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P094: DNA methylation patterns in Crohn's disease mucosal-derived fibroblastsECCO '17 Barcelona
Year: 2017
Authors:

te Velde A.A.*1, Li Yim A.Y.2,3, de Bruyn J.R.1,4, Duijvis N.W.1, de Jonge W.J.1, Wildenberg M.E.1, Mannens M.M.2, D'Haens G.R.4, Henneman P.2

1Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Academic Medical Center, Department of Clinical Genetics, Genome Diagnostics Laboratory, Amsterdam, Netherlands 3GlaxoSmithKline, Epinova Discovery Performance Unit, Stevenage, United Kingdom 4Academic Medical Center, Department of Gastroenterology, Amsterdam, Netherlands

P095: The genetic risk in ER stress and autophagy translates into quantifiable epithelial ER stress levels in IBD patientsECCO '17 Barcelona
Year: 2017
Authors:

Vanhove W.*1, Nys K.1, Arijs I.1,2, Cleynen I.3, de Bruyn M.1,4, Korf H.1,5, Ferrante M.1,6, Van Assche G.1,6, Vermeire S.1,6

1KU Leuven, Translational Research in Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, Leuven, Belgium 2Hasselt University, Faculty of Medicine and Life Sciences, Hasselt, Belgium 3KU Leuven, Laboratory for Complex Genetics, Department of Human Genetics, Leuven, Belgium 4KU Leuven, Laboratory of Immunobiology, Department of Microbiology and Immunology, Rega Institute for Medical Research, Leuven, Belgium 5KU Leuven, Hepatology, Department of Clinical and Experimental Medicine, Leuven, Belgium 6University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium

P096: Combined detection variants of NUDT15 could highly predict thiopurine-induced leukopenia in Chinese patients with inflammatory bowel disease: a multi-center analysisECCO '17 Barcelona
Year: 2017
Authors:

Chao K.*1, Zhu X.1, Cao Q.2, Yang H.3, Liang J.4, Lin L.1, Huang Z.1, Zhang Y.2, Huang Y.2, Sun Y.3, Xue X.4, Huang M.5, Hu P.1, Wu K.4, Lan P.6, Wang X.5, Qian J.3, Gao X.1

1The Sixth Affiliated Hospital, Sun Yat-sen University, Department of Gastroenterology, Guangzhou, China 2Sir Run Run Shaw Hospital, Department of Gastroenterology, Hangzhou, China 3Peking Union Medical College Hospital, Department of Gastroenterology, Beijing, China 4Xijing Hospital, Department of Gastroenterology, Xi'an, China 5School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China 6The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

P097: Th2 cytokines are potent stimulators of pro-fibrotic responses by human intestinal subepithelial myofibroblastsECCO '17 Barcelona
Year: 2017
Authors:

Filidou E.*1, Valatas V.2, Drygiannakis I.2, Arvanitidis K.1, Vradelis S.3, Kolios G.1

1Democritus University of Thrace, Laboratory of Pharmacology, Faculty of Medicine, Alexandroupolis, Greece 2University of Crete, Laboratory of Gastroenterology, Faculty of Medicine, Heraklion, Greece 3Democritus University of Thrace, 2nd Department of Internal Medicine of University Hospital of Alexandroupolis, Alexandroupolis, Greece

P098: Oregonin inhibits intestinal epithelial injury by modulating heme oxygenase-1ECCO '17 Barcelona
Year: 2017
Authors:

Seo G.S.*1, Chi J.-H.2, Jin H.3, Lee S.H.2

1Wonkwang University Hospital, Digestive Disease Research Institute, Department of Gastroenterology, Iksan, South Korea 2Wonkwang University, Institute of Pharmaceutical Research and Development, Department of Pharmacy, Iksan, South Korea 3Institute of Pharmaceutical Research and Development, Wonkwang University, Department of Pharmacy, Iksan, South Korea

P099: Altered intrinsic brain function in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Thomann A.*1, Griebe M.2, Thomann P.3, Reindl W.4, Wolf C.3

1Universitätsmedizin Mannheim, Department of Medicine II, Mannheim, Germany 2Universitätsmedizin Mannheim, Department of Neurology, Mannheim, Germany 3Universitätsklinik Heidelberg, Department of Psychiatry, Heidelberg, Germany 4Universitätsmedizin Mannheim, Department of Medicine II, Mannheim, Germany

P100: Intestinal epithelial cells under endoplasmic reticulum stress boosts serine proteolytic activity and modulates barrier functionECCO '17 Barcelona
Year: 2017
Authors:

Solà Tapias N., Denadai-Souza A., Rolland-Fourcade C., Blanpied C., Dietrich G., Bonnart C., Edir A., Rolland C., Deraison C., Vergnolle N., Barreau F.

Institut de Recherche en Santé Digestive (IRSD), Toulouse, France

P101: Interleukin-13 induces polarity defects in the intestinal epitheliaECCO '17 Barcelona
Year: 2017
Authors:

Lebenheim L., Kühnel A., Hering N., Bojarski C., Schulzke J.-D., Siegmund B., Schumann M.

