¹University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, ²KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium, ³University Hospitals Leuven, Department of Paediatric gastroenterology, Leuven, Belgium, ⁴Ziekenhuis Oost-Limburg-Campus Sint-Jan, Department of Gastroenterology and Hepatology, Genk, Belgium, ⁵CHU UCL Namur, Université catholique de Louvain, Yvoir, Belgium, ⁶Imeldaziekenhuis, Department of Gastroenterology and Hepatology, Bonheiden, Belgium, ⁷Mariaziekenhuis Noord-Limburg, Department of Gastroenterology and Hepatology, Overpelt, Belgium, ⁸Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium, ⁹University Hospital Antwerp, Department of Gastroenterology and Hepatology, Antwerp, Belgium, ¹⁰Sint-Trudo Ziekenhuis, Department of Gastroenterology and Hepatology, Sint-Truiden, Belgium, ¹¹AZ Vesalius, Department of Gastroenterology and Hepatology, Tongeren, Belgium, ¹²AZ Klina, Department of Gastroenterology and Hepatology, Brasschaat, Belgium, ¹³AZ Groeninge, Department of Gastroenterology and Hepatology, Kortrijk, Belgium

¹Icahn School of Medicine at Mount Sinai, Dr. Henry D. Janowitz Division of Gastroenterology, New York, NY, USA, ²UC San Diego School of Medicine, Division of Cardiovascular Medicine, La Jolla, CA, USA, ³Western University, Robarts Clinical Trials, London, ON, Canada, ⁴Presidio Columbus Fondazione Policlinico Gemelli Università Cattolica, IBD Unit, Rome, Italy, ⁵Pfizer Inc., Collegeville, PA, USA

¹Hospital Son Llàtzer, Palma, Spain, ²Universitat Autònoma de Barcelona, Barcelona, Spain, ³Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ⁴CIBERehd Instituto de Salud Carlos III, Madrid, Spain, ⁵Hospital Clínic, Barcelona, Spain, ⁶Hospital Reina Sofia, Córdoba, Spain, ⁷Hospital Puerta de Hierro, Majadahonda, Spain, ⁸Hospital Bellvitge, L’Hospitalet de Llobregat, Spain, ⁹Hospital Clínico San Carlos, Madrid, Spain, ¹⁰Hospital La Fe, Valencia, Spain, ¹¹Hospital Ramón y Cajal, Madrid, Spain, ¹²Hospital La Paz, Madrid, Spain, ¹³Hospital Clínico de Valencia, Valencia, Spain, ¹⁴Hospital La Princesa, Madrid, Spain, ¹⁵Hospital Universitario Miguel Servet, Zaragoza, Spain, ¹⁶Hospital Universitario Central de Asturias, Oviedo, Spain, ¹⁷Hospital Clínico Lozano Blesa, Zaragoza, Spain, ¹⁸Hospital Parc Taulí, Sabadell, Spain, ¹⁹Hospital Santa Creu i Sant Pau, Barcelona, Spain, ²⁰Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²¹Complexo Hospital Universitario de Vigo, Vigo, Spain, ²²Hospital Virgen de la Macarena, Sevilla, Spain, ²³Hospital Universitario Burgos, Burgos, Spain, ²⁴Hospital Río Hortega, Valladolid, Spain, ²⁵Hospital Mutua de Terrassa, Terrassa, Spain, ²⁶Hospital del mar, Barcelona, Spain, ²⁷Hospital General Universitario de Alicante, Alicante, Spain, ²⁸Hospital Clínico de Málaga, Málaga, Spain, ²⁹Hospital 12 de octubre, Madrid, Spain, ³⁰Hospital Universitario Fundación Alcorcón, Alcorcón, Spain, ³¹Hospital Dr Josep Trueta, Girona, Spain, ³²Hospital General Universitario de Elche, Elche, Spain, ³³Hospital General de Ciudad Real, Ciudad Real, Spain, ³⁴Hospital Universitario Fuenlabrada, Fuenlabrada, Spain, ³⁵Hospital Manises, Manises, Spain, ³⁶Consorci sanitari de Terrassa, Terrassa, Spain, ³⁷Hospital Santa Lucía, Cartagena, Spain, ³⁸Hospital Clínico Universitario Valladolid, Valladolid, Spain, ³⁹CH de Navarra, Pamplona, Spain, ⁴⁰Hospital Universitario de Salamanca, Salamanca, Spain, ⁴¹Hospital de Cruces, Barakaldo, Spain, ⁴²Hospital Galdakao, Galdakao, Spain, ⁴³Instituto Biodonostia UPV/EHU, (Donostia, Spain, ⁴⁴Hospital San Jorge, Huesca, Spain, ⁴⁵Hospital Nuestra Sra Candelaria, Sta Cruz Tenerife, Spain, ⁴⁶Hospital Mancha Centro, Alcazar de San Juan, Spain, ⁴⁷Hospital General Universitario Valencia, Valencia, Spain, ⁴⁸Hospital Moisès Broggi, St Joan Despí, Spain, ⁴⁹CH Santiago, Santiago de Compostela, Spain, ⁵⁰CH de Palencia, Palencia, Spain, ⁵¹Hospital Universitario de Canarias, La Laguna, Spain, ⁵²Hospital Torrejón, Torrejón, Spain, ⁵³HG de Castelló, Castelló, Spain, ⁵⁴Hospital Sant Joan de Déu-Althaia, Manresa, Spain, ⁵⁵Hospital General de Tomelloso, Tomelloso, Spain, ⁵⁶Hospital Basurto, Bilbao, Spain, ⁵⁷Hospital Viladecans, Viladecans, Spain, ⁵⁸Hospital Royo Vilanova, Zaragoza, Spain, ⁵⁹Hospital General, Segovia, Spain, ⁶⁰Hospital Son Espases, Palma, Spain, ⁶¹Hospital Arnau de Vilanova, Lleida, Spain, ⁶²Complejo Hospitalario de Jaén, Jaén, Spain

