P040: Caspase-8 blockade attenuates NSAID-induced colitis and cell death via NLRP3 inflammasome and NF-κB activationECCO’23 CopenhagenYear: 2023
Authors: Singh, R.(1,2);Rossini, V.(1);Stockdale , S.(1);Draper, L.(1);Hill, C.(1,3);Nally, K.(1,4);Shanahan, F.(1);Andersson-Engels, S.(5,6);MelgarPhD, S.(1)*;
(1)University College Cork, APC Microbiome Ireland, Cork, Ireland;(2)University College Cork, School of Medicine- Department of Medicine-, Cork, Ireland;(3)University College Cork, School of Microbiology, Cork, Ireland;(4)University College Cork, School of Biochemistry and Cell Biology, Cork, Ireland;(5)University College Cork, Department of Physics, Cork, Ireland;(6)Tyndall National Institute, Irish Photonics Integration Centre, Cork, Ireland;
P041: The upregulation of tissue factor in colonic mesenchymal cells in active ulcerative colitis is associated with severe and resistant to treatment disease, but tofacitinib has not effect on itECCO’23 CopenhagenYear: 2023
Authors: Drygiannakis, I.(1)*;Tzenaki, N.(1);Archontoulaki, E.(2);Filidou, E.(3);Kandilogiannakis, L.(3);Valatas, V.(1);Kolios, G.(3);Koutroubakis, I.E.(1);
(1)University of Crete, Gastroenterology Research Laboratory- School of Medicine, Heraklion, Greece;(2)Democritus University of Thrace, Department of Molecular Biology and Genetics- School of Health Sciences, Alexandroupolis, Greece;(3)Democritus University of Thrace, Laboratory of Pharmacology- Department of Medicine- School of Health Sciences, Alexandroupolis, Greece;
P042: Distinct gene expression profile associated to inflammation and neoplastic progression in longstanding ulcerative colitisECCO’23 CopenhagenYear: 2023
Authors: Alsøe, L.(1);Lefol, Y.(2);Wennerström, A.B.(3);Liu, Y.(3);Andersen, S.N.(4);Klepp, P.(5);Brackmann, S.(6)*;Nilsen, H.(3);
(1)University of Oslo, Department of Clinical Molecular Biology Akershus University Hospital, Nordbyhagen, Norway;(2)University of Oslo, Department of Microbiology, Oslo, Norway;(3)University of Oslo, Department of Clinical Molecular Biology- Akershus University Hospital, Nordbyhagen, Norway;(4)University of Oslo, Department of Pathology- Akershus University Hospital, Nordbyhagen, Norway;(5)Lovisenberg Diakonale Hospital, Medical department, Oslo, Norway;(6)Akershus University Hospital, Department of Gastroenterology, Nordbyhagen, Norway;
P044: Ex vivo effects of infliximab on the long non-coding RNAs expression levels in Crohn´s diseaseECCO’23 CopenhagenYear: 2023
Authors: Baldan-Martin, M.(1)*;Rubín de Célix, C.(1);Orejudo, M.(1);Ortega, L.(2);Fernández-Tomé, S.(1,3);Soleto, I.(1);Ramírez, C.(1);Arroyo, R.(4);Fernández, P.(4);Santander, C.(1);Moreno-Monteagudo, J.A.(1);Casanova, M.J.(1);Casals, F.(1);Casabona, S.(1);Becerro, I.(1);Marigorta, U.M.(5);Aransay, A.M.(6);Bernardo, D.(7);Chaparro, M.(1);Gisbert, J.P.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Unit, Madrid, Spain;(2)Área de Farmacología y Nutrición y Bromatología. Departamento Ciencias Básicas de la Salud- Universidad Rey Juan Carlos, Departamento Ciencias Básicas de la Salud, Madrid, Spain;(3)Departamento de Nutrición y Ciencia de los Alimentos- Facultad de Farmacia- Universidad Complutense de Madrid, Departamento de Nutrición y Ciencia de los Alimentos, Madrid, Spain;(4)Instituto de Medicina Molecular Aplicada Nemesio Díez IMMA-ND- Facultad de Medicina. Universidad San Pablo CEU, Instituto de Medicina Molecular Aplicada