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P025: Tonsil-derived mesenchymal stem cell ameliorate intestinal fibrosis in chronic murine colitis modelECCO '16 Amsterdam

Year: 2016

Authors:

E. M. Song*¹, S.-A. Jung¹, S.-E. Kim¹, K. E. Lee¹, J. Y. Chang¹, H. M. Son¹, M. S. Ryu¹, Y. H. Joo¹, C. H. Tae¹, C. M. Moon¹, H.-K. Jung¹, K.-N. Shim¹, I. H. Jo², Y. S. Yu²

¹Ewha Woman’s University School of Medicine, Department of Internal Medicine, Ewha Medical Research Institute, Seoul, South Korea, ²Ewha Woman’ University School of Medicine, Department of Molecular Medicine, Ewha Medical Research Institute, Seoul, South Korea

P026: Characterisation of mucosal CD4+ T-cells in peripheral blood of healthy controls and paediatric inflammatory bowel disease patientsECCO '16 Amsterdam

Year: 2016

Authors:

M. Joosse*¹, C. Menckeberg¹, L. de Ruiter¹, H. Raatgeep¹, L. van Berkel¹, F. Muskens², R. Hendriks², R. Hoogenboezem³, T. Cupedo³, L. de Ridder⁴, H. Escher⁴, S. Veenbergen¹, J. Samsom¹

¹Erasmus MC, Laboratory of Paediatrics, division Gastroenterology and Nutrition, Rotterdam, Netherlands, ²Erasmus MC, Department of Pulmonary Medicine, Rotterdam, Netherlands, ³Erasmus MC, Department of Haematology, Rotterdam, Netherlands, ⁴Erasmus MC, Department of Paediatric Gastroenterology, Rotterdam, Netherlands

P027: Characterisation of human intestinal dendritic cells and macrophages through the lower gastrointestinal tract.ECCO '16 Amsterdam

Year: 2016

Authors:

D. Bernardo*, A. C. Marín, P. M. Linares, M. Jiménez, M. Chaparro, J. P. Gisbert

Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Gastroenterology Unit, Madrid, Spain

P028: Inflammatory bowel disease is associated with cytoskeleton rearrangement in the epithelial cellsECCO '16 Amsterdam

Year: 2016

Authors:

A. Portyanko¹, P. Perevoschikov¹, K. Ruksha¹, J. Gorgun*²

¹Belarusian State Medical University, Department of Pathology, Minsk, Belarus, ²Belarusian Medical Academy of Postgraduate Education, Department of Gastroenterology and Nutrition, Minsk, Belarus

P029: Intestinal mesenchymal-specific IKK2 promotes initiation of colitis and colitis-associated cancerECCO '16 Amsterdam

Year: 2016

Authors:

V. Koliaraki*¹, M. Pasparakis², G. Kollias^{1, 3}

¹BSRC "Alexander Fleming", Vari, Greece, ²University of Cologne, Institute of Genetics, Cologne, Germany, ³University of Athens, Department of Physiology, Athens, Greece

P030: Development of small bowel tissue phantom for microultrasound  investigationECCO '16 Amsterdam

Year: 2016

Authors:

T. Anbarasan*¹, C. E. M. Démoré¹, H. Lay², M. R. S. Sunoqrot¹, R. Poltarjonoks¹, S. Cochran², B. F. Cox¹

¹University of Dundee, Dundee, United Kingdom, ²University of Glasgow, Glasgow, United Kingdom

P031: STAT6 deficiency alters macrophage polarisation and promotes fibrosis in a murine model of chronic inflammationECCO '16 Amsterdam

Year: 2016

Authors:

P. Salvador*¹, D. Ortiz-Masiá¹, D. C. Macias-Ceja^{1, 2}, J. Cosín-Roger¹, L. Gisbert-Ferrándiz¹, C. Hernández², S. Calatayud¹, M. D. Barrachina-Sancho¹

¹University of Valencia, Valencia, Spain, ²Fisabio Hospital Peset, Valencia, Spain

P032: IFN-γ controls the immunomodulatory properties of bone marrow mesenchymal stem cells via a microRNA29a/STAT-3 dependent mechanismECCO '16 Amsterdam

Year: 2016

Authors:

