P080: Mucosal clock and inflammation regulatory genes are disrupted in treatment naïve pediatric patients with ulcerative colitisECCO’23 CopenhagenYear: 2023
Authors: Labes, S.(1);Tabach, Y.(1);Matar, M.(2,3);Shamir, R.(2,3);Shouval, D.S.(2,3);Froy, O.(4);Weintraub, Y.(2,3)*;
(1)Hebrew University of Jerusalem, Department of Developmental Biology and Cancer Research- Institute for Medical Research Israel-Canada, Jerusalem, Israel;(2)Schneider Children's Medical Center of Israel, Institute of Gastroenterology- Nutrition and Liver Diseases, Petach Tikva, Israel;(3)Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel;(4)The Hebrew University, Institute of Biochemistry- Food Science and Nutrition- the Robert H Smith Faculty of Agriculture- Food and Environment-, Rehovot, Israel;
P081: The application of multiomics to investigate the evolution of inflammatory bowel disease in pediatric and adult patientsECCO’23 CopenhagenYear: 2023
Authors: Maccalli, C.(1)*; Gupta, I.(2);Toufiq, M.(3);Habib, T.(4); Mathew, R.(5); Shobha Manjunath, H.(5); Missous, G.N.(6); Mifsud, W.(7); Charles, A.(7); Ammar, A.A.(8);Tomei, S.(5); van Panhuys, N.(6); Al-Kaabi, S.(9);Akobeng, A.(10);Al-Mohannadi, M.J.(9); Elawad, M.(10);
(1)Sidra Medicine, Lab. Immune and Biological Therapy-Translational Medicine, Doha-Qatar, Italy;(2)Sidra Medicine, Laboratory of Immune Biological Therapy-Research Department, Doha, Qatar;(3)Sidra Medicine, Lab. System Biology, Doha, Qatar;(4)Sidra Medicine, Lab of System Biology, Doha, Qatar;(5)Sidra Medicine, Integrated Genomic laboratory-Omics Core, Doha, Qatar;(6)Sidra Medicine, Laboratory of Immunoregulation-Research Department, Doha, Qatar;(7)Sidra Medicine, Anatomical Pathology, Doha, Qatar;(8)Hamad Medical Corporation, Anatomical Pathology, Doha, Qatar;(9)Hamad Medical Corporation, Gastroenterology- Ambulatory Care Center, Doha, Qatar;(10)Sidra Medicine, Gastroenterology- Hepatology and Nutrition, Doha, Qatar;
P082: The CCR9/CCL25 axis is specific to the ileum and is correlated with stricturing diseaseECCO’23 CopenhagenYear: 2023
Authors: Gehrmann, U.(1)*;Csomor, E.(2);Monkley, S.(3);Georgi, B.(3);Tian, S.(2);Cairns, J.(3);Angermann, B.(3);Khan, E.(4);Nys, J.(5);Marks, D.(6);
(1)AstraZeneca, Translational Science & Experimental Medicine- Early Respiratory & Immunology, Mölndal, Sweden;(2)AstraZeneca, Translational Science & Experimental Medicine, Cambridge, United Kingdom;(3)AstraZeneca, Translational Science & Experimental Medicine, Mölndal, Sweden;(4)AstraZeneca, Late Clinical Development, Cambridge, United Kingdom;(5)AtraZeneca, Bioscience Asthma, Cambridge, United Kingdom;(6)AstraZeneca, Early Clinical Development, Cambridge, United Kingdom;
P083: JAK/STAT pathway and IL-6 activity in moderate to severe Ulcerative ColitisECCO’23 CopenhagenYear: 2023
Authors: Calviño Suárez, C.(1)*;Martinez-Rodriguez, A.L.(2);Baston-Rey, I.(1);Moreira-Alvarez, D.(2);Ferreiro-Iglesias, R.(1);Ardao-Palacios, I.(2);de la Iglesia-Garcia, D.(1);Porto-Silva, S.(1);Nieto-Garcia, L.(1);Varela-Liste, M.J.(2);Brea-Floriani, J.M.(2);Dominguez-Munoz, J.E.(1);Loza-Garcia, M.(2);Barreiro-de Acosta, M.(1);
(1)University Hospital Santiago De Compostela CHUS, Department of Gastroenterology- IBD Unit, Santiago De Compostela, Spain;(2)BioFarma Research Group- CIMUS Research Center and IDIS Health Research Institute, Department of Pharmacology, Santiago De Compostela, Spain;