Nemesio Díez, Madrid, Spain;(5)Integrative Genomics Lab- CIC bioGUNE-BRTA and IKERBASQUE- Basque Foundation for Science, Integrative Genomics Lab, Bilbao, Spain;(6)Genome Analysis Platform- CIC bioGUNE-BRTA and CIBERehd, Genome Analysis Platform, Derio, Spain;(7)Mucosal Immunology Lab- Unidad de Excelencia Instituto de Biomedicina y Genética Molecular IGBM- Universidad de Valladolid-CSIC and Centro de Investigación Biomédica en Red de Enfermedades Infecciosas CIBERINFEC, Mucosal Immunology Lab, Valladolid, Spain;
P045: Local administration of extracellular vesicles from adipose-derived stromal cells promote healing in a rat model of radiation colitis – a pilot studyECCO’23 CopenhagenYear: 2023
Authors: Sebbagh, A.(1)*;Mathieu, N.(2);Demarquay, C.(2);Geiger, M.(2);Sémont, A.(2);Simon, C.(3);Branchu, J.(3);Milliat, F.(2);Gazeau, F.(1);Wilhelm, C.(4);Silva Brun, A.(1);Rahmi, G.(5,6);
(1)Laboratoire Matière et Systèmes Complexes UMR 7057- Université Paris Cité/CNRS, MSC-Med, Paris, France;(2)Institut de radioprotection et de sûreté Nucléaire IRSN, PSE-SANTE/SERAMED/LRMed, Fontenay-aux-Roses, France;(3)EVerZom company, Internal research and development, Paris, France;(4)Institut Curie, Physico-Chimie Curie CNRS UMR 168, Paris, France;(5)Hôpital Européen Georges Pompidou- APHP.Centre – Université de Paris, Department of Gastroenterology and Endoscopy, Paris, France;(6)Paris Cardiovascular Research Center, Laboratoire Imagerie de l'Angiogénèse- Plateforme d'Imagerie du Petit Animal- Inserm UMR 970, Paris, France;
P046: Crohn Disease (CD) untargeted fecal metabolome shows strong correlation with specific salivary associated microbial taxa, and with disease activityECCO’23 CopenhagenYear: 2023
Authors: Levhar, N.(1)*;Hadar, R.(1);Braun, T.(1);Efroni, G.(1);Abramovich, I.(2);Gottlieb, E.(2);Granot, M.(1);Neuman, S.(3);Selinger, L.(3);Picard, O.(3);Yavzori, M.(3);Lahat, A.(3);Eliakim, R.(3);Weiss, B.(1);Kopylov, U.(3);Ben-Horin, S.(3);Amir, A.(1);Haberman Ziv, Y.(1);
(1)Sheba Medical Center, Pediatric Gastroenterology, Ramat Gan, Israel;(2)Technion Institute, The Ruth and Bruce Rappaport- Faculty of Medicine, Haifa, Israel;(3)Sheba Medical Center, Gastroenterology, Ramat Gan, Israel;
P047: Osteopontin in colitis-associated carcinoma (CAC)ECCO’23 CopenhagenYear: 2023
Authors: Manna, S.(1)*;Sehn, M.(2);Cardoso da Silva, D.(1);Heldt, C.(1);Horstkorte, L.(1);Elezkurtaj, S.(3);Siegmund, B.(1);Weixler, B.(2);Hummel, M.(3);Gröne, J.(2);Schumann, M.(1);
(1)Charité Universitätsmedizin Berlin, Department for Gastroenterology- Rheumatology and Infectious Diseases, Berlin, Germany;(2)Charité Universitätsmedizin Berlin, Department of Visceral Surgery, Berlin, Germany;(3)Charité Universitätsmedizin Berlin, Institute of Pathology and Molecular Pathology, Berlin, Germany;
P048: Deep phenotyping of the peripheral immune cell compartment in Crohn‘s DiseaseECCO’23 CopenhagenYear: 2023
Authors: Haag, L.M.(1)*;Walling, S.(2);Kunkel, D.(3);Hecker, J.(2);Letizia, M.(2);Huck, A.(2);Weidinger, C.(2);Glauben, R.(2);Kuehl, A.(4);Siegmund, B.(2);
(1)Charité Universitätsmedizin Berlin, Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Charité Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;(3)Berlin institute of Health, BIH Flow & Mass Cytometry Core Facility, Berlin, Germany;(4)Charité Universitätsmedizin Berlin, iPATH.Berlin – Core Unit Immunpathologie für Experimentelle Modelle, Berlin, Germany;
