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DOP001

Genetic and environmental risk model to predict intestinal inflammation in asymptomatic first-degree relatives of Crohns disease patients

Year: 2016
Authors:

K. M. Taylor*1, 2, N.S. Taylor3, S. H. Anderson1, P. M. Irving1, N. J. Prescott2, C. M. Lewis2, C. G. Mathew2, J. D. Sanderson1

1Guy’s & St Thomas’ NHS Foundation Trust, Department of Gastroenterology, London, United Kingdom, 2King’s College London, Department of Medical & Molecular Genetics, London, United Kingdom, 3University Hospital Southampton NHS Foundation Trust, Department of Gastroenterology, Southampton, United Kingdom

DOP002

Molecular response to ustekinumab in moderate-to-severe Crohns disease by serum protein analysis: results from the UNITI-1 and UNITI-2 Phase 3 induction studies

Year: 2016
Authors:

K. Li*, K. Hayden, E. Wadman, S. Bhagat, S. Emrich, J. R. Friedman, C. Gasink, C. Brodmerkel

Janssen R & D, LLC, Spring House, Pennsylvania, United States

DOP003

Gene expression profiling indicates similar molecular pathways are active in adult and paediatric ulcerative colitis

Year: 2016
Authors:

K. Li*1, J. Ouahed2, J. Friedman1, R. Strauss1, D. Chan1, S. Telesco1, D. Shouval3, J. Canavan4, C. Brodmerkel1, S. Snapper5

1Janssen R & D, LLC, Spring House, Pennsylvania, United States, 2Boston Children’s Hospital/Harvard Medical School, Boston, Massachusetts, United States, 3Boston Children’s Hospital/Harvard Medical School, Boston, Massachusetts, United States, 4Harvard Medical School/Brigham & Women’s Hospital, Boston, Massachusetts, United States, 5Boston Children’s Hospital/Harvard Medical School/Brigham & Women’s Hospital, Boston, Massachusetts United States

DOP004

Epigenetic control of colonic epithelial antigen processing, barrier function, and the microbiome via methyl-CpG binding domain protein 2

Year: 2016
Authors:

G.-R. Jones*1, A. MacDonald2, P. Cook2

1University of Edinburgh, Gastroenterology, Edinburgh, United Kingdom, 2University of Manchester, Department of Immunology, Manchester, United Kingdom

DOP005

A role for IL1 in mediating intestinal inflammation in IL10 receptor deficiency in mice and humans

Year: 2016
Authors:

D. Shouval*1, 2, A. Biswas2, Y.-H. Kang2, A. Griffith2, B. Horwitz2, A. Bousvaros2, S. Snapper2

1Safra Children’s Hospital, Paediatric Gastroenterology, Tel Hashomer, Israel, 2Boston Children’s Hospital, Boston, Massachusetts, United States

DOP006

Gut-homing adipose tissue T-cells might influence intestinal barrier function in Crohns disease and obesity

Year: 2016
Authors:

L. J. Jödicke*1, L. I. Kredel1, A. A. Kuehl1, I. Freise1, J. Gröne2, J. Ordemann3, B. Siegmund1

1Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, 2Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, General, Vascular and Thoracic Surgery, Berlin, Germany, 3Charité, Campus Mitte, Centre for Obesity and Metabolic Surgery, Berlin, Germany

DOP007

Interleukin-10 inhibits human IFNγ and IL-17-producing T helper cells indirectly by controlling antigen-presenting cell function

Year: 2016
Authors:

S. Veenbergen*1, P. Li2, H. Raatgeep1, D. Lindenbergh-Kortleve1, L. de Ruiter1, M. van Leeuwen1, D. Winter3, Y. Simons-Oosterhuis1, L. van Berkel1, S. Nugteren1, J. Arnold1, Y. Wakabayashi4, J. Zhu4, L. de Ridder3, G. Driessen5, J. Escher3, W. Leonard2, J. Samsom1

1Erasmus University Medical Centre, Laboratory of Paediatrics, division Gastroenterology and Nutrition, Rotterdam, Netherlands, 2National Heart, Lung and Blood Institute, National Institutes of Health, Laboratory of Molecular Immunology, Bethesda, Maryland, United States, 3Sophia Children’s Hospital-Erasmus Medical Centre, Department of Paediatric Gastroenterology, Rotterdam, Netherlands, 4National Heart, Lung and Blood Institute, National Institutes of Health, DNA Sequencing and Genomics Core, Bethesda, Maryland, United States, 5Erasmus University Medical Centre, Department of Paediatric Infectious Disease and Immunology, Rotterdam, Netherlands

