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P476 Efficacy and safety of 2 vedolizumab IV regimens in patients with perianal fistulising Crohn’s disease: results of the ENTERPRISE study

ECCO'20 Vienna

Year: 2020
Authors:

D. Schwartz1, L. Peyrin-Biroulet2, K. Lasch3, S. Adsul4, S. Danese5

1Inflammatory Bowel Disease Center, Vanderbilt University Medical Center, Nashville, USA, 2Department of Gastroenterology, Nancy University Hospital, Nancy, France, 3Medical Affairs, Takeda Pharmaceuticals USA, Deerfield, USA, 4Takeda Pharmaceuticals International AG, Chief Medical Office- Global Medical Affairs, Zurich, Switzerland, 5Department of Gastrointestinal Immunopathology, Humanitas University, Milan, Italy

P477 Italian real-life study evaluating the long-term effectiveness of vedolizumab for the treatment of inflammatory bowel disease: the elderly cohort

ECCO'20 Vienna

Year: 2020
Authors:

D. Pugliese, G. Privitera, A. Armuzzi, LIVE IG-IBD study group (Ambrogio Orlando and Federica Crispino – AZ.Osp. Ospedali Riuniti ‘Villa Sofia-Cervello’ Palermo Nicolò Mezzina and Alessandro Massari – ASST Fatebenefratelli Sacco Department of Biochemical and Clinical Sciences University of Milan Milan Lucienne Pellegrini and Fabiana Castiglione – AOU ‘Federico II’ Napoli Lucrezia Laterza and Franco Scaldaferri – CEMAD Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Anna Viola and Walter Fries – Policlinico Messina Pietro Soru and Flavio Caprioli – Fondazione IRCCS Cà Granda Ospedale Policlinico Milan Maria Cappello and Barbara Scrivo – Universita’ di Palermo Policlinico Paolo Giaccone Palermo Brigida Barberio and Edoardo Savarino – University of Padua - Azienza Ospedaliera di Padova Padova Chiara Ricci – Università degli Studi di Brescia Ospedali Civili Brescia Brescia Dario Pluchino – AOU Policlinico Vittorio Emanuele Catania Maria Lia Scribano – San Camillo-Forlanini Rome Lorenzo Bertani Azienda Ospedaliera Universitaria Pisana Pisa Renato Sablich – Azienda per l’Assistenza Sanitaria n. 5 ‘Friuli Occidentale’ Pordenone Luca Pastorelli – University of Milan IRCCS Policlinico San Donato Milan Francesco Manguso – AORN A. Cardarelli Napoli Angela Variola – IRCCS Sacro Cuore Don Calabria Negrar di Valpolicella (VR) Antonio Di Sario – Università Politecnica delle Marche Ospedali Riuniti - University Hospital Ancona Laurino Grossi – G d’Annunzio University Ospedale Spirito Santo Pescara Davide Giuseppe Ribaldone – University of Turin Turin Giuseppe Biscaglia – IRCCS Ospedale Casa Sollievo della Sofferenza San Giovanni Rotondo (FG) Pierenrico Lecis – Ospedale S.Maria del Prato - ULSS 1 Dolomiti Belluno Paola Balestrieri – Unviersità Campus Biomedico Roma Gianmarco Mocci – AOU G Brotzu Cagliari Angelo Viscido – University of L’Aquila L’Aquila Maria Carla Di Paolo Azienda Ospedaliera San Giovanni Addolorata Roma Sara Onali – University of Rome Tor Vergata Rome Stefano Rodinò – Azienda Ospedaliera ‘Pugliese-Ciaccio’ Catanzaro Marina Coletta – ASST Santi Paolo e Carlo-Ospedale San Paolo Polo Universitario Milano Mariabeatrice Principi – Azienda Ospedaliera Universitaria Policlinico di Bari Bari Agnese Miranda – Università della Campania Luigi Vanvitelli II Policlinico di Napoli Napoli Arnaldo Amato – Valduce hospital Como Cristina Bezzio – Rho Hospital ASST Rhodense Rho Carlo Petruzzellis – Istituto Ospedaliero Fondazione Poliambulanza Brescia Silvia Mazzuoli – Osp San Nicola Pellegrino ASL BT Trani Stefano Festa – San Filippo Neri Hospital Rome Alessandro Sartini – Azienda Ospedaliero-Universitaria Policlinico di Modena Modena Libera Frangiulo – Ospedale SS. Annunziata di Taranto Taranto Sara Gallina – Ospedale Belcolle Viterbo Giorgia Bodini – University of Genoa Genoa)