P084: Response to appendectomy in refractory Ulcerative Colitis appears based on two distinct inflammatory phenotypesECCO’23 CopenhagenYear: 2023
Authors: Beckerdrs., M.(1)*;Heuthorst, L.(2);van Roest, M.(1);van der Bilt, J.(3);Buskens, C.(2);Wildenberg, M.(1);
(1)Tytgat Institute for Liver and Intestinal Research, Gastroenterology and Hepatology, Amsterdam, The Netherlands;(2)Amsterdam UMC, Surgery, Amsterdam, The Netherlands;(3)Flevoziekenhuis, Surgery, Almere, The Netherlands;
P085: Gut microbiota profile changes in patients with Ulcerative ColitisECCO’23 CopenhagenYear: 2023
Authors: Inčiūraitė, R.(1)*;Gedgaudas, R.(1);Lukosevicius, R.(1);Plingyte, K.(1);Muskieta, T.(1);Juzenas, S.(1);Kupcinskas, J.(1);Skieceviciene, J.(1);
(1)Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania;
P087: Calcitonin gene related peptide beta (CGRPβ): a new player in inflammatory bowel disease pathophysiologyECCO’23 CopenhagenYear: 2023
Authors: Pascual, M.(1)*;Gárate, G.(2);Serrano, M.S.(3);García García, M.J.(1);Castro, B.(3);González Quintanilla, V.(2);Crespo, J.(1);Pascual, J.(2);Rivero, M.(1);
(1)Marqués de Valdecilla University Hospital- Universidad de Cantabria- Instituto de Investigación Valdecilla IDIVAL, Gastroenterology and Hepatology, Santander, Spain;(2)Marqués de Valdecilla University Hospital- Universidad de Cantabria- Instituto de Investigación Valdecilla IDIVAL, Neurology, Santander, Spain;(3)Marqués de Valdecilla University Hospital- Instituto de Investigación Valdecilla IDIVAL, Gastroenterology and Hepatology, Santander, Spain;
P088: Restoration of gut microbiota and changes in inflammatory susceptibility by dextran sulfate sodium after antibiotic treatment in miceECCO’23 CopenhagenYear: 2023
Authors: Jeong, E.S.(1)*;Bae, S.(1);Song, E.M.(2);Byeon, J.R.(2);Lee, A.(1);Choe, A.R.(2);Hong, J.T.(1);Park, Y.H.(2);Tae, C.H.(2);Moon, C.M.(1);Jung, H.K.(1);Shim, K.N.(2);Jung, S.A.(2);Kim, S.E.(1);
(1)Ewha Womans University Mokdong Hospital, Internal medicine, Seoul, Korea- Republic Of;(2)Ewha Womans University Seoul Hospital, Internal Medicine, Seoul, Korea- Republic Of;
P089: Colonic explant lactate concentration and inflammatory protein secretion in ulcerative colitisECCO’23 CopenhagenYear: 2023
Authors: McShane, C.(1,2)*;Corcoran, R.(1,3);O'Connell, F.(2);McDonagh, P.(1);O'Sullivan, J.(2);Kevans, D.(1);
(1)St. James's Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity Translational Medicine Institute, Department of Surgery, Dublin, Ireland;(3)Trinity Translational Medicine Institute, Department of Gastroenterology, Dublin, Ireland;
P090: Low-density neutrophils are higher in individuals with active ulcerative colitisECCO’23 CopenhagenYear: 2023
Authors: Mendieta Escalante, E.A.(1)*;Dijkstra, G.(1);Faber, K.N.(1);Yamamoto Furusho, J.K.(2);Barrera-Vargas, A.(3);Torres-Ruiz, J.J.(4);Merayo-Chalico, F.(3);
(1)University Medical Center of Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(2)National Institute of Medical Sciences and Nutrition Salvador Zubirán, Inflammatory Bowel Disease Clinic, Mexico City, Mexico;(3)National Institute of Medical Sciences and Nutrition Salvador Zubirán, Rheumatology, Mexico City, The Netherlands;(4)National Institute of Medical Sciences and Nutrition Salvador Zubirán, Rheumatology, Mexico City, Mexico;
