Yonsei University College of Medicine, Internal medicine, Seoul, South Korea

¹Chiba University, Department of Gastroenterology, Chiba, Japan, ²Chiba University, Kashiwanoha Clinic of East Asian Medicine, Kashiwa, Japan

¹IBD Clinic, Instituto Nacional de Ciencias Medicas y Nutricion, Gastroenterology, Mexico, Mexico, ²Hospital San Jose Tec de Monterrey, Monterrey, Mexico, ³Hospital Universitario Dr. Jose e Gonzalez, Department of Gastroenterology, Monterrey, Mexico, ⁴Hospital de Especialidades Centro Medico Nacional General Manuel Avila Camacho IMSS, Gastroenterology, Puebla, Mexico, ⁵Hospital de Alta Especialidad ISSSTE, Gastroenterology, Morelia, Mexico, ⁶Hospital General Regional 110 IMSS, Gastroenterology, Guadalajara, Mexico, ⁷Centro Médico ISSEMyM, Gastroenterology, Toluca, Mexico, ⁸Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”, Colorectal Surgery, Guadalajara, Mexico, ⁹Hospital “Gomez Farias” ISSSTE, Endoscopy, Guadalajara, Mexico, ¹⁰Hospital General 450 Secretaría de Salud, Gastroenterology, Durango, Mexico, ¹¹Hospital Regional 25 IMSS, Gastroenterology, Mexico, Mexico, ¹²EPIMEX Study Group, Gastroenterology, Whole country, Mexico

¹University of Szeged, 1st Department of Medicine, Szeged, Hungary, ²St. Francis Hospital, Kalocsa, Hungary, ³Csolnoky Ferenc Veszprém County Hospital, Veszprém, Hungary, ⁴Semmelweis University, 2nd Department of Medicine, Budapest, Hungary, ⁵State Health Centre, Department of Gastroenterology, Budapest, Hungary, ⁶University of Pécs, 1st Department of Internal Medicine, Pécs, Hungary, ⁷Péterfy Sándor Hospital and Trauma Center, Budapest, Hungary, ⁸Bekes County Pandy Kalman Hospital, Gyula, Hungary, ⁹Tolna County Balassa Janos Hospital, Gastroenterology Department, Szekszárd, Hungary, ¹⁰Bács-Kiskun County University Teaching Hospital, Kecskemét, Hungary, ¹¹University of Pécs, 2nd Department of Internal Medicine and Nephrology Centre, Pécs, Hungary, ¹²University of Debrecen, Debrecen, Hungary, ¹³Budai Irgalmasrendi Hospital, Budapest, Hungary, ¹⁴University of Debrecen, 2nd Department of Internal Medicine, Debrecen, Hungary, ¹⁵Semmelweis University, 1st Department of Surgery, Budapest, Hungary, ¹⁶Semmelweis University, 1st Department of Medicine, Budapest, Hungary, ¹⁷Semmelweis University, Department of Pediatrics, Budapest, Hungary

¹Yokohama City University Medical Centre, Inflammatory Bowel Disease Centre, Yokohama, Japan, ²Yokohama City University Graduate School of Medicine, Department of Gastroenterology, Yokohama, Japan, ³Yokohama City University, Advanced Medical Research Centre, Yokohama, Japan, ⁴Niigata University Graduate School of Medical and Dental Sciences, Division of Molecular and Diagnostic Pathology, Niigata, Japan, ⁵Yokohama City University Medical Centre, Division of Endoscopy, Yokohama, Japan, ⁶Osaka City Juso Hospital, Department of Gastroenterology and Hepatology, Osaka, Japan, ⁷Yokohama City University Medical Centre, Department of Diagnostic Pathology, Yokohama, Japan

¹Wilhelmina Children’s Hospital, University Medical Center Utrecht (UMCU), Department of Pediatric Gastroenterology, Utrecht, The Netherlands, ²University Medical Center Utrecht (UMCU), Regenerative Medicine Center, Utrecht, The Netherlands, ³Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Boztug Laboratory, Vienna, Austria, ⁴CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, ⁵Ankara University, Department of Pediatric Gastroenterology, Ankara, Turkey, ⁶Medical University of Innsbruck, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck, Austria, ⁷Akdeniz University Medicine Hospital, Pediatric Gastroenterology Department, Antalya, Turkey, ⁸Başkent University, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, Ankara, Turkey, ⁹University Medical Center Groningen, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gronigen, The Netherlands, ¹⁰Medical University of Innsbruck, Department of Pediatrics I, Innsbruck, Austria, ¹¹University Medical Center Utrecht (UMCU), Department of Medical Genetics, Utrecht, The Netherlands, ¹²Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Vienna, Austria, ¹³Medical University of Vienna, St. Anna Kinderspital and Children’s Cancer Research Institute, Department of Pediatrics, Vienna, Austria