A. Oikonomopoulos*¹, P. Lacey¹, T. Tomakili¹, D. Iliopoulos²,  D. W. Hommes¹

¹UCLA Centre for Inflammatory Bowel Diseases, Division of Digestive Diseases, Los Angeles, California, United States, ²UCLA Centre for Systems Biomedicine, Division of Digestive Diseases, Los Angeles, California, United States

P033: Anti-TNF-α therapy normalises aberrant cytokine production and homing profile of circulating dendritic cells in Crohn’s diseaseECCO '16 Amsterdam

Year: 2016

Authors:

P. Hendy*^{1, 2}, D. Reddi², D. Bernardo³, L. Durant², A. Noble², N. English², S. Knight², A. Hart¹

¹St Mark’s Hospital, Gastroenterology, LONDON, United Kingdom, ²Imperial College, Antigen Presentation Research Group, London, United Kingdom, ³Hospital Universitario de La Princesa, Department of Immunology, Madrid, Spain

P034: Immunoregulatory properties of human adipose–derived stem cells in inflammatory diseases: differences between Crohn´s disease and obesityECCO '16 Amsterdam

Year: 2016

Authors:

C. Serena*^{1, 2}, N. Keiran², M. Millan², M. Ejarque^{1, 2}, R. Fradera³, E. Espin⁴, K. Roche^{1, 2}, J. Vendrell^{1, 2}, S. Fernandez-Veledo^{1, 2}

¹Health Institute Pere Virgili, Research Unit, Tarragona, Spain, ²Hospital Joan XXIII, Tarragona, Spain, ³Hospital St. Pau i Sta Tecla, Tarragona, Spain, ⁴Hospital Vall d’Hebron, Barcelona, Spain

P035: Lamina propria CD4+LAP+ Foxp3- regulatory cells are involved in limiting the disease extension in Ulcerative ColitisECCO '16 Amsterdam

Year: 2016

Authors:

A. Butera¹, A. Amendola¹, M. Sanchez², S. Piroli³, A. Pronio³, D. De Nitto⁴, R. Pica⁴, M. Boirivant*¹

¹Istituto Superiore di Sanità, Dept Infectious, Parasitic and Immune-mediated Diseases, Roma, Italy, ²Istituto Superiore di Sanità, Dept Cell Biology and Neurosciences, Rome, Italy, ³University ‘Sapienza’, Dept General Surgery, ‘P. Stefanini’, Roma, Italy, ⁴Sandro Pertini Hospital, IBD, GE Unit, Roma, Italy

P036: Colon targeted delivery of tofacitinib inhibits oxazolone-induced colitis in mice, despite low systemic exposureECCO '16 Amsterdam

Year: 2016

Authors:

F. Shen*, P. Brassil, S. Hegde, D. Beattie

Theravance Biopharma, South San Francisco, California, United States

P037: Remodelling events preceding clinical onset of intestinal inflammation reveal the predictive power of the extracellular matrix ECCO '16 Amsterdam

Year: 2016

Authors:

E. Shimshoni*¹, R. Afik¹, L. Puricelli², A. Shenoy³, T. Geiger³, A. Podestà², I. Sagi¹

¹Weizmann Institute of Science, Biological Regulation, Rehovot, Israel, ²University of Milan, Physics, Milan, Italy, ³Tel Aviv University, Human Genetics, Tel Aviv, Israel

P038: Revised roles of matrix metalloproteinase/MMP-9 in inflammatory bowel diseases: from target to biomarkerECCO '16 Amsterdam

Year: 2016

Authors:

M. de Bruyn*^{1, 2}, C. Breynaert³, I. Arijs², G. De Hertogh⁴, K. Geboes⁴, G. Thijs¹, J. Hu⁵, J. Van Damme¹, B. Arnold⁶, M. Ferrante⁷, S. Vermeire⁷, G. Van Assche⁷, J. Ceuppens³, G. Opdenakker¹

¹Rega Institute for Medical Research, KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium, ²Translational Research Centre for Gastrointestinal Disorders (TARGID), KU Leuven, Department of Clinical and Experimental Medicine, Leuven, Belgium, ³Laboratory of Clinical Immunology, KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium, ⁴Translational Cell and Tissue Research, KU Leuven, Department of Imaging and Pathology, Leuven, Belgium, ⁵Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Ministry of Education, Nanjing, China, ⁶German Cancer Research Centre (DKFZ), Department of Molecular Immunology, Heidelberg, Germany, ⁷University Hospitals Leuven, KU Leuven, Department of Gastroenterology, Leuven, Belgium