Fondazione Policlinico Universitario A Gemelli IRCCS- Università Cattolica del Sacro Cuore, IBD Unit Presidio Columbus, Rome, Italy

P478 Thiopurines’ metabolites levels and drug toxicity: a systematic review and meta-analysis

ECCO'20 Vienna

Year: 2020
Authors:

P.C. Sousa1, M. Estevinho2, C.C. Dias3, D. Martins1, E. Cancela1, F. Pires1, C. Carvalho1, P. Ministro1, F. Magro2

1Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal, 2Department of Biomedicine, University of Porto, Oporto, Portugal, 3Faculty of Medicine of University of Porto, Unit of Pharmacology and Therapeutics, Oporto, Portugal

P479 The effect of adalimumab on linear growth in children with Crohn’s disease: a post hoc analysis of the PAILOT randomised control trial

ECCO'20 Vienna

Year: 2020
Authors:

M. Matar1, R. Shamir2, D. Turner3, E. Broide4, B. Weiss5, O. Ledder6, A. Guz-Mark2, F. Rinawi2, S. Cohen7, C. Topf-Olivestone8, R. Shaoul9, B. Yerushalmi10, S. Ben-Horin11, A. Assa2

1Institute of Gastroenterology- Nutrition and Liver Diseases, Shneider Children’s Medical Center, Petach Tikva, Israel, 2The Institute of Gastroenterology- Nutrition and Liver Diseases, Schneider Children’s Hospital, Petach-Tikva, Israel, 3The Juliet Keidan Institute of Pediatric Gastroenterology, Shaare Zedek Medical Center, Jerusalem, Israel, 4Pediatric Gastroenterology Unit, Shamir Assaf Harofeh Medical Center, Zerifin, Israel, 5Pediatric Gastroenterology Unit, Sheba Medical Center- Edmond and Lily Safra Children’s Hospital-Tel-Hashomer, Ramat-Gan, Israel, 6The Juliet Keidan Institute of Pediatric Gastroenterology, Shaare Zedek Medical Center-, Jerusalem, Israel, 7Pediatric Gastroenterology Unit, ‘Dana-Dwek’ Children’s Hospital- Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, 8Pediatric Gastroenterology Unit, Kaplan Medical Center, Rehovot, Israel, 9Pediatric Gastroenterology Unit, Rambam Medical Center, Haifa, Israel, 10Pediatric Gastroenterology Unit, Saban Pediatric Medical Center- Soroka University Hospital and Faculty of Health Sciences, Beer-Sheva, Israel, 11Department of Gastroenterology, Sheba Medical Center- Tel-Hashomer, Ramat-Gan, Israel

P480 Efficiency and safety of endoscopic balloon dilatation of ileocolonic anastomotic strictures in patients with Crohn’s disease: A multicentric retrospective study

ECCO'20 Vienna

Year: 2020
Authors:

M. Lukáš1, M. Kolar1, M. Vasatko1, P. Klvana2, V. Leksa3, J. Dyntr4, L. Baca5, B. Pipek5, B. Bahnikova6, S. Summerova7

1ISCARE I.V.F. a.s., IBD Clinical and Research Centre, Prague, Czech Republic, 2Hospital Frydek-Mistek, Beskydy Gastroenterology Center- Department of Internal Medicine, Frydek-Mistek, Czech Republic, 3Pardubice Hospital, Endoscopy- Internal Department, Pardubice, Czech Republic, 4Krajska zdravotni- a.s.- Masaryk Hospital Usti nad Labem, Gastroenterology, Usti nad Labem, Czech Republic, 5Vitkovice Hospital, Digestive Diseases Center, Ostrava, Czech Republic, 6Regional Hospital Liberec, Gastroenterology and Hepatology, Liberec, Czech Republic, 7Thomayer Hospital and Third Faculty of Medicine- Charles University, Department of Internal Medicine, Prague, Czech Republic

