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P094: Strain dependent difference in the progression of dextran sulphate sodium induced colitis is a consequence of the cross-talk between colon-infiltrating dendritic cells and T regulatory cellsECCO '18 Vienna
Year: 2018
Authors:

B. Simovic Markovic1*, A. Acovic2, M. Gazdic1, A. Arsenijevic1, A. Volarevic3, T. Kanjevac2, N. Jovicic1, J. Jakovljevic1, M. Arsenijevic1, N. Arsenijevic1, M.L. Lukic1, V. Volarevic1

1Centre for Molecular Medicine and Stem Cell research, Faculty of Medical Sciences University of Kragujevac Serbia, Department of Microbiology and Immunology, Kragujevac, Serbia, 2Faculty of Medical Sciences, University of Kragujevac Serbia, Department of Dentistry, Kragujevac, Serbia, 3Faculty of Medical Sciences, University of Kragujevac Serbia, Department of Psychology, Kragujevac, Serbia

P095: Consequences of an IL2RA locus duplication in a very early onset inflammatory bowel disease patientECCO '18 Vienna
Year: 2018
Authors:

M. Joosse1*, F. Charbit-Henrion2, H. Raatgeep1, D.J. Lindenbergh-Kortleve1, L.M. Costes1, S. Nugteren1, V. Malan2, J. Nowak3, M.L. Mearin4, J. Escher5, N. Cerf-Bensussan2, J.N. Samsom1

1Erasmus MC, Laboratory of Pediatrics, division Gastroenterology and Nutrition, Rotterdam, The Netherlands, 2INSERM, Institut Imagine and Université Paris-Descartes, Laboratory of Intestinal Immunity, Paris, France, 3Poznan University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland, 4Leiden University Medical Center (LUMC), Department of Paediatric Gastroenterology, Leiden, The Netherlands, 5Erasmus Medical Center Children's Hospital, Department of Paediatric Gastroenterology, Rotterdam, The Netherlands

P096: Failure to control inflammation as a driving force of symptoms and phenotype in the NSG mouse model of ulcerative colitis.ECCO '18 Vienna
Year: 2018
Authors:

H. Jodeleit1*, P. Palamides2, O. Al-amodi1, G. Beikircher3, S. Schönthaler3, F. Beigel4, E. Wolf2, A. Weinhäusel3, M. Siebeck1, R. Gropp1

1Hospital of the Ludwig Maximilian Universität, General-, Visceral and Transplantation surgery, Munich, Germany, 2Ludwig Maximilian Universität, Institute of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Munich, Germany, 3Austrian Institute of Technology, Vienna, Austria, 4Hospital of the Ludwig Maximilian Universität, Medicine II-Grosshadern, Munich, Germany

P097: BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, ameliorates DSS-induced colitis in miceECCO '18 Vienna
Year: 2018
Authors:

H.J. Cho1*, E.S. Kim1, H. Lee1, J.-A. Kim2, B.-S. Jeong2, T.-g. Nam3, Y.-J. Lee1

1Kyungpook National University School of Medicine, Internal Medicine, Daegu, South Korea, 2Yeungnam University College of Pharmacy, Pharmacy, Daegu, South Korea, 3Hanyang University College of Pharmacy, Pharmacy, Ansan, South Korea

P098: Aryl hydrocarbon receptor ameliorates intestinal barrier dysfunction in colitis by regulating the myosin light-chain kinase signalling pathwayECCO '18 Vienna
Year: 2018
Authors:

H. Ma*, H. Zhang

First Affiliated Hospital of Nanjing Medical University, Department of Gastroenterology, Nanjing, China

P099: Postprandial intestinal motility and related physiology in active small-bowel Crohn’s diseaseECCO '18 Vienna
Year: 2018
Authors:

A. Khalaf1,2, C.L. Hoad2,3, A. Menys4, S. Radford2, A. Nowak2, S. Paparo1,2, M. Lingaya2, Y. Falcone2, G. Singh2, S.A. Taylor4, R.C. Spiller1,2, P.A. Gowland3, L. Marciani1,2, G.W. Moran1,2*

1Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham UK, Nottingham, UK, 2National Institute of Health Research (NIHR) Biomedical Research Centre in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK, 3Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham UK, Nottingham, UK, 4Centre for Medical Imaging, Division of Medicine, UCL UK, London, UK

P100: Guanosine prevents nuclear factor-κB nuclear translocation ameliorating experimental colitis in ratsECCO '18 Vienna
Year: 2018
Authors:

M.G. Zizzo1,2*, G. Caldara3, A. Bellanca2, D. Nuzzo4, M. Di Carlo4, R. Serio1

1University of Palermo, Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Palermo, Italy, 2University of Palermo, Advanced Technologies Network (ATeN) Center, Palermo, Italy, 3University of Palermo, Palermo, Italy, 4Institute of Biomedicine and Molecular Immunology "Alberto Monroy" (IBIM), Consiglio Nazionale delle Ricerche (CNR), Palermo, Italy

P101: Innate immunity and Crohn’s disease recurrence after surgeryECCO '18 Vienna
Year: 2018
Authors:

L. Saadeh1*, I. Angriman1, A. Kotsafti2, C. Mescoli3, T. Odorizzi1, M. Scarpa2, F. Cavallin2, M. Rugge4, R. Bardini1, I. Castagliuolo5, M. Scarpa2

1University of Padova, Department of Surgery, Oncology and Gastroenterology, Padova, Italy, 2IRCCS IOV Istituto Oncologico Veneto, Padova, Italy, 3Azienda Ospedaliera - Università di Padova, Padova, Italy, 4University of Padova, Department of Medicine, Padova, Italy, 5University of Padova, Department of Molecular Medicine, Padova, Italy

P102: Increased abundance of gut microbial virulence genes and pro-inflammatory pathways during Crohn’s disease exacerbationsECCO '18 Vienna
Year: 2018
Authors:

M. Klaassen*, F. Imhann, V. Collij, A. Vich Vila, R. Gacesa, J. Fu, A. Zhernakova, C. Wijmenga, R. Weersma

University Medical Center of Groningen, Groningen, The Netherlands

P103: The identification of lesion-specific gene expression in intestinal epithelial cells of ulcerative colitis by comparing colonic organoids from lesion and non-lesion parts of same patientsECCO '18 Vienna
Year: 2018
Authors:

R. Nishimura1*, K. Tsuchiya1, T. Shirasaki1, S. Watanabe1, S. Hibiya1, R. Okamoto2, T. Nakamura3, M. Watanabe1

1Tokyo Medical and Dental University, Gastroenterology and Hepatology, Tokyo, Japan, 2Tokyo Medical and Dental University, Center for Stem Cell and Regenerative Medicine, Tokyo, Japan, 3Tokyo Medical and Dental University, Advanced Therapeutics for Gastrointestinal Diseases, Tokyo, Japan

P104: Gene expression profiles in inflamed colonic biopsies from newly diagnosed Crohn’s disease and ulcerative colitis patients differ depending on the age at diagnosisECCO '18 Vienna
Year: 2018
Authors:

S. Verstockt1*, B. Verstockt2,3, J. Van Bouwel4,5, W. Meert4,5, A. Cortes Calabuig5, V. Brys4,5, V. Ballet2, E. Glorieus6, M. De Decker7, G. Van Assche2,3, P. Hindryckx6, M. Ferrante2,3, D. Laukens6, F. Mana7, M. De Vos6, S. Vermeire2,3, I. Cleynen1

1University of Leuven, Department of Human Genetics, Laboratory for Complex Genetics, Leuven, Belgium, 2University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, 3University of Leuven, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Leuven, Belgium, 4University of Leuven, Department of Human Genetics, Leuven, Belgium, 5University Hospitals Leuven, Genomics Core, Leuven, Belgium, 6University Hospital Ghent, Department of Gastroenterology, Ghent, Belgium, 7University Hospital Brussels, Department of Gastroenterology, Brussels, Belgium

P105: Human neutrophil elastase degrades the therapeutic monoclonal antibodies effective in IBDECCO '18 Vienna
Year: 2018
Authors:

K. Kok1,2*, R. Curciarello3, T. Sobande1, S. Jones1, G. Docena3, T. MacDonald1

1Blizard Institute, Barts and the London School of Medicine and Dentistry, Centre for Immunobiology, London, UK, 2Barts Health, London, UK, 3Instituto de Estudios Inmunológicos y Fisiopatológicos-IIFP-CONICET-Universidad Nacional de La Plata, La Plata, Argentina

P106: Bifidobacterium longum subsp. longum microbiota-secreted bioactive peptide as a novel immunomodulatory compound in the human gastrointestinal tractECCO '18 Vienna
Year: 2018
Authors:

S. Fernández Tomé1,2,3*, A. Montalbán-Arqués1,2,3, A. Díaz-Guerra1,2,3, J.M. Galván Román2,4, A.C. Marín1,2,3, I. Mora-Gutiérrez1,2,3, C. Santander1,2,3,5, B. Sánchez6, M. Chaparro1,2,3,5, J.P. Gisbert1,2,3,5, D. Bernardo1,2,3

