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P074: Decreased levels of circulating protein S (PROS1) in patients with active Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Sambuelli A.*1, Chavero P.2, de Larrañaga G.3, Errasti A.4, Carrera Silva A.5, Tessone L.6, Peres S.7, Negreira S.2, Gil A.2, Bellicoso M.2, Goncalves S.2, Huernos S.2, Tirado P.2, Rothlin C.8

1Hospital Bonorino Udaondo, IBD Section - Medicine, Buenos Aires, Argentina 2IBD Section - Hospital Bonorino Udaondo, Medicine, Buenos Aires, Argentina 3Hospital of Infectious Diseases F. J. Muñiz, Hemostasis and Thrombosis Laboratory, Buenos, Argentina 4Facultad de Medicina Universidad de Buenos Aires, Instituto de Farmacología, Buenos Aires, Argentina 5Academia Nacional de Medicina, Instituto de Medicina Experimental (IMEX), Buenos Aires, Argentina 6Facultad de Medicina Universidad de Buenos Aires, Hemostasis and Thrombosis Laboratory, Buenos Aires, Argentina 7Hospital of Infectious Diseases F. J. Muñiz, Hemostasis and Thrombosis Laboratory, Buenos Aires, Argentina 8Yale University School of Medicine, Department of Immunobiology, New Haven, United States

P075: Calponin 2 protects against colitis associated cancer in mice through mediating inflammatory responsesECCO '17 Barcelona
Year: 2017
Authors:

Xu B., Jiang M., Qiu Z., Li X., Chen D., Chu Y., Wang W., Liang J., Wu K.

The Fourth Military Medical University, State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xi'an, Shaanxi, China

P076: IL-26 genetic polymorphisms impair cytokine response to bacterial DNA translocation and increase anti-TNF consumption in patients with Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Piñero P.*1, Juanola O.1, Gutiérrez A.1, Zapater P.1, Giménez P.1, Steinert A.2, Sempere L.1, Gonzalez-Navajas J.M.1, Niess J.2, Francés R.1

1CIBERehd - Hospital General Universitario de Alicante, Alicante, Spain 2Basel University, Basel, Switzerland

P077: Histological remission in ulcerative colitis: an analysis of two independent cohortsECCO '17 Barcelona
Year: 2017
Authors:

Li K.*1, Strauss R.1, Marano C.1, Greenbaum L.1, Brodmerkel C.1, De Hertogh G.2

1Janssen Research & Development, LLC, Spring House, United States 2University Hospitals Leuven, Pathology, Leuven, Belgium

P078: Gut microbiome profiling of MMP-9 deficient mice and their wild-type littermates in a model of acute DSS-induced colitisECCO '17 Barcelona
Year: 2017
Authors:

de Bruyn M.*1,2, Sabino J.2, Vandeputte D.3, Vermeire S.2,4, Raes J.3, Opdenakker G.1

1Rega Institute for Medical Research, KU Leuven, Department of Microbiology and Immunology, Laboratory of Immunobiology, Leuven, Belgium 2KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium 3Rega Institute for Medical Research, KU Leuven, Department of Microbiology and Immunology, Laboratory of Molecular Bacteriology, Leuven, Belgium 4University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium

P079: Association of gut microbiota with mucosal inflammation in ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Quraishi M.N.*1,2, Rossiter A.3, Chung B.4,5, Beaumont M.6, Liaskou E.4, Horniblow R.1, Beggs A.1, Withers D.7, Ghosh S.2,8, Tselepis C.1, Hirschfield G.4, Iqbal T.H.1,2

1University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, United Kingdom 2University Hospital Birmingham, Department of Gastroenterology, Birmingham, United Kingdom 3University of Birmingham, Institute of Microbiology and Infection, Birmingham, United Kingdom 4University of Birmingham, Centre for Liver Research and National Institute of Health Research (NIHR) Birmingham, Liver Biomedical Research Unit (BRU), Institute of Immunology and Immunotherapy, Birmingham, United Kingdom 5Oslo University Hospital Rikshospitalet, University of Oslo, Norwegian PSC Research Center and Institute of Clinical Medicine, Oslo, Norway 6Kings College London, Twin Research & Genetic Epidemiology, London, United Kingdom 7University of Birmingham, Institute of Immunology and Immunotherapy, Birmingham, United Kingdom 8University Hospital Birmingham, Institute of Translational Medicine, Birmingham, United Kingdom

P080: IL-10 induction properties of the TLR-9 agonist cobitolimod – a candidate for treatment of active ulcerative colitis in late stage of clinical developmentECCO '17 Barcelona
Year: 2017
Authors:

Admyre C.1, Zargari A.1, Atreya R.2, Knittel T.*1

1Index Pharmaceuticals, Stockholm, Sweden 2University of Erlangen-Nürnberg, Department of Medicine 1, Erlangen, Germany

P081: 10 years of the UK Inflammatory Bowel Disease (IBD) Audit and the journey is just beginningECCO '17 Barcelona
Year: 2017
Authors:

Protheroe A., Murray S.