P481 Repeated surgery for recurrent ileocolonic Crohn’s disease: does the outcome keep worsening operation after operation? A comparative study of 1224 consecutive procedures

ECCO'20 Vienna

Year: 2020
Authors:

F. Colombo1, A. Frontali1, C. Baldi1, G.M.B. Lamperti1, G. Maconi2, S. Ardizzone2, D. Foschi2, G. Sampietro1

1General Surgery, L.Sacco University Hospital, Milan, Italy, 2Gastroenterology Unit, L.Sacco University Hospital, Milan, Italy

P482 Patient and physician perspectives on the management of inflammatory bowel disease: Disease remission and durability of treatment

ECCO'20 Vienna

Year: 2020
Authors:

A. Afzali1, A. Armuzzi2, Y. Bouhnik3, B. Bressler4, A. Hart5, D. Rubin6, M. Sans7, B. Siegmund8, C. Sninsky9

1*All authors are IBD Global Assessment of Patient Unmet Needs Survey (GAPPS) Steering Committee members (listed αbetically), 1The Ohio State University Wexner Medical Center, Inflammatory Bowel Disease Center, Columbus, USA, 2Fondazione Policlinico A. Gemelli IRCCS - Universita’ Cattolica, Inflammatory Bowel Disease, Rome, Italy, 3Inserm et Université Paris, Gastroenterology, Paris, France, 4Gastroenterology, Univeristy of British Columbia, Vancouver BC, Canada, 5Gastroenterology, St. Mark’s Hospital, London, UK, 6Gastroenterology Hepatology and Nutrition, University of Chicago, Chicago, USA, 7Gastroenterology, Centro Médico Teknon, Barcelona, Spain, 8Gastroenterology- Infectiology and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 9Gastroenterology, Digestive Disease Associates, Gainesville, USA

P483 Vedolizumab serum drug levels are not associated with clinical outcomes or markers of disease activity in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

S. Shields1, J.P. Seenan1, E. Nowell1, A. Dunlop2, P. Galloway2, J. Macdonald1

1Gastroenterology, Queen Elizabeth University Hospital, Glasgow, UK, 2Biochemistry, Queen Elizabeth University Hospital, Glasgow, UK

P484 Effectiveness and safety of ustekinumab in patients with Crohn’s disease: a real-world experience

ECCO'20 Vienna

Year: 2020
Authors:

D. Mohammad1, A. Alshahrani1,2, Y. Bao1, R. Alramdan1, A. Rajani1, U. Chauhan1, B. Salena1, F. Tse1, E. Greenwald1, S. Albashir1, S. Halder1, D. Armstrong1, J. Marshall1, N. Narula1

1Gastroenterology, McMaster University Medical Centre and Farncombe Family Digestive Health Diseases Research Institute, Hamilton, Canada, 2Gastroenterology, Najran University, Najran, Saudi Arabia

P485 Switching infliximab biosimilar: No adverse impact on inflammatory bowel disease control or drug levels with the first or second switch

ECCO'20 Vienna

Year: 2020
Authors:

R. Luber1, R. O’Neill2, S. Singh2, Z. Arkir3, P. Irving1

1Department of Gastroenterology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, 2Department of Pharmacy, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, 3Guy’s and St Thomas’ NHS Foundation Trust, Viapath, London, UK

P486 Assessing the efficacy of biologics in ucerative colitis: a real-life, observational retrospective multicentre study with propensity score analysis (AURORA): Focus on patients naive to biologics

ECCO'20 Vienna

Year: 2020
Authors:

A. Cassinotti1, N. Mezzina1, D. Di Paolo2, M.V. Lenti3, C. Bezzio4, D. Stradella5, M. Mauri6, V. Zadro1, C. Cortellezzi7, C. Ricci8, V. Casini9, E. Radice10, A. Massari1, S. Ardizzone1, L. Pastorelli2, A. Di Sabatino3, G. Manes4, F. Caprioli11, M. Vecchi11, R. Tari5, P. Occhipinti5, M. Fichera6, P. Invernizzi6, M. Parravicini7, S. Segato7, F. Pace9, P.A. Testoni10, C. Tinelli12, A. De Silvestri12