1Hospital Universitario de La Princesa, Gastroenterology Unit, Madrid, Spain, 2Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain, 3Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain, 4Hospital Universitario de La Princesa, Immunology Unit, Madrid, Spain, 5Universidad Autónoma de Madrid, Madrid, Spain, 6Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Department of Microbiology and Biochemistry of Dairy Products, Villaviciosa, Spain

P107: MicroRNA signatures can differentiate the inflamed colonic mucosa from non-inflamed mucosa in ulcerative colitis patientsECCO '18 Vienna
Year: 2018
Authors:

S. Valmiki1*, V. Ahuja2, J. Paul1, R. Ranjha1, R. Ranjha1

1Jawaharlal Nehru University, School of Life Sciences, New Delhi, India, 2All India Institute of Medical Sciences, Department of Gastroenterology, New Delhi, India

P108: Differential expression in colitis-associated cancer compared with Crohn’s disease and ulcerative colitisECCO '18 Vienna
Year: 2018
Authors:

M. Sehn1, S. Elezkurtaj2, D. Cardoso da Silva3, B. Siegmund4, M. Kreis1, C. Holmer1, M. Hummel5, J. Gröne6, M. Schumann3*

1Charite - University Hospital Berlin, Department of Surgery, Berlin, Germany, 2Charité university medicine, Pathology, Berlin, Germany, 3Charité university medicine, Gastroenterology, Berlin, Germany, 4Charité - University Hospital Berlin, Campus Benjamin Franklin, Department of Gastroenterology and Medicine I, Berlin, Germany, 5Charité university medicine, Institute of Molecular Pathology, Berlin, Germany, 6DRK Klinikum, Department of General and Visceral Surgery, Bremen, Germany

P109: Rifaximin and Saccharomyces boulardii increase stress resilience in TNBS-induced colitisECCO '18 Vienna
Year: 2018
Authors:

P. Konturek1*, Y. Zopf2, W. Dieterich2, S. Wirtz3, M.F. Neurath2, T. Brzozowski4

1Thuringia Clinic, Department of Medicine, Saalfeld, Germany, 2University Erlangen-Nuremberg, Department of Medicine, Erlangen, Germany, 3University Erlangen-Nuremberg, Department of Medicine, Erlangen, Ghana, 4University Cracow, Department of Physiology, Cracow, Poland

P110: TIGIT expression identifies circulating CD38+ effector T cells with immune regulatory properties whose frequencies at diagnosis predict disease course of paediatric IBD patientsECCO '18 Vienna
Year: 2018
Authors:

M. Joosse1*, C. Menckeberg1, L.F. de Ruiter1, H. Raatgeep1, L.A. van Berkel1, Y. Simons-Oosterhuis1, M. Joosse2, R.W. Hendriks2, R.M. Hoogenboezem3, T. Cupedo3, L. de Ridder4, J. Escher4, S. Veenbergen1, J.N. Samsom1

1Erasmus MC, Laboratory of Pediatrics, division Gastroenterology and Nutrition, Rotterdam, The Netherlands, 2Erasmus MC, Department of Pulmonology, Rotterdam, The Netherlands, 3Erasmus MC, Department of Hematology, Rotterdam, The Netherlands, 4Erasmus Medical Center Children's Hospital, Department of Paediatric Gastroenterology, Rotterdam, The Netherlands

P111: Extracellular Nicotinamide Phosphoribosyltransferase (eNAMPT): A possible new target in inflammatory bowel diseasesECCO '18 Vienna
Year: 2018
Authors:

C. Travelli1*, G. Colombo1, C. Porta1,2, F. Malavasi3, A.A. Genazzani1

1Università del Piemonte Orientale, Dipartimento di Scienze del Farmaco, Novara, Italy, 2University of Piemonte Orientale, Novara, Italy, 3University of Torino, Torino, Italy

P112: LXR-ABCA1 pathway: a therapeutic target in inflammatory bowel disease?ECCO '18 Vienna
Year: 2018
Authors:

J. Miranda-Bautista1*, J.A. Rodriguez-Feo1, B. Lopez Cauce1, M. Puerto1, J.M. Lara2, R. Bañares1, L. Menchén1

1Hospital General Universitario Gregorio Marañón, Servicio de Aparato Digestivo, Madrid, España, Gastroenterology Unit, Madrid, Spain, 2Hospital General Universitario Gregorio Marañón, Servicio de Aparato Digestivo, Madrid, España, Pathology, Madrid, Spain

P113: Effects of change in the gut microbiota on colon tumorigenesis in AOM-DSS modelECCO '18 Vienna
Year: 2018
Authors:

C.S. Eun*, D.S. Han, C.H. Park, A.R. Lee

Hanyang University Guri Hospital, Gastroenterology, Guri, South Korea