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DOP042: Need for ileocaecal resections, but not ileo-colic re-resections, has decreased: a nationwide study of temporal trends in Crohn surgery in Sweden 1990–2014ECCO '18 Vienna
Year: 2018
Authors:

D. Kalman1*, C. Nordenvall2, A. Hallqvist Everhov3, M.C. Sachs4, J.F. Ludvigsson5, A. Ekbom6, P. Myrelid1, O. Olén7

1Division of Surgery, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University and Department of Surgery, County Council of Östergötland, Linköping, Sweden, 2Department of Molecular Medicine and Surgery, Karolinska Institutet; Center for Digestive Disease, Division of Coloproctology, Karolinska University Hospital, Stockholm, Sweden, 3Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, 4Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 5Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA, Stockholm, Sweden, 6Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, 7Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of pediatric gastroenterology and nutrition, Sachs' Children and Youth Hospital, Stockholm, Sweden

DOP043: Comparative outcomes of ileal pouch revision vs. excision for pouch failure within the American College of Surgeon National Surgical Quality Improvement ProgrammeECCO '18 Vienna
Year: 2018
Authors:

S. Holubar1*, P. Neary2, S. Shawki2, A. Aiello2, C. Delaney2, S. Steele2, T. Hull2, L. Stocchi2

1Cleveland Clinic, Department of Colon and Rectal Surgery, Cleveland, USA, 2Cleveland Clinic, Clinical Transformation, Cleveland, USA

DOP044: Efficacy, safety and long-term outcome of endoscopic dilation therapy for Crohn’s disease strictures of the upper gastrointestinal tract: an international multicentre cohort study including 99 patients with 129 dilation proceduresECCO '18 Vienna
Year: 2018
Authors:

D. Bettenworth1,2*, M. Mücke3, A. Singh4, R. Lopez5, M. Goetz6, T. Matsui7, J.G. Karstensen8, N.S. Ding9, T.B. Qiu9, J. Hampe10, K. Matthes10, P.V. Valli111, F. Guo12, W. Zhu13, G. Rogler11, F. Rieder14,15

1University Hospital Münster, Department of Medicine B, Gastroenterology and Hepatology, Münster, Germany, 2University Hospital Münster, Department of Medicine B, Münster, Germany, 3University Hospital Frankfurt, Department of Internal Medicine 1, Frankfurt a.M., Germany, 4Cleveland Clinic Foundation, Cleveland, Ohio, USA, Department of Hospital Medicine, Medicine Institute, Cleveland, USA, 5Cleveland Clinic Foundation, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, USA, 6University Hospital Tübingen, First Department of Internal Medicine I, Tübingen, Germany, 7Fukuoka University Chikushi Hospital, Department of Gastroenterology, Chikushino, Japan, 8Copenhagen University Hospital, Gastro Unit, Division of Endoscopy, Herlev, Denmark, 9St. Vincent Hospital, Department of Gastroenterology, Melbourne, Australia, 10University Hospital Dresden, Technical University Dresden, Medical Department 1, Dresden, Germany, 11University Hospital Zurich, Departement of Gastroenterology and Hepatology, Zurich, Switzerland, 12Jinling Hospital, School of Medicine, Nanjing University, Department of General Surgery, Nanjing, China, 13Jinling Hospital, School of Medicine Nanjing University, Department of General Surgery, Nanjing, China, 14Cleveland Clinic Foundation, Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institut, Cleveland, USA, 15Cleveland Clinic, Department of Pathobiology, Lerner Research Institute, Cleveland, USA

DOP045: Combination therapy with anti-TNF and immunosuppressive therapies is the most effective medication to prevent and treat endoscopic postoperative recurrence in patients with Crohn’s diseaseECCO '18 Vienna
Year: 2018
Authors:

A. Buisson1,2*, L. Cannon3, K. Umanskiy3, R.D. Hurst3, N.H. Hyman3, A. Sakuraba4, J. Pekow4, S. Dalal4, R.D. Cohen4, B. Pereira5, D.T. Rubin4

1University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France, 2UMR 1071 Inserm/Université d'Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the Host, Clermont-Ferrand, France, 3University of Chicago Medicine, Department of Surgery, Chicago, USA, 4Inflammatory Bowel Disease Center University of Chicago Medicine, Chicago, USA, 5University Hospital, Biostatistics Unit, DRCI, Clermont-Ferrand, France

