¹Division of Surgery, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University and Department of Surgery, County Council of Östergötland, Linköping, Sweden, ²Department of Molecular Medicine and Surgery, Karolinska Institutet; Center for Digestive Disease, Division of Coloproctology, Karolinska University Hospital, Stockholm, Sweden, ³Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁵Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA, Stockholm, Sweden, ⁶Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ⁷Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of pediatric gastroenterology and nutrition, Sachs' Children and Youth Hospital, Stockholm, Sweden

¹Cleveland Clinic, Department of Colon and Rectal Surgery, Cleveland, USA, ²Cleveland Clinic, Clinical Transformation, Cleveland, USA

¹University Hospital Münster, Department of Medicine B, Gastroenterology and Hepatology, Münster, Germany, ²University Hospital Münster, Department of Medicine B, Münster, Germany, ³University Hospital Frankfurt, Department of Internal Medicine 1, Frankfurt a.M., Germany, ⁴Cleveland Clinic Foundation, Cleveland, Ohio, USA, Department of Hospital Medicine, Medicine Institute, Cleveland, USA, ⁵Cleveland Clinic Foundation, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, USA, ⁶University Hospital Tübingen, First Department of Internal Medicine I, Tübingen, Germany, ⁷Fukuoka University Chikushi Hospital, Department of Gastroenterology, Chikushino, Japan, ⁸Copenhagen University Hospital, Gastro Unit, Division of Endoscopy, Herlev, Denmark, ⁹St. Vincent Hospital, Department of Gastroenterology, Melbourne, Australia, ¹⁰University Hospital Dresden, Technical University Dresden, Medical Department 1, Dresden, Germany, ¹¹University Hospital Zurich, Departement of Gastroenterology and Hepatology, Zurich, Switzerland, ¹²Jinling Hospital, School of Medicine, Nanjing University, Department of General Surgery, Nanjing, China, ¹³Jinling Hospital, School of Medicine Nanjing University, Department of General Surgery, Nanjing, China, ¹⁴Cleveland Clinic Foundation, Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institut, Cleveland, USA, ¹⁵Cleveland Clinic, Department of Pathobiology, Lerner Research Institute, Cleveland, USA

¹University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France, ²UMR 1071 Inserm/Université d'Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the Host, Clermont-Ferrand, France, ³University of Chicago Medicine, Department of Surgery, Chicago, USA, ⁴Inflammatory Bowel Disease Center University of Chicago Medicine, Chicago, USA, ⁵University Hospital, Biostatistics Unit, DRCI, Clermont-Ferrand, France

¹Academic Medical Center (AMC), Hospital Pharmacy, Amsterdam, The Netherlands, ²Academic Medical Center (AMC), Gastroenterology and Hepatology, Amsterdam, The Netherlands, ³AZ Delta Roeselare-Menen, Gastroenterology, Roeselare-Menen, Belgium, ⁴Erasmus University Medical Center, Gastroenterology and Hepatology, Rotterdam, The Netherlands, ⁵Radboud University Medical Center, Gastroenterology and Hepatology, Nijmegen, The Netherlands, ⁶Imelda GI Clinical Research Center, Gastroenterology, Bonheiden, Belgium, ⁷Erasme Hospital, Gastroenterology, Brussels, Belgium, ⁸Sanquin Research and Landsteiner Laboratory, Immunopathology, Amsterdam, The Netherlands, ⁹Sanquin Diagnostic Services, Biologicals Lab, Amsterdam, The Netherlands, ¹⁰University Hospitals Leuven, Gastroenterology and Hepatology, Leuven, Belgium

¹KU Leuven, Departement of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium, ²Academic Medical Centre, Amsterdam, The Netherlands, ³AZ Delta, Roeselare, Belgium, ⁴Hospital Claude Huriez, Lille, France, ⁵Hospital Beaujon, Clichy, France, ⁶Erasmus MC, Rotterdam, The Netherlands, ⁷CHU, Toulouse, Belgium, ⁸Hospital Haut-Lévêque, Bordeaux, France, ⁹University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, ¹⁰KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium

