¹University of Greenwich, Faculty of Education and Health, London, UK, ²Bart's Health NHS Trust, Academic Research Centre, London, UK, ³King's College London, Florence Nightingale School of Nursing and Midwifery, London, UK, ⁴Stats Consultancy, Amersham, UK

¹Hospital Central do Funchal, Gastroenterology, Funchal, Portugal, ²Hospital Central do Funchal, Clinical Pathology, Funchal, Portugal

Faculdade de Medicina da USP, Gastroenterology, São Paulo, Brazil

¹Singapore General Hospital, Pharmacy, Singapore, Singapore, ²Singapore General Hospital, Department of Gastroenterology and Hepatology, Singapore, Singapore, ³Duke-NUS Medical School, Singapore, Singapore

¹Hospital de Braga, Gastroenterology, Braga, Portugal, ²School of Health Sciences, University of Minho, Braga, Portugal

¹TopiVert Pharma Ltd., London, UK, ²Oxford University Hospitals Trust, Translational Gastroenterology Unit, Oxford, UK

¹John Radcliffe Hospital, Translational Gastroenterology Unit, Oxford, UK, ²University of Oxford, Nuffield Department of Population Health, Oxford, UK, ³Big Data Institute, Oxford, UK, ⁴Mathematical Institute, Oxford, UK, ⁵University of Oxford, Psychiatry Department, Oxford, UK, ⁶Weatherall Institute of Molecular Medicine, Oxford, UK, ⁷University of Oxford, Centre for Statistics in Medicine, Oxford, UK

¹MassGeneral Hospital for Children, Pediatric Gastroenterology, Boston, USA, ²Harvard Medical School, Boston, USA, ³Cincinnati Children's Hospital, Cincinnati, USA, ⁴Children’s Mercy Hospital, Kansas City, USA, ⁵University of Texas-Southwestern/Children's Medical Center, Dallas, USA, ⁶The Children’s Hospital at Montefiore, Bronx, USA, ⁷Mayo Clinic-Children’s Center, Rochester, USA, ⁸Takeda Pharmaceuticals USA, Deerfield, USA, ⁹University of Vermont College of Medicine, Burlington, USA

¹Sapienza University, Department of Internal Medicine and Medical Specialties, Rome, Italy, Rome, Italy, ²Cristo Re, Hospital, Internal Medicine, “Cristo Re” Hospital, Rome, Italy, Rome, Italy

¹Stanford University School of Medicine, Gastroenterology and Hepatology, Stanford, California, USA, ²Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, New York, USA, ³Frederiksberg Hospital, Clinical Epidemiology, Frederiksberg, Denmark, ⁴Montefiore Medical Center, Gastroenterology, Bronx, USA

¹La Fe University and Polytechnic Hospital and CIBER-EHD, Department of Gastroenterology, Valencia, Spain, ²La Fe University and Polytechnic hospital of Valencia, Department of Gastroenterology and Hepatology, Valencia, Spain, ³University Clinic Hospital of Valencia, Department of Gastroenterology and Hepatology, Valencia, Spain, ⁴Hospital de Sagunto (Sagunto), Department of Gastroenterology, Valencia, Spain

¹Hospital for Sick Children, University of Toronto, Toronto, Canada, ²University of Calgary, Medicine, Calgary, Canada, ³Ludwig-Maximilians-University Munich, Munich, Germany, ⁴Center of Endoscopy, Starnberg, Germany

¹Bicêtre Hospital - APHP, Gastro-enterology, Kremlin-Bicêtre, France, ²University Hospital Paul Brousse, Liver and biliary-tract disease center, Villejuif, France, ³Universite Paris Sud, Institut Gustave Roussy, Centre for Research in Epidemiology and Population Health / INSERM, UMRS 1018, Team 9, Villejuif, France

¹University of Calgary, IBD Unit, Division of Gastroenterology and Hepatology, Calgary, Canada, ²Mayo Clinic Rochester, Division of Colorectal Surgery, Rochester, USA, ³Mayo Clinic Rochester, Division of Gastroenterology and Hepatology, Rochester, USA

NHS Lothian, Gastroenterology, Edinburgh, UK

¹University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France, ²University Hospital, Gastroenterology Department, Lille, France, ³CHU de Montpellier, Department of Gastroenterology, Montpellier, France, ⁴Archet 2 University Hospital, Department of Gastroenterology, Nice, France, ⁵Hospital Henri-Mondor, Department of Gastroenterology, Creteil, France, ⁶University Hospital of Besançon, Gastroenterology, Besançon, France, ⁷University Hospital, Gastroenterology Department, Amiens, France, ⁸University Hospital of Lille, Gastroenterology, Lille, France, ⁹University Hospital, Biostatistics Unit, DRCI, Clermont-Ferrand, France, ¹⁰UMR 1071 Inserm/Université d'Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the Host, Clermont-Ferrand, France

¹Academic Medical Center (AMC), Department of Surgery, Amsterdam, The Netherlands, ²Academic Medical Center (AMC), Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands

¹University Medical Center Dresden, Department of Medicine I, Dresden, Germany, ²University Hospital Schleswig-Holstein, Department of Internal Medicine I, Kiel, Germany, ³University Hospital Schleswig-Holstein, Institute of Clinical Molecular Biology, Kiel, Germany, ⁴Christian-Albrechts-Universität zu Kiel, Institute of Immunology, Kiel, Germany

¹Brighton and Sussex University Hospitals NHS Trust, UK, Gastroenterology, Brighton and Hove, UK, ²Sussex Partnership NHS Foundation Trust, UK, Liason Psychiatry, Brighton and Hove, UK

University of Chicago, Chicago, USA