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ECCO IBD Curriculum

6.4. Understands the evidence base behind different therapeutic strategies and when they might be appropriate (conventional step care, optimised step up, top down and treat to target).
Exit StrategiesECCO e-Learning
Year: 2017
Authors: Johan Burisch, Ren Mao, Edyta Szymanska, Glen Doherty

This course has been developed for gastroenterologists, surgeons, paediatricians, pathologists and other interdisciplinary medical experts interested in Inflammatory Bowel Disease(s) (IBD). One major aim of this e-learning activity is to provide evidence-based guidance for clinical practice so that physicians can make informed decisions in partnership with their patients regarding their optimal exit strategies.

After this course you will:

  • To recognise risks, benefits and timing of stopping anti-TNF used as monotherapy or in combination with IM in IBD.
  • To know optimal monitoring following withdrawal of biologic therapy

Use of exclusive enteral nutrition in CDECCO e-Learning
Year: 2017
Authors: Richard K. Russell, Simona Gatti, Rotem Sigall-Boneh, Arie Levine

This course has been developed for gastroenterologists, dietitians, surgeons, paediatricians, nurses and other interdisciplinary medical experts interested in Inflammatory Bowel Disease(s) (IBD). The major aims of this e-learning activity are to provide an evidence-based but also practical approach to dietary therapy for the management of Crohn's Disease (CD). This case was developed by a multidisciplinary team and places emphasis both on the use of exclusive enteral nutrition and on the provision of the best possible nutritional and patient support based on clinical practice in experienced centres.

After this case you will:

  • Know how to use exclusive enteral nutrition 
  • Understand the rationale and current evidence regarding the use of exclusive enteral nutrition
  • Understand how to use your multidisciplinary team to optimise outcomes

Medical treatment11th N-ECCO School
Year: 2020
Authors: Dominik Bettenworth
Files: 1
Crohn's disease: Perianal disease e-Coursee-Course
Year: 2020
Authors: Federica Furfaro, Kostas Katsanos, Pascal Juillerat, Pierre Ellul

This course has been developed by physicians who had recently participated in the writing of the ECCO Crohn's disease consensus Guidelines. This course is intended for those who are interested in Inflammatory Bowel Disease(s) (IBD). One major aim of this e-learning activity is to increase competence and knowledge with regard to Perianal disease in order to improve patient outcomes.

After this case you will:

  • To appreciate the Crohn’s disease natural history
  • To appreciate the rationale behind specific treatment decisions
  • To understand the right investigations to prescribe to Crohn’s disease patient in specific settings
  • To learn appropriate clinical management of Crohn’s disease patients with perianal involvement

Luminal Crohn's disease e-Coursee-Course
Year: 2020
Authors: João Sabino, Bram Verstockt, Kostas Katsanos, Pascal Juillerat, Pierre Ellul

This course has been developed by physicians who had recently participated in the writing of the ECCO Crohn's disease consensus Guidelines. This course is intended for those who are interested in Inflammatory Bowel Disease(s) (IBD). One major aim of this e-learning activity is to increase competence and knowledge with regard to Luminal disease in order to improve patient outcomes.

Upon completion of this case you will:

  • Know the evidence for induction of remission in mild-to-moderate Crohn’s disease;
  • Know the evidence for maintaining remission in  Crohn’s disease;
  • Know the evidence on how to react upon disease flares, immediately after induction therapy or during maintenance therapy; 
  • Understand the benefits and risks of several medical therapies;
  • Achieve familiarity how to use immunomodulatory agents in mono- or combination therapy;
  • Achieve familiarity how to monitor Crohn’s disease patients who initiated medical therapy or who underwent surgery;
  • Recognise indications for surgical management.

