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P005: Variability in Vedolizumab Exposure between Patients with Inflammatory Bowel DiseaseECCO '16 Amsterdam
Year: 2016
Authors:

A. Gils1, E. Dreesen*1, M. Peeters1, E. Brouwers1, M. Ferrante2, G. Van Assche2, S. Vermeire2

1KU Leuven, P.O. Box 820 Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium, 2KU Leuven, P.O. Box 7003, Department of Clinical and Experimental Medicine, Leuven, Belgium

P006: Correlation of small intestinal permeability, faecal calprotectin and barrier genes in multiple-affected families with inflammatory bowel diseaseECCO '16 Amsterdam
Year: 2016
Authors:

M. Vancamelbeke*1, V. Ballet1, A. Luypaerts1, T. Vanuytsel1, M. Ferrante1, R. Farré1, K. Verbeke1, S. Vermeire1, I. Cleynen2

1University Hospitals Leuven - KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Centre for Gastrointestinal Disorders (TARGID), Leuven, Belgium, 2KU Leuven, Department of Human Genetics, Leuven, Belgium

P007: IL-36 α expression is elevated in ulcerative colitis and promotes colonic inflammationECCO '16 Amsterdam
Year: 2016
Authors:

S. E. Russell1, 2, R. M. Horan1, 2, A. M. Stefanska1, 2, A. Carey1, 2, 
G. Leon2, M. Aguilera3, D. Statovci3, T. Moran2, P. G. Fallon2, F. Shanahan3, E. K. Brint4, S. Melgar*3, S. Hussey2, 5, P. T. Walsh1, 2

1Trinity College Dublin, Dublin, Ireland, 2National Children’s Research Centre, Our Lady’s Children Hospital, Dublin, Ireland, 3University College Cork, APC Microbiome Institute, Cork, Ireland, 4University College Cork, Department of Pathology, Cork, Ireland, 5University College Dublin, Academic Centre for Paediatric Research, Dublin, Ireland

P008: Targeting of TSLP by miR-31 may play an important role in mucosal healing, in ulcerative colitis.ECCO '16 Amsterdam
Year: 2016
Authors:

S. Whiteoak*1, 2, A. Claridge1, 3, T. Sanchez-Elsner*1, J. F. Cummings2

1University of Southampton, Clinical and Experimental Sciences, Southampton, United Kingdom, 2University of Southampton, Department of Gastroenterology, Southampton, United Kingdom, 3Great Western Hospitals NHS Foundation Trust, Department of Gastroenterology, Swindon, United Kingdom

P009: Lipid biomarkers to diagnose Crohn’s disease using metabonomic profiling approach in serum and faeces.ECCO '16 Amsterdam
Year: 2016
Authors:

N. S. Ding*1, 2, M. Sarafian1, 2, R. Misra1, P. Hendy1, L. Penez1, E. Holmes2, A. Hart1

1St Mark’s Hospital, IBD, London, United Kingdom, 2Imperial College London, Department of Surgery and Cancer, London, United Kingdom

P010: Infliximab skews macrophages towards an IL10-high/IL12p40-low phenotype in an Fc region dependent mannerECCO '16 Amsterdam
Year: 2016
Authors:

F. Bloemendaal*1, M. Wildenberg1, A. Levin1, P. Koelink1, A.C. Vos2, G. D’Haens1, G. van den Brink1

1Academic Medical Centre, Gastroenterology, Amsterdam, Netherlands, 2Leiden University Medical Centre, Gastroenterology, Leiden, Netherlands

P011: Distinct inflammatory signatures in primary sclerosing cholangitis associated with inflammatory bowel diseaseECCO '16 Amsterdam
Year: 2016
Authors:

A. Gwela1, P. Siddhanathi1, R. W. Chapman1, C. Arancibia1, S. P .L. Travis1, F. Powrie2, A. Geremia*1

1John Radcliffe Hospital, Department of Translational Gastroenterology, Oxford, United Kingdom, 2University of Oxford, Kennedy Institute for Rheumatology, Oxford, United Kingdom

