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P034: Altered microbiota and host-bacterial interactions during the spontaneous development of colitis in IL-10 knockout miceECCO '17 Barcelona
Year: 2017
Authors:

Lόpez-Estévez S., Aguilera M., Martínez V.

Universitat Autònoma de Barcelona, Cell Biology, Physiology and Immumology, Bellaterra, Spain

P035: TNF-driven pathways are increased at baseline in Crohn's disease patients not responding to infliximabECCO '17 Barcelona
Year: 2017
Authors:

Verstockt B.*1,2, Arijs I.1,3,4, de Bruyn M.1,5, Verstockt S.6, Van Assche G.1,7, Breynaert C.8, Vermeire S.1,7, Ferrante M.1,7

1KU Leuven, Department of Clinical and Experimental Medicine, TARGID-IBD, Leuven, Belgium 2University of Cambridge, School of Clinical Medicine, Cambridge, Biomedical Campus, Department of Medicine and Cambridge Institute for Medical Research, Cambridge, United Kingdom 3Hasselt University, Faculty of Medicine and Life Sciences, Hasselt, Belgium 4Jessa Hospital, Hasselt, Belgium 5KU Leuven, Rega Institute for Medical Research, Department of Microbiology and Immunology, Leuven, Belgium 6KU Leuven, Laboratory of Complex Genetics, Department of Human Genetics, Leuven, Belgium 7University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium 8KU Leuven, Laboratory of Clinical Immunology, Department of Microbiology and Immunology, Leuven, Belgium

P036: Human peripheral blood monocytes and intestinal macrophage populations activate transforming growth factor beta via expression of the integrin alpha v beta 8ECCO '17 Barcelona
Year: 2017
Authors:

Shuttleworth E.*1,2,3, Kelly A.1,2,3, Fenton T.1,2,3, Smedley C.1,2,3, Levison S.4, Travis M.1,2,3

1University of Manchester, MCCIR, Manchester, United Kingdom 2University of Manchester, Wellcome Trust Centre for Cell-Matrix Research, Manchester, United Kingdom 3University of Manchester, Manchester Immunology Group, Manchester, United Kingdom 4Central Manchester NHS Hospitals Foundation Trust, Department of Gastroenterology, Manchester, United Kingdom

P037: MDR1-deficiency unmasks mitochondrial dysfunction as a pathogenic mechanism in IBDECCO '17 Barcelona
Year: 2017
Authors:

Ho G.-T.*1, Aird R.1, Boyapati R.1, Liu B.2, Kennedy N.1, Shimizu T.3, Sartor B.2, Satsangi J.1

1University of Edinburgh, MRC Centre for Inflammation Research, Edinburgh, United Kingdom 2University of North Carolina, Chapel Hill, United States 3University of Chiba, Chiba, Japan

P038: Tissue differences in the pro-inflammatory activation of ER stress of patients with Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Coope A.*1, Botezelli J.D.2, Bitencourt Pascoal L.1, Ramos Silva F.1, Ayrizono M.L.S.1, Milanski M.2, Velloso L.A.3, Leal R.F.1

1University of Campinas, Coloproctology Unit, Surgery Department, Campinas, Brazil 2University of Campinas, Campinas, Brazil 3University of Campinas, Laboratory of Cell Signaling, Internal Medicine Department, Campinas, Brazil

P039: Suppression of phospholipase A2 of intestinal microbiota by the phospholipid-bile acid conjugate ursodeoxycholate-lysophoshatidylethanolamide ameliorates mucosal inflammation in a genetic mouse model of ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Stremmel W., Staffer S., Stuhrmann N., Gauss A., Burger N., Hornuss D.

University Hospital of Heidelberg, Internal Medicine IV, Dept. of Gastroenterology, Heidelberg, Germany

P040: Intestinal EP4 receptor is required for homeostasis of the colon in miceECCO '17 Barcelona
Year: 2017
Authors:

Matsumoto Y., Fukuda A., Seno H.

