¹Friedrich-Alexander-University Erlangen-Nürnberg, First Department of Medicine, Erlangen, Germany, ²Friedrich-Alexander-University Erlangen-Nürnberg, Department of Biology, Erlangen, Germany, ³Sana Kliniken Ostholstein, Eutin, Germany, ⁴Friedrich-Alexander-University Erlangen-Nürnberg, Deparment of Pathology, Erlangen, Germany, ⁵Friedrich-Alexander-University Erlangen-Nürnberg, Department of Surgery, Erlangen, Germany, ⁶Friedrich-Alexander-University Erlangen-Nürnberg, Department of Anesthesiology, Erlangen, Germany

¹Wellcome Trust Sanger Institute, Hinxton, UK, ²University of Exeter, IBD Pharmacogenetics, Exeter, UK

¹University Medical Center Groningen, Groningen, The Netherlands, ²Massachusetts Institute of Technology, Boston, USA, ³Maastricht University Medical Center (MUMC), Maastricht, The Netherlands, ⁴Broad Institute, Boston, USA

¹Medical University of Vienna, Vienna, Austria, ²University of Calgary, Calgary, Canada, ³Imelda General Hospital, Bonheiden, Belgium, ⁴AZ Delta Roeselare-Menen, Menen, Belgium, ⁵Presidio Columbus, Fondazione Policlinico Gemelli Università Cattolica, Rome, Italy, ⁶Oxford University Hospitals, Oxford, UK, ⁷Istituto Clinico Humanitas, Milan, Italy, ⁸University of California San Diego, La Jolla, USA, ⁹Academic Medical Center, Amsterdam, The Netherlands, ¹⁰AbbVie AB, Solna, Sweden, ¹¹AbbVie Inc., North Chicago, USA, ¹²Icahn School of Medicine at Mount Sinai, New York, USA

¹Division of Surgery, Department of Clinical and Experimental Medicine, Faulty of Health Sciences, Linköping University and Department of Surgery, County Council of Östergötland, Linköping, Sweden, ²Department of Molecular Medicine and Surgery, Karolinska Institutet; Center for Digestive Disease, Division of Coloproctology, Karolinska University Hospital, Stockholm, Sweden, ³Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA, Stockholm, Sweden, ⁵Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁶Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ⁷Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Pediatric Gastroenterology and Nutrition, Sachs’ Children and Youth Hospital, Stockholm, Sweden

¹Università della Campania, Unit of Colorectal Surgery, Naples, Italy, ²St Mark's Hospital, Fistula Research Unit, London, UK, ³Imperial College, Department of Surgery and Cancer, London, UK, ⁴Oxford University Hospital NHS Trust - Churchill Hospital, Department of Colorectal Surgery, Oxford, UK, ⁵Faculty of Medicine, University of Kelaniya, Department of Surgery, Kelaniya, Sri Lanka, ⁶Humanitas University, Colon and Rectal Surgery Unit, Department of General Surgery, Rozzano, Italy, ⁷Humanitas University, Humanitas University, Department of Biomedical Sciences, Rozzano, Italy

¹Humanitas Research Institute, IBD Center Laboratory of Immunology in Gastroenterology, Rozzano, Italy, ²Humanitas University, Department of Biomedical Sciences, Rozzano, Italy, ³Catholic University of Rome, Institute of Pathology, Rome, Italy, ⁴Humanitas Reseach Institute, Colon and Rectal Surgery, Rozzano, Italy

¹University of New South Wales, Sydney, Australia, ²Icahn School of Medicine at Mount Sinai, New York, USA, ³St Vincent’s Hospital, Melbourne, Australia, ⁴University of Melbourne, Melbourne, Australia, ⁵Liverpool Hospital, Sydney, Australia, ⁶St Vincent’s Hospital, Sydney, Australia, ⁷Nambour General Hospital, Nambour, Australia, ⁸Bankstown-Lidcombe Hospital, Sydney, Australia, ⁹Centre for Digestive Diseases, Sydney, Australia

¹Clinic for Visceral Surgery and Medicine, Gastroenterology, Bern, Switzerland, ²University of Bern, Department of Biomedical Research, Bern, Switzerland, ³University Hospital Zurich, Division of Gastroenterology and Hepatology, Zurich, Switzerland