1Department of Gastroenterology, Luigi Sacco University Hospital, Milan, Italy, 2Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese - Milano, Italy, 3First Department of Medicine, Istituto di Ricovero e Cura a Carattere Scientifico San Matteo Hospital Foundation - University of Pavia, Istituto di Ricovero e Cura a Carattere Scientifico San Matteo Hospital Foundation - University of Pavia, Pavia, Italy, 4Department of Gastroenterology, ASST Rhodense - Rho and Garbagnate Milanese Hospital, Milano, Italy, 5Department of Gastroenterology, ‘Maggiore Della Carità’ Hospital - Novara, Novara, Italy, 6Gastroenterology Division, San Gerardo Hospital- ASST Monza, Monza, Italy, 7ASST Sette Laghi- Ospedale di Circolo Fondazione Macchi, Division of Gastroenterology, Varese, Italy, 8Spedali Civili and University of Brescia, Gastroenterology Section - 1st Medical Clinic, Brescia, Italy, 9Gastroenterology, ASST Bergamo EST-Ospedale Bolognini, Bergamo, Italy, 10Gastroenterology Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy, 11Department of Gastroenterology and Endoscopy, IRCCS Ca’ Granda Foundation - University of Milan, Milano, Italy, 12Fondazione IRCCS Policlinico San Matteo, Servizio di Epidemiologia Clinica e Biometria Direzione Scientifica, Pavia, Italy

P487 Development and validation of a new patient-reported outcome measure for Crohn’s perianal fistula: Crohn’s anal fistula quality-of-life (CAF-QoL) scale

ECCO'20 Vienna

Year: 2020
Authors:

S. Adegbola1, L. Dibley2, K. Sahnan1, P. Tozer1, T. Wade3, A. Verjee4, R. Sawyer4, S. Mannick4, D. McCluskey4, N. Yassin1, R. Phillips1, C. Norton3, A. Hart1

1Department of Colorectal Surgery, St. Mark’s Hospital, Harrow, UK, 2Faculty of Health and Education, University of Greenwich, London, UK, 3King’s College London, Florence Nightingale Faculty of Nursing, London, UK, 4Patient and Public Involvement Team, Patient and Public Involvement Team, London, UK

P488 How reliable is the online medical information on paediatric inflammatory bowel diseases?

ECCO'20 Vienna

Year: 2020
Authors:

M. Velasco Rodríguez-Belvís1, L.M. Palomino Pérez1, C. Sánchez Fernández-Bravo1, A. Sanchiz Perea2, L.F. Jose Luis1, G. Domínguez Ortega1, E. Cañedo Villarroya1, C.C. Pedrón Giner1, M.P. Jorge1, S. Rodríguez Manchón1, A. Muñoz González1, R.A. Muñoz Codoceo1

1Department of Gastroenterology and Nutrition, Hospital Infantil Universitario Niño Jesús, Madrid, Spain, 2Department of Pediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

P489 Are patients with inflammatory bowel disease receiving an adequate immunisation?

ECCO'20 Vienna

Year: 2020
Authors:

D. Simian1, P. Núñez2, L. Flores1, C. Figueroa1, P. Ibáñez1, U. Kronberg1, J. Lubascher1, G. Pizarro1, R. Quera1

1Clínica Las Condes, Gastroenterology Department - Inflammatory Bowel Disease, Santiago, Chile, 2Gastroenterology Department - IBD Fellow Clínica Las Condes, San Juan de Dios Hospital, Santiago, Chile

P490 Assessment of body weight changes in patients with inflammatory bowel diseases initiating biologic therapy: A prospective cohort study

ECCO'20 Vienna

Year: 2020
Authors:

N. Borren, W. Tan, A. Jess, P.H.M. Li, J. Garber, J. Luther, F. Colizzo, H. Khalili, A. Ananthakrishnan

Division of Gastroenterology, Massachusetts General Hospital, Boston, USA

P491 De-escalation of dose-intensified anti-TNF therapy in IBD patients in sustained deep remission

