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P040: Caspase-8 blockade attenuates NSAID-induced colitis and cell death via NLRP3 inflammasome and NF-κB activationECCO’23 Copenhagen
Year: 2023
Authors: Singh, R.(1,2);Rossini, V.(1);Stockdale , S.(1);Draper, L.(1);Hill, C.(1,3);Nally, K.(1,4);Shanahan, F.(1);Andersson-Engels, S.(5,6);MelgarPhD, S.(1)*;
(1)University College Cork, APC Microbiome Ireland, Cork, Ireland;(2)University College Cork, School of Medicine- Department of Medicine-, Cork, Ireland;(3)University College Cork, School of Microbiology, Cork, Ireland;(4)University College Cork, School of Biochemistry and Cell Biology, Cork, Ireland;(5)University College Cork, Department of Physics, Cork, Ireland;(6)Tyndall National Institute, Irish Photonics Integration Centre, Cork, Ireland;
P041: The upregulation of tissue factor in colonic mesenchymal cells in active ulcerative colitis is associated with severe and resistant to treatment disease, but tofacitinib has not effect on itECCO’23 Copenhagen
Year: 2023
Authors: Drygiannakis, I.(1)*;Tzenaki, N.(1);Archontoulaki, E.(2);Filidou, E.(3);Kandilogiannakis, L.(3);Valatas, V.(1);Kolios, G.(3);Koutroubakis, I.E.(1);
(1)University of Crete, Gastroenterology Research Laboratory- School of Medicine, Heraklion, Greece;(2)Democritus University of Thrace, Department of Molecular Biology and Genetics- School of Health Sciences, Alexandroupolis, Greece;(3)Democritus University of Thrace, Laboratory of Pharmacology- Department of Medicine- School of Health Sciences, Alexandroupolis, Greece;
P042: Distinct gene expression profile associated to inflammation and neoplastic progression in longstanding ulcerative colitisECCO’23 Copenhagen
Year: 2023
Authors: Alsøe, L.(1);Lefol, Y.(2);Wennerström, A.B.(3);Liu, Y.(3);Andersen, S.N.(4);Klepp, P.(5);Brackmann, S.(6)*;Nilsen, H.(3);
(1)University of Oslo, Department of Clinical Molecular Biology Akershus University Hospital, Nordbyhagen, Norway;(2)University of Oslo, Department of Microbiology, Oslo, Norway;(3)University of Oslo, Department of Clinical Molecular Biology- Akershus University Hospital, Nordbyhagen, Norway;(4)University of Oslo, Department of Pathology- Akershus University Hospital, Nordbyhagen, Norway;(5)Lovisenberg Diakonale Hospital, Medical department, Oslo, Norway;(6)Akershus University Hospital, Department of Gastroenterology, Nordbyhagen, Norway;
P043: ALI culture derived from human organoids recapitulates cell composition during intestinal crypt formationECCO’23 Copenhagen
Year: 2023
Authors: Dotti, I.(1)*;Álvarez, I.(1);Esteller, M.(1);Ricart, E.(1);Salas, A.(1);
(1)IDIBAPS- Hospital Clínic- CIBER-EHD, Department of Gastroenterology, Barcelona, Spain;
P044: Ex vivo effects of infliximab on the long non-coding RNAs expression levels in Crohn´s diseaseECCO’23 Copenhagen
Year: 2023
Authors: Baldan-Martin, M.(1)*;Rubín de Célix, C.(1);Orejudo, M.(1);Ortega, L.(2);Fernández-Tomé, S.(1,3);Soleto, I.(1);Ramírez, C.(1);Arroyo, R.(4);Fernández, P.(4);Santander, C.(1);Moreno-Monteagudo, J.A.(1);Casanova, M.J.(1);Casals, F.(1);Casabona, S.(1);Becerro, I.(1);Marigorta, U.M.(5);Aransay, A.M.(6);Bernardo, D.(7);Chaparro, M.(1);Gisbert, J.P.