UC Update e-Coursee-Course
Year: 2016
Authors: Gianluca Pellino, Tim Raine, Dominik Bettenworth, Johan Burisch, Kristzina Gecse, Pieter Hindryck, Antonio López-Sanromán

This course is designed for gastroenterologists, surgeons, paediatricians, pathologists and other interdisciplinary medical experts interested in Inflammatory Bowel Disease(s) (IBD). One major aim of this e-learning activity is to increase competence and knowledge with regard to the prediction, diagnosis and management of Ulcerative Colitis (UC) patients and to harmonise diagnostics and treatment in order to improve patient outcomes.

Upon completion of this activity learners will:

  • Have insights into the basic epidemiology of ulcerative colitis
  • Know current treatment options for severe ulcerative colitis, including colectomy
  • Be able to use ciclosporin correctly in severe ulcerative colitis
  • Understand when to order thiopurine methyltransferase (TPMT) activity when starting azathioprine

'Mainstream' biologicals: When to use?6th Basic ECCO: EduCational COurse for Industry
Year: 2022
Authors: Jean-Frédéric Colombel
'Older' medication: Still useful?6th Basic ECCO: EduCational COurse for Industry
Year: 2022
Authors: Uri Kopylov
Summary content

An overview of the use of 5-ASA, steroids and immunomodulators in IBD 

Anti-IL 12/2320th IBD Intensive Course for Trainees
Year: 2022
Authors: Marc Ferrante
Summary content

Educational objectives:
1. To understand the role of IL-12 and IL-23 in the development of IBD
2. To review the pivotal UNITI and UNIFI trials
3. To review the place of ustekinumab in IBD therapy
4. To have an overview on practical modalities of ustekinumab therapy
5. To get insight in the anti-IL23 drugs that are in development

Anti-integrins20th IBD Intensive Course for Trainees
Year: 2022
Authors: James Lindsay
Summary content

Educational objectives:
1. To understand the mechanism of action of vedolizumab and other anti interns
2. To review the key phase III clinical data
3. To highlight studies from real world cohort and discuss the safety profile of Vedolizumab
4. To understand how to position Vedolizumab in clinical practice

Combination of biologic therapies16th N-ECCO Network Meeting
Year: 2022
Authors: Bram Verstockt
Summary content

Educational objectives: 

1. To understand why combination therapy is being considered? 
2. To review what we have learned from the past, when combination works
3. To review what we have learned from the past, when combination does not work
4. To review what we have learned from the past, when combination is bad and dangerous
5. To discuss and review combination therapy in IBD today and tomorrow 

First presentation at the clinic (Tandem talk)6th Basic ECCO: EduCational COurse for Industry
Year: 2022
Authors: Herbert Tilg; Nelly Teix
Summary content

 
Educational objectives:

1. Typical symptoms presented by a patient

2. Epidemiological IBD data from Austria

3. Ulcerative colitis: typical symptoms, endoscopy examples, complications, extraintestinal involvement, differential diagnoses

4. Crohn´s disease: typical symptoms, clinical investigation, typical endoscpy, differential diagnoses, environmental risk factors, extraintestinal complications

JAK inhibitors20th IBD Intensive Course for Trainees
Year: 2022
Authors: Silvio Danese
Summary content

Educational objectives:
1. Learn about the mechanisms of action of tofacitinib
2. Understand the clinical and endoscopic efficacy of tofacitinib in UC
3. Discuss the safety profile of tofacitinib

New drugs and 'old buddies in new bodies'16th N-ECCO Network Meeting
Year: 2022
Authors: James Lindsay
Summary content

1) Description of immune pathways that drive inflammation in IBD
2) Discussion of the pathways targeted by current and future therapies
3) review of clinical evidence supporting use of novel therapies (selective Jaki, Sphingosine modulators, anti p19 therapies)
4) Highlight the data on adverse effects of new therapies
5) Stem cell therapies for perianal fistulae
6) Discuss novel formulations of existing agents (low systemic bioavailable steroids)



Positioning therapeutic strategies in IBD20th IBD Intensive Course for Trainees
Year: 2022
Authors: Shomron Ben-Horin
Summary content