DOP008

Human intestinal Vδ2+ T-cells acquire antigen-presenting potency upon exposure to microbial phosphoantigen: modulation by mucosal inflammation and vedolizumab therapy

Year: 2016
Authors:

C. Tyler1, N. McCarthy*2, B. Moser1, A. Stagg2, M. Eberl1, J. Lindsay2, 3

1Cardiff University, Cardiff Institute of Infection & Immunity, School of Medicine, Cardiff, United Kingdom, 2Barts and The London School of Medicine and Dentistry, Queen Mary University of London, The Blizard Institute, Centre for Immunobiology, London, United Kingdom, 3Barts Health NHS Trust, Department of Gastroenterology, Barts and The London Hospitals, London, United Kingdom

DOP009

An autoimmunity-associated variant in PTPN22 protects from disease onset in mouse models of colitis

Year: 2016
Authors:

M. Spalinger*1, S. Kasper1, C. Gottier1, S. Lang1, M. Fried1, 2, G. Rogler1, 2, M. Scharl1, 2

1University Hospital Zürich, Division of Gastroenterology and Hepatology, Zürich, Switzerland, 2University of Zürich, Zürich Centre for Integrative Human Physiology, Zürich, Switzerland

DOP010

Frequency and characteristics of infusion reactions during biosimilar infliximab treatment in inflammatory bowel diseases: results from a Central European nationwide cohort

Year: 2016
Authors:

A. Bálint*1, K. Farkas1, M. Rutka1, Z. Végh2, Z. Kürti3, J. Banai4, L. Bene5, B. Gasztonyi6, T. Kristóf7, L. Lakatos8, P. Miheller9, K. Palatka10, A. Patai11, A. Salamon12, T. Szamosi4, Z. Szepes1, G.T. Tóth13, A. Vincze14, R. Bor1, A. Milassin1, F. Nagy1, M. Kolar15, 16, M. Bortlik15, 17, D. Duricova15, 18, V. Hruba15, M. Lukas15, K. Mitrova15, 19, K. Malickova20, M. Lukas15, 20, P.L. Lakatos2, T. Molnár1

1University of Szeged, First Department of Medicine, Szeged, Hungary, 2Semmelweis University, First Department of Medicine, Budapest, Hungary, 3Semmelweis University, First Department of Internal Medicine, Budapest, Hungary, 4Military Hospital – State Health Centre, Budapest, Hungary, 5Peterfy Hospital, First Department of Medicine, Budapest, Hungary, 6Zala County Hospital, Second Department of Medicine, Zalaegerszeg, Hungary, 7B-A-Z County and University Teaching Hospital, Second Department of Medicine, Miskolc, Hungary, 8Csolnoky Ferenc Regional Hospital, Department of Internal Medicine, Veszprem, Hungary, 9Semmelweis University, Second Department of Internal Medicine, Budapest, Hungary, 10University of Debrecen, Second Department of Medicine, Debrecen, Hungary, 11Markusovszky Hospital, Department of Medicine and Gastroenterology, Szombathely, Hungary, 12Tolna County Teaching Hospital, Department of Gastroenterology, Szekszard, Hungary, 13Janos Hospital, Department of Gastroenterology, Budapest, Hungary, 14University of Pécs, First Department of Medicine, Pécs, Hungary, 15IBD Clinical and Research Centre, Iscare a.s, Prague, Czech Republic, 16Charles University, First Medical Faculty, Prague, Czech Republic, 17Military Hospital, Charles University, Department of Internal Medicine, Prague, Czech Republic, 18First Medical Faculty, Charles University, Institute of Pharmacology, Prague, Czech Republic, 19Faculty Hospital Motol, Second Medical Faculty, Charles University, Department of Paediatrics, Prague, Czech Republic, 20First Medical Faculty and General Teaching Hospital, Charles University, Institute of Medical Biochemistry and Laboratory Diagnostics, Prague, Czech Republic

DOP011

Early immunomodulator exposure and the long-term outcome of Crohns disease: target for changing the natural history

Year: 2016
Authors:

