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P027: Comparing the immunological signatures of inflammatory diseasesECCO '17 Barcelona
Year: 2017
Authors:

McDonald E.*1, Wright P.1, Zangerle-Murray T.2, Jung J.1, Gaya D.3, Siebert S.1, McInnes I.1, Milling S.1

1University of Glasgow, Infection, Immunity and Inflammation, Glasgow, United Kingdom 2University of Manchester, Manchester, United Kingdom 3Glasgow Royal Infirmary, Glasgow, United Kingdom

P028: Oligonol attenuates dextran sulfate sodium-induced colitis and reduces flare-UP in mice by enhancing host defense mechanismECCO '17 Barcelona
Year: 2017
Authors:

Kim K.-J.*1, Park J.-M.2, Han Y.-M.2, Lee S.G.2, Shin S.A.2, Hahm K.-B.2

1Asan Medical Center, Gastroenterology, Seoul, South Korea 2Cha Bundang Medical Center, Cha University, Department of Gastroenterology, Seongnam-Si, South Korea

P029: Azelnidipine, a novel calcium channel blocker, ameliorates severity of colitis in DSS induced colitis in mice possibly by modulating tissue levels of TNF-alpha and IL-6ECCO '17 Barcelona
Year: 2017
Authors:

Kav T., Akyol A., Aksoy E., Ozer C., Torgutalp M., Sivri B.

Hacettepe University, Gastroenterology, Ankara, Turkey

P030: Inhibitory activity of 6-amino-2,4,5-trimethylpyridin-3-ols against inflammatory cell adhesion and recruitment to colon epitheliumECCO '17 Barcelona
Year: 2017
Authors:

Jeong B.-S.*1, Banskota S.1, Kang H.-e.2, Kim J.-A.1, Nam T.-g.2

1Yeungnam University, College of Pharmacy, Gyeongsan, South Korea 2Hanyang University, College of Pharmacy, Ansan, South Korea

P031: Identification of alternative splicing in transcript isoforms in patients with ulcerative colitis: effects of disease durationECCO '17 Barcelona
Year: 2017
Authors:

Low E.N.D.*1, Wong Z.1, Ngiu C.S.1, Nazefah A.H.2, Rafiz A.R.3, Mokhtar N.1, Raja Ali R.A.1

1Universiti Kebangsaan Malaysia, Medicine, Kuala Lumpur, Malaysia 2Universiti Sains Islam Malaysia, Medicine, Kuala Lumpur, Malaysia 3Universiti Teknologi MARA, Medicine, Kuala Lumpur, Malaysia

P032: The pharmacological profile of TOP1288, a narrow spectrum kinase inhibitor in clinical development as an anti-inflammatory treatment for ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Foster M.*1, Biancheri P.2, Fyfe M.1, MacDonald T.3, Rowley A.1, Sirohi S.1, Solanke Y.1, Webber S.1, Walshe C.1

1Topivert Pharma Ltd, London, United Kingdom 2University of East Anglia, Norwich Medical School, Norwich, United Kingdom 3Barts and London School of Medicine and Dentistry, Centre of Immunobiology, London, United Kingdom

P033: DSS-induced colitis is attenuated in sigma-1 receptor knockout miceECCO '17 Barcelona
Year: 2017
Authors:

Lόpez-Estévez S.*1, Aguilera M.1, Gris G.2, de la Puente B.2, Codony X.2, Zamanillo D.2, Martínez V.1

1Universitat Autònoma de Barcelona, Cell Biology, Physiology and Immumology, Bellaterra, Spain 2Esteve, Department of Pharmacology, Drug Discovery & Preclinical Development, Barcelona, Spain

P034: Altered microbiota and host-bacterial interactions during the spontaneous development of colitis in IL-10 knockout miceECCO '17 Barcelona
Year: 2017
Authors:

Lόpez-Estévez S., Aguilera M., Martínez V.