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Unit, Madrid, Spain;(2)Área de Farmacología y Nutrición y Bromatología. Departamento Ciencias Básicas de la Salud- Universidad Rey Juan Carlos, Departamento Ciencias Básicas de la Salud, Madrid, Spain;(3)Departamento de Nutrición y Ciencia de los Alimentos- Facultad de Farmacia- Universidad Complutense de Madrid, Departamento de Nutrición y Ciencia de los Alimentos, Madrid, Spain;(4)Instituto de Medicina Molecular Aplicada Nemesio Díez IMMA-ND- Facultad de Medicina. Universidad San Pablo CEU, Instituto de Medicina Molecular Aplicada Nemesio Díez, Madrid, Spain;(5)Integrative Genomics Lab- CIC bioGUNE-BRTA and IKERBASQUE- Basque Foundation for Science, Integrative Genomics Lab, Bilbao, Spain;(6)Genome Analysis Platform- CIC bioGUNE-BRTA and CIBERehd, Genome Analysis Platform, Derio, Spain;(7)Mucosal Immunology Lab- Unidad de Excelencia Instituto de Biomedicina y Genética Molecular IGBM- Universidad de Valladolid-CSIC and Centro de Investigación Biomédica en Red de Enfermedades Infecciosas CIBERINFEC, Mucosal Immunology Lab, Valladolid, Spain;
P045: Local administration of extracellular vesicles from adipose-derived stromal cells promote healing in a rat model of radiation colitis – a pilot studyECCO’23 Copenhagen
Year: 2023
Authors: Sebbagh, A.(1)*;Mathieu, N.(2);Demarquay, C.(2);Geiger, M.(2);Sémont, A.(2);Simon, C.(3);Branchu, J.(3);Milliat, F.(2);Gazeau, F.(1);Wilhelm, C.(4);Silva Brun, A.(1);Rahmi, G.(5,6);
(1)Laboratoire Matière et Systèmes Complexes UMR 7057- Université Paris Cité/CNRS, MSC-Med, Paris, France;(2)Institut de radioprotection et de sûreté Nucléaire IRSN, PSE-SANTE/SERAMED/LRMed, Fontenay-aux-Roses, France;(3)EVerZom company, Internal research and development, Paris, France;(4)Institut Curie, Physico-Chimie Curie CNRS UMR 168, Paris, France;(5)Hôpital Européen Georges Pompidou- APHP.Centre – Université de Paris, Department of Gastroenterology and Endoscopy, Paris, France;(6)Paris Cardiovascular Research Center, Laboratoire Imagerie de l'Angiogénèse- Plateforme d'Imagerie du Petit Animal- Inserm UMR 970, Paris, France;
P046: Crohn Disease (CD) untargeted fecal metabolome shows strong correlation with specific salivary associated microbial taxa, and with disease activityECCO’23 Copenhagen
Year: 2023
Authors: Levhar, N.(1)*;Hadar, R.(1);Braun, T.(1);Efroni, G.(1);Abramovich, I.(2);Gottlieb, E.(2);Granot, M.(1);Neuman, S.(3);Selinger, L.(3);Picard, O.(3);Yavzori, M.(3);Lahat, A.(3);Eliakim, R.(3);Weiss, B.(1);Kopylov, U.(3);Ben-Horin, S.(3);Amir, A.(1);Haberman Ziv, Y.(1);
(1)Sheba Medical Center, Pediatric Gastroenterology, Ramat Gan, Israel;(2)Technion Institute, The Ruth and Bruce Rappaport- Faculty of Medicine, Haifa, Israel;(3)Sheba Medical Center, Gastroenterology, Ramat Gan, Israel;
P047: Osteopontin in colitis-associated carcinoma (CAC)ECCO’23 Copenhagen
Year: 2023
Authors: Manna, S.(1)*;Sehn, M.(2);Cardoso da Silva, D.(1);Heldt, C.(1);Horstkorte, L.(1);Elezkurtaj, S.(3);Siegmund, B.(1);Weixler, B.(2);Hummel, M.(3);Gröne, J.(2);Schumann, M.(1);
(1)Charité Universitätsmedizin Berlin, Department for Gastroenterology- Rheumatology and Infectious Diseases, Berlin, Germany;(2)Charité Universitätsmedizin Berlin, Department of Visceral Surgery, Berlin, Germany;(3)Charité Universitätsmedizin Berlin, Institute of Pathology and Molecular Pathology, Berlin, Germany;
P048: Deep phenotyping of the peripheral immune cell compartment in Crohn‘s DiseaseECCO’23 Copenhagen
Year: 2023
Authors: Haag, L.M.(1)*;Walling, S.(2);Kunkel, D.(3);Hecker, J.(2);Letizia, M.(2);Huck, A.(2);Weidinger, C.(2);Glauben, R.(2);Kuehl, A.(4);Siegmund, B.(2);
(1)Charité Universitätsmedizin Berlin, Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Charité Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;(3)Berlin institute of Health, BIH Flow & Mass Cytometry Core Facility, Berlin, Germany;(4)Charité Universitätsmedizin Berlin, iPATH.Berlin – Core Unit Immunpathologie für Experimentelle Modelle, Berlin, Germany;
P049: Proteomic characterization of serum extracellular vesicles from newly diagnosed patients with inflammatory bowel diseaseECCO’23 Copenhagen
Year: 2023
