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DOP01: Extracellular Nicotinamide Phosphoribosyltransferase (eNAMPT): possible new target and biomarker in inflammatory bowel diseases

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Colombo*1, C. Travelli1, C. Porta1, G. Stocco2, F. Malavasi3, A. A. Genazzani1

1Università del Piemonte Orientale, Department of Pharmaceutical Sciences UNIUPO, Novara, Italy, 2Università degli studi di Trieste, Departement of Chemical and Pharmaceutical Sciences, Trieste, Italy, 3Università degli Studi di Torino, Department of Medical Science, Torino, Italy

DOP02: Supplementation with butyrate producing bacteria reduces tumour load in a mouse model of colitis-associated cancer

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Montalban Arques*1, I. Olivares Rivas1, K. Atrott1, C. Gottier1, S. Lang1, G. Leventhal2, T. DeWouters3, M. Scharl1, M. Spalinger1

1University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland, 2Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, USA, 3Pharmabiome, Zurich, Switzerland

DOP03: The correlation of regulatory miRNAs with cytokine serum levels and cytokine genes’ polymorphisms

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Surowiecka-Pastewka*1,2, M. Zagozda2, E. Zakościelna2, M. Durlik1,2

1CSK Mswia, Department of Gastroenterological Surgery and Transplantation, Warsaw, Poland, 2Mossakowski Medical Research Centre of the Polish Academy of Sciences, Department of Surgical Research and Transplantology, Warsaw, Poland

DOP04: The ability of epithelial regeneration is reduced in the Crohn’s disease patient-derived organoids, especially in TNF-α enriched condition

ECCO '19 Copenhagen

Year: 2019
Authors:

J. H. Song1, S. N. Hong*1, G. Seong1, T. J. Kim1, E. R. Kim1, D. K. Chang1, Y-H. Kim1, C. Lee1, C. Lee1

1Samsung Medical Center, Seoul, South Korea

DOP05: Adipose-derived stem cells from Crohn’s disease patients show antigen presenting cell-like properties

ECCO '19 Copenhagen

Year: 2019
Authors:

C. Serena*1, M. Terrón-Puig1, M. Ejarque1, F. Algaba-Chueca1, E. Maymó-Masip1, M. Millan2, M. Menacho3, E. Espin4, M. Martí4, S. Fernández-Veledo1, J. Vendrell1

1Health Institute Pere Virgili, Hospital Joan XXIII, Tarragona, Spain, 2Hospital Joan XXIII, Colorectal Surgery Unit, Tarragona, Spain, 3Hospital Joan XXIII, Digestive Unit, Tarragona, Spain, 4Hospital Vall Hebrón, Colorectal Surgery Unit, General Surgery Service, Barcelona, Spain

DOP06: Dynamic shifts in the balance of gut homing Treg and Th17 cells play a critical role in ulcerative colitis and may predict response to vedolizumab therapy

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Hermangild Kottoor*1, Z. Kassam1, P. Pavlidis1,2, E. Alberts1, H. Ibraheim1,2, L. Constable1, J. Digby-Bell1, D. Warren2, S. Odukwe2, M. Samaan2, P. Irving2, J. Sanderson2, N. Powell1,2

1King’s College London, School of Immunology and Microbial sciences, London, UK, 2Guy’s and St Thomas’ NHS Foundation Trust, London, UK

DOP07: IMP761, a novel anti-LAG-3 agonist antibody for the treatment of auto-immune diseases

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Angin*1, C. Brignone1, F. Triebel1

1Immutep, Orsay, France

DOP08: The regulatory landscape of intestinal cells—investigating the transcriptional effect of autophagy impairment observed in Crohn’s disease using organoid and network biology approaches

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Treveil*1,2, P. Sudhakar1,3, Z. Matthews4, T. Wrzesinkski1, E. Jones1,2, P. Powell4, T. Wileman2,4, I. Hautefort1, L. Hall2, F. Di Palma1, W. Haerty1, T. Korcsmaros1,2

1Earlham Institute, Norwich, UK, 2Quadram Institute, Norwich, UK, 3Catholic University of Leuven, Translational Research in Gastrointestinal Disorders, Leuven, Belgium, 4University of East Anglia, Norwich Medical School, Norwich, UK

DOP09: Interleukin-20 subfamily cytokines in controlling intestinal inflammation and epithelial barrier integrity

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Moniruzzaman*1,2, R. Wang2, K. Wong2, H. Tong2, M. McGuckin3, S. Hasnain1,2

1Faculty of Medicine, The University of Queensland, Brisbane, Australia, 2Immunopathology Group, Mater Research Institute – The University of Queensland, Translational Research Institute, Brisbane, Australia, 3Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia

DOP10: Serum N-glycomic biomarkers predict treatment escalation in inflammatory bowel disease

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Shubhakar*1, B. Jansen1, A. Adams2, K. Reiding3, N. Ventham4, D. Bergemalm5, P. Urbanowicz1, R. Gardner1, IBD-BIOM Consortium1, J. Halfvarson6, J. Satsangi2, D. Fernandes1, M. Wuhrer7, D. Spencer1

1Ludger Ltd., Abingdon, UK, 2University of Oxford, Translational Gastroenterology Unit, Oxford, UK, 3Utrecht University, Division of Biomolecular Mass Spectrometry, Utrecht, The Netherlands, 4University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, UK, 5Örebro University, Department of Gastroenterology, Örebro, Sweden, 6Örebro University, Örebro, Sweden, 7Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, The Netherlands