Universitat Autònoma de Barcelona, Cell Biology, Physiology and Immumology, Bellaterra, Spain

P035: TNF-driven pathways are increased at baseline in Crohn's disease patients not responding to infliximabECCO '17 Barcelona
Year: 2017
Authors:

Verstockt B.*1,2, Arijs I.1,3,4, de Bruyn M.1,5, Verstockt S.6, Van Assche G.1,7, Breynaert C.8, Vermeire S.1,7, Ferrante M.1,7

1KU Leuven, Department of Clinical and Experimental Medicine, TARGID-IBD, Leuven, Belgium 2University of Cambridge, School of Clinical Medicine, Cambridge, Biomedical Campus, Department of Medicine and Cambridge Institute for Medical Research, Cambridge, United Kingdom 3Hasselt University, Faculty of Medicine and Life Sciences, Hasselt, Belgium 4Jessa Hospital, Hasselt, Belgium 5KU Leuven, Rega Institute for Medical Research, Department of Microbiology and Immunology, Leuven, Belgium 6KU Leuven, Laboratory of Complex Genetics, Department of Human Genetics, Leuven, Belgium 7University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium 8KU Leuven, Laboratory of Clinical Immunology, Department of Microbiology and Immunology, Leuven, Belgium

P036: Human peripheral blood monocytes and intestinal macrophage populations activate transforming growth factor beta via expression of the integrin alpha v beta 8ECCO '17 Barcelona
Year: 2017
Authors:

Shuttleworth E.*1,2,3, Kelly A.1,2,3, Fenton T.1,2,3, Smedley C.1,2,3, Levison S.4, Travis M.1,2,3

1University of Manchester, MCCIR, Manchester, United Kingdom 2University of Manchester, Wellcome Trust Centre for Cell-Matrix Research, Manchester, United Kingdom 3University of Manchester, Manchester Immunology Group, Manchester, United Kingdom 4Central Manchester NHS Hospitals Foundation Trust, Department of Gastroenterology, Manchester, United Kingdom

P037: MDR1-deficiency unmasks mitochondrial dysfunction as a pathogenic mechanism in IBDECCO '17 Barcelona
Year: 2017
Authors:

Ho G.-T.*1, Aird R.1, Boyapati R.1, Liu B.2, Kennedy N.1, Shimizu T.3, Sartor B.2, Satsangi J.1

1University of Edinburgh, MRC Centre for Inflammation Research, Edinburgh, United Kingdom 2University of North Carolina, Chapel Hill, United States 3University of Chiba, Chiba, Japan

P038: Tissue differences in the pro-inflammatory activation of ER stress of patients with Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Coope A.*1, Botezelli J.D.2, Bitencourt Pascoal L.1, Ramos Silva F.1, Ayrizono M.L.S.1, Milanski M.2, Velloso L.A.3, Leal R.F.1

1University of Campinas, Coloproctology Unit, Surgery Department, Campinas, Brazil 2University of Campinas, Campinas, Brazil 3University of Campinas, Laboratory of Cell Signaling, Internal Medicine Department, Campinas, Brazil

P039: Suppression of phospholipase A2 of intestinal microbiota by the phospholipid-bile acid conjugate ursodeoxycholate-lysophoshatidylethanolamide ameliorates mucosal inflammation in a genetic mouse model of ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Stremmel W., Staffer S., Stuhrmann N., Gauss A., Burger N., Hornuss D.

University Hospital of Heidelberg, Internal Medicine IV, Dept. of Gastroenterology, Heidelberg, Germany

P040: Intestinal EP4 receptor is required for homeostasis of the colon in miceECCO '17 Barcelona
Year: 2017
Authors:

Matsumoto Y., Fukuda A., Seno H.

