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P034: Validation of a novel xenograft mouse model for intestinal fistulasECCO '18 Vienna
Year: 2018
Authors:

R.S. Bruckner1,2*, N. Marsiano3, E. Nissim-Eliraz3, E. Nir3, M. Leutenegger1, C. Gottier1, S. Lang1,2, M. Spalinger1,2, G. Rogler1,4, S. Yagel5, SysmedIBD EU research consortium, N.Y. Shpigel 3*

1University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland, 2University of Zurich, Zurich, Switzerland, 3Hebrew University of Jerusalem, Koret School of Veterinary Medicine, Rehovot, Israel, 4University of Zurich, Zurich Center for Integrative Human Physiology, Zurich, Switzerland, 5Hadassah University Hospital, Obstetrics and Gynecology, Jerusalem, Israel

P035: Serum markers predict outcome to ustekinumab in patients with refractory Crohn’s disease and provide insides in the mechanism of actionECCO '18 Vienna
Year: 2018
Authors:

B. Verstockt1,2*, S. Vermeire1,2, S. Verstockt3, B. Creyns4, N. Ardeshir Davani2, C. Breynaert4, G. Van Assche1,2, G. Van Assche1,2, M. Ferrante1,2

1University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, 2KU Leuven, Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium, 3KU Leuven, Laboratory of Complex Genetics, Department of Human Genetics, Leuven, Belgium, 4KU Leuven, Laboratory for Clinical Immunology, Department of Microbiology and Immunology, Leuven, Belgium

P036: Faecalibacterium prausnitzii produces butyrate to maintain Th17/Treg balance and to ameliorate colorectal colitis by inhibiting histone deacetylase 1ECCO '18 Vienna
Year: 2018
Authors:

L. Zhou1*, M. Zhang1,2,3, Y. Wang1, T. Yu1,4, X. Chen1, D. Tang1, L. Xu1, Y. Yin1, Y. Pan5, Q. Zhou6, Y. Zhou1, C. Yu1,2

1Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, 2Jiangsu Clinical Medical Center of Digestive Disease, Nanjing, China, 3Fudan University, Nanjing, China, 4Zhongda Hospital, Nanjing, China, 5Huashan Hospital, Shanghai, China, 6Fudan University, Shanghai, China

P037: Bacterial handling defect in macrophages of patients with defects in glucose-6-phosphate metabolism and Crohn’s disease like intestinal inflammationECCO '18 Vienna
Year: 2018
Authors:

S. Pandey1*, K. Balagopal1, D. Aschenbrenner1, M. Capitani1, C. Weidinger2, E. Pires3, J. McCullagh3, S. Travis1, J. Ziegler2, B. Siegmund2, H.H. Uhlig1

1University of Oxford, Translational Gastroenterology Unit, Oxford, UK, 2Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, 3University of Oxford, Chemistry Research Laboratory, Oxford, UK

P038: Th17 cells dominate the colonic mucosal immune response in primary sclerosing cholangitis associated colitisECCO '18 Vienna
Year: 2018
Authors:

M.N. Quraishi1,2,3*, A. Acharjee2,4, E. Liaskou1, A. Rossiter5, C. Tselepis4, G. Gkoutos2,4, S. Ghosh2,3, G. Hirschfield1, D. Withers6, T.H. Iqbal2,3

1University of Birmingham, Centre for Liver Research and National Institute of Health Research (NIHR) Birmingham, Liver Biomedical Research Unit (BRU), Institute of Immunology and Immunotherapy, Birmingham, UK, 2University of Birmingham, Institute of Translational Medicine, Birmingham, UK, 3University Hospital Birmingham, Department of Gastroenterology, Birmingham, UK, 4University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, UK, 5University of Birmingham, Institute of Microbiology and Infection, Birmingham, UK, 6University of Birmingham, Institute of Immunology and Immunotherapy, Birmingham, UK

P039 has been withdrawn.: ECCO '18 Vienna
Year: 2018
Authors:

P040: Paeoniflorin attenuates ulcerative colitis by inhibiting dendritic cells maturity and Th17/Treg differentiation in naive CD4+ T cells and TNBS-induced ColitisECCO '18 Vienna
Year: 2018
Authors:

K. Zheng1*, H. Shen1, J. Jia2

1Affiliated Hospital of Nanjing University of Chinese Medicine, Gastroenterology, Nanjing, China, 2Affiliated Hospital of Nanjing University of Chinese Medicine, Endocrinology, Nanjing, China

P041: Targeting fibroblast activation protein in Crohn’s disease intestinal strictures restores balanced deposition of extracellular matrix and reduces fibrosisECCO '18 Vienna
Year: 2018
Authors:

M. Truffi1*, L. Sorrentino1, M. Monieri1, S. Mazzucchelli1, P. Fociani2, G.M. Sampietro3, A. Di Sabatino4, F. Corsi1,5

1University of Milan, Department of Biomedical and Clinical Sciences "L. Sacco", Milan, Italy, 2ASST Fatebenefratelli - Sacco, Department of Pathology, Milan, Italy, 3ASST Fatebenefratelli - Sacco, Department of Surgery, IBD unit, Milan, Italy, 4University of Pavia, Department of Medicine I, Pavia, Italy, 5ICS Maugeri S.p.A. SB, Department of Surgery, Pavia, Italy

P042: Decreased leukocyte trafficking may contribute to vedolizumab refractory disease after anti-TNF exposure in patients with ulcerative colitisECCO '18 Vienna
Year: 2018
Authors:

B. Verstockt1,2*, S. Verstockt3, M. de Bruyn2, K. Machiels2, H. Blevi2, V. Ballet1, G. Van Assche1,2, S. Vermeire1,2, M. Ferrante1,2

1University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, 2KU Leuven, Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium, 3KU Leuven, Laboratory of Complex Genetics, Department of Human Genetics, Leuven, Belgium

P043: The effects of IBD biologic drugs on the propagation of lymphomatous transformation of EBV-infected peripheral blood mononuclear cellsECCO '18 Vienna
Year: 2018
Authors:

N. Levhar1, B. Ungar1*, U. Kopylov1, M. Yavzori1, E. Fudim1, O. Picard1, R. Eliakim1, N. Amariglio2, S. Ben-Horin1

1Sheba Medical Center and Sackler School of Medicine, Gastroenterology, Tel Hashomer, Israel, 2Sheba Medical Center, Hematology lab, Ramat Gan, Israel

P044: T cells expressing integrin α4β7 are abundant in fistula tracts of Crohn’s disease patientsECCO '18 Vienna
Year: 2018
Authors:

M. de Krijger1,2*, C.J. Buskens3, M.E. Wildenberg1,2, C. Verseijden1, W.J. de Jonge1, C.Y. Ponsioen2

1Academic Medical Center (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands, 2Academic Medical Center (AMC), Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands, 3Academic Medical Center (AMC), Department of Surgery, Amsterdam, The Netherlands

P045: Dried blood spot sampling can facilitate therapeutic drug monitoring of vedolizumab therapyECCO '18 Vienna
Year: 2018
Authors:

S. Bian1*, L. Vandersmissen1, S. Tops1, E. Dreesen1, M. Ferrante2, S. Vermeire2, A. Gils1

1KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium, 2University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium

P046: Presence of an autoimmunity-associated variant in PTPN22 promotes chronic colitis in a microbiota dependent mannerECCO '18 Vienna
Year: 2018
Authors:

M. Spalinger1*, M. Schwarzfischer1, L. Hering1, A. Geirnaert2, C. Gottier1, S. Lang1, C. Lacroix2, G. Rogler1, M. Scharl1

1University Hospital Zürich, Gastroenterology and Hepatology, Zürich, Switzerland, 2ETH Zurich, Department for Food and Nutrition, Zurich, Switzerland

P047: Superoxide production and enhanced NOX2 induction through JAK/STAT signalling mediate IL-6-induced inflammatory responses of colon epithelial cellsECCO '18 Vienna
Year: 2018
Authors:

P. Grung1*, S. Banskota1, B.-S. Jeong1, T.-g. Nam2, J.-A. Kim1

1Yeungnam University, College of Pharmacy, Gyeongsan, South Korea, 2Hanyang University, College of Pharmacy, Ansan, South Korea