P012: MAIT cell activation reflects mucosal inflammation in ulcerative colitisECCO '16 Amsterdam
Year: 2016
Authors:

K. Haga*1, A. Chiba2, T. Shibuya1, T. Osada1, D. Ishikawa1, T. Kodani1, O. Nomura1, S. Watanabe1, S. Miyake2

1Juntendo University, Department of Gastroenterology, Tokyo, Japan, 2Juntendo University, Department of Immunology, Tokyo, Japan

P013: Automated image analysis in the diagnosis of microscopic colitis: validation and implications for diagnosis and researchECCO '16 Amsterdam
Year: 2016
Authors:

P. J. H. Engel*1, 2, L. K. Munck2, 3, U. H. Engel4, S. Holck4, A.-M. Kanstrup-Fiehn1, M. Kristensson5

1Roskilde Hospital, Department of Pathology, Roskilde, Denmark, 2University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark, 3Koege Sygehus, Department of Gastroenterology, Koege, Denmark, 4Copenhagen University Hospital, Department of Pathology, Hvidovre, Denmark, 5Visiopharm, Hoersholm, Denmark

P014: Tofacitinib and a selective Janus kinase 1 inhibitor are equally potent in suppressing human macrophage function and T-cell proliferationECCO '16 Amsterdam
Year: 2016
Authors:

L. De Vries*1, 2, M. Wildenberg2, V. Ludbrook3, G. D’Haens1, 
W. De Jonge2

1Academic Medical Centre (AMC), Gastroenterology & Hepatology, Amsterdam, Netherlands, 2Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 3GlaxoSmithKline, ImmunoInflammation Therapy Area, Stevenage, United Kingdom

P015: Interaction between enteric glia and myeloid cells as critical players in intestinal immune homeostasis.ECCO '16 Amsterdam
Year: 2016
Authors:

G. Goverse*, M. Stakenborg, M. van Winge, E. Labeeuw, G. Farro, M. Hao, P. J. Gomez Pinilla, G. Boeckxstaens, G. Matteoli

KU Leuven, P.O. Box 701, Department of Clinical and Experimental Medicine, Leuven, Belgium

P016: Guggulsterone ameliorates colitis by suppressing TREM-1 hyperactivation and modulating macrophage phenotypesECCO '16 Amsterdam
Year: 2016
Authors:

X. Che*1, 2, K. C. Park3, S. J. Park1, 4, Y. H. Kang1, H. A. Jin1, 2, D. H. Seo1, 2, S. W. Kim1, 2, 4, T. I. Kim1, W. H. Kim1, J. H. Cheon1, 2, 4

1Yonsei University, Internal Medicine and Institute of Gastroenterology, Seoul, South Korea, 2Yonsei University, Brain Korea 21 PLUS Project for Medical Science, Seoul, South Korea, 3Yonsei University, Seoul, South Korea, 4Severance Biomedical Science Institute, Seoul, South Korea

P017: Periostin aggravates the development of colitis-associated colon cancer in miceECCO '16 Amsterdam
Year: 2016
Authors:

S.-J. Koh*1, J. W. Kim1, B. G. Kim1, K. L. Lee1, J. S. Kim2

1Seoul National University Boramae Hospital, Seoul National University College of Medicine, Internal Medicine, Seoul, South Korea, 2Seoul National University College of Medicine, Internal Medicine and Liver Research Institute, Seoul, South Korea

P018: Biologic functions between non-affected and affected margins of ileum samples from Crohn’s disease patients who will develop post-surgical recurrence.ECCO '16 Amsterdam
Year: 2016
Authors:

V. Loren*1, 2, A. Garcia-Jaraquemada1, A. Aterido3, F. Kamberovic1, A. Julià3, Y. Zabana4, A. Alonso3, M. Mañosa2, 5, S. Marsal3, E. Domènech2, 5, E. Cabré2, 5, J. Manyé2, 6