¹Medical College of Wisconsin, Gastroenterology and Hepatology, Milwaukee, USA, ²Prometheus Laboratories, San Diego, USA

¹Military Medical Academy, Belgrade, Serbia, ²University of Chicago Medicine, Inflammatory Bowel Disease Center, Chicago, USA, ³Clinical Center Vojvodina, Novi Sad, Serbia

¹Grenoble Alpes University Hospital, University Clinic of Hepato-Gastroenterology, Grenoble, France, ²Lyon Sud University Hospital, Department of Gastroenterology, Lyon, France

¹Icahn School of Medicine at Mount Sinai, New York, USA, ²Cleveland Clinic Foundation, Cleveland, USA, ³University of California - San Diego, La Jolla, USA, ⁴Montefiore Medical Center, New York, USA, ⁵Mayo Clinic, Rochester, USA, ⁶Dartmouth-Hitchcock Medical Center, Lebanon, USA, ⁷Takeda Pharmaceuticals U.S.A., Inc., Deerfield, USA, ⁸Indiana University, Indianapolis, USA, ⁹New York University (NYU), New York, USA, ¹⁰North Shore University Hospital, Manhasset, USA, ¹¹Lenox Hill Hospital, New York, USA, ¹²University of Mississippi, Jackson, USA

¹Radboudumc, Nijmegen, The Netherlands, ²Maastricht University Medical Center (MUMC), Maastricht, The Netherlands, ³Erasmus Medical Center, Rotterdam, The Netherlands, ⁴Leiden University Medical Center (LUMC), Department of Gastroenterology and Hepatology, Leiden, The Netherlands, ⁵University Medical Center Groningen, Groningen, The Netherlands, ⁶VU University Medical Centre Institute of Education, Department of Gastroenterology and Hepatology, Room J393, Amsterdam, The Netherlands, ⁷University Medical Centre Utrecht, Utrecht, The Netherlands, ⁸Academic Medical Center (AMC), Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands, ⁹Radboudumc, Department of Gastroenterology and Hepatology, Nijmegen, The Netherlands

¹New York University (NYU), New York, USA, ²Cleveland Clinic Foundation, Cleveland, USA, ³Icahn School of Medicine at Mount Sinai, New York, USA, ⁴University of California - San Diego, La Jolla, USA, ⁵Montefiore Medical Center, New York, USA, ⁶Mayo Clinic, Rochester, USA, ⁷Dartmouth-Hitchcock Medical Center, Lebanon, USA, ⁸Takeda Pharmaceuticals U.S.A., Inc., Deerfield, USA, ⁹Indiana University, Indianapolis, USA, ¹⁰North Shore University Hospital, Manhasset, USA, ¹¹Lenox Hill Hospital, New York, USA, ¹²University of Mississippi, Jackson, USA

¹Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, USA, ²University Hospitals Leuven and TARGID, Division of Gastroenterology and Hepatology, Leuven, Belgium, ³Takeda Pharmaceuticals International AG, Zurich, Switzerland, ⁴Takeda Pharmaceuticals International AG, Global Medical Affairs, Zurich, Switzerland

¹Friedrich-Alexander University Erlangen-Nürnberg, Department of Medicine I, Erlangen, Germany, ²Asklepios Westklinikum, Department of Internal Medicine/Gastroenterology, Hamburg, Germany, ³Christian Albrechts University Kiel, Department of Internal Medicine/Gastroenterology, Kiel, Germany, ⁴Sterna Biologicals GmbH Co & KG, Marburg, Germany, ⁵Institute of Pathology, Bayreuth, Germany, ⁶Philipps University Marburg, Marburg, Germany