DOP11: Lymphocyte activation gene (LAG)-3 on T cells is a potential therapeutic target in ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Slevin*1, M. Tan1, C. Lahiff1, L. M. Wang2, B. Greenaway1, K. Lynch1, A. Geremia1, S. Hughes3, K. Leavens3, K. Nevin3, D. J. B. Marks3, R. Tarzi3, N. Srinivasan3, S. Travis1, C. Arancibia1, S. Keshav1

1University of Oxford, Translational Gastroenterology Unit, Oxford, UK, 2Changi General Hospital, SingHealth, Department of Laboratory Medicine, Singapore, Singapore, 3GlaxoSmithKline, Experimental Medicine Unit, Stevenage, UK

DOP12: Mutations in the X-linked inhibitor of apoptosis protein promote susceptibility to microbiota-induced intestinal inflammation

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Gopalakrishnan1,2, Y. Zeissig2, A. Strigli1, M. Basic3, J. Hartwig2, J. Wang4, M. Muders5, G. Barreton5, J. F. Baines4, A. Bleich3, J. Hampe1,5, S. Zeissig*1,2,5

1Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany, 2University Hospital Schleswig-Holstein, Kiel, Germany, 3Hannover Medical School, Hannover, Germany, 4Max-Planck Institute for Evolutinary Biology, Kiel, Germany, 5University Hospital Carl-Gustav Carus, Dresden, Germany

DOP13: Immune profiling of adipose tissue in murine models of inflammatory bowel disease (IBD)

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Letizia*1, Y. Rodriguez Sillke1, F. Schmidt1, C. Günther2, D. Kunkel3, R. Glauben1, B. Siegmund1, C. Weidinger1

1Charité – Universitätsmedizin Berlin, Gastroenterologie, Infektiologie und Rheumatologie, Berlin, Germany, 2Universitätsklinikum Erlangen, Gastroenterologie, Erlangen, Germany, 3Charité – Universitätsmedizin Berlin, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany

DOP14: TiO2 nanoparticles abrogate the protective effect of the autoimmunity-associated PTPN22R619W variant during acute DSS colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Schwarzfischer*1, L. Hering1, E. Katkeviciute1, A. Niechcial1, K. Atrott1, K. Bäbler1, P. Busenhart1, G. Rogler1, M. Scharl1, M. Spalinger1

1Department of Gastroenterology and Hepatology, University of Zürich, Zürich, Switzerland

DOP15: Metabolomics coupled with pathway analysis characterise metabolic changes in treatment-naive ulcerative colitis patients

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Diab*1, T. Hansen1, R. Goll2, E. Jensen1, T. Moritz3, J. Florholmen4, G. Forsdahl1

1Natural Products and Medicinal Chemistry Research Group, Department of pharmacy, University of Tromsø The Arctic University of Norway, Tromsø, Norway, 2Research Group of Gastroenterology and Nutrition, Department of Clinical Medicine, University of Tromsø The Arctic University of Norway, Tromsø, Norway, 3Swedish Metabolomics Center, Swedish University of Agricultural Sciences, Umeå, Sweden, 4Research Group of Gastroenterology and Nutrition, Department of Clinical Medicine, Tromsø, Norway

DOP16: Endoplasmic reticulum stress in subepithelial myofibroblasts increases the TGF-β1 activity that regulates fibrosis in Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

C. Li*1, J. Kuemmerle1

1Virginia Commonwealth University, Internal Medicine, Richmond, USA

DOP17: AZD4205, a potent, GI tract-enriched, JAK1-selective inhibitor for treatment of inflammatory bowel disease (IBD)

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Wang*1, T. John2, L. Zhang1, L. Zhu1, Y. Xu1, K. Chen1, S. Han1, J. Li1, F. Wang1, C. Deceneux3,4, A. Behren3,4, Z. Yang1

1Dizal (Jiangsu) Pharmaceutical Co., Ltd., Shanghai, China, 2Austin Health, Heidelberg, Australia, 3Olivia Newton-John Cancer Research Institute, Heidelberg, Australia, 4La Trobe University, School of Cancer Medicine, Heidelberg, Australia

DOP18: OSM neutralisation in IBD mucosal explant cultures reduces pro-inflammatory cytokine production

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Vossenkamper1, K. Foster2, K. Nevin2, G. Tannahill*2, S. Flint2, T. T. McDonald1

1Blizard Institute, Barts and the London School of Medicine and Dentistry, Immunobiology, London, UK, 2GlaxoSmithKline, Immunoinflammation Unit, Stevenage, UK

DOP19: Spermidine treatment ameliorates experimental colitis in vivo

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Niechcial*1, E. Katkeviciute1, L. Hering1, M. Wawrzyniak1, M. Schwarzfischer1, K. Bäbler1, K. Attrot1, M. Scharl1,2, M. R. Spalinger1

1University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland, 2University of Zurich, Zurich Center for Integrative Human Physiology, Zurich, Switzerland

DOP20: Drugs that modulate histone acetylation disrupt TGF-β-signalling and reduce collagen I expression in models of stricturing Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Lewis*1, A. Nijhuis1, G. Berti1, C. Felice2, R. Jeffrey1, S. Iqbal1, A. B. Pomeranc1, S. Aldelemi1, S. Mehta1, E. Giannoulatou3, R. Feakins4, A. Armuzzi2, J. O. Lindsay5, A. Silver1

1Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Genomics and Child Health, London, UK, 2IBD Unit, Presidio Columbus, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy, 3Victor Chang Cardiac Research Institute and 4St Vincent’s Clinical School, University of New South Wales, Sydney, Australia, 4Department of Histopathology, The Royal London Hospital, London, UK, 5Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Immunobiology, London, UK

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