P039: Expression of the liver homing receptor CXCR3+ on colonic CD8+ T lymphocytes in patients with primary sclerosing cholangitis provides a possible link between colonic and biliary duct inflammation.ECCO '16 Amsterdam

Year: 2016

Authors:

M. Lampinen*¹, A. Fredricsson¹, J. Vessby¹, A. Wanders², F. Rorsman¹, M. Carlson¹

¹Uppsala University, Medical Sciences, Uppsala, Sweden, ²Umeå University, Medical Biosciences, Umeå, Sweden

P040: Sonic hedgehog inhibitor prevented colitis-associated cancer via concerted mechanisms of IL-6/gp130 inhibition, 15-prostaglandin dehydrogenase induction, Bcl-2 abrogation, and tumour sphere inhibitionECCO '16 Amsterdam

Year: 2016

Authors:

K. B. Hahm*¹, N. Kangwan¹, Y. J. Kim²

¹CHA University, Gastroenterology, Seongnam, South Korea, ²Gachon University, Gastroenterology, Incheon, South Korea

P041: Automated image analysis as a diagnostic tool in discriminating between subgroups of microscopic colitisECCO '16 Amsterdam

Year: 2016

Authors:

A.-M. Kanstrup-Fiehn¹, M. Kristensson², U. H. Engel³, L. K. Munck^{4, 5},  S. Holck³, P. J. H. Engel*^{1, 5}

¹Roskilde Hospital, Department of Pathology, Roskilde, Denmark, ²Visiopharm, Hoersholm, Denmark, ³Copenhagen University Hospital, Department of Pathology, Hvidovre, Denmark, ⁴Koege Sygehus, Department of Gastroenterology, Koege, Denmark, ⁵University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark

P042: Circulating IL9 in inflammatory bowel disease: possible marker of mucosal non-healingECCO '16 Amsterdam

Year: 2016

Authors:

K. Neubauer*¹, M. Krzystek-Korpacka², M. Matusiewicz², M. Zawadzki³, I. Bednarz-Misa², S. Górska⁴, W. Witkiewicz⁵, A. Gamian^{6, 7}

¹Wroclaw Medical University, Gastroenterology and Hepatology, Wroclaw, Poland, ²Wroclaw Medical University, Medical Biochemistry, Wroclaw, Poland, ³Regional Specialist Hospital, Vascular Surgery, Wroclaw, Poland, ⁴LudwikHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Laboratory of Medical Microbiology, Wroclaw, Poland, ⁵Research and Development Centre at Regional Specialist Hospital, Wroclaw, Poland, ⁶Medical Wroclaw University, Medical Biochemistry, Wroclaw, Poland, ⁷LudwikHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

P043: Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitisECCO '16 Amsterdam

Year: 2016

Authors:

N. Duijvis*¹, C. Kunne¹, M. Slaman¹, F. van Dooren¹, E. Vogels¹, S. Meijer², K. Fluiter³, P. Moerland³, A. te Velde¹

¹Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, ²Academic Medical Centre (AMC), Department of Pathology, Amsterdam, Netherlands, ³Academic Medical Centre (AMC), Department of Clinical Epidemiology, Amsterdam, Netherlands

P044: Roles of IL-33 on murine colitis and M2 macrophage differentiation in inflammatory bowel diseasesECCO '16 Amsterdam

Year: 2016

Authors:

D. H. Seo*^{1, 2}, M. S. Kawk¹, X. Che^{1, 2}, H. W. Ma^{1, 2}, J. H. Kim^{1, 2}, D. H. Kim¹, T. I. Kim¹, W. H. Kim¹, S. W. Kim^{1, 2, 3}, J. H. Cheon^{1, 2, 3}

¹Yonsei University, Department of Internal Medicine and Institute of Gastroenterology, College of Medicine, Seoul, South Korea, ²Yonsei University, Brain Korea 21 PLUS Project for Medical Science, College of Medicine, Seoul, South Korea, ³Yonsei University, Severance Biomedical Science Institute, College of Medicine, Seoul, South Korea