Kyoto University Graduate School of Medicine, Gastroenterology and Hepatology, Kyoto, Japan

P041: C-jun n-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestineECCO '17 Barcelona
Year: 2017
Authors:

Mandić A.D.1, Bennek E.1, Verdier J.1, Zhang K.2, Roubrocks S.1, Davis R.J.3, Denecke B.4, Gassler N.5, Streetz K.6, Kel A.7, Hornef M.2, Cubero F.J.1, Trautwein C.1, Sellge G.*1

1University Hospital RWTH Aachen, Department of Internal Medicine III, Aachen, Germany 2University Hospital RWTH Aachen, Department of Microbiology, Aachen, Germany 3Howard Hughes Medical Institute and University of Massachusetts Medical School, Worcester, United States 4University Hospital RWTH Aachen, Interdisciplinary Center for Clinical Research (IZKF), Aachen, Germany 5Klinikum Braunschweig, Institute of Pathology, Braunschweig, Germany 6Gemeinschaftsklinikum Mittelrhein - Kemperhof, Department of Gastroenterology, Kobelnz, Germany 7geneXplain GmbH, Wolfenbüttel, Germany

P042: Expression of IL-38 and their antagonists in patients with inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Fonseca Camarillo G.*1, Furuzawa Carballeda J.2, Iturriaga Goyon E.1, Yamamoto Furusho J.K.1

1Instituto Nacional de Ciencias Médicas y Nutriciόn Salvador Zubiran, Inflammatory Bowel Disease Clinic. Department of Gastroenterology, Mexico City, Mexico 2Instituto Nacional de Ciencias Médicas y Nutriciόn, Department of Immunology and Rheumatology, Mexico, Mexico

P043: Ulcerative colitis is characterised by an exaggerated onset of acute inflammation with delayed resolutionECCO '17 Barcelona
Year: 2017
Authors:

Marks D.*1,2, Wysoczanski R.1, Kendall A.3, Motwani M.4, Vega R.2, Rahman F.2, McCartney S.2, Bloom S.2, Nicolaou A.3, Gilroy D.4, Segal A.1

1University College London, Molecular Medicine, London, United Kingdom 2University College London Hospital, Gastroenterology, London, United Kingdom 3University of Manchester, Division of Pharmacy and Optometry, Manchester, United Kingdom 4University College London, Clinical Pharmacology, London, United Kingdom

P044: Therapeutic effects of mesenchymal stem cells induced regulatory dendritic cells on chronic colitis model in miceECCO '17 Barcelona
Year: 2017
Authors:

Kim H.-S.*1, Jo H.1, Eom Y.W.2, Cho M.Y.3

1Yonsei University Wonju College of Medicine, Internal medicine, Wonju, South Korea 2Yonsei University Wonju College of Medicine, Cell Therapy and Tissue Engineering Center, Wonju, South Korea 3Yonsei University Wonju College of Medicine, Pathology, Wonju, South Korea

P045: 5-Aminosalicylates promote inflammation resolution in ulcerative colitis through generation of anti-inflammatory hydroxy fatty acidsECCO '17 Barcelona
Year: 2017
Authors:

Wysoczanski R.*1, Kendall A.2, Motwani M.3, Vega R.4, Rahman F.4, McCartney S.4, Bloom S.4, Nicolaou A.2, Gilroy D.3, Segal A.1, Marks D.1,4

1University College London, Molecular Medicine, London, United Kingdom 2University of Manchester, Division of Pharmacy and Optometry, Manchester, United Kingdom 3University College London, Clinical Pharmacology, London, United Kingdom 4University College London Hospital, Gastroenterology, London, United Kingdom

P046: Starch consumption is associated with serologic responses in patients with ulcerative colitis and an ileo-anal pouchECCO '17 Barcelona
Year: 2017
Authors:

Goren I.1,2, Godny L.2,3, Maharshak N.3,4, Tulchinsky H.4,5, Dotan I.*2,5

1Tel Aviv Medical Center, IBD unit, Department of Gastroenterology and hepatology, Tel Aviv, Israel 2Sackler Faculty of Medicine, Tel Aviv Israel, IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 3Tel Aviv Medical Center, IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 4Sackler Faculty of Medicine, Tel Aviv Israel, Department of Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 5Tel Aviv Medical Center, Tel Aviv Israel, Pouch Clinic, IBD Center, Tel Aviv, Israel

P047: Therapeutic dosing of filgotinib (GS-6034, GLPG0634) is efficacious in the mouse DSS model of colitisECCO '17 Barcelona
Year: 2017
Authors:

Kim S., Zheng J., Lu B., Alonzo D., Kanwar B., Smith V.

