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P054: Metformin protects against intestinal barrier disruption via AMPKα1-dependent inhibition of JNK signaling pathwayECCO '17 Barcelona
Year: 2017
Authors:

Deng J., Chen Y., Zeng L.

Nanfang Hospital, Southern Medical Universit, Department of Gastroenterology, Guangzhou, China

P055: Mitochondrial DNA is a damage-associated molecular pattern released during active IBD promoting TLR9-mediated inflammationECCO '17 Barcelona
Year: 2017
Authors:

Boyapati R., Dorward D., Tamborska A., Kalla R., Ventham N., Rossi A., Satsangi J., Ho G.-T.

University of Edinburgh, MRC Centre for Inflammation Research, Edinburgh, United Kingdom

P056: Gut microbiota characterisation in South Asian IBD patients resident in the UKECCO '17 Barcelona
Year: 2017
Authors:

Quraishi M.N.*1,2, Rossiter A.3, Bhala N.2, Beaumont M.4, Pathmakanthan S.2, Ghosh S.2,5, Iqbal T.H.1,2

1University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, United Kingdom 2University Hospital Birmingham, Department of Gastroenterology, Birmingham, United Kingdom 3University of Birmingham, Institute of Microbiology and Infection, Birmingham, United Kingdom 4Kings College London, Twin Research & Genetic Epidemiology, London, United Kingdom 5University Hospital Birmingham, Institute of Translational Medicine, Birmingham, United Kingdom

P057: IL-6 induces NLRP3 inflammasome activation through JAK/STAT3-dependent NOX2 induction in colon epithelial cellsECCO '17 Barcelona
Year: 2017
Authors:

Kim J.-A.*1, Grung P.1, Banskota S.1, Jeong B.-S.1, Nam T.-g.2

1Yeungnam University, College of Pharmacy, Gyeongsan, South Korea 2Hanyang University, College of Pharmacy, Ansan, South Korea

P058: Comparison of Calprotectin levels in stool and rectal mucus in subjects with suspected or confirmed inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

McLaughlin J.*1, Hedley A.D.2, Treasure P.3, Collins C.M.2, Craven R.A.2

1University of Manchester, School of Medical Sciences, Manchester, United Kingdom 2Origin Sciences, Cambridge, United Kingdom 3statistics@petertreasure.com, King's Lynn, United Kingdom

P059: Mucosal inflammation promotes activation of circulating Vδ2+ T-cells in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

McCarthy N.*1, Gordon H.1, Rahman S.1, Harrow P.1,2, Stagg A.1, Lindsay J.1,2

1The Blizard Institute, Queen Mary University of London, Centre for Immunobiology, London, United Kingdom 2Barts Health NHS Trust, Department of Gastroenterology, London, United Kingdom

P060: Role of innate lymphoid cells in the chronic colitis under anti-il-17a therapyECCO '17 Barcelona
Year: 2017
Authors:

Eun C.S., Han D.S., Park C.H., Lee A.R., Lee Y.R.

Hanyang University Guri Hospital, Gastroenterology, Guri, South Korea

P061: Epigenetic alterations at diagnosis predict susceptibility, prognosis and treatment escalation in inflammatory bowel disease – IBD CharacterECCO '17 Barcelona
Year: 2017
Authors:

Adams A.*1, Kalla R.1, Vatn S.2, Bonfiglio F.3, Nimmo E.1, Kennedy N.1, Ventham N.1, Vatn M.2, Ricanek P.4, Bergemalm D.5, Halfvarson J.5, Söderholm J.6, Pierik M.7, Törkvist L.8, Gomollόn F.9, Gut I.10, Jahnsen J.2, Satsangi J.1 IBD Character Consortium

1University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom 2University of Oslo, Institute of Clinical Medicine, EpiGen, Campus Ahus, Oslo, Norway 3BioCruces Health Research Institue, Bilbao, Spain 4Akershus University, Department of Gastroenterology, Akershus, Norway 5Örebro University, Department of Gastroenterology, Faculty of Medicine and Health, Örebro, Sweden 6Linköping University Hospital, Department of Surgery, Linköping, Sweden 7Maastricht University Medical Center (MUMC), Department of Gastroenterology and Hepatology, Maastricht, Netherlands 8Karolinska Institute, Department of Clinical Science, Intervention and Technology, Stockholm, Sweden 9University Hospital Clinic Lozano Blesa, Zaragoza, Spain 10CNAG-CRG Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain

P062: The narrow spectrum kinase inhibitor TOP1288 demonstrates potent anti-inflammatory effects in a T cell adoptive transfer colitis model through a topical mode of actionECCO '17 Barcelona
Year: 2017
Authors:

Solanke Y., Foster M., Fyfe M., Rowley A., Sirohi S., Webber S., Walshe C.

Topivert Pharma Ltd, London, United Kingdom

P063: HDAC as versatile regulators of the intestinal epithelial barrier in inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Friedrich M., Ganther J., Breiderhoff T., Rosenthal R., Glauben R., Siegmund B.

