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DOP027: Long-term efficacy and safety of ustekinumab in refractory Crohn's disease patients: a multicenter retrospective experienceECCO '17 Barcelona
Year: 2017
Authors:

Wils P.*1, Bouhnik Y.2, Michetti P.3, Flourie B.4, Brixi H.5, Bourrier A.6, Allez M.7, Duclos B.8, Serrero M.9, Buisson A.10, Amiot A.11, Fumery M.12, Roblin X.13, Peyrin-Biroulet L.14, Filippi J.15, Bouguen G.16, Abitbol V.17, Coffin B.18, Simon M.19, Laharie D.20, Pariente B.1

1University of Lille 2, Department of Gastroenterology, Lille, France 2Beaujon Hospital, Gastroenterology Unit, Clichy, France 3University Hospital Lausanne, Division of Gastroenterology & Hepatology, Lausanne, Switzerland 4Centre Hospitalier Lyon-Sud, Service d'Hépato-gastro-entérologie, Lyon, France 5CHU de Reims, Gastroenterologie, Reims, France 6University Hospital of Saint Antoine, APHP, Gastroenterology, Paris, France 7APHP, Hopital Saint Louis, Department of Gastroenterology, Paris, France 8Université de Strasbourg, Gastroenterology, Strasbourg, France 9Hospital Nord Assistance Publique de Marseille, Department of Gastroenterology, Marseille, France 10Clermont-Ferrand University, Clermont-Ferrand, France 11Hospital Henri-Mondor, Department of Gastroenterology, Creteil, France 12Amiens University Hospital, Gastroenterology, Amiens, France 13University of Saint Etienne, Department of Gastroenterology, Saint Etienne, France 14CHU Nancy, Department of Gastroenterology, Nancy, France 15CHU de Nice, Department of Gastroenterology, Nice, France 16CHU Rennes, Department of HepatoBiliary Surgery and Digestive, Rennes, France 17Cochin University Hospital, Gastroenterology, Paris, France 18Hopital Louis-Mourier, Gastroenterologie, Colombes, France 19Institut Mutualiste Montsouris, Gastroenterology, Paris, France 20CHU de Bordeaux, Gastroenterology, Pessac, France

DOP028: Antibodies towards vedolizumab appear from week 2 onwards and disappear upon treatmentECCO '17 Barcelona
Year: 2017
Authors:

Bian S.*1, Tang H.T.1, Peeters M.1, Compernolle G.1, Dreesen E.1, Van Assche G.2, Ferrante M.2, Vermeire S.2, Gils A.1

1KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium 2University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium

DOP029: Clinical relevance of detecting anti-infliximab antibodies with a drug-tolerant assay: post-hoc analysis of the taxit trialECCO '17 Barcelona
Year: 2017
Authors:

Van Stappen T.*1, Vande Casteele N.1, Van Assche G.2, Ferrante M.2, Vermeire S.2, Gils A.1

1KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium 2UZ Leuven, Department of Clinical and Experimental Medicine, Leuven, Belgium

DOP030: Anti-TNF re-induction is as effective, simpler and cheaper compared with dose interval shortening following secondary loss of response in Crohn's disease: a dual centre “real world” studyECCO '17 Barcelona
Year: 2017
Authors:

Srinivasan A.*1, Vasudevan A.1,2,3, McFarlane A.1, Gibson P.2,3, Sparrow M.2,3, van Langenberg D.1,2

1Eastern Health, Gastroenterolgy, Melbourne, Australia 2Monash University, Melbourne, Australia 3Alfred Health, Gastroenterology, Melbourne, Australia

DOP031: Subtherapeutic serum infliximab trough levels and complete mucosal healing are associated with sustained clinical remission after infliximab discontinuation in paediatric Crohn's disease patientsECCO '17 Barcelona
Year: 2017
Authors:

Kang B.*1, Lee K.1, Kim K.2, Lee J.H.3, Choe Y.H.1

1Samsung Medical Center, Sungkyunkwan University School of Medicine, Department of Pediatrics, Seoul, South Korea 2Samsung Medical Center, Biostatistics and Clinical Epidemiology Center, Seoul, South Korea 3Chungbuk National University Hospital, Chungbuk National University College of Medicine, Department of Pediatrics, Cheongju, South Korea

DOP032: Hydrocortisone premedication withdrawal in patients on stable infliximab maintenance: clinical and pharmacokinetic outcomesECCO '17 Barcelona
Year: 2017
Authors:

Tran-Minh M.-L.*1, Maillet M.1, Auzolle C.1,2, Simon M.3, Cathala A.L.1, Aparicio T.1,2, Baudry C.1, Bonnet J.1, Lourenco N.1, Houze P.4, Gornet J.-M.1, Allez M.1,2

1Saint Louis Hospital, Gastroenterology, Paris, France 2INSERM, U940, Paris, France 3Institut Montsouris, Gastroenterology, Paris, France 4Saint Louis Hospital, Pharmacology, Paris, France