¹Tokyo Medical and Dental University, Gastroenterology and Hepatology, Tokyo, Japan, ²Keio University School of Medicine, Internal Medicine, Gastroenterology and Hepatology, Tokyo, Japan, ³Nagoya City University Graduate School of Medical Sciences, Gastroenterology and Metabolism, Aichi, Japan, ⁴Kanazawa University Hospital, Gastroenterology, Ishikawa, Japan, ⁵Fukuoka University Chikushi Hospital, Gastroenterology, Fukuoka, Japan, ⁶Chiba University Hospital, Gastroenterology, Chiba, Japan, ⁷Asahikawa Medical University, Gastroenterology and Hematology/Oncology, Hokkaido, Japan, ⁸Mie University Hospital, Endoscopy, Mie, Japan, ⁹Osaka City General Hospital, Gastroenterology, Osaka, Japan, ¹⁰Urasoe General Hospital, Center for Gastroenterolog, Okinawa, Japan, ¹¹Hyogo College of Medicine, Inflammatory Bowel Disease, Hyogo, Japan, ¹²Iwate Medical University, Internal Medicine, School of Medicine, Gastroenterology, Iwate, Japan, ¹³Kyushu University Graduate School of Medical Sciences, Medicine and Clinical Science, Fukuoka, Japan, ¹⁴Kurume University School of Medicine, Inflammatory Bowel Disease Center, Fukuoka, Japan, ¹⁵The Jikei University School of Medicine, Gastroenterology and Hepatology, Tokyo, Japan, ¹⁶Kagoshima University Graduate School of Medicine and Dental Sciences, Digestive and Lifestyle Diseases, Kagoshima, Japan, ¹⁷Eisai. Co., Ltd., Tokyo, Japan, ¹⁸EA Pharma Co., Ltd., Tokyo, Japan, ¹⁹KAN Research Institute, Hyogo, Japan, ²⁰Kagoshima City Hospital, Kagoshima, Japan, ²¹Kitasato University Kitasato Institute Hospital, Center for Advanced IBD Research and Treatment, Tokyo, Japan

¹Sheffield Teaching Hospitals, NHS Foundation Trust, Haematology, Sheffield, UK, ²Hospital Clínic, IDIBAPS, CIBERehd, Gastroenterology, Barcelona, Spain, ³Charité – University Medicine Berlin, 1. Department of Rheumatology and Clinical Immunology, Berlin, Germany, ⁴Hôpital Saint Louis, APHP, INSERM U1160, Paris Diderot, Sorbonne Paris-Cité University, Gastroenterology, Paris, France, ⁵DIBIC - ASST Fatebenefratelli Sacco - University of Milan, Gastroenterology, Milan, Italy, ⁶University Hospitals Leuven, Haematology, Leuvan, Belgium, ⁷Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Department of Medicine II, Freiburg, Germany, ⁸University of Nottingham, Nottingham Digestive Diseases Centre, Nottingham, UK, ⁹Guys & St Thomas’ NHS Foundation Trust, Haematology, London, UK, ¹⁰The Royal London Hospital, Barts Health NHS Trust and Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Gastroenterology, London, UK, ¹¹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico – University of Milan, Hematology-BMT Center, Milan, UK, ¹²Careggi University Hospital, Department of Haematology, Firenze, Italy, ¹³University hospitals Leuven, Department of Gastroenterology, Leuven, Belgium, ¹⁴IDIBAPS, Hospital Clinic, BMT Unit, Hematology Department and Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain

¹Moscow Clinical Research Center, Department of Inflammatory Bowel Disease, Moscow, Russian Federation, ²Moscow Clinical Research Center, Department of Pathology, Moscow, Russian Federation, ³Moscow Clinical Research Center, Moscow, Russian Federation, ⁴Medical Radiological Scientific Center, Department of Stem Cells Therapy, Obninsk, Russian Federation

¹Moscow Clinical Research Center, Department of Inflammatory Bowel Disease, Moscow, Russian Federation, ²Moscow Clinical Research Center, Department of Radiology, Moscow, Russian Federation, ³Medical Radiological Scientific Center, Department of Stem Cells Therapy, Obninsk, Russian Federation

¹Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ²Gastroenterology and Hepatology Unit, Monash Medical Centre, Melbourne, Australia, ³Hudson Institute for Medical Research, Melbourne, Australia

¹Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ²Gastroenterology and Hepatology Unit, Monash Medical Centre, Melbourne, Australia, ³Hudson Institute for Medical Research, Melbourne, Australia