P091: Gender focused investigation of sexual dysfunction, sexual satisfaction and body schema disorders in male and female patients with Inflammatory Bowel DiseaseECCO’23 CopenhagenYear: 2023
Authors: Kranzeder, A.(1);Lindenthal, D.(2);Hirning, C.(1);von Wietersheim, J.(1);Klaus, J.(2)*;
(1)University Hospital Ulm, Department of Psychosomatic Medicine and Psychotherapy, Ulm, Germany;(2)University Hospital Ulm, Department of Internal Medicine I, Ulm, Germany;
P092: Punica Granatum affects gut biofilm-forming bacteria and promotes intestinal mucosal healing regulating the crosstalk between epithelial cells and intestinal fibroblastsECCO’23 CopenhagenYear: 2023
Authors: Rizzo, G.(1,2)*;Pineda Chavez, S.E.(1,2);Vandenkoornhuyse, E.(1);Cardenas, C.(1);Cento, V.(1,3);Meanti, L.(2);Roda, G.(4);Loy, L.(5);Dal Buono, A.(5);Gabbiadini, R.(5);Lovisa, S.(1);Rusconi, R.(1);Repici, A.(1,6);Armuzzi, A.(1,5);Vetrano, S.(1,2);
(1)Humanitas University, Biomedical Sciences, Pieve Emanuele MI, Italy;(2)IRCCS Humanitas Research Hospital, Department of Gastroenterology- Laboratory of Gastrointestinal Immunopathology, Rozzano MI, Italy;(3)IRCCS Humanitas Research Hospital, Unit of microbiology and Virology, Rozzano MI, Italy;(4)Gruppioni Hospital, Internal Medicine, Bologna, Italy;(5)IRCCS Humanitas Research Hospital, Department of Gastroenterology- IBD Unit, Rozzano MI, Italy;(6)Humanitas Clinical and Research Center-IRCCS, Department of Gastroenterology- Digestive Endoscopy Unit, Rozzano MI, Italy;
P093: Creeping fat-derived long chain free fatty acids drive intestinal muscularis propria muscle cell proliferation via carnitine palmitoyltransferase 1 (CPT-1) – a relevant mechanism for stricturing Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Le, T.H.N.(1);Mao, R.(2);Liu, W.(1);Czarnecki, D.(1);Chandra, J.(1);Gordon, I.O.(3);Plesec, T.(3);Wang, J.(4);Lin, S.(2);Zhao, S.(1);Dejanovic, D.(1);Mukherjee, P.(1);West, G.(1);Fiocchi, C.(1);Brown, J.M.(5);Rieder, F.(6)*;
(1)Cleveland Clinic, Inflammation and Immunity, Cleveland, United States;(2)First Affiliated Hospital of Sun Yat-sen University, Gastroenterology, Guangzhou, China;(3)Cleveland Clinic, Pathology, Cleveland, United States;(4)Xinxiang Medical University, Henan Key Laboratory of Immunology and Targeted Drug, Cleveland, United States;(5)Cleveland Clinic, Cardiovascular and Metabolic Sciences, Cleveland, United States;(6)Cleveland Clinic, Gastroenterology- Hepatology and Nutrition, Cleveland, United States;
P094: Impacts of 5-aminosalicylic acid on the intestinal microbiota leading to the anti-inflammatory effectECCO’23 CopenhagenYear: 2023
Authors: Wada, H.(1)*;Miyoshi, J.(1);Kuronuma, S.(2);Hibi, N.(1);Nishinarita, Y.(1);Oguri, N.(1);Matsuura, M.(1);Takeuchi, O.(2);Kobayashi, T.(3);Akimoto, Y.(4);Hibi, T.(3);Hisamatsu, T.(1);
(1)Kyorin University School of Medicine, Department of Gastroenterology and Hepatology, Mitaka-shi, Japan;(2)Kitasato University Kitasato Institute Hospital, Department of Research- BioMedical Laboratory, Minato-ku, Japan;(3)Kitasato University Kitasato Institute Hospital, Center for Advanced IBD Research and Treatment, Minato-ku, Japan;(4)Kyorin University School of Medicine, Department of Anatomy, Mitaka-shi, Japan;
P095: Newly discovered gut matrikines from Crohn's disease intestinal tissue induce cell proliferation, activation and inflammatory response in intestinal myofibroblasts in vitroECCO’23 CopenhagenYear: 2023