DOP033: Severely active ulcerative colitis is associated with high baseline infliximab clearance, reduced serum half-life and worse endoscopic outcomesECCO '17 Barcelona
Year: 2017
Authors:

Vande Casteele N.*1,2, Jairath V.3,4, Levesque B.1,2, Feagan B.3,4, Sandborn W.1,2

1University of California, San Diego, United States 2Robarts Clinical Trials, Inc., San Diego, United States 3University of Western Ontario, London, Canada 4Robarts Clinical Trials, Inc., London, Canada

DOP034: Serum adalimumab concentration 3 months after surgery is correlated with endoscopic recurrence in Crohn's disease patients treated with adalimumab for prevention of postoperative recurrenceECCO '17 Barcelona
Year: 2017
Authors:

Boivineau L.*1, Bourgaux J.F.2, Pineton de Chambrun G.1, Caillo L.2, Danan G.1, Boitard J.1, Liautard J.1, Guillon F.1, Altwegg R.1

1CHU St Eloi, Hepato-gastro-enterology, Montpellier, France 2CHU Nimes, Hepato-Gastro-Enterology, Nimes, France

DOP035: High gammaglobulin and low albumin serum levels independently predict secondary loss of response to anti-TNFα therapy in IBDECCO '17 Barcelona
Year: 2017
Authors:

Schoenefuss F., Hoffmann P.

Kliniken Essen Mitte, Gastroenterology, Essen, Germany

DOP036: The therapeutic efficacy of anti-TNF requires Fc-gamma receptors and can be improved by antibody hypo-fucosylationECCO '17 Barcelona
Year: 2017
Authors:

Bloemendaal F.*1, Levin A.2, Wildenberg M.2, Koelink P.2, Visser R.3, Claassens J.4, Bradford M.5, D'Haens G.2, Verbeek S.4, Vidarsson G.3, van den Brink G.2

1University of Amsterdam, Gastroenterology, Amsterdam, Netherlands 2Academic Medical Center, Gastroenterology, Amsterdam, Netherlands 3Sanquin Research, Department of Experimental Immunohematology, Amsterdam, Netherlands 4Leiden University Medical Center, Department of Human Genetics, Leiden, Netherlands 5Abbvie Bioresearch Center, Worcester, United States

DOP037: A model for prediction of early surgery and complications in paediatric Crohn's disease: results of the prospective GROWTH CD studyECCO '17 Barcelona
Year: 2017
Authors:

Levine A.*1,2, Hussey S.3, Kolho K.L.4, Sladek M.5, de Carpi J.M.6, Turner D.7, Russell R.K.8, Cohen-Dolev N.9, Escher J.10 Porto-ECCO GROWTH CD Study Group

1Edith Wolfson Medical Center, Department of Paediatric Gastroenterology and Nutrition Unit, Holon, Israel 2Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel 3National Children's Research Centre, UCD and RCSI, Dublin, Ireland 4Children's Hospital, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland 5Jagiellonian University Medical College, Krakow, Poland 6Hospital Sant Joan de Deu, Department of Paediatric Gastroenterology, Barcelona, Spain 7Shaare Zedek Medical Center, Department of Paediatric Gastroenterology, Jerusalem, Israel 8The Royal Hospital for Children, Department of Paediatric Gastroenterology, Glasgow, United Kingdom 9Edith Wolfson Medical Center, PIBD Research Center, Department of Paediatric Gastroenterology and Nutrition Unit, Holon, Israel 10Children's Hospital Erasmus MC Sophia, Department of Paediatric Gastroenterology, Rotterdam, Netherlands

DOP038: Increased number of enteric glial cells in proximal margin of resection is associated with postoperative recurrence of Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Li Y., Zhu W., Gong J., Guo Z.

Jinling Hospital, Medical School of Nanjing University, Department of General Surgery, Nanjing, China

DOP039: Postoperative infectious complications in Crohn's disease: results from PRACTICROHN studyECCO '17 Barcelona
Year: 2017
Authors:

Gutiérrez A.*1, Taxonera C.2, García V.3, Minguez M.4, Martín Arranz M.D.5, Castro M.6, Barreiro-de Acosta M.7, Juliá B.8, Cea-Calvo L.8, Romero C.8, Domènech E.9

1Hospital General Universitario Alicante, Gastroenterology unit, Alicante, Spain 2Hospital Clinico San Carlos, Gastroenterology Unit, Madrid, Spain 3Hospital Universitario Reina Sofia, Unidad Clinica de Aparato Digestivo, Cordoba, Spain 4Unidad de Gastroenterología, Hospital General de Valencia, Valencia, Spain 5Hospital Universitario La Paz, Gastroenterology Unit, Madrid, Spain 6Unidad de Gastroenterología, Hospital de Valme, Sevilla, Spain 7Complejo Hospitalario Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain 8MSD Spain, Medical Department, Madrid, Spain 9Hospital Universitari Germans Trias i Pujol and CIBERehd, Gastroenterology Unit, Badalona, Spain

DOP040: Postoperative surgical recurrence in Crohn's disease decreases significantly in the biologic eraECCO '17 Barcelona
Year: 2017
Authors:

Beelen E.M.J.*1, Schouten W.R.2, Oldenburg B.3, van der Meulen-de Jong A.E.4, Ponsioen C.I.J.5, Dijkstra G.6, Pierik M.J.7, de Jong D.J.8, de Boer N.K.H.9, van der Woude C.J.1, De Vries A.C.1

1Erasmus MC, Department of Gastroenterology and Hepatology, Rotterdam, Netherlands 2Erasmus MC, Department of General Surgery, Rotterdam, Netherlands 3University Medical Center Utrecht, Department of Gastroenterology and Hepatology, Utrecht, Netherlands 4Leiden University Medical Center, Department of Gastroenteorlogy and Hepatology, Leiden, Netherlands 5Academic Medical Center (AMC), Department of Gastroenterology and Hepatology, Amsterdam, Netherlands 6University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands 7Maastricht University Medical Center (MUMC), Department of Gastroenterology and Hepatology, Maastricht, Netherlands 8Radboud University Medical Centre, Department of Gastroenterology and Hepatology, Nijmegen, Netherlands 9VU University Medical Centre, Department of Gastroenterology and Hepatology, Amsterdam, Netherlands

DOP041: Prepouch ileitis after ileal pouch anal anastomosis for ulcerative colitis: patterns of presentation and risk factors for failure of treatmentECCO '17 Barcelona
Year: 2017
Authors:

Rottoli M., Vallicelli C., Bigonzi E., Di Simone M., Gionchetti P., Boschi L., Poggioli G.

Alma Mater Studiorum University of Bologna, Sant'Orsola - Malpighi Hospital, Digestive Disease, Bologna, Italy

DOP042: Omentectomy is not necessary during laparoscopic total coloproctectomy and ileal pouch-anal anastomosis for inflammatory bowel disease. A comparative study in 247 consecutive patients from 4 expert centresECCO '17 Barcelona
Year: 2017
Authors:

Mege D.*1, Germain A.2, Stellingwerf M.3, Colombo F.4, Maggiori L.1, De Buck van Overstraeten A.2, Buskens C.3, Foschi D.4, Sampietro G.4, Bemelman W.3, D'Hoore A.2, Panis Y.1

1Beaujon Hospital, Colorectal Surgery, Clichy, France 2Leuven, Digestive Surgery, leuven, Belgium 3AMC, Digestive Surgery, Amsterdam, Netherlands 4ASST, Digestive Surgery, Milan, Italy

DOP043: High risk of pouch dysplasia in IBD-PSC patients following total proctocolectomyECCO '17 Barcelona
Year: 2017
Authors:

Palmela C.*1,2, Castaneda D.3, Shah S.1, ten Hove J.4, Ullman T.1, Itzkowitz S.H.1, Torres J.1,2

1Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, United States 2Hospital Beatriz Ângelo, Department of Gastroenterology, Loures, Portugal 3Mount Sinai St. Luke's and Mount Sinai West Hospitals, Division of Internal Medicine, New York, United States 4University Medical Center Utrecht, Department of Gastroenterology and Hepatology, Utrecht, Netherlands

DOP044: Relationship between microbiota and development of early postoperative Crohn's disease recurrenceECCO '17 Barcelona
Year: 2017
Authors:

Machiels K.*1, Pascal V.2, Sabino J.1, Santiago A.2, Campos D.2, Wolthuis A.3, De Buck van Overstraeten A.3, D'Hoore A.3, Van Assche G.1, Ferrante M.1, Rutgeerts P.1, Manichanh C.2, Vermeire S.1

1University Hospitals Leuven, KU Leuven, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium 2Vall d'Hebron Research Institute, Barcelona, Spain 3University Hospitals Leuven, Department of Abdominal Surgery, Leuven, Belgium

DOP045: Post-operative complications in elderly-onset inflammatory bowel disease: a population-based studyECCO '17 Barcelona
Year: 2017
Authors:

Sacleux S.-c.*1, Charpentier C.1, Sarter H.2, Fumery M.3, Guillon-Dellac N.4, Laberenne E.5, Pariente B.6, Peyrin-biroulet L.7, Gower-Rousseau C.8, Savoye G.1

1CHU Rouen, Department of Gastroenterology and Hepatology, Rouen, France 2CHRU Lille, Department of Biostatistics EA 2694, Lille, France 3Amiens University Hospital, Department of Gastroenterology and Hepatology, Amiens, France 4CHRU Lille, Department of Epidemiology, Lille, France 5CH Seclin, Department of Gastroenterology, Seclin, France 6CHRU Lille, Department of Gastroenterology, Lille, France 7CHU Nancy, Department of Gastroenterology and Hepatology, Vandoeuvre-Lès-Nancy, France 8CHRU Lille, Department of Epidemiology, EPIMAD Registry, Lille, France

DOP046: Genome-wide association study of baseline disease characteristics and response to Ustekinumab in moderate to severe Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Hart A., Li K., Gasink C., Jacobstein D., Brodmerkel C.

Janssen Research & Development, LLC, Spring House, United States