S. Jeuring*1, 2, D. Wintjens1, A. Wesselius3, T. Van den Heuvel1, 2, 
M. Zeegers3, 4, W. Hameeteman1, M. Romberg-Camps5, L. Oostenbrug6, A. Masclee1, 2, D. Jonkers1, 2, M. Pierik1, 2

1Maastricht University Medical Centre, Internal Medicine - Division of Gastroenterology and Hepatology, Maastricht, Netherlands, 2Maastricht University Medical Centre, NUTRIM - School for Nutrition and Translational Research in Metabolism, Maastricht, Netherlands, 3Maastricht University Medical Centre, Complex Genetics - School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht, Netherlands, 4Maastricht University Medical Centre, CAPHRI - School for Public Health and Primary Care, Maastricht, Netherlands, 5Zuyderland Medical Centre, Internal Medicine and Gastroenterology-Hepatology, Sittard-Geleen, Netherlands, 6Zuyderland Medical Centre, Internal Medicine and Gastroenterology-Hepatology, Heerlen, Netherlands

DOP012

Do ulcerative colitis patients treated with corticosteroids at diagnosis really have a more aggressive disease course?

Year: 2016
Authors:

L. Bertani*1, N. de Bortoli1, G. Bodini2, G. Mumolo3, L. Ceccarelli4, M. C. Plaz Torres2, G. Laino1, M. Bellini3, A. Ricchiuti3, V. Savarino2, S. Marchi1, F. Costa3

1University of Pisa, Department of Gastroenterology, Pisa, Italy, 2University of Genoa, Department of Gastroenterology, Genoa, Italy, 3Pisa University Hospital, Department of Gastroenterology, Pisa, Italy, 4SSD Endoscopy ASL 1, Massa, Italy

DOP013

A 104 week mucosal healing assessment of symptomatic small bowel Crohns disease

Year: 2016
Authors:

B. Hall*1, G. Holleran1, L. Chapman1, B. Ryan1, N. Mahmud2, D. McNamara1

1Adelaide & Meath Hospital, Dublin, Incorporating The National Children’s Hospital, Department of Gastroenterology, Dublin, Ireland, 2Trinity College Dublin, St James Hospital, Department of Gastroenterology, Dublin, Ireland

DOP014

Nutritional optimisation of presurgical Crohns disease patients with enteral nutrition significantly decreases length of stay and need for a stoma

Year: 2016
Authors:

K. V. Patel*1, A. M. Sandall2, D. V. O’Hanlon3, A. A. Darakhshan4, A. B. Williams4, S. H. Anderson1, P. M. Irving1, M. C. Lomer5, J. D. Sanderson1

1Guy’s and St Thomas’ NHS Foundation Trust, Gastroenterology, London, United Kingdom, 2King’s College London, Diabetes and Nutritional Sciences Division, London, United Kingdom, 3Guy’s and St Thomas’ NHS Foundation Trust, Dietetics, London, United Kingdom, 4Guy’s and St Thomas’ NHS Foundation Trust, Colorectal Surgery, London, United Kingdom, 5King’s College London, Diabetes and Nutritional Sciences Division, London, United Kingdom

DOP015

Myenteric plexitis is a risk factor for endoscopic and clinical postoperative recurrence after ileocolonic resection in Crohns disease

Year: 2016
Authors:

S. Decousus1, A.-L. Boucher2, J. Joubert1, M. Goutte2, 3, F. Goutorbe2, A. Dubois4, B. Pereira5, P. Dechelotte1, G. Bommelaer2, 3, A. Buisson*2, 3

1University Hospital Estaing, Pathology Department, Clermont-Ferrand, France, 2University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France, 3UMR 1071 Inserm/Université d’Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the host, Clermont-Ferrand, France, 4CHU Estaing, Department of Digestive surgery, Clermont-Ferrand, France, 5GM – Clermont-Ferrand University and Medical Centre, Biostatistics Unit, Clermont-Ferrand, France

DOP016

Postoperative clinical recurrence is not different in Crohns disease patients classified as i2 on the Rutgeerts score with lesions confined to the ileocolonic anastomosis than in those with lesions of the neoterminal ileum

Year: 2016
Authors:

P. Bayart*1, N. Duveau1, M. Nachury1, P. Zerbib1, R. Gerard1, J. Branche1, V. Maunoury1, A. Boruchowicz2, M. Boualit2, J.-E. Laberenne3, O. Manolache3, G. Pineton de Chambrun4, B. Pariente1