Charité - Universitätsmedizin Berlin, Medical department for Gastroenterology, Infectious Diseases and Rheumatology, Berlin, Germany

P064: EBI2 and oxysterols in the development of intestinal lymphoid structures and colitisECCO '17 Barcelona
Year: 2017
Authors:

Wyss A.*1, Raselli T.1, Schmelczer G.1, Spalinger M.1, Atrott K.1, Frey-Wagner I.1, Sailer A.W.2, Rogler G.1, Misselwitz B.1

1University of Zurich, Zurich, Switzerland 2Novartis Institutes for BioMedical Research, Basel, Switzerland

P065: Effects of gut bacteria on the intestinal immune cell composition and barrier functionECCO '17 Barcelona
Year: 2017
Authors:

Schmidt F.*1, Dahlke K.2, Batra A.1,3, Ring C.2, Keye J.1, Loh G.2,4, Schumann M.1, Kühl A.1, Blaut M.2, Siegmund B.1

1Charité - Universitätsmedizin Berlin, Medical Department for Gastroenterology, Infectious Diseases and Rheumatology, Berlin, Germany 2German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Gastrointestinal Microbiology, Nuthetal, Germany 3Takeda Pharma Vertrieb GmbH & Co. KG, Berlin, Germany 4Max Rubner-Institute, Institute of Physiology and Biochemistry of Nutrition, Nutrition and Intestinal Microbiota, Karlsruhe, Germany

P066: Fibrostenotic phenotype of fibroblasts in Crohn's disease is dependent on tissue stiffness and reversed by LOX inhibitionECCO '17 Barcelona
Year: 2017
Authors:

de Bruyn J.*1, van den Brink G.1, Steenkamer J.1, Buskens C.2, Bemelman W.2, Meisner S.3, Muncan V.3, te Velde A.3, D'Haens G.4, Wildenberg M.1

1Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Academic Medical Center, Surgery, Amsterdam, Netherlands 3Academic Medical Center (AMC), Tytgat Institute for Intestinal and Liver Research, Amsterdam, Netherlands 4Academic Medical Center, Gastroenterology & Hepatology, Amsterdam, Netherlands

P067: Molecular profiling of early Crohn's disease reveals a prominent role for WNT5AECCO '17 Barcelona
Year: 2017
Authors:

Verstockt S.*1, Van der Goten J.2, Vancamelbeke M.2, Verstockt B.2, Van Lommel L.3, Schuit F.3, Rutgeerts P.2, Ferrante M.2, Vermeire S.2, Arijs I.2,4,5, Cleynen I.1

1KU Leuven, Department of Human Genetics, Leuven, Belgium 2KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, Leuven, Belgium 3KU Leuven, Department of Cellular and Molecular Medicine, Gene Expression Unit, Leuven, Belgium 4Hasselt University, Faculty of Medicine and Life Sciences, Hasselt, Belgium 5Jessa Hospital, Hasselt, Belgium

P068: Evaluation of the therapeutic potential of metformin-pretreated tonsil-derived mesenchymal stem cells in a chronic colitis modelECCO '17 Barcelona
Year: 2017
Authors:

Lee K.E.*1, Jung S.-A.1, Joo Y.-H.1, Tae C.H.1, Moon C.M.1, Kim S.-E.1, Jung H.-K.1, Shim K.-N.1, Yoo K.1, Yu Y.s.2, Jo I.h.2

1Ewha Womans University School of Medicine, Department of Internal Medicine, Seoul, South Korea 2Ewha Womans University School of Medicine, Department of Molecular Medicine, Seoul, South Korea

P069: Sympathetic but not vagal intestinal innervation regulates murine dextran sodium sulphate-induced colitisECCO '17 Barcelona
Year: 2017
Authors:

Willemze R.*1, Welting O.1, van Hamersveld P.1, Sridhar A.2, Vervoordeldonk M.2, Seppen J.1, de Jonge W.1

1Academic Medical Center (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Galvani, Bioelectronics, Stevenage, United Kingdom

P070: TNFα production by classical monocytes is poorly controlled by IL-10 in patients with IBDECCO '17 Barcelona
Year: 2017
Authors:

Hoti I., McCarthy N.E., Giles E.M., Ayada I., Gordon H., Stagg A.J., Lindsay J.O.

Blizard Institute, London, United Kingdom

P071: The mesentery in Crohn's disease displays mesenchymal abnormalitiesECCO '17 Barcelona
Year: 2017
Authors:

Walsh L.*1, Kiernan M.2, Sahebally S.1, Kiely P.2, Waldron D.3, Moloney M.4, Skelly M.4, Hidayat H.3, Faul P.5, O'Leary D.P.3, Lowery A.1, Dunne C.2, Coffey J.C.2

1University of Limerick, Department of Surgery, Limerick, Ireland 2University of Limerick, Graduate Entry Medical School, 4i Centre for Interventions in Infection, Inflammation and Immunity, Limerick, Ireland 3University Hospital Limerick, Department of Surgery, Limerick, Ireland 4University Hospital Limerick, Department of Gastroenterology, Limerick, Ireland 5University Hospital Limerick, Department of Histopathology, Limerick, Ireland

P072: The role of the rs8005161 polymorphism on pH-sensing G protein-coupled receptor GPR65 (TDAG8) signalling in intestinal inflammationECCO '17 Barcelona
Year: 2017
Authors:

Tcymbarevich I.1, Obialo N.2, Cosin-Roger J.1, Seuwen K.3, Rogler G.1,2, Misselwitz B.2, de Vallière C.*1

1University of Zurich, Zurich, Switzerland 2University Hospital Zürich, Department of Gastroenterology and Hepatology, Zurich, Switzerland 3Novartis Institute for Biomedical Research, Basel, Switzerland

P073: Age dependent decrease in gut-homing CD4 lymphocytesECCO '17 Barcelona
Year: 2017
Authors:

Oh S.*1, Lee C.H.2, Hsu P.3, Hu M.4, Nanan B.4, Gaskin K.2, Leong R.5, Nanan R.4

1University of New South Wales, Kensington, Australia 2James Fairfax Institute of Paediatric Clinical Nutrition, University of Sydney, Sydney, Australia 3The Children's Hospital at Westmead, Department of Allergy and Immunology, Westmead, Australia 4University of Sydney, Nepean Clinical School, Sydney, Australia 5Concord and Bankstown Hospitals, Department of Gastroenterology, Sydney, Australia