Gilead Sciences, Inc, Foster City, United States

P048: Decreased expression of aquaporins in colonic biopsies from collagenous colitis patients. A novel diarrhoeal pathomechanism?ECCO '17 Barcelona
Year: 2017
Authors:

Holm A.1, Mancebo Giménez A.1, Loitto V.1, Vikström E.1, Magnusson K.-E.1, Münch A.*2

1Linköping University, Department of Clinical and Experimental Medicine, Linköping, Sweden 2University Hospital, Dept of Gastroenterology, Linköping, Sweden

P049: Lewis score: a useful tool for the diagnosis but not for the definition of prognosis in suspected Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Silva M., Cardoso H., Peixoto A., Marques M., Rodrigues-Pinto E., Nunes A.C.-R., Lopes S., Magro F., Macedo G.

Centro Hospitalar São João, Department of Gastroenterology, Porto, Portugal

P050: Centrally-determined standardization of flow cytometry methods reduces inter-laboratory variation in a prospective multicenter studyECCO '17 Barcelona
Year: 2017
Authors:

Westera L.1, van Viegen T.2, Jeyarajah J.3, Azad A.4, Bilsborough J.5, van den Brink G.1, Danese S.6, D'Haens G.2,7, Eckmann L.8, Faubion W.9, Korf H.10, McGovern D.5, Panes J.11, Salas A.11, Sandborn W.8,12, Silverberg M.4, Smith M.4, Vermeire S.10, Vetrano S.6, Shackelton L.3, Stitt L.3, Jairath V.3,13, Levesque B.8,12, Spencer D.3, Feagan B.3,13, Vande Casteele N.*8,12

1Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Robarts Clinical Trials, Inc., Amsterdam, Netherlands 3Robarts Clinical Trials, Inc., London, Canada 4Mount Sinai Hospital, Toronto, Canada 5F. Widjaja Foundation Inflammatory Bowel and Immunobiology Institute, Los Angeles, United States 6Humanitas University, Milan, Italy 7Academic Medical Center, Amsterdam, Canada 8University of California, San Diego, United States 9Mayo Clinic, Rochester, United States 10University of Leuven, Leuven, Belgium 11Hospital Clínic Barcelona, Barcelona, Spain 12Robarts Clinical Trials, Inc., San Diego, United States 13University of Western Ontario, London, Canada

P051: Use of digital technology to boost patient recruitment in inflammatory bowel disease clinical trialsECCO '17 Barcelona
Year: 2017
Authors:

Bouhnik Y.*1, Amiot A.2, Alexandre N.1, Attar A.1, Kondamudi P.K.3, Stéfanescu C.1

1Beaujon Hospital, Gastroenterology, Clichy, France 2University Paris, Paris, France 3CTMA- Clinical Trials Mobile Application, Paris, France

P052: The role of TDAG8 in intestinal inflammationECCO '17 Barcelona
Year: 2017
Authors:

Tcymbarevich I.1, de Vallière C.*1, Spalinger M.1, Cosin-Roger J.1, Atrott K.1, Richards S.2, Seuwen K.2, Frey-Wagner I.1, Rogler G.1,3

1University of Zurich, Zurich, Switzerland 2Novartis Institute for Biomedical Research, Basel, Switzerland 3University Hospital Zürich, Department of Gastroenterology and Hepatology, Zurich, Switzerland

P053: Circulating non-classical monocytes are reduced in patients with active IBD but increase after vedolizumab: a role for α4β7 in myeloid cell recruitment to the inflamed intestineECCO '17 Barcelona
Year: 2017
Authors:

Gordon H.*1, Hoti I.2, Lindsay J.O.1,3, Stagg A.2

1Royal London Hospital, Gastroenterology, London, United Kingdom 2The Blizard Institute, Centre for Immunobiology, Barts and the London School of Medicine, London, United Kingdom 3The Blizard Institute, Centre for Immunology, Barts and the London School of Medicine, London, United Kingdom