DOP046: Higher serum concentrations of vedolizumab are associated with superior endoscopic outcomes in Crohn’s disease: data from the LOVE-CD trialECCO '18 Vienna
Year: 2018
Authors:

S. Berends1,2*, M. Löwenberg2, F. Baert3, R. Mathôt1, E. Clasquin2, C. Van Der Woude4, F. Hoentjen5, P. Bossuyt6, D. Franchimont7, T. Rispens8,9, A. De Vries9, S. Vermeire10, G. D'Haens2

1Academic Medical Center (AMC), Hospital Pharmacy, Amsterdam, The Netherlands, 2Academic Medical Center (AMC), Gastroenterology and Hepatology, Amsterdam, The Netherlands, 3AZ Delta Roeselare-Menen, Gastroenterology, Roeselare-Menen, Belgium, 4Erasmus University Medical Center, Gastroenterology and Hepatology, Rotterdam, The Netherlands, 5Radboud University Medical Center, Gastroenterology and Hepatology, Nijmegen, The Netherlands, 6Imelda GI Clinical Research Center, Gastroenterology, Bonheiden, Belgium, 7Erasme Hospital, Gastroenterology, Brussels, Belgium, 8Sanquin Research and Landsteiner Laboratory, Immunopathology, Amsterdam, The Netherlands, 9Sanquin Diagnostic Services, Biologicals Lab, Amsterdam, The Netherlands, 10University Hospitals Leuven, Gastroenterology and Hepatology, Leuven, Belgium

DOP047: Infliximab exposure predicts superior endoscopic outcomes in patients with active Crohn’s disease: pharmacokinetic–pharmacodynamic analysis of TAILORIXECCO '18 Vienna
Year: 2018
Authors:

E. Dreesen1*, G. D'Haens2, F. Baert3, B. Pariente4, Y. Bouhnik5, J. vander Woude6, J. Moreau7, D. Laharie8, S. Vermeire9,10, A. Gils1

1KU Leuven, Departement of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium, 2Academic Medical Centre, Amsterdam, The Netherlands, 3AZ Delta, Roeselare, Belgium, 4Hospital Claude Huriez, Lille, France, 5Hospital Beaujon, Clichy, France, 6Erasmus MC, Rotterdam, The Netherlands, 7CHU, Toulouse, Belgium, 8Hospital Haut-Lévêque, Bordeaux, France, 9University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, 10KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium

DOP048: Vedolizumab levels during induction are associated with long-term clinical and endoscopic remission in patients with inflammatory bowel diseaseECCO '18 Vienna
Year: 2018
Authors:

A. Yarur1*, A. Bruss1, C. Fox1, P. Beniwal-Patel1, A. Patel1, B. Berens1, S. Naik2, D. Stein1

1Medical College of Wisconsin, Gastroenterology and Hepatology, Milwaukee, USA, 2Prometheus Laboratories, San Diego, USA

DOP049: Combination therapy of cyclosporine and vedolizumab is effective and safe for severe, steroid-resistant ulcerative colitis patients: A prospective studyECCO '18 Vienna
Year: 2018
Authors:

D. Tarabar1*, K. El Jurdi2, O. Yvellez2, Z. Milenkovic1, S. Petrovic1, B. Subotic1, T.P. Brocic1, I. Brcerevic1, O. Latinovic3, D.T. Rubin2

1Military Medical Academy, Belgrade, Serbia, 2University of Chicago Medicine, Inflammatory Bowel Disease Center, Chicago, USA, 3Clinical Center Vojvodina, Novi Sad, Serbia

DOP050: Influence of disease location on vedolizumab efficacy in inflammatory bowel disease: a real-life multicentre experienceECCO '18 Vienna
Year: 2018
Authors:

S. Pestour1*, S. Nancey2, A.L. Charlois2, B. Bonaz1, B. Flourie2, G. Boschetti2, N. Mathieu1

1Grenoble Alpes University Hospital, University Clinic of Hepato-Gastroenterology, Grenoble, France, 2Lyon Sud University Hospital, Department of Gastroenterology, Lyon, France

DOP051: Shorter disease duration is associated with higher response rates to vedolizumab in Crohn’s disease but not ulcerative colitis: a multi-centre consortium analysisECCO '18 Vienna
Year: 2018
Authors:

D. Faleck1, A. Winters1, S. Chablaney1, P. Shashi2, J. Meserve3, A. Weiss4, S. Aniwan5, J.L. Koliani-Pace6, G. Kochhar2, B. Boland3, S. Singh3, R. Hirten1, E. Shmidt1, K. Lasch7, M. Luo7, M. Bohm8, S. V Sagi8, M. Fischer8, D. Hudesman9, S. Chang9, D. Lukin4, K. Sultan10, A. Swaminath11, N. Gupta12, C.A. Siegel6, B. Shen2, W.J. Sandborn3, S. Kane5, E.V. Loftus5, B.E. Sands1, J.-F. Colombel1, P.S. Dulai3*, R. Ungaro1

1Icahn School of Medicine at Mount Sinai, New York, USA, 2Cleveland Clinic Foundation, Cleveland, USA, 3University of California - San Diego, La Jolla, USA, 4Montefiore Medical Center, New York, USA, 5Mayo Clinic, Rochester, USA, 6Dartmouth-Hitchcock Medical Center, Lebanon, USA, 7Takeda Pharmaceuticals U.S.A., Inc., Deerfield, USA, 8Indiana University, Indianapolis, USA, 9New York University (NYU), New York, USA, 10North Shore University Hospital, Manhasset, USA, 11Lenox Hill Hospital, New York, USA, 12University of Mississippi, Jackson, USA

DOP052: Vedolizumab vs. ustekinumab for Crohn’s disease: comparative effectiveness in a real-life observational cohort study (ICC case series)ECCO '18 Vienna
Year: 2018
Authors:

V. Biemans1,2*, C. van der Woude3, A. van der Meulen - de Jong4, G. Dijkstra5, N. de Boer6, B. Oldenburg7, C. Ponsioen8, A. de Vries3, D. Wintjens2, F. Hoentjen9, M. Pierik2, Dutch Initiative on Crohn and Colitis (ICC)

1Radboudumc, Nijmegen, The Netherlands, 2Maastricht University Medical Center (MUMC), Maastricht, The Netherlands, 3Erasmus Medical Center, Rotterdam, The Netherlands, 4Leiden University Medical Center (LUMC), Department of Gastroenterology and Hepatology, Leiden, The Netherlands, 5University Medical Center Groningen, Groningen, The Netherlands, 6VU University Medical Centre Institute of Education, Department of Gastroenterology and Hepatology, Room J393, Amsterdam, The Netherlands, 7University Medical Centre Utrecht, Utrecht, The Netherlands, 8Academic Medical Center (AMC), Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands, 9Radboudumc, Department of Gastroenterology and Hepatology, Nijmegen, The Netherlands

DOP053: Impact of concomitant immunomodulator use on vedolizumab effectiveness: a multicentre consortium propensity score-matched analysisECCO '18 Vienna
Year: 2018
Authors:

D. Hudesman1, S. Chang1, P. Shashi2, A. Winters3, S. Chablaney3, J. Meserve4, A. Weiss5, S. Aniwan6, D. Faleck3, J.L. Koliani-Pace7, G. Kochhar2, B. Boland4, S. Singh4, R. Hirten3, E. Shmidt3, K. Lasch8, M. Luo8, M. Bohm9, S. V Sagi9, M. Fischer9, D. Lukin5, K. Sultan10, A. Swaminath11, N. Gupta12, C.A. Siegel7, B. Shen2, S. Kane6, E.V. Loftus6, B.E. Sands3, W.J. Sandborn4, J.-F. Colombel3, P.S. Dulai4*

1New York University (NYU), New York, USA, 2Cleveland Clinic Foundation, Cleveland, USA, 3Icahn School of Medicine at Mount Sinai, New York, USA, 4University of California - San Diego, La Jolla, USA, 5Montefiore Medical Center, New York, USA, 6Mayo Clinic, Rochester, USA, 7Dartmouth-Hitchcock Medical Center, Lebanon, USA, 8Takeda Pharmaceuticals U.S.A., Inc., Deerfield, USA, 9Indiana University, Indianapolis, USA, 10North Shore University Hospital, Manhasset, USA, 11Lenox Hill Hospital, New York, USA, 12University of Mississippi, Jackson, USA

DOP054: Vedolizumab in combination with steroids for induction therapy in Crohn’s disease: an exploratory analysis of the GEMINI 2 and GEMINI 3 studiesECCO '18 Vienna
Year: 2018
Authors:

B.E. Sands1, G. Van Assche2, D. Tudor3, T. Tan4*

1Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, USA, 2University Hospitals Leuven and TARGID, Division of Gastroenterology and Hepatology, Leuven, Belgium, 3Takeda Pharmaceuticals International AG, Zurich, Switzerland, 4Takeda Pharmaceuticals International AG, Global Medical Affairs, Zurich, Switzerland

DOP055: Luminal application of a GATA3-specific DNAzyme ameliorates mucosal inflammation in a randomised trial with active ulcerative colitis patientsECCO '18 Vienna
Year: 2018
Authors:

R. Atreya1*, T. Kühbacher2,3, H. Schmitt1, S. Hirschmann1, M.J. Waldner1, O. Drvarov2, S. Fischer1, M. Vetter1, B. Weigmann1, A. Turowska4, T. Mühl4, U. Homburg4, J. Renz4, M. Vieth5, H. Garn6, H. Renz6, M.F. Neurath1

1Friedrich-Alexander University Erlangen-Nürnberg, Department of Medicine I, Erlangen, Germany, 2Asklepios Westklinikum, Department of Internal Medicine/Gastroenterology, Hamburg, Germany, 3Christian Albrechts University Kiel, Department of Internal Medicine/Gastroenterology, Kiel, Germany, 4Sterna Biologicals GmbH Co & KG, Marburg, Germany, 5Institute of Pathology, Bayreuth, Germany, 6Philipps University Marburg, Marburg, Germany

DOP056: Efficacy and safety of anti-fractalkine monoclonal antibody, E6011, in patients with Crohn’s disease who had lost response to anti-TNFα agents: A multicentre, open-label, Phase 1/2 studyECCO '18 Vienna
Year: 2018
Authors:

K. Matsuoka1*, M. Naganuma2, S. Tanida3, K. Kitamura4, T. Matsui5, M. Arai6, M. Fujiya7, N. Horiki8, H. Nebiki9, F. Kinjo10, T. Miyazaki11, T. Matsumoto12, M. Esaki13, K. Mitsuyama14, M. Saruta15, A. Ido16, S. Hojo17, O. Takenaka17, K. Oketani18, T. Imai19, H. Tsubouchi20, T. Hibi21, T. Kanai2

1Tokyo Medical and Dental University, Gastroenterology and Hepatology, Tokyo, Japan, 2Keio University School of Medicine, Internal Medicine, Gastroenterology and Hepatology, Tokyo, Japan, 3Nagoya City University Graduate School of Medical Sciences, Gastroenterology and Metabolism, Aichi, Japan, 4Kanazawa University Hospital, Gastroenterology, Ishikawa, Japan, 5Fukuoka University Chikushi Hospital, Gastroenterology, Fukuoka, Japan, 6Chiba University Hospital, Gastroenterology, Chiba, Japan, 7Asahikawa Medical University, Gastroenterology and Hematology/Oncology, Hokkaido, Japan, 8Mie University Hospital, Endoscopy, Mie, Japan, 9Osaka City General Hospital, Gastroenterology, Osaka, Japan, 10Urasoe General Hospital, Center for Gastroenterolog, Okinawa, Japan, 11Hyogo College of Medicine, Inflammatory Bowel Disease, Hyogo, Japan, 12Iwate Medical University, Internal Medicine, School of Medicine, Gastroenterology, Iwate, Japan, 13Kyushu University Graduate School of Medical Sciences, Medicine and Clinical Science, Fukuoka, Japan, 14Kurume University School of Medicine, Inflammatory Bowel Disease Center, Fukuoka, Japan, 15The Jikei University School of Medicine, Gastroenterology and Hepatology, Tokyo, Japan, 16Kagoshima University Graduate School of Medicine and Dental Sciences, Digestive and Lifestyle Diseases, Kagoshima, Japan, 17Eisai. Co., Ltd., Tokyo, Japan, 18EA Pharma Co., Ltd., Tokyo, Japan, 19KAN Research Institute, Hyogo, Japan, 20Kagoshima City Hospital, Kagoshima, Japan, 21Kitasato University Kitasato Institute Hospital, Center for Advanced IBD Research and Treatment, Tokyo, Japan

DOP057: ECCO-EBMT joint paper: autologous haematopoietic stem cell transplantation (AHSCT) in severe Crohn’s disease: Summary of the ECCO-EBMT joint reviewECCO '18 Vienna
Year: 2018
Authors:

J. Snowden1*, J. Panes2, T. Alexander3, M. Allez4, S. Ardizzone5, D. Dierickx6, J. Finke7, P. Hasselblatt7, C. Hawkey8, M. Kazmi9, J. Lindsay10, F. Onida11, A. Salas2, R. Saccardi12, S. Vermeire13, M. Rovira14, E. Ricart2

1Sheffield Teaching Hospitals, NHS Foundation Trust, Haematology, Sheffield, UK, 2Hospital Clínic, IDIBAPS, CIBERehd, Gastroenterology, Barcelona, Spain, 3Charité – University Medicine Berlin, 1. Department of Rheumatology and Clinical Immunology, Berlin, Germany, 4Hôpital Saint Louis, APHP, INSERM U1160, Paris Diderot, Sorbonne Paris-Cité University, Gastroenterology, Paris, France, 5DIBIC - ASST Fatebenefratelli Sacco - University of Milan, Gastroenterology, Milan, Italy, 6University Hospitals Leuven, Haematology, Leuvan, Belgium, 7Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Department of Medicine II, Freiburg, Germany, 8University of Nottingham, Nottingham Digestive Diseases Centre, Nottingham, UK, 9Guys & St Thomas’ NHS Foundation Trust, Haematology, London, UK, 10The Royal London Hospital, Barts Health NHS Trust and Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Gastroenterology, London, UK, 11Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico – University of Milan, Hematology-BMT Center, Milan, UK, 12Careggi University Hospital, Department of Haematology, Firenze, Italy, 13University hospitals Leuven, Department of Gastroenterology, Leuven, Belgium, 14IDIBAPS, Hospital Clinic, BMT Unit, Hematology Department and Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain

DOP058: Combined stem cells and anticytokine therapy contributes to a more pronounced decrease in the degree of inflammation of the intestinal mucosa in Crohn’s diseaseECCO '18 Vienna
Year: 2018
Authors:

N. Fadeeva1*, O. Knyazev1, A. Kagramanova1, E. Dobroluybova1, I. Donchenko1, S. Khomeriki2, A. Babayan1, A. Lishchinskaya3, A. Konoplyannikov4

1Moscow Clinical Research Center, Department of Inflammatory Bowel Disease, Moscow, Russian Federation, 2Moscow Clinical Research Center, Department of Pathology, Moscow, Russian Federation, 3Moscow Clinical Research Center, Moscow, Russian Federation, 4Medical Radiological Scientific Center, Department of Stem Cells Therapy, Obninsk, Russian Federation

DOP059: Combined anticytokine and local mesenchymal stem cells therapy promotes longer healing of simple fistulas in patients with Crohn’s diseaseECCO '18 Vienna
Year: 2018
Authors:

N. Belyakov1*, O. Knyazev1, N. Fadeeva1, N. Orlova2, A. Konoplyannikov3, A. Parfenov1

1Moscow Clinical Research Center, Department of Inflammatory Bowel Disease, Moscow, Russian Federation, 2Moscow Clinical Research Center, Department of Radiology, Moscow, Russian Federation, 3Medical Radiological Scientific Center, Department of Stem Cells Therapy, Obninsk, Russian Federation

DOP060: Human amnion epithelial cells and their conditioned media reduces intestinal inflammation and fibrosis in a murine model of chronic colitisECCO '18 Vienna
Year: 2018
Authors:

N. Kuk1,2*, J. Correia1,2, M. Alhomrani1,2,3, R. Lim3, W. Sievert1,2, A. Hodge1,2, G. Moore1,2

1Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, 2Gastroenterology and Hepatology Unit, Monash Medical Centre, Melbourne, Australia, 3Hudson Institute for Medical Research, Melbourne, Australia

DOP061: Human amnion epithelial cells reduce intestinal inflammation in a 2,4,6-trinitrobenzene sulfonic acid induced model of acute colitisECCO '18 Vienna
Year: 2018
Authors:

N. Kuk1,2*, J. Correia1,2, M. Alhomrani1,2,3, R. Lim3, W. Sievert1,2, A. Hodge1,2, G. Moore1,2

1Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, 2Gastroenterology and Hepatology Unit, Monash Medical Centre, Melbourne, Australia, 3Hudson Institute for Medical Research, Melbourne, Australia