1Health Sciences Research Institute of the ‘Germans Trias i Pujol’ Foundation (IGTP), Inflammatory Bowel Disease Unit, Badalona, Spain, 2Centro de Investigación Biomédica en Red (CIBER), Madrid, Spain, 3Institute for research in Biomedicine, Rheumatology Research Group, Barcelona, Spain, 4Mútua de Terrassa Hospital, Terrassa, Spain, 5Germans Trias i Pujol Hospital, Inflammatory Bowel Disease Unit, Badalona, Spain, 6Health Sciences Research Institute of the ‘Germans Trias i Pujol’ Foundation (IGTP), Inflammatory Bowel Disease Unit, Badalona, Spain

P019: Informing ulcerative colitis pathophysiology and outcomes through metabolic pofilingECCO '16 Amsterdam
Year: 2016
Authors:

S. Fong*1, C. Le Roy2, J. Sanderson1, S. Claus2

1Guy’s and St Thomas’ NHS Foundation Trust, IBD Centre, London, United Kingdom, 2University of Reading, Department of Food and Nutritional Sciences, Reading, United Kingdom

P020: The efficacy of tofacitinib and a selective Janus kinase 1 inhibitor in dextran sulphate sodium colitis modelsECCO '16 Amsterdam
Year: 2016
Authors:

L. De Vries*1, 2, F. van Leeuwen-Hilbers2, P. van Hamersveld2, V. Ludbrook3, G. D’Haens1, W. De Jonge2

1Academic Medical Centre (AMC), Gastroenterology & Hepatology, Amsterdam, Netherlands, 2Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 3GlaxoSmithKline, Immuno-Inflammation Therapy Area, Stevenage, United Kingdom

P021: Inflammatory monocytes are key regulators of colonic inflammation in murine and human IBDECCO '16 Amsterdam
Year: 2016
Authors:

G.-R. Jones*1, P. Cook2, A. MacDonald2, T. Fenton2, A. Kelly2, M. Travis2, S. Campbell3

1University of Edinburgh, Gastroenterology, Edinburgh, United Kingdom, 2University of Manchester, Department of Immunology, Manchester, United Kingdom, 3University of Manchester / Manchester Royal Infirmary, Department of Gastroenterology, Jean Mcfarlane Building; School for Nursing, Manchester, United Kingdom

P022: Parthenolide enhances the efficacy of anti-tumour effect of balsalazide in human colon cancer cells and colitis-associated colorectal cancer by blockade of NF-kB activationECCO '16 Amsterdam
Year: 2016
Authors:

G. S. Seo1, S.-L. Kim2, S. W. Kim*2

1Wonkwang university college of medicine, Internal medicine, Iksan, South Korea, 2Chonbuk national university hospital, Internal medicine, Jeonju, South Korea

P023: Development of methods to investigate effects of narrow spectrum kinase inhibitors on cellular phosphorylation of kinase substratesECCO '16 Amsterdam
Year: 2016
Authors:

S. Sirohi*, M. Foster, M. Fyfe, Y. Solanke, S. Webber, C. Walshe

Topivert Pharma, London, United Kingdom

P024: Therapeutic potential of the human amniotic fluid mesenchymal stem cells/stroma cells secreted molecules in a mice model of colitisECCO '16 Amsterdam
Year: 2016
Authors:

M. Gazouli*1, E. Legaki1, M. Roubelakis1, A. Lazaris2, G. Karamanolis3, E. Marinos1, G. Theodoropoulos4

1School of Medicine, University of Athens, Biology, Athens, Greece, 2School of Medicine, University of Athens, Pathology, Athens, Greece, 3School of Medicine, University of Athens, Gastroenterology, Athens, Greece, 4School of Medicine, University of Athens, Surgery, Athens, Greece