ECCO'20 Vienna

Year: 2020
Authors:

I. Chu1,2, R. Little1,2, M. Sparrow1,2, M. Ward1,2

1Gastroenterology, Alfred Hospital- Alfred Health, Melbourne, Australia, 2Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, Australia

P492 Use of bowel ultrasound to assess disease activity in Crohn’s disease patients after induction therapy with infliximab

ECCO'20 Vienna

Year: 2020
Authors:

C. Frias Gomes1, C. Neto Nascimento1, F. Pereira2, A. Caldeira2, R. Sousa2, C. Arieira3, S. Xavier3, S. Monteiro3, F. Dias de Castro3, S. Leite3, J. Cotter3, A.A. Santos1, M. Cravo1, J. Torres1, C. Palmela1

1Surgery Department- Gastroenterology Division, Hospital Beatriz Ângelo, Loures, Portugal, 2Gastroenterology Department, Hospital Amato Lusitano, Castelo Branco, Portugal, 3Gastroenterology Department, Hospital da Senhora da Oliveira, Guimarães, Portugal

P493 Segmental colectomy vs. extended colectomy for colonic Crohn’s disease: results from 112 consecutive patients

ECCO'20 Vienna

Year: 2020
Authors:

A. Frontali1, A. Chierici1, X. Treton2, L. Maggiori1, Y. Bouhnik2, Y. Panis3

1Beaujon Hospital, Colorectal Surgery, Clichy, France, 2Gastroenterology, Beaujon Hospital, Clichy, France, 3Department of Colorectal Surgery, APHP Beaujon, Clichy, France

P494 The efficacy and safety of adalimumab for patients with moderately to severely active ulcerative colitis and predictors of response in Korea

ECCO'20 Vienna

Year: 2020
Authors:

S. Shin Shin1, S.J. Park2, Y. Kim1, J.P. Im3, H.J. Kim4, K.M. Lee5, J.W. Kim6, S.A. Jung7, J. Lee8, S.B. Kang9, S.J. Shin10, E.S. Kim11, Y.S. Kim12, T.O. Kim13, H.S. Kim14, D.I. Park15, H.K. Kim16, E.S. Kim17, Y.H. Kim18, D.H. Kim19, D. Teng20, J.H. Kim1, W.Y. Kim1, C.H. Choi1

1Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea, 2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea, 3Department of Internal medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, 4Department of Gastroenterology, Kyung Hee University Hospital, Seoul, Republic of Korea, 5Department of Gastroenterology, The Catholic University of Korea St. Vincent’s Hospital, Suwon, Republic of Korea, 6Department of Gastroenterology, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea, 7Department of Gastroenterology, Ewha Womans University Hospital, Seoul, Republic of Korea, 8Department of Internal Medicine, Chosun University College of Medicine, Gwagju, Republic of Korea, 9Department of Gastroenterology, The Catholic University of Korea Daejeon ST. Mary’s Hospital, Daejeon, Republic of Korea, 10Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea, 11Department of Gastroenterology, Korea University Anam Hospital, Seoul, Republic of Korea, 12Department of Gastroenterology, Inje University Seoul Paik Hospital, Seoul, Republic of Korea, 13Department of Gastroenterology, Inje University Haeundae Paik Hospital, Busan, Republic of Korea, 14Department of Gastroenterology, Chonnam National University Hospital, Gwagju, Republic of Korea, 15Department of Internal Medicine, Sungkyunkwan University School of Medicine- Kangbuk Samsung Hospital, Seoul, Republic of Korea, 16Department of Gastroenterology, Inha University Hospital, Incheon, Republic of Korea, 17Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea, 18Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 19Abbvie Ltd., Abbvie Ltd., Seoul, Republic of Korea, 20AbbVie Pte. Ltd., AbbVie Pte. Ltd., Singapore, Singapore

P495 Usefulness of a capsule endoscopy scoring system in understanding the disease state of Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

T. Omori, H. Kambayashi, S. Murasugi, A. Ito, M. Yonezawa, K. Tokushige

Institute of Gastroenterology, Tokyo Women’s Medical University, Tokyo, Japan