¹IDIBAPS-Hospital Clínic Barcelona, CIBER-EHD, Barcelona, Spain, ²AbbVie Inc., North Chicago, USA

¹IRCCS, Casa Sollievo della Sofferenza, Hospital, UOC Gastroenterology, San Giovanni Rotondo, Italy, ²IRCCS Casa Sollievo della Sofferenza, Unit of Bioinformatics, San Giovanni Rotondo, Italy

¹Institut für Klinische Molekularbiologie, Kiel, Germany, ²Yonsei University College of Medicine, Internal Medicine and Institute of Gastroenterology, Seoul, South Korea, ³Yonsei University College of Medicine, Pediatrics, Seoul, South Korea

University of Edinburgh, IGMM, EDINBURGH, UK

¹Ludwig Boltzmann Institute Rare and Undiagnosed Diseases, Vienna, Austria, ²CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, ³Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria, ⁴St. Anna Kinderspital and Childrens‘ Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, Vienna, Austria

¹Western University, Department of Gastroenterology, London, Canada, ²Western University, London, Canada, ³Western University, Department of Medicine, London, Canada

¹Janssen Research and Development, LLC, Spring House, USA, ²Icahn School of Medicine at Mount Sinai, New York, USA, ³Novo Nordisk, Inc., Princeton, USA, ⁴Hôpital Saint-Louis, Dpt. Gastroenterology and Hepatology, Paris, France

¹Institute for Research and Innovation in Health (i3S), Porto, Portugal, ²Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Porto, Portugal, ³Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium, ⁴Centro Hospitalar do Porto, Department of Gastroenterology, Porto, Portugal, ⁵Faculty of Medicine, University of Porto, Porto, Portugal, ⁶Department of Gastroenterology, Centro Hospitalar de São João, Porto, Portugal

¹University Hospital Tuebingen, Internal Medicine I, Tuebingen, Germany, ²Universtiy Hosptial Tuebingen, Internal Medicine VIII, Tuebingen, Germany, ³Universtiy of Laval, Department for Medicine, Quebec, Canada, ⁴Defensin Therapeutics, Copenhagen, Denmark

¹State Research Institute of Highly Pure Biopreparations of FMBA, Department of Microbiology, St. Petersburg, Russian Federation, ²North-Western State Medical University named after I.I. Mechnikov, Department of Internal Diseases, Gastroenterology and Dietetics, St. Petersburg, Russian Federation, ³Kirov Military Medical Academy, St. Petersburg, Russian Federation, ⁴Institute of Toxicology of FMBA, St. Petersburg, Russian Federation, ⁵Institute of Experimental Medicine, St. Petersburg, Russian Federation, ⁶Almazov Federal Medical Research Centre, St. Petersburg, Russian Federation

University of Alberta, Edmonton, Canada

¹KU Leuven, The Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Leuven, Belgium, ²UZ Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, ³KU Leuven, Rega Institute, Department of Microbiology and Immunology, Leuven, Belgium

¹UniversityHospital of Zurich, Gastroenterology and Hepatology, Zurich, Switzerland, ²University of Bern, Department of Clinical Research Gastroenterology and Mucosal Immunology, Bern, Switzerland, ³Lausanne University Hospital, Institute of Social and Preventive Medicine, Lausanne, Switzerland, ⁴Klinik Hirslanden, Center of Gastroenterology, Zurich, Switzerland, ⁵Gastroenterology Bethanien, Zurich, Switzerland, ⁶Center of Gastroenterology and Hepatology, Zurich, Switzerland, ⁷UniversityHospital of Zurich, Hematology and Oncology, Zurich, Switzerland, ⁸Inselspital Bern University Hospital, Department of Visceral Surgery and Medicine, Bern, Switzerland, ⁹Clinic Barmelweid, Department of Psychosomatic Medicine, Barmelweid, Switzerland

¹Human Nutrition, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK, ²Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK, ³Warwick Medical School, University of Warwick, Warwick, UK, ⁴School of Engineering, University of Glasgow, Glasgow, UK, ⁵Institute of Infection, Immunity and Inflammation, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK, ⁶Queen Elizabeth University Hospital, Glasgow, UK, ⁷Institute of Veterinary Pathology, Freie Universitaet, Berlin, Germany, ⁸Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UK, ⁹Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children, Glasgow, UK