¹Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ²Gastroenterology and Hepatology Unit, Monash Medical Centre, Melbourne, Australia, ³Hudson Institute for Medical Research, Melbourne, Australia

¹Clinic of the Goethe University, Frankfurt, Germany, ²German Red Cross Blood Service Institution, Frankfurt, Germany, ³Institute of Pathology and Cytology, Limburg, Germany

¹Seoul National University Hospital Healthcare System Gangnam Center, Department of Internal Medicine and Healthcare Research Institute, Seoul, South Korea, ²Samsung Changwon Hospital, Department of Internal Medicine, Changwon, South Korea, ³Seoul National University Boramae Hospital, Department of Internal Medicine, Seoul, South Korea, ⁴Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Instutute, Seoul, South Korea

Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Antwerp, Belgium

¹Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Department of Medicine II, Freiburg, Germany, ²Faculty of Medicine, University of Freiburg, Berta-Ottenstein-Programme, Freiburg, Germany, ³Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Department of Surgery, Freiburg, Germany

¹Mimetas BV, Leiden, The Netherlands, ²Roche Innovation Center Basel, F. Hoffmann‐La Roche Ltd., Basel, Switzerland, ³Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands

¹Hospital Universitari Mútua Terrassa, Department of Gastroenterology, Terrassa (Barcelona), Spain, ²Centro de Investigación biomédica en red de enfermedades hepáticas y digestivas (CIBERehd), Terrassa (Barcelona), Spain, ³Laboratori de recerca. Fundació Mútua de Terrassa, Terrassa (Barcelona), Spain, ⁴Hospital Universitari Mútua Terrassa, Department of Pathology, Terrassa (Barcelona), Spain

Charité , Campus Benjamin Franklin, Medizinische Klinik mit Schwerpunkt Gastroenterologie, Infektiologie und Rheumatologie, Berlin, Germany

¹Technion-Israel Institute of Technology, Faculty of Medicine, Haifa, Israel, ²Rambam Health Care Campus, Gastroenterology Department, Haifa, Israel, ³Stanford University, Stanford Center for Biomedical Informatics Research, Palo Alto, USA, ⁴Stanford University, Stanford Institute for Immunity, Transplantation and Infection, Palo Alto, USA, ⁵Tel Aviv Sourasky Medical Center, Department of Gastroenterology and Liver Diseases, Tel Aviv, Israel, ⁶Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel, ⁷Rambam Health Care Campus, Department of Pathology, Haifa, Israel

¹Hospital of the Ludwig Maximilian Universität, General-, Visceral and Transplantation surgery, Munich, Germany, ²Hospital of the Ludwig Maximilian Universität, Medicine II-Grosshadern, Munich, Germany, ³Ludwig Maximilian Universität, Institute of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Munich, Germany, ⁴Hospital of the LMU, General-, visceral and transplantation surgery, Munich, Germany

¹KU Leuven, Department Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, ²KU Leuven, Department of Human Genetics, Laboratory of Complex Genetics, Leuven, Belgium, ³University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium

Takeda Development Center Americas, Deerfield, IL, USA

¹Wroclaw Medical University, Department of Gastroenterology and Hepatology, Wroclaw, Poland, ²Wroclaw Medical University, Department of Medical Biochemistry, Wroclaw, Poland

University Hospital Zurich, University of Zurich, Gastroenterology and Hepatology, Zurich, Switzerland

¹Rijnstate Crohn and Colitis Centre, Department of Gastroenterology and Hepatology, Arnhem, The Netherlands, ²Rijnstate Hospital, Department of Microbiology and Immunology, Arnhem, The Netherlands

¹CHA University, Gastroenterology, Seongnam, South Korea, ²CHA Cancer preventive Research center, Seongnam, South Korea, ³CHA University, Seongnam, South Korea

¹Unit of Pathology, “Villa Sofia-Cervello” Hospital, Palermo, Italy, ²Division of Internal Medicine, “Villa Sofia-Cervello” Hospital, Palermo, Italy, ³Gastroenterology and Endoscopy Unit, “Villa Sofia-Cervello” Hospital, Palermo, Italy

¹University of Antwerp, Laboratory of Experimental Medicine and Pediatrics, Antwerp, Belgium, ²Antwerp University Hospital, Gastroenterology and Hepatology, Antwerp, Belgium

¹Nordic Bioscience A/S, Herlev, Denmark, ²Odense University Hospital, Department of Medical Gastroenterology, Odense, Denmark, ³Lillebaelt Hospital Vejle, Department of Internal Medicine, Section of Gastroenterology, Vejle, Denmark

¹Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Trondheim, Norway, ²Norwegian University of Science and Technology, Centre of Molecular Inflammation Research (CEMIR), Trondheim, Norway, ³St. Olav’s University Hospital, Department of Infectious Diseases, Trondheim, Norway, ⁴St. Olav’s University Hospital, Trondheim, Department of Gastroenterology and Hepatology, Trondheim, Norway, ⁵St. Olav’s University Hospital, Trondheim, Clinic of Medicine, Trondheim, Norway, ⁶University of Oslo, K.G Jebsen Inflammation Research Center, Oslo, Norway, ⁷Oslo University Hospital Rikshospitalet and Univesity of Oslo, Department of Immunology, Oslo, Norway, ⁸Nordland Hospital, Research Laboratory, Bodø, Norway, ⁹University of Tromsø, K.G. Jebsen Thrombosis Research and Expertise Center, Institute of Clinical Medicine, Tromsø, Norway