P048: MRI T2 relaxometry-based measures of intestinal inflammation in a human intestinal permeability model: a pilot studyECCO '18 Vienna
Year: 2018
Authors:

R. Scott1,2*, C. Hoad1,3, H. Williams3, C. Ortori4, J. Grove1,2, G. Moran1,2, P. Gowland1,3, G. Aithal1,2

1National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre at the Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK, 2Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK, 3Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, USA Minor Outlying Islands, 4Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham, UK

P049: HLA B27 transgenic rat: a new animal model of ileitis post-surgery reproducing inflammatory bowel diseaseECCO '18 Vienna
Year: 2018
Authors:

A. Chau1*, L. Schneider1, C. Chater1, S. Speca2, M. Djouina2, C. Dubuquoy2, L. Dubuquoy2, C. Neut2, D. Koriche1, F.R. Pruvot1, P. Desreumaux2,3, P. Zerbib1, B. Pariente2,3

1Lille University North of France; INSERM U995, Lille, France; CHRU Lille, Department of Surgery, Claude Huriez Hospital, Lille, France, Lille, France, 2Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, University Lille, F-59000, Lille, France, 3Hepato-Gastroenterology Department, Claude Huriez Hospital, University of Lille 2, Lille, France

P050: Enterocyte microvillus length and associated gene expression are reduced in Crohn’s diseaseECCO '18 Vienna
Year: 2018
Authors:

K.L. VanDussen1, K. Li2*, A. Stojmirović2, T.-C. Liu1, P.K. Kimes1, J.G. Perrigoue2, J.R. Friedman2, J.E. Towne2, R.D. Head1, T. Stappenbeck1

1Washington University School of Medicine, St. Louis, USA, 2Janssen Research and Development, LLC, Spring House, USA

P051: Lower incidence of herpes zoster in vedolizumab-treated vs. tofacitinib-treated patients with ulcerative colitisECCO '18 Vienna
Year: 2018
Authors:

F. Caldera1*, K. Lasch2, T. Lissoos2, C. Cao2, F. Bhayat3

1University of Wisconsin School of Medicine and Public Health, Department of Gastroenterology and Hepatology, Madison, USA, 2Takeda Pharmaceuticals U.S.A., Inc., Deerfield, USA, 3Takeda Pharmaceuticals U.S.A., Inc., Cambridge, USA

P052: Protein biomarkers identify subclinical inflammation patterns in first-degree relatives of patients with inflammatory bowel diseaseECCO '18 Vienna
Year: 2018
Authors:

M. Vancamelbeke1*, V. Ballet2, N. Ardeshir Davani1, G. Van Assche1,2, M. Ferrante1,2, I. Cleynen3, S. Vermeire1,2

1KU Leuven, Department Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, 2University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, 3KU Leuven, Department of Human Genetics, Laboratory of Complex Genetics, Leuven, Belgium

P053: Impact of N- acyl-homoserine lactone 3-oxo-C12:2, a major quorum sensing molecule from gut microbiota, on intestinal epithelial barrier functionECCO '18 Vienna
Year: 2018
Authors:

D. Aguanno1, E. Quevrain2, E. Le Balc’h2, C. Landman2,3, L. Brot2, A. Peyrottes2,4, J.-M. Mallet4, A. Leturque1, P. Seksik2,3*, J.-P. Grill2, S. Thenet1,5

1Sorbonne Universités, UPMC Univ Paris 06, Sorbonne Cités, UPD Univ Paris 05, INSERM, CNRS, Centre de Recherche des Cordeliers, UMR_S1138, Paris, France, 2Sorbonne Universités, UPMC Univ Paris 06,, INSERM ERL 1157, Laboratoire des Biomolécules, École normale supérieure, DHU I2B, Paris, France, 3Sorbonne Universités, AP-HP, Department of Gastroenterology, Hospital Saint-Antoine, Paris, France, 4École Normale Supérieure-PSL Research University, Department of Chemistry, Paris, France, 5EPHE, PSL Research University, Paris, France