Charité - University Hospital Berlin, Campus Benjamin Franklin, Department of Gastroenterology and Medicine I, Berlin, Germany

P102: Hypoxia reduces inflammation through the downregulation of NLRP3/mTOR signaling and the activation of autophagyECCO '17 Barcelona
Year: 2017
Authors:

Cosin-Roger J.*1, Simmen S.1, Melhem H.1, Atrott K.1, Frey-Wagner I.1, Hausmann M.1, de Vallière C.1, Spalinger M.R.1, Spielmann P.2,3, Wagner R.H.2,3, Zeitz J.1, Vavricka S.R.1, Rogler G.1, Ruiz P.A.1

1University of Zurich, Gastroenterology, Zurich, Switzerland 2Institute of Physiology, University of Zurich, Zurich, Switzerland 3Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland

P103: Evaluation of efficacy of new vectors for siRNA CYCLIN D1 and E2F1 delivery in control of cancer progression in inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Russo I.*1, Bochicchio S.2, Piazza O.3, Barba A.A.2, Lamberti G.4, Carrizzo A.5, Zeppa P.6, Vecchione C.6, Iovino P.6, Ciacci C.6

1University of Salerno, Department of Medicine and Surgery, Baronissi Campus (Salerno), Italy 2University of Salerno, Department of Pharmacy, Fisciano, Italy 3Department of Medicine and Surgery, Department of Medicine and Surgery, Baronissi, Italy 4University of Salerno, Department of Industrial Engineering, Fisciano, Italy 5University of Salerno, Department of Medicine and Surgery, Fisciano, Italy 6University of Salerno, Department of Medicine and Surgery, Baronissi, Italy

P104: Rebamipide, sucralfate, and rifaximin have the suppressive effects on radiation-induced inflammation in the intestine of mouseECCO '17 Barcelona
Year: 2017
Authors:

Moon W., Park S.J., Kim J.H., Park M.I., Kim S.E., Jung K.W.

Kosin University College of Medicine, Department of Internal Medicine, Busan, South Korea

P105: An experimental examination of appetite and disordered eating in Crohn's disease patientsECCO '17 Barcelona
Year: 2017
Authors:

Wardle R.1, Thapaliya G.1, Nowak A.1, Dalton M.2, Finlayson G.2, Moran G.*1

1University Hospitals Nottingham, NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham, United Kingdom 2University of Leeds, Institute of Psychological Sciences, Leeds, United Kingdom

P106: Binding properties of human TLR-9 receptor to cobitolimod – a candidate for treatment of active ulcerative colitis in late stage of clinical developmentECCO '17 Barcelona
Year: 2017
Authors:

Zargari A., Admyre C., Knittel T.

Index Pharmaceuticals, Stockholm, Sweden

P107: Lactobacillus plantarum 06CC2 induces intestinal IL-10–producing dendritic cells to ameliorate acute experimental colitis in miceECCO '17 Barcelona
Year: 2017
Authors:

Tanaka A.*1,2, Kanmura S.1, Arima S.1, Sasaki F.1, Nasu Y.1, Tanoue S.1, Hashimoto S.1, Setoyama H.1, Ido A.1

1Kagoshima University Graduate School of Medical and Dental Sciences, Digestive and Lifestyle Diseases, Kagoshima, Japan 2Kagoshima Kosiren hospital, Kagoshima, Japan

P108: Oleuropein decreases interleukin-17 and attenuates inflammatory damage in colonic mucosa from ulcerative colitis patientsECCO '17 Barcelona
Year: 2017
Authors:

Larussa T.*1, Oliverio M.1, Suraci E.1, Greco M.1, Placida R.1, Gervasi S.1, Marasco R.1, Imeneo M.1, Paolino D.1, Tucci L.2, Gulletta E.1, Fresta M.1, Procopio A.1, Luzza F.1

1University of Catanzaro Magna Graecia, Health of Sciences, Catanzaro, Italy 2Azienda Ospedaliera Pugliese - Ciaccio, Catanzaro, Italy

P109: Profiling of receptor for advanced glycation end products expression in cases of primary sclerosing cholangitis with ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Udupa V.1, Baird A.2, Winter D.*3

1St Vincent's University Hospital, Dept of Surgery, Dublin, Ireland 2University College Dublin, Veterinary Science centre, School Of Veterinary Medicine, Dublin, Ireland 3St Vincent's University Hospital, Dept of Colorectal Surgery, Dublin, Ireland

P110: Characterization of human intestinal macrophage subsets in health and inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Bernardo D.*1, Mora-Gutierrez I.1, Marin A.c.1, Díaz-Guerra A.1, Caminero-Fernández R.2, Caldas M.2, De la Morena F.2, Jiménez M.2, Chaparro M.1, Gisbert J.P.1

1Hospital Universitario de La Princesa, CIBERehd, Madrid, Spain 2Hospital Universitario de La Princesa, Department of Gastroenterology, Madrid, Spain

P111: The anti-inflammatory effect of a serine protease inhibitor in a chronic colitis transfer model is mediated by the suppression of Th1 cell differentiationECCO '17 Barcelona
Year: 2017
Authors:

Van Spaendonk H.*1, Francque S.1,2, De Man J.1, De Winter B.1

1University of Antwerp, Laboratory of Experimental Medicine and Pediatrics, Antwerp, Belgium 2Antwerp University Hospital, Gastroenterology and Hepatology, Antwerp, Belgium

P112: Short-chain fatty acids administration is protective in colitis-associated colorectal cancer developmentECCO '17 Barcelona
Year: 2017
Authors:

Tian Y.*1, Wang K.1, Ji G.2

1The Second Affiliated Hospital of Nanjing Medical University, Department of Oncology, Nanjing, China 2The Second Affiliated Hospital of Nanjing Medical University, Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Nanjing, China

P113: Model based predictions of the PTG-100 pharmacodynamic responses in ulcerative colitis patientsECCO '17 Barcelona
Year: 2017
Authors:

Mattheakis L.*1, Fosser C.2, Saralaya R.2, Horsch K.2, Rao N.1, Bai L.1, Zhao L.1, Annamalai T.1, Liu D.1

1Protagonist Therapeutics, Milpitas, United States 2Cytel Inc., Cambridge, United States