¹Oxford University Hospitals, Department of Haematology, Oxford, UK, ²Département d’Hématologie Gustave Roussy, Programme de transplantation des cellules souches, Villejuif, France, ³Université Pierre et Marie Curie, Saint Antoine Hospital, EBMT Paris Study Office, Department of Haematology, Paris, France, ⁴Hospital Clínic of Barcelona, Haematology Department, Barcelona, Spain, ⁵Hospital Clínic of Barcelona, Gastroenterology Department, Barcelona, Spain, ⁶University Hospitals Leuven, Department of Haematology, Leuven, Belgium, ⁷University Hospitals Leuven, Department of Gastroenterology, Leuven, Belgium, ⁸Medical Faculty and University Hospital Freiburg, Department of Medicine II, Freiburg, Germany, ⁹University of Freiburg, Department of Gastroenterology, Freiburg, Germany, ¹⁰Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Haematology - BMT Centre, Milan, Spain, ¹¹Luigi Sacco University Hospital, Gastroenterology Unit, Milan, Italy, ¹²Western General Hospital, University of Edinburgh, Gastro-intestinal Unit, Institute of Genetics and Molecular Medicine, Edinburgh, UK, ¹³Guy’s and St Thomas’ NHS Foundation Trust and King’s College Hospital, Department of Haematology, London, UK, ¹⁴Ramon y Cajal Hospital, Gastroenterology and Hepatology Department, Madrid, Spain, ¹⁵AP-HP Hôpital Saint-Louis, Centre de Référence des Maladies auto-immunes systémiques Rares d’Ile-de-France (site constitutif), Filière FAI2R, Internal Medicine, Autoimmune and Vascular Diseases Unit, UF 04, Paris, France, ¹⁶Oxford University Hospitals, Translational Gastroenterology Unit, Oxford, UK, ¹⁷Queen’s Medical Centre, Nottingham Digestive Diseases Centre, School of Clinical Sciences, Nottingham, UK, ¹⁸Sheffield Teaching Hospitals NHS Foundation Trust, Department of Haematology, Sheffield, UK

¹University Hospital Schleswig-Holstein, Kiel, Germany, ²University of Lorraine, Nancy, France, ³University of California, San Diego, San Diego, USA, ⁴University of Michigan, Ann Arbor, USA, ⁵Presidio Columbus, Fondazione Policlinico Gemelli Università Cattolica, Rome, Italy, ⁶University of California, San Francisco, Medical Center at Parnassus, San Francisco, USA, ⁷AbbVie Inc., North Chicago, USA, ⁸AbbVie Spain S.L.U., Madrid, Spain

¹Humanities University, IBD Center, Humanitas Clinical and Research Center, Rozzano, Milan, Italy, ²University of Western Ontario, Robarts Clinical Trials, London, Ontario, Canada, ³University of California, Inflammatory Bowel Disease Center, Division of Gastroenterology, San Diego, USA, ⁴Icahn School of Medicine at Mount Sinai, Department of Gastroenterology, New York, NY, USA, ⁵University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, ⁶Europe Development Centre, Takeda R&D, London, UK, ⁷Takeda Pharmaceuticals International Co., Cambridge, MA, USA

¹Academic Medical Centre, Amsterdam, The Netherlands, ²Medical University of Vienna, Vienna, Austria, ³University of Washington, Seattle, USA, ⁴Clinic of Gastroenterology and Hepatology, Military Medical Academy, Belgrade, Serbia, ⁵University Hospital CHU of Liège, Liège, Belgium, ⁶Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland, ⁷Universitatsklinikum Ulm, Ulm, Germany, ⁸University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany, ⁹Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, South Korea, ¹⁰Université de Nice Sophia Antipolis, Hôpital de l’Archet, Nice, France, ¹¹Shire, Lexington, USA, ¹²Pfizer, Cambridge, USA, ¹³Zymo Consulting Group, Newtown Square, USA, ¹⁴University of California San Diego, La Jolla, USA

¹Indiana University, Indianapolis, USA, ²Mayo Clinic, Rochester, USA, ³University of California - San Diego, La Jolla, USA, ⁴Montefiore Medical Center, New York, USA, ⁵Cleveland Clinic Foundation, Cleveland, USA, ⁶Icahn School of Medicine at Mount Sinai, New York, USA, ⁷Dartmouth-Hitchcock Medical Center, Lebanon, USA, ⁸Takeda Pharmaceuticals U.S.A., Inc., Deerfield, USA, ⁹New York University (NYU), New York, USA, ¹⁰North Shore University Hospital, Manhasset, USA, ¹¹Lenox Hill Hospital, New York, USA, ¹²University of Mississippi, Jackson, USA

¹Icahn School of Medicine at Mount Sinai, New York, USA, ²Cleveland Clinic Foundation, Cleveland, USA, ³University of California – San Diego, La Jolla, USA, ⁴Indiana University, Indianapolis, USA, ⁵Montefiore Medical Center, New York, USA, ⁶Mayo Clinic, Rochester, USA, ⁷Dartmouth-Hitchcock Medical Center, Lebanon, USA, ⁸Takeda Pharmaceuticals U.S.A., Inc., Deerfield, USA, ⁹New York University (NYU), New York, USA, ¹⁰North Shore University Hospital, Manhasset, USA, ¹¹Lenox Hill Hospital, New York, USA, ¹²University of Mississippi, Jackson, USA

¹Fisabio, Hospital Dr Peset, Valencia, Spain, ²University of Valencia, Valencia, Spain, ³University of Zurich, Gastroenterology, Zurich, Switzerland

¹University Medical Center Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands, ²The Broad Institute of MIT and Harvard, Cambridge, USA

¹Technical University Munich, III. Medizinische Klinik, Munich, Germany, ²Ludwig-Maximilian University of Munich, Department for Cell Biology, Munich, Germany, ³Technical University Munich, Institut for Pathologie, Munich, Germany

¹University Hospital Zurich, Division of Gastroenterology and Hepatology, Zurich, Switzerland, ²University of Zurich, Institute of Experimental Immunologx, Zurich, Switzerland

¹University of Exeter, IBD Pharmacogenetics, Exeter, UK, ²Abbvie, Chicago, USA, ³St Mark’s Hospital, IBD Unit, London, UK