P049: Proteomic characterization of serum extracellular vesicles from newly diagnosed patients with inflammatory bowel diseaseECCO’23 CopenhagenYear: 2023
Authors: Soleto, I.(1)*;Baldan, M.(1);Ramírez, C.(1);Orejudo, M.(1);García, S.(1);Mercado, J.(1);Azkargorta, M.(2);Lloro, I.(2);Ortega Moreno, L.(3);Aldars Garcia, L.(1);Riestra, S.(4);Rivero, M.(5);Gutiérrez, A.(6);Rodríguez-Lago, I.(7);Fernández, L.(8);Ceballos, D.(9);Benítez, J.M.(10);Aguas, M.(11);Bastón Rey, I.(12);Bermejo, F.(13);Casanova, M.J.(1);Lorente, R.(14);Ber, Y.(15);Ginard, D.(16);Esteve, M.(17);Elortza, F.(2);Gisbert, J.P.(1);Martin-Cofreces, N.(18);Chaparro, M.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Unit, Madrid, Spain;(2)Proteomics Platform- CIC bioGUNE- BRTA Basque Research & Technology Alliance- CIBERehd, Proteomics Platform, Derio, Spain;(3)Área de Farmacología y Nutrición y Bromatología. Departamento Ciencias Básicas de la Salud. Universidad Rey Juan Carlos, Gastroenterology Unit, Madrid, Spain;(4)Hospital Universitario Central de Asturias and Instituto de Investigación sanitaria del Principado de Asturias ISPA, Gastroenterology Unit, Asturias, Spain;(5)Hospital Universitario Marqués de Valdecilla and IDIVAL, Gastroenterology Unit, Santander, Spain;(6)Hospital General Universitario de Alicante, Gastroenterology Unit, Alicante, Spain;(7)Hospital Galdakao-Usansolo, Gastroenterology Unit, Vizcaya, Spain;(8)Hospital Clínico Universitario de Valladolid, Gastroenterology Unit, Valladolid, Spain;(9)Hospital Universitario de Gran Canaria Dr. Negrín, Gastroenterology Unit, Las Palmas de Gran Canaria, Spain;(10)Hospital Universitario Reina Sofía and IMIBIC, Gastroenterology Unit, Córdoba, Spain;(11)Hospital Universitari i Politecnic La Fe and Health Research Institute IISLaFe, Gastroenterology Unit, Valencia, Spain;(12)Complexo Hospitalario Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain;(13)Hospital Universitario de Fuenlabrada, Gastroenterology Unit, Madrid, Spain;(14)Hospital General Universitario de Ciudad Real, Gastroenterology Unit, Ciudad Real, Spain;(15)Hospital San Jorge, Gastroenterology Unit, Huesca, Spain;(16)Hospital Universitari Son Espases, Gastroenterology Unit, Palma de Mallorca, Spain;(17)Hospital Universitari Mutua Terrasa- Terrasa- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Unit, Terrasa, Spain;(18)Immunology Unit from Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa- Universidad Autonoma de Madrid UAM- Centro de Investigación Biomédica en Red Cardiovascular CIBERCV, Immunology Unit, Madrid, Spain;
P050: Intraperitoneally injected 3-dimensional cultured tonsil-derived mesenchymal stem cells in murine colitis model form aggregates with mouse immune cells: A preliminary studyECCO’23 CopenhagenYear: 2023
Authors: Byeon, J.R.(1)*;Song, E.M.(1);Joo, Y.H.(1);Park, Y.(1);Shim , K.N.(1);Choe, A.R.(1);Tae, C.H.(1);Kim, S.E.(1);Moon, C.M.(1);Jung, H.K.(1);Hong, J.T.(1);Jung, S.A.(1);
(1)Ewha Womans University College of Medicine, Department of Internal Medicine, Seoul, Korea- Republic Of;
P051: Immune phenotypes in acute severe ulcerative colitisECCO’23 CopenhagenYear: 2023
Authors: Meringer, H.(1)*;Canales-Herrerias, P.(2);Jha, D.(2);Livanos, A.(2);Jougon, J.(2);Cossarini, F.(3);Tankelevich, M.(2);Kayal, M.(2);Colombel, J.F.(2);Mehandru, S.(2);