Authors: Soleto, I.(1)*;Baldan, M.(1);Ramírez, C.(1);Orejudo, M.(1);García, S.(1);Mercado, J.(1);Azkargorta, M.(2);Lloro, I.(2);Ortega Moreno, L.(3);Aldars Garcia, L.(1);Riestra, S.(4);Rivero, M.(5);Gutiérrez, A.(6);Rodríguez-Lago, I.(7);Fernández, L.(8);Ceballos, D.(9);Benítez, J.M.(10);Aguas, M.(11);Bastón Rey, I.(12);Bermejo, F.(13);Casanova, M.J.(1);Lorente, R.(14);Ber, Y.(15);Ginard, D.(16);Esteve, M.(17);Elortza, F.(2);Gisbert, J.P.(1);Martin-Cofreces, N.(18);Chaparro, M.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Unit, Madrid, Spain;(2)Proteomics Platform- CIC bioGUNE- BRTA Basque Research & Technology Alliance- CIBERehd, Proteomics Platform, Derio, Spain;(3)Área de Farmacología y Nutrición y Bromatología. Departamento Ciencias Básicas de la Salud. Universidad Rey Juan Carlos, Gastroenterology Unit, Madrid, Spain;(4)Hospital Universitario Central de Asturias and Instituto de Investigación sanitaria del Principado de Asturias ISPA, Gastroenterology Unit, Asturias, Spain;(5)Hospital Universitario Marqués de Valdecilla and IDIVAL, Gastroenterology Unit, Santander, Spain;(6)Hospital General Universitario de Alicante, Gastroenterology Unit, Alicante, Spain;(7)Hospital Galdakao-Usansolo, Gastroenterology Unit, Vizcaya, Spain;(8)Hospital Clínico Universitario de Valladolid, Gastroenterology Unit, Valladolid, Spain;(9)Hospital Universitario de Gran Canaria Dr. Negrín, Gastroenterology Unit, Las Palmas de Gran Canaria, Spain;(10)Hospital Universitario Reina Sofía and IMIBIC, Gastroenterology Unit, Córdoba, Spain;(11)Hospital Universitari i Politecnic La Fe and Health Research Institute IISLaFe, Gastroenterology Unit, Valencia, Spain;(12)Complexo Hospitalario Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain;(13)Hospital Universitario de Fuenlabrada, Gastroenterology Unit, Madrid, Spain;(14)Hospital General Universitario de Ciudad Real, Gastroenterology Unit, Ciudad Real, Spain;(15)Hospital San Jorge, Gastroenterology Unit, Huesca, Spain;(16)Hospital Universitari Son Espases, Gastroenterology Unit, Palma de Mallorca, Spain;(17)Hospital Universitari Mutua Terrasa- Terrasa- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Unit, Terrasa, Spain;(18)Immunology Unit from Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa- Universidad Autonoma de Madrid UAM- Centro de Investigación Biomédica en Red Cardiovascular CIBERCV, Immunology Unit, Madrid, Spain;
P050: Intraperitoneally injected 3-dimensional cultured tonsil-derived mesenchymal stem cells in murine colitis model form aggregates with mouse immune cells: A preliminary studyECCO’23 Copenhagen
Year: 2023
Authors: Byeon, J.R.(1)*;Song, E.M.(1);Joo, Y.H.(1);Park, Y.(1);Shim , K.N.(1);Choe, A.R.(1);Tae, C.H.(1);Kim, S.E.(1);Moon, C.M.(1);Jung, H.K.(1);Hong, J.T.(1);Jung, S.A.(1);
(1)Ewha Womans University College of Medicine, Department of Internal Medicine, Seoul, Korea- Republic Of;
P051: Immune phenotypes in acute severe ulcerative colitisECCO’23 Copenhagen
Year: 2023
Authors: Meringer, H.(1)*;Canales-Herrerias, P.(2);Jha, D.(2);Livanos, A.(2);Jougon, J.(2);Cossarini, F.(3);Tankelevich, M.(2);Kayal, M.(2);Colombel, J.F.(2);Mehandru, S.(2);
(1)Assuta Ashdod medical center affiliated with Ben-Gurion university- Beer Sheva, Department of Gastroenterology and liver diseases, Ashdod, Israel;(2)Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, United States;(3)Icahn School of Medicine at Mount Sinai, Department of Infectious Diseases, New York, United States;
P052: IL-12p70 as a potential driver of pathogenic IL-17+IFNγ+ mucosal memory TIGITneg T cells in a subgroup of severe CD patientsECCO’23 Copenhagen
Year: 2023
Authors: Heredia, M.(1)*;Barendregt, D.M.H.(1);van den Bogaerdt, S.(1);Samsom, J.N.(1);
