics and treatment in order to improve patient outcomes.

Upon completion of this activity learners will:

  • Achieve familiarity with predictors of fibrostenosing CD.
  • Understand the role of cross-sectional imaging in the diagnostic work-up of patients with suspected fibrostenosing CD.
  • Understand the current management of fibrostenosing CD.
  • Recognise the therapeutic capabilities of anti-inflammatory therapy, endoscopic dilatation and surgery in the setting of fibrostenosing CD.

UC Update e-Coursee-Course
Year: 2016
Authors: Gianluca Pellino, Tim Raine, Dominik Bettenworth, Johan Burisch, Kristzina Gecse, Pieter Hindryck, Antonio López-Sanromán

This course is designed for gastroenterologists, surgeons, paediatricians, pathologists and other interdisciplinary medical experts interested in Inflammatory Bowel Disease(s) (IBD). One major aim of this e-learning activity is to increase competence and knowledge with regard to the prediction, diagnosis and management of Ulcerative Colitis (UC) patients and to harmonise diagnostics and treatment in order to improve patient outcomes.

Upon completion of this activity learners will:

  • Have insights into the basic epidemiology of ulcerative colitis
  • Know current treatment options for severe ulcerative colitis, including colectomy
  • Be able to use ciclosporin correctly in severe ulcerative colitis
  • Understand when to order thiopurine methyltransferase (TPMT) activity when starting azathioprine

'New' kids on the block6th Basic ECCO: EduCational COurse for Industry
Year: 2022
Authors: Britta Siegmund
Summary content

Two new drugs have recently been approved by the European Medical Agency and one additional strategy will soon follow. With regard to the first part, this includes Filgotinib, an addition to the Janus Kinase inhibitor class with a higher specificity to Jak1. Furthermore, an entire new class has entered the field of IBD by the introduction of Ozanimod the first S1P receptor modulator. Last, anti-IL-23 antibodies are expected to be approved soon. The data of the clinical studies will be shortly summarized and all three drugs will be placed in our current treatment algorithm by discussing efficacy, side-effects as well as the role with regard to extraintestinal manifestations.

Educational Objectives:
1. To understand the mode of action of the three drugs described
2. To review the clinical trials that resulted in the approval of these drugs.
3. To know potential side-effects and required strategies.
4. Identify a possible role within the treatment algorithm.

'Special' treatments6th Basic ECCO: EduCational COurse for Industry
Year: 2022
Authors: Harry Sokol
Summary content

- Role and efficacy of Fecal microbiota transplantation in IBD
- Role and efficacy of new nutritional intervention in IBD

IBD: Epidemiology, Immunopathogenesis, and their relevance to therapeutics20th IBD Intensive Course for Trainees
Year: 2022
Authors: Iris Dotan
Summary content

1. To review recent epidemiologic data, highlighting the importance of environmental factors
2. To understand the complexity and multiple factors contributing to IBD pathogenesis
3. To acknowledge how the complexity of IBD may affect treatment effects

JAK inhibitors20th IBD Intensive Course for Trainees
Year: 2022
Authors: Silvio Danese
Summary content

Educational objectives:
1. Learn about the mechanisms of action of tofacitinib
2. Understand the clinical and endoscopic efficacy of tofacitinib in UC
3. Discuss the safety profile of tofacitinib

Medication in the pipeline20th IBD Intensive Course for Trainees
Year: 2022
Authors: Laurent Peyrin-Biroulet
Summary content

Numerous small molecules and biologics are being tested in phase 1-3 trials. Regarding JAK inihibitors, we still do not know whether JAK selectivity is associated with an improved risk-benefit profile, especially regading zoster risk. TYK2, gut selective or not, look promising and also showed very encouraging results in psoriasis.  Other small molecules targeting integrins or PDE4 may be approbed in a near future. Regarding biologics and beyond biosimilars, many compounds are being developed such as Abivax. One question remains after 2 decades of biologics development : who will beat infliximab? Combination of biologics and bispecific antibodies might tackle this issue. Pending these molecules, many head to head trials are ongoing.

 

New drugs and 'old buddies in new bodies'16th N-ECCO Network Meeting
Year: 2022
Authors: James Lindsay
Summary content

1) Description of immune pathways that drive inflammation in IBD
2) Discussion of the pathways targeted by current and future therapies
3) review of clinical evidence supporting use of novel therapies (selective Jaki, Sphingosine modulators, anti p19 therapies)
4) Highlight the data on adverse effects of new therapies
5) Stem cell therapies for perianal fistulae
6) Discuss novel formulations of existing agents (low systemic bioavailable steroids)



Highlights of ECCO'20Talking Heads
Year: 2020
Authors: Silvio Danese, Laurent Peyrin-Biroulet
2nd Edition of Top Strategy TrialsTalking Heads
Year: 2019
Authors: John Mansfield, Dominik Bettenworth
Fair Data PrinciplesTalking Heads
Year: 2019
Authors: Valérie Pittet & Naila Arebi
Mechanisms of Future DrugsTalking Heads
Year: 2019
Authors: Gionata Fiorino, Iris Dotan
Scientific Highlights of ECCO'19Talking Heads
Year: 2019
Authors: Silvio Danese, Julio Panes
Save the patient – Medical treatments 12th N-ECCO Network Meeting
Year: 2018
Authors: Hindryckx Pieter
N-ECCO_10
Files: 1
Scientific Highlights of ECCO'18Talking Heads
Year: 2018
Authors: Julián Panés, Silvio Danese
New drugs in IBDTalking Heads
Year: 2017
Authors: Antonio López-Sanromán, Peter Irving
Scientific Highlights of ECCO'17 Talking Heads
Year: 2017
Authors: Julián Panés, Séverine Vermeire
Top Strategy TrialsTalking Heads
Year: 2017
Authors: Krisztina Gecse, Dominik Bettenworth
Transatlantic Talking Heads: Perspectives on BiosimilarsTalking Heads
Year: 2017
Authors: David Rubin, Millie Long, Silvio Danese

Talking Heads recorded by the Crohn's and Colitis Foundation in cooperation with ECCO.