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P114: Fecal loss of infliximab is underestimated due to proteolysisECCO '17 Barcelona
Year: 2017
Authors:

Strik A.*1, Brandse J.1, Koelink P.2, Wildenberg M.2, De Vries A.3, Boshuizen R.3, van den Brink G.1, D'Haens G.1

1Academic Medical Center, Gastroenterology and Hepatology, Amsterdam, Netherlands 2Academic Medical Center (AMC), Tytgat Institute for Intestinal and Liver Research, Amsterdam, Netherlands 3Sanquin Blood Supply - Diagnostic Services, Biologicals Laboratory, Amsterdam, Netherlands

P115: Escherichia coli Nissle 1917 modulate gut microbiota composition in ulcerative colitis patientsECCO '17 Barcelona
Year: 2017
Authors:

Graziani C.1, Petito V.1, Del Chierico F.2, Mangiola F.1, Pecere S.1, Schiavoni E.1, Pizzoferrato M.1, Lopetuso L.R.1, Putignani L.2, Gasbarrini A.1, Scaldaferri F.*1

1Fondazione Policlinico Gemelli, Università Cattolica del Sacro Cuore, Gastroenterological Area, Gastroenterological and Endocrino-Metabolical Sciences Department, Rome, Italy 2Bambino Gesù Children Hospital, Department of Microbiology, Rome, Italy

P116: Escherichia coli Nissle 1917 distinctively regulates apoptosis and cell cycling of Caco-2 cellsECCO '17 Barcelona
Year: 2017
Authors:

Schirbel A.*1, Sturm A.2

1Charité Campus Virchow Klinikum, Berlin, Germany 2DRK Klinikum Westend, Gastroenterology, Berlin, Germany

P117: Functional implications of microRNAs in Crohn's disease revealed by integrating microRNA and messenger RNA expression profilingECCO '17 Barcelona
Year: 2017
Authors:

Palmieri O.*1, Creanza T.2, Bossa F.1, Latiano T.1, Corritore G.1, Palumbo O.3, Martino G.1, Biscaglia G.1, Scimeca D.1, Carella M.3, Ancona N.2, Andriulli A.1, Latiano A.1

1IRCCS, Casa Sollievo della Sofferenza, Hospital, UOC Gastroenterology, San Giovanni Rotondo, Italy 2CNR, Institute of Intelligent Systems for Automation, Bari, Italy 3IRCCS, Casa Sollievo della Sofferenza, Hospital, Medical Genetics, San Giovanni Rotondo, Italy

P118: Balancing JAK/STAT-signaling with Tofacitinib in monocytes of healthy controls and IBD patientsECCO '17 Barcelona
Year: 2017
Authors:

Cordes A.F.*1, Lenker E.2, Weinhage T.2, Varga G.2, Foell D.2

1University Hospital Münster, Department of Gastroenterology, Münster, Germany 2University Children's Hospital Münster, Department of Pediatric Rheumatology and Immunology, Münster, Germany

P119: Higher levels of infliximab may alleviate the need of azathioprine comedication in the treatment of patients with Crohn's disease: a SONIC post hoc analysisECCO '17 Barcelona
Year: 2017
Authors:

Colombel J.-F.*1, Adedokun O.J.2, Gasink C.2, Tang K.2, Cornillie F.3, D'Haens G.4, Rutgeerts P.5, Reinisch W.6, Sandborn W.7, Hanauer S.8

1Icahn School of Medicine at Mt Sinai, New York, United States 2Janssen Research & Development, LLC, Spring House, United States 3MSD International GmbH, Kriens, Switzerland 4Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands 5University Hospital, Gasthuisberg, Leuven, Belgium 6Universitätsklinik für Innere Medizin III and McMaster University, Vienna and Hamilton, Austria 7University of California San Diego, La Jolla, United States 8Northwestern University Feinberg School of Medicine, Chicago, United States

P120: A single-nucleotide polymorphism in the vitamin D receptor gene is associated with a B3-penetrating phenotype in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Gisbert-Ferrándiz L.*1, Salvador P.1, Ortiz-Masiá D.1, Macias-Ceja D.C.2, Calatayud S.1,3, Hinojosa J.4, Oltra-Camps L.4, Barrachina M.D.1,3, Hernández C.2

1University of Valencia, Valencia, Spain 2Fisabio Hospital Dr Peset, Valencia, Spain 3CIBERehd, Valencia, Spain 4Hospital of Manises, Valencia, Spain