1CHRU de Lille, Lille, France, 2CH Valenciennes, Valenciennes, France, 3CH Seclin, Seclin, France, 4CHU Montpellier, Montpellier, France

DOP017

Colectomy-free survival is independent of initial infliximab dosing strategy in hospitalised ulcerative colitis patients

Year: 2016
Authors:

S. Shah*, S. Naymagon, B. Sands, B. Cohen, M. Dubinsky

Mount Sinai Hospital, Gastroenterology, New York, New York, United States

DOP017

Patterns of anti-TNF use and associated treatment outcomes in inflammatory bowel disease patients: results from an analysis of Dutch health insurance claims data

Year: 2017
Source:

1Academic Medical Center (AMC), Department of Gastroenterology and Hepatology, Amsterdam, Netherlands 2Academic Medical Center (AMC), Department of Pediatric Gastroenterology and Nutrition, Amsterdam, Netherlands 3Achmea Health Insurance, Amersfoort, Netherlands

Authors:

Bots S.*1, Hoekman D.1,2, Benninga M.2, Ponsioen C.1, Smeets H.3, D'Haens G.1, Löwenberg M.1

DOP018

Long-term follow-up after ileorectal anastomosis in ulcerative colitis (UC) identified factors associated with rectal outcome: a multicentre retrospective cohort of 343 patients from the GETAID/GETAID Surgery

Year: 2016
Authors:

M. Uzzan*1, J. Cosnes2, N. Oubaya3, A. Amiot4, N. Gault3, J.-M. Gornet5, P. Seksik2, S. Nancey6, E. Cotte7, M. Allez5, D. Laharie8, N. De angelis4, M. Nachury9, A.-L. Pelletier10, V. Abitbol11, M. Fumery12, A. Brouquet13, A. Buisson14, R. Altwegg15, Y. Panis16, X. Treton1

1APHP Beaujon, Department of Gastroenterology, Clichy, France, 2APHP St. Antoine Hospital, Department of Gastroenterology, Paris, France, 3APHP Beaujon, Epidémiologie et Recherche clinique, Clichy, France, 4CHU Henri Mondor, Digestive Surgery, Creteil, France, 5Hospital Saint-Louis, Department of Gastroenterology, Paris, France, 6Centre Hospitalier Lyon-Sud, Department of Gastroenterology, Pierre-bénite, France, 7Lyon-Sud Hospital, Department of Digestive Surgery, Pierre-Bénite, France, 8Hospital Haut-Leveque, Department of Gastroenterology and Hepatology, Pessac, France, 9CHRU Lille, Department of Gastroenterology, Lille, France, 10Hospital Bichat Claude Bernard, Department of Gastroenterology, Paris, France, 11Cochin Hospital, Department of Gastroenterology, Paris, France, 12Amiens University Hospital, Department of Gastroenterology, Amiens, France, 13CHU Bicêtre, Digestive Surgery, Le Kremlin-Bicêtre, France, 14CHU Estaing, Department of Gastroenterology, Clermont-Ferrand, France, 15CHU Montpellier Saint Eloi Hospital, Department of Gastroenterology, Montpellier, France, 16APHP Beaujon, Department of Colorectal Surgery, Clichy, France

DOP019

Efficacy of autologous haematopoietic stem cell transplantation for refractory Crohns disease

Year: 2016
Authors:

A. López García1, M. Rovira2, A. Jauregui Amezaga1, P. Marin3, A. Salas1, S. Pinó Donnay1, R. Barastegui1, F. Feu1, J. Elizalde1, F. Fernández-Avilés2, C. Martínez4, G. Gutierrez2, L. Rosiñol2, E. Carreras2, A. Urbano2, M. Lozano3, J. Cid3, M. Suárez-Lledó2, J. Mensa5, J. Rimola6, S. Rodriguez6, M. C. Masamunt1, D. Comas1, A. Ramirez Morros1, M. Gallego1, I. Ordás1, J. Panés1, E. Ricart*1

1Hospital Clinic Barcelona, Gastroenterology, Barcelona, Spain, 2Hospital Clinic Barcelona, Haematology, Barcelona, Spain, 3Hospital Clinic Barcelona, Biomedic Diagnostic Centre, Barcelona, Spain, 4Hospital Clinic Barcelona, Ginecology, Barcelona, Spain, 5Hospital Clinic Barcelona, Internal Medicine, Barcelona, Spain, 6Hospital Clinic Barcelona, Radiology, Barcelona, Spain

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