Learning Objectives:
1. Aspects of risk stratification
2. Utility of drugs that may alter the natural history (reducing rates of surgeries and complications)
3. Timing of intervention
4. Evidence base data  comparing different classes
5. Economic consideration/medical economics including the utility of biosimilars

Safety after all6th Basic ECCO: EduCational COurse for Industry
Year: 2022
Authors: Laurent Beaugerie
Summary content

The educational objectives of the presentation are:
1. To understand that the choice of long-term treatment of IBD must take into account the benefit-risk balance of old and new IBD drugs
2. To review the most important aspects of IBD drug-induced cancers and serious infections
3. To understand that in most cases benefits outweigh risks, and that patients should not be undertreated
4. To understand, based on the example of tofacitinib, that it is important keep prudent with recently approved IBD drugs until powered data is available

After introducing the concept of benefit-risk balance, the presentation will review the three major aspects of IBD drug potential complications: drug-class specific complications, malignancies, and serious infections, including opportunistic infections.  A special focus will be made on thiopurine-induced lymphomas, thiopurine and anti-TNF-induced serious bacterial and viral infections, and how to manage these risks. We will then discuss the difficult choice of immunosuppressants in frail and older patients, based on drug-class specific safety data. Finally, using the example of tofacitinib, we will illustrate the importance of prescribing with caution recently approved drugs, until we have extensive safety data.

Therapeutic Drug Monitoring20th IBD Intensive Course for Trainees
Year: 2022
Authors: Filip J. Baert; Pascal Juillerat
Summary content

Learning Objectives:
1. Optimisation, Therapeutic Drug Monitoring of biological
2. Management of anti-drug-antibodies, allergic reaction
3. Strategies PRO / RE-active

When and how to start biologics?20th IBD Intensive Course for Trainees
Year: 2022
Authors: Gerassimos Mantzaris; Britta Siegmund
Summary content

Learning Objectives:
1. Screening before immunosuppression and immunisation
2. Indications for biological therapy
3. Evaluation of response

IBD patients are eligible to treatment with biologic agents if they have failed or cannot tolerate conventional treatment with corticosteroids and/or immunomodulators (IMMs) or are corticosteroid dependent. Early introduction of biologic therapy is also recommended for patients who at diagnosis have clinical features that predict a disabling course of disease. Ideally, patients should be screened for infectious diseases, malignancies, and complete all essential vaccinations before starting any therapy. Selecting the best biologic amongst the currently available different classes, depends on several patient- and disease-related parameters, such as age, disease activity, comorbidities, and the overall burden of disease. As for any therapy, it is important to define short-, medium- and long-term goals, monitor the progress of disease and adapt treatment accordingly (treat to target).

The first biologic is the best shot. Thus, it is key to adapt dosing to disease activity to avoid primary non-response or partial response and thus achieve a better long-term response. Co-treatment with an IMM may influence the pharmacokinetics in particular of anti-TNF and prevent early development of anti-drug antibodies ADA). Once clinical remission has been achieved, patients should be closely followed by monitoring clinical activity (patient reported outcomes), biomarkers (serum CRP, faecal calprotectin), imaging (US, MRE), endoscopy and/or histology. Treatment optimization in case patient loses response can be achieved either empirically (Standard of Care) by increasing the dose of the biologic or halving the administration interval, or both, or by adding an IMM, or by therapeutic drug monitoring (TDM), i.e., by measuring drug levels and ADA. Pro-active TDM has not been proven superior to reactive TDM, still, it serves to discriminate between pharmacokinetic and pharmacodynamic failure of treatment. However, proactive TDM is increasingly used to achieve clinical response and/or remission during induction, to de-escalate, or stop biologic therapy.

4. Screening before immunosuppression and immunisation
5. Indications for biological therapy
6. Evaluation of response

CD Management11th N-ECCO School
Year: 2020
Authors: Marieke Pierik
Highlights of ECCO'20Talking Heads
Year: 2020
Authors: Silvio Danese, Laurent Peyrin-Biroulet