P121: Antimicrobial antibodies and inflammatory markers are present in the serum of patients with IBD years before diagnosis and can predict diseaseECCO '17 Barcelona
Year: 2017
Authors:

Torres J.*1, Wang P.2, Princen F.3, Stockfisch T.3, Petralia F.2, Choung R.S.4, Telesco S.5, Strauss R.5, Porter C.6, Murray J.4, Riddle M.6, Colombel J.-F.1

1Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, United States 2Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York, United States 3Prometheus Lab Inc., San Diego, United States 4Mayo Clinic, Gastroenterology, Rochester, United States 5Janssen R&D, Spring House, United States 6Naval Medical Research Center, Silver Spring, United States

P122: Magnetic resonance index of activity (MaRIA) and Clermont score are two MRI indices which are highly and equally effective in detecting mucosal healing in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Buisson A.*1,2, Pereira B.3, Goutte M.1,2, Reymond M.1, Allimant C.1, Bommelaer G.1,2, Hordonneau C.4

1University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France 2UMR 1071 Inserm/Université d'Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the host, Clermont-Ferrand, France 3University Hospital, Biostatistics Unit, DRCI, Clermont-Ferrand, France 4University Hospital Estaing, Radiology Department, Clermont-Ferrand, France

P123: MRI remission after therapeutic intervention is associated with more time spent in clinical corticosteroids-free remission and decreased risk of surgery in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Buisson A.*1,2, Hordonneau C.3, Goutorbe F.1,4, Allimant C.1, Goutte M.1,2, Reymond M.1, Pereira B.5, Bommelaer G.1,2

1University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France 2UMR 1071 Inserm/Université d'Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the host, Clermont-Ferrand, France 3University Hospital Estaing, Radiology Department, Clermont-Ferrand, France 4Hospital of Bayonne, Gastroenterology Department, Bayonne, France 5University Hospital, Biostatistics Unit, DRCI, Clermont-Ferrand, France

P124: Disagreement among gastroenterologists in the endoscopic evaluation using the Mayo endoscopic score and the Rutgeerts postoperative scoreECCO '17 Barcelona
Year: 2017
Authors:

Raimundo Fernandes S.*1, Pinto J.2, Marques da Costa P.1, Correia L.1 Grupo de Estudos de Doença Inflamatόria Intestinal

1Hospital de Santa Maria, Serviço de Gastrenterologia e Hepatologia, Lisboa, Portugal 2Hospital Amato Lusitano, Serviço de Gastrenterologia, Castelo Branco, Portugal

P125: Rapid increase in pan-treatment refractory Crohn's disease after transition to adult services: a regional cohort studyECCO '17 Barcelona
Year: 2017
Authors:

Merrick V.*1, Henderson P.1, Rogers P.2, Arnott I.3, Satsangi J.4, Wilson D.1

1University of Edinburgh, Child Life and Health, Edinburgh, United Kingdom 2Royal Hospital for Sick Children, Paediatric Gastroenterology, Edinburgh, United Kingdom 3Western General Hospital, Gastrointestinal Unit, Edinburgh, United Kingdom 4University of Edinburgh, Gastrointestinal Unit, Centre for Genomic and Experimental Medicine, Edinburgh, United Kingdom

P126: Experience of 3D modelling in perianal fistula disease and survey of international surgical interestECCO '17 Barcelona
Year: 2017
Authors:

Sahnan K.*1, Adegbola S.O.1, Tozer P.J.1, Burling D.2, Warusavitarne J.1, Faiz O.D.1, Phillips R.K.1, Hart A.L.3, Lung P.F.2

1St Mark's Hospital, Colorectal Surgery, London, United Kingdom 2St Mark's Hospital, Gastrointestinal Imaging, London, United Kingdom 3St Mark's Hospital, IBD/Physiology, London, United Kingdom

P127: An assessment of a pancolonic adaptation of the ulcerative colitis endoscopic index of severity in comparison to clinical and biochemical markers of disease activity in paediatric ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Ricciuto A., Fish J., Carman N., Crowley E., Muise A., Church P., Walters T., Kamath B.M., Griffiths A.

