1. Should the target be histology?
2. Basic histology and definitions
3 Standardization - scoring
4. Histological remission and response
5. Usefulness of histology
6. Possible solutions and improvements

This talk aims to help developers of clinical practice guidelines learn how to use the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to frame health care questions, select and rate the importance of outcomes, grade the quality of evidence, create Summary of Findings Tables, and move from evidence to making recommendations.

Educational Objectives:
1. To understand the way of dosing and administration of ustekinumab in UC
2. To understand dosing, efficacy, side-effects of Tofacitinib 
3. To be familiar with the sc administration of Vedolizumab
4. To be familiar with the sc Administration of infliximab

safety and benefit of drug 
risk and knowledge about a drug 
timing for safety evaluation 

To assess differential conditions mimicking the perianal Crohn's disease
To review and recognize proctological lesions not related to inflammatory bowel disease
To have an overview over the main principles of their management
To assist patients with perianal complains


Summary

The literature on perianal Crohn's disease lesion focuses mainly on primary lesions, ulcerations, fistulae and strictures. However, patients with IBD may present similar proctological conditions as the general population, which will need to be diagnosed and managed in a way that is appropriate to the general disease. Among these lesions, the diagnosis of common proctological lesions will often be easy, but their management, particularly surgery, will have to be carried out with caution and with a drastic selection of patients. Among the alternative perianal lesion, hydradenitis suppurativa, frequently associated with Crohn's disease, is probably the most difficult to diagnose and its management remains complex. Finally, the management of patients with Crohn's disease should not be limited to the treatment of anatomical lesions, but should also take into account the functional complaints that may largely alter the quality of life of these patients.

1. To review the relative benefits and limitations of drug therapy versus dietary intervention for the treatment of IBD 
2. To understand circumstances in which one may consider using drug therapy, dietary intervention or combine the two
3. To consider how treatment paradigms may change in the future to include increased emphasis on the role of dietary interventions

Nathalie Auger and Marianne Bilodeau-Bertrand describe their absolutely enormous epidemiological study of 3 decades of data from Quebec, Canada identifying birth-defects for offspring of almost 22,000 mothers with IBD.