(1)Assuta Ashdod medical center affiliated with Ben-Gurion university- Beer Sheva, Department of Gastroenterology and liver diseases, Ashdod, Israel;(2)Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, United States;(3)Icahn School of Medicine at Mount Sinai, Department of Infectious Diseases, New York, United States;
P053: Ustekinumab decreases circulating Th1, Th17, and MAIT cells in Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Lord, J.(1)*;Konecny, A.(2);Shows, D.(1);
(1)Benaroya Research Institute, Translational Research, Seattle, United States;(2)University of Washington, Immunology, Seattle, United States;
P054: Secreted inflammatory protein profiles following treatment of ex-vivo human inflammatory bowel disease explants with licenced biologic therapiesECCO’23 CopenhagenYear: 2023
Authors: Corcoran, R.(1)*;O'Connell, F.(2);O'Sullivan, J.(2);Kevans, D.(3);
(1)St James's Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity College Dublin, Trinity Translational Medicine Institute, Dublin, Ireland;(3)St James's Hospital, Department of Gastroenterology, Dublin, Ireland;
P056: Exposures linked with urban and rural living indicate that living in rural area but spending above 50% of daily-life in urban environment is linked with reduction in alpha-diversity, reduced rural index, and reduced microbial health index mirroring CD profileECCO’23 CopenhagenYear: 2023
Authors: Haberman Ziv, Y.(1)*;Feng, R.(2);Mao, R.(2);Braun, T.(1);Zhuo, S.(2);Toren, I.(1);Efroni, G.(1);Malik, A.(3);Picard, O.(3);Yavzori, M.(3);Hadar, R.(1);Amir, A.(1);Chen, M.(2);Ben-Horin, S.(3);
(1)Sheba Medical Center, Pediatric Gastroenterology, Ramat Gan, Israel;(2)The First Affiliated Hospital- Sun Yat-Sen University, Gastroenterology, Guangzhou, China;(3)Sheba Medical Center, Gastroenterology, Ramat Gan, Israel;The Leona M. and Harry B. Helmsley Charitable Trust SOURCE consortium investigators
P057: Development and evaluation of the i-Tracker Certolizumab and i-Tracker Anti-Certolizumab kits: rapid and innovative tests intended for monitoring patients treated with Certolizumab.ECCO’23 CopenhagenYear: 2023
Authors: Khater, G.(1)*;Noguier, G.(2);Daviere, S.(1);Guilbert, V.(2);Montaillier, C.(2);
(1)Theradiag, Theranostic, Croissy Beaubourg, France;(2)Theradiag, Research & Development, Croissy Beaubourg, France;
P058: Immunological effects of hepatitis B virus vaccination in inflammatory bowel disease patientsECCO’23 CopenhagenYear: 2023
Authors: Soleto, I.(1)*;C. Marin, A.(1);Mora, I.(1);Villagrasa, J.R.(2);Baldan-Martin, M.(1);Ramírez, C.(1);Bernardo, D.(3);Chaparro, M.(1);P. Gisbert, J.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd- Madrid. Spain, gastrointestinal unit, Madrid, Spain;(2)Hospital Universitario de La Princesa, Unidad de medicina preventiva, Madrid, Spain;(3)Mucosal Immunology Lab- instituto de Biología y Genética Molecular IBGM- Universidad de Valladolid-CISC- Valladolid- Spain, Mucosal Immunology Lab, Valladolid, Spain;
P059: Klebicin as a novel therapy for Klebsiella infection managementECCO’23 CopenhagenYear: 2023
Authors: Karaliute, I.(1)*;Tilinde, D.(1);Ramonaite, R.(1);Kupcinskas, J.(2);Misiunas, A.(3);Denkovskiene, E.(3);Gleba, Y.(4);Razanskiene, A.(3);Skieceviciene, J.(1);
(1)Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania;(2)Lithuanian University of Health Sciences, Department of Gastroenterology, Kaunas, Lithuania;(3)Nomads UAB, Nomads UAB, Vilnius, Lithuania;(4)Biozentrum Halle, Nomad Bioscience GmbH, Halle, Germany;