¹University of Exeter, IBD Pharmacogenetics, Exeter, UK, ²Royal Devon and Exeter NHS Foundation Trust, Department of Gastroenterology, Exeter, UK, ³University of Exeter, Exeter Medical School Bioinformatics Team, Exeter, UK, ⁴University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands, ⁵The Broad Institute of MIT and Harvard, Cambridge, USA, ⁶Massachusetts General Hospital, Analytical and Translational Genetics Unit, Boston, USA, ⁷Hôpital Saint-Antoine, Service de Gastroentérologie et Nutrition, Paris, France, ⁸Cedars-Sinai Medical Center, Inflammatory Bowel Disease Center, Division of Gastroenterology, Los Angeles, USA

¹Radboud University Nijmegen Medical Centre, Gastroenterology and Hepatology, Nijmegen, The Netherlands, ²Jeroen Bosch Hospital, Gastroenterology and Hepatology, S Hertogenbosch, The Netherlands, ³Radboud University Nijmegen Medical Centre, Pathology, Nijmegen, The Netherlands

¹University Hospital Zurich, Division of Gastroenterology and Hepatology, Zurich, Switzerland, ²University Hospital Lausanne - CHUV, Institute of Social and Preventive Medicine, Lausanne, Switzerland

¹University of Erlangen-Nuremberg, Department of Medicine I, Erlangen, Germany, ²Academic Medical Center, Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands

¹Tokyo Medical and Dental University, Center for Stem Cell and Regenerative Medicine, Tokyo, Japan, ²Tokyo Medical and Dental University, Advanced Therapeutics for Gastrointestinal Diseases, Tokyo, Japan, ³Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Tokyo, Japan

¹Blizard Institute, London, UK, ²Barts Health NHS Trust, Histopathology, London, UK, ³Barts Health NHS Trust, Gastroenterology, London, UK

¹The University of Liverpool, Cellular and Molecular Physiology, Liverpool, UK, ²Royal Liverpool and Broadgreen University Hospital Trust, Liverpool, UK, ³University of Manchester, Department of Immunology, Manchester, UK, ⁴GeneXplain, Wolfenbüttel, Germany

¹Natural Products and Medicinal Chemistry Research Group, Department of pharmacy, University of Tromsø The Arctic University of Norway, Tromsø, Norway, ²Swedish Metabolomics Center, Swedish University of Agricultural Sciences, Umeå, Sweden, ³Research Group of Gastroenterology and Nutrition, Department of Clinical Medicine, University of Tromsø The Arctic University of Norway, Tromsø, Norway

¹Translational Research center for GastroIntestinal Disorders (TARGID), Chronic Diseases, Metabolism and Ageing (CHROMETA), Leuven, Belgium, ²Rega Institute for Medical Research, Microbiology and Immunology, Leuven, Belgium, ³McGill University, Gastroenterology, Montreal, Canada, ⁴Prometheus Laboratories, Research and Development, San Diego, USA, ⁵Hasselt University/Jessa Hospital, Faculty of Medicine and Life Sciences, Hasselt, Belgium, ⁶University Hospitals Leuven, Gastroenterology and Hepatology, Leuven, Belgium

¹The University of Nottingham, National Institute for Health Research (NIHR) Biomedical Research Centre in Gastrointestinal and Liver disease at Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus, Nottingham, UK, ²The University of Nottingham, Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, Nottingham, UK

University Hospital Zurich, Zurich, Switzerland

¹Universidad de Valencia, Pharmacology, Valencia, Spain, ²FISABIO Hospital Peset, Pharmacology, Valencia, Spain, ³Hospital de Sagunto, Surgical Department, Sagunto, Spain, ⁴Hospital de Manises, Gastroenterology Department, Manises, Spain, ⁵Institut d’Investigació Germans Trias i Pujol, Badalona, Spain, ⁶Universidad de Valencia-CIBERehd, Pharmacology, Valencia, Spain, ⁷Universidad de Valencia, Medicine, Valencia, Spain

¹M2iSH Laboratory UMR 1071 Inserm / UCA, Clermont-Ferrand, France, ²Gastroenterology Department, University Hospital Estaing, Clermont-Ferrand, France, ³Biostatistics unit, Auvergne University, Clermont-Ferrand, France, ⁴UMR843, Inserm, Assistance Publique Hôpitaux de Paris et Université, Paris Diderot, Clermont-Ferrand, France, ⁵Biochemistry laboratory, University Hospital Estaing, Clermont-Ferrand, France

¹University Hospitals Leuven, KU Leuven, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, ²University Hospitals Leuven, Abdominal surgery, Leuven, Belgium

¹John Radcliffe Hospital, University of Oxford, Translational Gastroenterology Unit, Oxford, UK, ²Kennedy Institute of Rheumatology, Department of NDORMS, Oxford, UK

Korea University, Internal medicine, Seoul, South Korea

¹Icahn School of Medicine at Mount Sinai, Genetics and Genomics Sciences, New York, USA, ²Icahn Institute for Genomics and Multiscale Biology, New York, USA, ³Icahn School of Medicine at Mount Sinai, Hematology and Medical Oncology, New York, USA, ⁴Icahn School of Medicine at Mount Sinai, Human Immune Monitoring Center, New York, USA, ⁵Janssen R&D, Spring House, PA, USA, ⁶Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, USA, ⁷Icahn School of Medicine at Mount Sinai, Pediatric GI and Hepatology, New York, USA, ⁸Icahn School of Medicine at Mount Sinai, Population Health Science and Policy, New York, USA