Royal College of Physicians, Clinical Effectiveness and Evaluation Unit, London, United Kingdom

P082: An investigation of azathioprine on autophagy pathway activityECCO '17 Barcelona
Year: 2017
Authors:

Hooper K.*1, Barlow P.1, Henderson P.2,3, Stevens C.1

1Edinburgh Napier University, Edinburgh, United Kingdom 2Royal Hospital For Sick Children, Department of Pediatric Gastroenterology, Edinburgh, United Kingdom 3University Of Edinburgh, Department of Child Life and Health, Edinburgh, United Kingdom

P083: The protective role of vitamin D3 on colitis-associated colorectal cancer in a mouse modelECCO '17 Barcelona
Year: 2017
Authors:

Ma L.*1, Xin Y.1, Lv H.1, Wang H.2, Qian J.1

1Peking Union Medical College Hospital, Gastroenterology, Beijing, China 2Cancer Hospital Chinese Academy of Medical Sciences, Beijing, China

P084: Investigation of non-coding RNAs as molecular markers during glucocorticoid treatment in children with inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Lucafò M.*1, Di Silvestre A.2, Romano M.3, Martelossi S.4, Naviglio S.2, Tommasini A.4, Stocco G.3, Ventura A.1,4, Decorti G.1,4, De Iudicibus S.4

1University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy 2University of Trieste, PhD School in Science of Reproduction and Development, Trieste, Italy 3University of Trieste, Department of Life Sciences, Trieste, Italy 4Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Trieste, Italy

P085: The effect of vitamin D on macrophage function and polarization in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Dionne S., Duchatellier C.-F., Seidman E.

Research Institute of the McGill University Hospital, Gastroenterology, Montreal, Canada

P086: MMP-12, a novel mediator of nociception in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Tranter M., Barakat F., Dogra H., Lindsay J., Croft N., Bulmer D.

Queen Mary University of London, London, United Kingdom

P087: Increased wnt ligands expression in M2c macrophages is associated with fibrosis in Stat6 knockout miceECCO '17 Barcelona
Year: 2017
Authors:

Ortiz-Masia D.*1,2, Salvador P.3, Macias-Ceja D.C.4, Gisbert-Ferrándiz L.3, Hernandez C.4, Calatayud S.3, Esplugues J.V.3,4, Barrachina D.3

1Universidad de Valencia-CIBERehd, Pharmacology, Valencia, Spain 2Universidad de Valencia, Medicine, Valencia, Spain 3Universidad de Valencia, Pharmacology, Valencia, Spain 4FISABIO Hospital Peset, Pharmacology, Valencia, Spain

P088: Evaluation of Free Vitamin D levels in IBD pediatric patients: the role of inflammationECCO '17 Barcelona
Year: 2017
Authors:

Strisciuglio C.*1, Cenni S.2, Giugliano F.P.2, Miele E.2, Cirillo G.1, Martinelli M.2, Vitale A.1, Staiano A.2, Miraglia del Giudice E.1, Perrone L.1

1Second University of Naples, Department of Woman, Child and General and Specialistic Surgery, Naples, Italy 2University Federico II of Naples, Department of Translational Medical Science, Section of Pediatrics, Naples, Italy

P089: Extracellular matrix fragments as markers of cytokine driven intestinal damage or protection; test in a novel intestinal ex vivo modelECCO '17 Barcelona
Year: 2017
Authors:

Olesen M.L.*1,2, Krag A.2, Karsdal M.1, Kjeldsen J.2, Bay-Jensen A.-C.1, Mortensen J.H.1

1Nordic Bioscience A/S, Biomarkers and Research, Herlev, Denmark 2University of Southern Denmark and Odense University Hospital, Department of Medical Gastroenterology, Odense, Denmark

P090: Metformin induces late Apoptosis and modulates dysbiosis in western-style diet induced colitic cancerECCO '17 Barcelona
Year: 2017
Authors:

Chung E.J.*1, Do E.J.2, Myung S.-J.1,2

1Asan Medical Center, Seoul, South Korea 2Asan Institute for Life Science, Seoul, South Korea

P091: Usefulness of transcriptional whole blood biomarkers as a non-invasive surrogate marker of mucosal healing and endoscopic response in ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Planell N.*1,2, Masamunt M.C.1, Franco Leal R.3, Rodríguez L.4, Esteller M.1, Lozano J.J.2, Ramírez A.1, Setsuko Ayrizono M.d.L.3, Saddy Rodrigues Coy C.3, Alfaro I.1, Ordás I.1, Visvanathan S.5, Ricart E.1, Guardiola J.4, Panés J.1, Salas A.1

1IDIBAPS, Hospital Clínic, CIBER-EHD, Gastroenterology, Barcelona, Spain 2CIBER-EHD, Bioinformatics Platform, Barcelona, Spain 3IBD Research Laboratory, University of Campinas, Surgery, Sao Paulo, Brazil 4Hospital Universitari de Bellvitge - Institut d'Investigaciό Biomèdica de Bellvitge, Gastroenterology, Barcelona, Spain 5Boehringer-Ingelheim Pharmaceuticals Inc, Ridgefield, United States

P092: Exogenous administration of IL-4-treated macrophages prevents intestinal fibrosis in Stat6 knockout miceECCO '17 Barcelona
Year: 2017
Authors:

Salvador P.*1, Ortiz-Masià D.1, Macias-Ceja D.C.2, Gisbert-Ferrándiz L.1, Hernández C.2,3, Esplugues J.V.1,2,3, Barrachina-Sancho M.D.1,3, Calatayud S.1,3

1University of Valencia, Valencia, Spain 2Fisabio Hospital Peset, Valencia, Spain 3CIBERehd, Valencia, Spain

P093: Dysregulation of cellular vs humoral immunity to the intestinal microbiota in inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Noble A.*1, Durant L.2, Hoyles L.2, McCartney A.L.3, Man R.4, Costello S.P.5, Hendy P.4, Reddi D.2, Segal J.4, Lim D.4, Bolton M.4, Hart A.L.4, Carding S.R.6, Knight S.C.2

1Imperial College London, Antigen Presentation Research Group, Harrow, United Kingdom 2Imperial College London, London, United Kingdom 3University of Reading, Reading, United Kingdom 4Northwick Park & St Mark's Hospital, Harrow, United Kingdom 5Queen Elizabeth Hospital, Adelaide, Australia 6Institute of Food Research, Norwich, United Kingdom