(1)Erasmus Medical Center, Laboratory of Pediatrics division Gastroenterology & Nutrition, Rotterdam, The Netherlands;
P053: Ustekinumab decreases circulating Th1, Th17, and MAIT cells in Crohn's diseaseECCO’23 Copenhagen
Year: 2023
Authors: Lord, J.(1)*;Konecny, A.(2);Shows, D.(1);
(1)Benaroya Research Institute, Translational Research, Seattle, United States;(2)University of Washington, Immunology, Seattle, United States;
P054: Secreted inflammatory protein profiles following treatment of ex-vivo human inflammatory bowel disease explants with licenced biologic therapiesECCO’23 Copenhagen
Year: 2023
Authors: Corcoran, R.(1)*;O'Connell, F.(2);O'Sullivan, J.(2);Kevans, D.(3);
(1)St James's Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity College Dublin, Trinity Translational Medicine Institute, Dublin, Ireland;(3)St James's Hospital, Department of Gastroenterology, Dublin, Ireland;
P055: Exosomal miR-103a-3p from Crohn's creeping fat-derived ASCs contributes to intestinal fibrosis by targeting TGFBR3 and activating fibroblastsECCO’23 Copenhagen
Year: 2023
Authors: Qian, W.(1)*;Li, Y.(2);Zhu, W.(2);
(1)Jinling Hospital- Medical School of Southeast University, Department of General Surgery, Nanjing, China;(2)Jinling Hospital, Department of General Surgery, Nanjing, China;
P056: Exposures linked with urban and rural living indicate that living in rural area but spending above 50% of daily-life in urban environment is linked with reduction in alpha-diversity, reduced rural index, and reduced microbial health index mirroring CD profileECCO’23 Copenhagen
Year: 2023
Authors: Haberman Ziv, Y.(1)*;Feng, R.(2);Mao, R.(2);Braun, T.(1);Zhuo, S.(2);Toren, I.(1);Efroni, G.(1);Malik, A.(3);Picard, O.(3);Yavzori, M.(3);Hadar, R.(1);Amir, A.(1);Chen, M.(2);Ben-Horin, S.(3);
(1)Sheba Medical Center, Pediatric Gastroenterology, Ramat Gan, Israel;(2)The First Affiliated Hospital- Sun Yat-Sen University, Gastroenterology, Guangzhou, China;(3)Sheba Medical Center, Gastroenterology, Ramat Gan, Israel;The Leona M. and Harry B. Helmsley Charitable Trust SOURCE consortium investigators
P057: Development and evaluation of the i-Tracker Certolizumab and i-Tracker Anti-Certolizumab kits: rapid and innovative tests intended for monitoring patients treated with Certolizumab.ECCO’23 Copenhagen
Year: 2023
Authors: Khater, G.(1)*;Noguier, G.(2);Daviere, S.(1);Guilbert, V.(2);Montaillier, C.(2);
(1)Theradiag, Theranostic, Croissy Beaubourg, France;(2)Theradiag, Research & Development, Croissy Beaubourg, France;
P058: Immunological effects of hepatitis B virus vaccination in inflammatory bowel disease patientsECCO’23 Copenhagen
Year: 2023
Authors: Soleto, I.(1)*;C. Marin, A.(1);Mora, I.(1);Villagrasa, J.R.(2);Baldan-Martin, M.(1);Ramírez, C.(1);Bernardo, D.(3);Chaparro, M.(1);P. Gisbert, J.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd- Madrid. Spain, gastrointestinal unit, Madrid, Spain;(2)Hospital Universitario de La Princesa, Unidad de medicina preventiva, Madrid, Spain;(3)Mucosal Immunology Lab- instituto de Biología y Genética Molecular IBGM- Universidad de Valladolid-CISC- Valladolid- Spain, Mucosal Immunology Lab, Valladolid, Spain;
P059: Klebicin as a novel therapy for Klebsiella infection managementECCO’23 Copenhagen
Year: 2023
Authors: Karaliute, I.(1)*;Tilinde, D.(1);Ramonaite, R.(1);Kupcinskas, J.(2);Misiunas, A.(3);Denkovskiene, E.(3);Gleba, Y.(4);Razanskiene, A.(3);Skieceviciene, J.(1);
(1)Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania;(2)Lithuanian University of Health Sciences, Department of Gastroenterology, Kaunas, Lithuania;(3)Nomads UAB, Nomads UAB, Vilnius, Lithuania;(4)Biozentrum Halle, Nomad Bioscience GmbH, Halle, Germany;