Hospital for Sick Children, University of Toronto, Toronto, Canada

P128: Diagnostic accuracy of faecal calprotectin in Crohn's disease – Does disease location matter?ECCO '17 Barcelona
Year: 2017
Authors:

Simon E.*1,2, Wardle R.2, Thi A.A.3, Eldridge J.4, Samuel S.2, Moran G.2

1Christian Medical College, Gastroenterology, Vellore, India 2NIHR NDD BRU, NUH NHS Trust and University of Nottingham, Nottingham, United Kingdom 3NUH NHS Trust, Gastroenterology, Nottingham, United Kingdom 4University of Nottingham, Libraries Research & Learning Resources, Nottingham, United Kingdom

P129: Persistent intestinal inflammation leads to surgical intervention in Crohn's patients: a nested case-control studyECCO '17 Barcelona
Year: 2017
Authors:

Pavlidis P.*1,2, Cockroft A.2, Chatu S.1, Choong L.M.1, Medcalf L.1, Tumova J.1, Srirajaskanthan R.1, Chung-Faye G.1, Dubois P.1, Sherwood R.3, Bjarnason I.1, Hayee B.H.1

1King's College Hospital, Department of Gastroenterology, London, United Kingdom 2King's College London, Experimental Immunobiology, London, United Kingdom 3King's College Hospital, Department of Biochemistry, Viapath, London, United Kingdom

P130: Ingestion of 100ml and 300ml blood mimicking upper gi bleeding leads to significant calprotectin elevation in healthy volunteers – results from the “Vampire study”ECCO '17 Barcelona
Year: 2017
Authors:

Vavricka S.*1,2, Heinrich H.2, Misselwitz B.2, Buetikofer S.1,2, Burri E.3,4, Rogler G.2, Breitenmoser F.1, Schneider X.5, Zeitz J.2, Biedermann L.2, Sauter M.1,2

1Triemli Hospital, Division of Gastroenterology, Zurich, Switzerland 2University Hospital Zurich, Division of Gastroenterology and Hepatology, Zurich, Switzerland 3Cantonal Hospital Liestal, Department of Gastroenterology, University Medical Clinic, Liestal, Switzerland 4University Hospital Basel, Division of Gastroenterology and Hepatology, Basel, Switzerland 5Triemli Hospital, Institute of Laboratory Medicine, Zurich, Switzerland

P131: Fecal micro-RNAs indicate disease activity in ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Verdier J.1, Breunig I.1, Ohse M.C.1, Roy S.1, Groner S.1, Roubrocks S.1, Streetz K.2, Trautwein C.1, Roderburg C.1, Sellge G.*1

1University Hospital RWTH Aachen, Dep. of Internal Medicine III, Aachen, Germany 2Gemeinschaftsklinikum Mittelrhein - Kemperhof, Dep. of Gastroenterology, Kobelnz, Germany

P132: Cooperation to improve quality of IPAA surgery in IBD: south Netherlands experienceECCO '17 Barcelona
Year: 2017
Authors:

Stassen L.*1, Sahari B.2, Lubbers T.2, van Bodegraven A.3, Pierik M.4, Stoot J.5, Belgers E.5

1Maastricht University Medical Center (MUMC), Department of GI surgery, Maastricht, Netherlands 2Maastricht University Medical Center (MUMC), Department of GI Surgery, Maastricht, Netherlands 3Zuyderland Medical Center, Department of Gastroenterology and Hepatology, Heerlen, Netherlands 4Maastricht University Medical Center (MUMC), Department of Gastroenterology, Maastricht, Netherlands 5Zuyderland Medical Center, Department of Surgery, Heerlen, Netherlands

P133: A novel candidate pathway for development of neoplasms with serrated morphology in patients with ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Nishio M.*1, Shibata W.2,3, Ajioka Y.4, Hirasawa K.5, Ueda W.6, Okawa K.6, Otake H.1, Ogashiwa T.1, Takase A.7, Chiba S.7, Inayama Y.7, Kimura H.1, Kunisaki R.1, Maeda S.2

1Yokohama City University Medical Centre, Inflammatory Bowel Disease Centre, Yokohama, Japan 2Yokohama City University Graduate School of Medicine, Department of Gastroenterology, Yokohama, Japan 3Yokohama City University, Advanced Medical Research Centre, Yokohama, Japan 4Niigata University Graduate School of Medical and Dental Sciences, Division of Molecular and Diagnostic Pathology, Niigata, Japan 5Yokohama City University Medical Centre, Division of Endoscopy, Yokohama, Japan 6Osaka City Juso Hospital, Department of Gastroenterology and Hepatology, Osaka, Japan 7Yokohama City University Medical Centre, Department of Pathology, Yokohama, Japan