Kyoto University Graduate School of Medicine, Gastroenterology and Hepatology, Kyoto, Japan

P041: C-jun n-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestineECCO '17 Barcelona
Year: 2017
Authors:

Mandić A.D.1, Bennek E.1, Verdier J.1, Zhang K.2, Roubrocks S.1, Davis R.J.3, Denecke B.4, Gassler N.5, Streetz K.6, Kel A.7, Hornef M.2, Cubero F.J.1, Trautwein C.1, Sellge G.*1

1University Hospital RWTH Aachen, Department of Internal Medicine III, Aachen, Germany 2University Hospital RWTH Aachen, Department of Microbiology, Aachen, Germany 3Howard Hughes Medical Institute and University of Massachusetts Medical School, Worcester, United States 4University Hospital RWTH Aachen, Interdisciplinary Center for Clinical Research (IZKF), Aachen, Germany 5Klinikum Braunschweig, Institute of Pathology, Braunschweig, Germany 6Gemeinschaftsklinikum Mittelrhein - Kemperhof, Department of Gastroenterology, Kobelnz, Germany 7geneXplain GmbH, Wolfenbüttel, Germany

P042: Expression of IL-38 and their antagonists in patients with inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Fonseca Camarillo G.*1, Furuzawa Carballeda J.2, Iturriaga Goyon E.1, Yamamoto Furusho J.K.1

1Instituto Nacional de Ciencias Médicas y Nutriciόn Salvador Zubiran, Inflammatory Bowel Disease Clinic. Department of Gastroenterology, Mexico City, Mexico 2Instituto Nacional de Ciencias Médicas y Nutriciόn, Department of Immunology and Rheumatology, Mexico, Mexico

P043: Ulcerative colitis is characterised by an exaggerated onset of acute inflammation with delayed resolutionECCO '17 Barcelona
Year: 2017
Authors:

Marks D.*1,2, Wysoczanski R.1, Kendall A.3, Motwani M.4, Vega R.2, Rahman F.2, McCartney S.2, Bloom S.2, Nicolaou A.3, Gilroy D.4, Segal A.1

1University College London, Molecular Medicine, London, United Kingdom 2University College London Hospital, Gastroenterology, London, United Kingdom 3University of Manchester, Division of Pharmacy and Optometry, Manchester, United Kingdom 4University College London, Clinical Pharmacology, London, United Kingdom

P044: Therapeutic effects of mesenchymal stem cells induced regulatory dendritic cells on chronic colitis model in miceECCO '17 Barcelona
Year: 2017
Authors:

Kim H.-S.*1, Jo H.1, Eom Y.W.2, Cho M.Y.3

1Yonsei University Wonju College of Medicine, Internal medicine, Wonju, South Korea 2Yonsei University Wonju College of Medicine, Cell Therapy and Tissue Engineering Center, Wonju, South Korea 3Yonsei University Wonju College of Medicine, Pathology, Wonju, South Korea

P045: 5-Aminosalicylates promote inflammation resolution in ulcerative colitis through generation of anti-inflammatory hydroxy fatty acidsECCO '17 Barcelona
Year: 2017
Authors:

Wysoczanski R.*1, Kendall A.2, Motwani M.3, Vega R.4, Rahman F.4, McCartney S.4, Bloom S.4, Nicolaou A.2, Gilroy D.3, Segal A.1, Marks D.1,4

1University College London, Molecular Medicine, London, United Kingdom 2University of Manchester, Division of Pharmacy and Optometry, Manchester, United Kingdom 3University College London, Clinical Pharmacology, London, United Kingdom 4University College London Hospital, Gastroenterology, London, United Kingdom

P046: Starch consumption is associated with serologic responses in patients with ulcerative colitis and an ileo-anal pouchECCO '17 Barcelona
Year: 2017
Authors:

Goren I.1,2, Godny L.2,3, Maharshak N.3,4, Tulchinsky H.4,5, Dotan I.*2,5

1Tel Aviv Medical Center, IBD unit, Department of Gastroenterology and hepatology, Tel Aviv, Israel 2Sackler Faculty of Medicine, Tel Aviv Israel, IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 3Tel Aviv Medical Center, IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 4Sackler Faculty of Medicine, Tel Aviv Israel, Department of Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 5Tel Aviv Medical Center, Tel Aviv Israel, Pouch Clinic, IBD Center, Tel Aviv, Israel