1. To understand the role of head to head trials in positioning therapies

2. To be familiar with the large pipeline of new agents for IBD including the late stage products focused on JAK inhibition, anti-p19 (interleukin 23) antibodies, and S1P modulators

3. To be familiar with the multiple agents targeting gut delivery that in early stage development

4. To be familiar with the evolving role of precision medicine and artificial intelligence in the care of IBD patients

5. To be familiar with novel clinical trial approaches are increasingly being employed in IBD including adaptive design, umbrella trials, basket trials, and platform trials

Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic, progressive, disabling condition. Since strategies targeting the control of symptoms do not significantly change the natural course of the diseases, mucosal healing has become the therapeutic goal to prevent disease recurrence and structural damage. However, frequent colonoscopies (CS) are expensive, invasive, and not well tolerated by patients, thus non-invasive tools for assessment and monitoring are strongly needed.

Bowel ultrasound (US) is a well-tolerated, non-invasive, patient friendly, cheap, easy-to-use tool to manage IBD patients in clinical practice. In addition, its ability to be performed as point-of-care bowel US may drastically change frequency of the assessment of treatment response, speeding the clinical decision-making process

This presentation aims to review the evidence for the use of bowel US, alternatively to CS, for the assessment and monitoring of disease activity in IBD.

Technical features of Entero-MRI (E-MRI) will be briefly illustrated from basic to advanced sequences.
Imaging findings of ileal Crohn’s disease will be reviewed in this talk with emphasis on their clinical meaning according to literature and Ecco/Esgar  statements.
After this talk participants of the workshop will be able to approach in a critical manner E-MRI studies and MRI structured reports giving a guide to appreciate those findings more relevant in clinical practice in patient management.
Emphasis will be given in the definition of relevant findings such as strictures, penetrating lesions, edema and fibrosis of bowel wall.
Criteria to assess inflammation activity as well as  MR scores of activity will be illustrated.
Strength and weak points  of E-MRI will be discussed

Educational objectives: 

1. To understand the risk management prior to surgery and how to prevent enterocutaneous fistulas
2. To briefly understand the pre- and peroperative management of enterocutaneous fistulas

Educational objectives:
1. To understand the rationale for FMT as a treatment for IBD.
2. To be updated on trial data for FMT in IBD.
3. To understand some emerging predictors of efficacy for FMT in IBD.
4. To understand the infrastructural needs for FMT as a therapy.
5. To understand the evolving regulatory landscape and governance issues for FMT.

Educational objectives
•What is fermentation? What are fermented food?
•History of fermented foods
•Do fermented foods necessarily contain live microorganisms?
•Are fermented foods the same as probiotic foods?
•Do microorganisms in fermented foods become established in the gut or influence gut microbiota?
•Do fermented foods provide health benefits?
• Main studies on fermented foods and gastrointestinal tract: yogurt, cheese, kefir , sourdough bread, sauerkraut, kimchi, fermented soy products

new endpoints for multiple orphan indications are being defined in this lecture

Inflammation in the Inflammatory bowel diseases may be driven by diet , as evidenced to date by the return of inflammation in patients transitioning from exclusive enteral nutrition to partial enteral nutrition. Exclusion diets such as the Crohn’s disease exclusion diets cause a decrease in inflammation and mucosal healing in Crohn’s disease. These findings suggest that certain dietary components may be one of the culprits in driving the surge of IBD around the globe. One of the key suspects are dietary additives.
In the current talk we will review the effects of dietary additives such as:
maltodextrins
carrageenans
 gums
emulsifiers
and the effects upon the microbiome and goblet cells.

Elucidate factors that help to make the successful transition from the bench to research group leader.

Understand the clinical features of IBD
Recognise the endoscopic findings in IBD
Review the potential treatments for IBD

1. To understand the objectives and necessity of head to head trials of new targeted therapies against active comparators in IBD

2. To understand the types of head to head trials in IBD

3. To follow the details of completed head to head trials in IBD and their conclusions

4. To interpret recently completed head to head trials in IBD 

Hot topics list (2020-2021)
1.Disease mechanisms
2.(Differential) diagnoses
3.COVID-19
4.Endoscopy scoring
5.Histology
6.Clinical trials involving histology
7.IBD-associated neoplasia

1. To address the importance of developing high-quality guidelines
2. To address some of the issues behind guideline quality variability
3. To discuss the different domains that dictate standards of quality in guidelines

We will review the following items with respect to IBD:
1. History & epidemiology
2. pathogenesis 
3. genetics
4. environmental factors

Educational objectives: 

1. To emphasise the role of investigator-initiated studies compared to phase 3 randomized controlled trials in assessing the safety profile of IBD related treatments
2. To review the definition of real world data and the different types of real world data
3. To provide examples on investigator-initiated cohorts assessing the safety profile of IBD related treatments
4. To have an overview of the main administrative health databases used in the assessment of the safety profile of IBD related treatment

Aims of this talk are to:

     - Introduce the concepts of machine learning
     - Relay how machine learning is currently being applied in the filed of IBD
     - Present some applications using 'Omics data
     - Suggest how advancing applications might relate to treatment in IBD