Authors: Papatheodoridi, M.(1)*;Giuffrida , P.(1);Canetti, D.(2);Yutaka, Y.(3);Hodgetts, H.(1);Di Sabatino, A.(4);Johnston, H.(5);Verona, G.(6);Rendell, N.(6);Al-Akkad, W.(1);Frenguelli, L.(1);Hall, A.(1);Luong , T.(1);Sampietro, G.(7);Pinzani, M.(1);Rombouts, K.(1);Belloti, V.(6);Mazza, G.(1);
(1)University College London, Institute for Liver and Digestive Health, London, United Kingdom;(2)University College London, Centre for Amyloidosis and Acute Phase Protein, London, United Kingdom;(3)Institute for Liver and Digestive Health, University College London, London, United Kingdom;(4)University of Pavia- San Matteo Hospital Foundation, First Department of Internal Medicine, Pavia, Italy;(5)UCL EGA Institute for Women's Health, Cancer Proteomics- Women's cancer-, London, United Kingdom;(6)University College London, Centre for Amyloidosis and Acute Phase Proteins, London, United Kingdom;(7)Università degli Studi di Milano, ivision of General and HPB Surgery, Milan, Italy;
P096: Characterization of suppressive immune cell subsets in mouse models of colitis-associated colorectal cancerECCO’23 CopenhagenYear: 2023
Authors: Frigerio, S.(1)*;Saris, J.(1);Franco Fernandez, R.(1);Koelink, P.(1);van Roest, M.(1);Wildenberg, M.(1);D'Haens, G.(1);Grootjans, J.(1);
(1)Tytgat Institute for Liver and Intestinal Research- Amsterdam University Medical Centers- Location AMC- AGEM Amsterdam, Department of Gastroenterology and Hepatology- Amsterdam University Medical Centers- Location AMC, Amsterdam, The Netherlands;
P097: Various regulatory single nucleotide polymorphisms regulate similar biological pathways in Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Modos, D.(1,2);Poletti, M.(1,2);Brooks-Warburton, J.(3,4)*;Bohar, B.(2,5);Madgwick, M.(2);Verstockt, B.(6,7);Vermeire, S.(6,7);Carding, S.(1,8);Korcsmaros, T.(1,2,9);
(1)Quadram Institute Bioscience, Gut Microbes & Health, Norwich, United Kingdom;(2)Earlahm Institute, Organisms and Ecosystems, Norwich, United Kingdom;(3)Lister Hospital, Department of Gastroenterology-, Stevenage, United Kingdom;(4)University of Hertfordshire, Department of Clinical- Pharmaceutical and Biological Sciences, Hertford, United Kingdom;(5)Eötvös Loránd University, Department of Genetics, Budapest, Hungary;(6)KU Leuven, University Hospitals Leuven- Department of Gastroenterology and Hepatology, Leuven, Belgium;(7)KU Leuven, Department of Chronic diseases and Metabolism, Leuven, Belgium;(8)University of East Anglia, Norwich Medical School, Norwich, United Kingdom;(9)Imperial College London, Department of Metabolism- Digestion and Reproduction, London, United Kingdom;
P099: IL-33 activates CD73-expressing cells promoting tumorigenesis during colitis-associated colorectal cancerECCO’23 CopenhagenYear: 2023
Authors: Lopetuso, L.R.(1)*;Privitera, G.(2);Di Martino, L.(3);Scaldaferri, F.(1);Gasbarrini, A.(1);Cominelli, F.(3);De Salvo, C.(2);Pizarro, T.(2);
(1)Fondazione Policlinico Universitario "A. Gemelli" IRCCS- Università Cattolica del Sacro Cuore, IBD Unit- Centro Malattie dell'Apparato Digerente - CEMAD, Roma, Italy;(2)Case Western Reserve University, Pathology, Cleveland, United States;(3)Case Western Reserve University, Digestive Health Institute, Cleveland, United States;
