¹Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, ²Digestive Disease Research Institute, Tehran, Iran, Islamic Republic of, ³Department of Gastroenterology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, ⁴Gastroenterology Section, Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, Islamic Republic of, ⁵Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran, Islamic Republic of, ⁶Department of Gastroenterology and Hepatology, Ghaem Hospital, Medical Faculty, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of, ⁷Department of Medicine, Ardabil University of Medical Science, Ardabil, Iran, Islamic Republic of, ⁸Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of, ⁹Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of, ¹⁰Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of, ¹¹Deputy of Research, Ministry of Health and Medical Education, Tehran, Iran, Islamic Republic of, ¹²Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of

¹Copenhagen University Hospital Hvidovre, The Gastro Unit, Hvidovre, Denmark, ²Zealand University Hospital, Medical Department, Koege, Denmark, ³Copenhagen University Hospital Herlev, Deparment of Endocrinology, Herlev, Denmark

¹Southampton Children's Hospital, Department of Paediatric Surgery, Southampton, UK, ²University Hospital Southampton, Department of Human Genetics and Genomic Medicine, Southampton, UK, ³University Hospital Southampton, NIHR Southampton Biomedical Research Centre, Southampton, UK

¹Lille University Hospital, Gastroenterology Unit, Hôpital Huriez, Lille, France, ²Lille University, CHRU de Lille, Lille Inflammation Research International Centre LIRIC - UMR 995 Inserm, Lille, France, ³Lille University and Hospital, Public Health, Epidemiology and Economic Health, Register Epimad, Lille, France, ⁴CHU Amiens Sud, l, Amiens University Hospital, Gastroenterology Unit, Epimad Registry, Amiens, France, ⁵Hôpital Charles Nicolle, Rouen University Hospital, Gastroenterology Unit, Epimad Registry, Rouen, France

¹Agaplesion Markus Hospital, Frankfurt/Main, Germany, ²Adelphi Real World, Bollington, UK, ³Pfizer Inc., Groton, CT, USA, ⁴Pfizer Inc., Collegeville, PA, USA, ⁵Pfizer Germany GmbH, Berlin, Germany, ⁶Pfizer Inc., New York, NY, USA

¹Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel; Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel., Haifa, Israel, ²Shaare Zedek Medical Center, The Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Jerusalem, Israel, ³Shaare Zedek Medical Center, Jerusalem, Jerusalem, Israel, ⁴Clalit Research Institute, Chief’s Office, Clalit Health Services, Tel Aviv, Israel, Tel Aviv, Israel, ⁵6 Leumit Health Services, Tel Aviv, Israel, Tel Aviv, Israel, ⁶Maccabi Healthcare Services, Tel Aviv, Israel, Tel Aviv, Israel, ⁷Meuhedet Health Services, Tel Aviv, Israel, Tel Aviv, Israel, ⁸Institute of Gastroenterology and Liver Diseases, Hadassah Medical Center, Hebrew University, Jerusalem, Israel, Jerusalem, Israel

¹Clinical Hospital Centre Zagreb, Department of Gastroenterology and Hepatology, Zagreb, Croatia, ²Unit of Clinical Nutrition, University Hospital Zagreb, Zagreb, Croatia, ³Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia, ⁴University of Zagreb, School of Medicine, Zagreb, Croatia, ⁵University Hospital Centre Rijeka, Department of gastroenterology and hepatology, Rijeka, Croatia, ⁶University of Rijeka, School of Medicine, Rijeka, Croatia

¹University Medical Center Groningen/University of Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands, ²University Medical Center Groningen/University of Groningen, Epidemiology, Groningen, The Netherlands

¹University Hospital of Heraklion, Department of Gastroenterology, Heraklion, Greece, ²Evangelismos General Hospital, Department of Gastroenterology, Athens, Greece, ³Venizeleio General Hospital, Department of Gastroenterology, Heraklion, Greece

¹Claude Huriez Hospital, Gastroenterology Unit, Lille, France, ²University of Lille, Epidemiology Unit, EPIMAD registry, Lille, France, ³Amiens Hospital, Amiens, France, ⁴Takeda, Paris, France, ⁵Rouen Hospital, Rouen, France, ⁶Claude Huriez Hospital, University of Lille, Gastroenterology unit, Lille, France

¹Ludwig Boltzmann-Institute of Osteology at the Hanusch Hospital of WGKK and Trauma Centre Meidling of AUVA, 1st Medical Department, Hanusch Hospital, Vienna, Austria, ²Sickness Fund Burgenland, Burgenländische Gebietskrankenkasse, Eisenstadt, Austria

¹Seoul National University College of Medicine, Department of Internal Medicine, Seoul, South Korea, ²the Catholic University of Korea, Seoul St. Mary's Hospital, Department of Medical Statistics, Seoul, South Korea, ³Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Department of Internal Medicine, Seoul, South Korea

¹The sixth hospital affiliated to sun yat-sen university, Gastroenterology dept., Guangzhou, China

¹Bispebjerg and Frederiksberg Hospital, Center for Clinical Research and Prevention, Frederiksberg, Denmark, ²Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark

¹Icahn School of Medicine at Mount Sinai Hospital, Department of Genetics and Genomic Sciences, New York, USA, ²Icahn School of Medicine at Mount Sinai Hospital, Department of Environmental Medicine and Public Health, New York, USA, ³Hospital Beatriz Ângelo, Surgical Department, Gastroenterology Division, Loures, Portugal, ⁴Icahn School of Medicine at Mount Sinai Hospital, Division of Gastroenterology, Department of Medicine, New York, USA

¹ASST Rhodense, Rho, Italy

¹University of Montreal, Montreal, Canada, ²CHU Sainte-Justine, Department of Pediatrics, Unit of Gastroenterology, Montreal, Canada, ³Research center CHU Sainte Justine, Montreal, Canada

¹University of Ulsan College of Medicine, Asan Medical Center, Department of Gastroenterology, Seoul, South Korea, ²University of Ulsan College of Medicine, Asan Medical Center, Department of Biochemistry, Seoul, South Korea, ³University of Ulsan College of Medicine, Asan Medical Center, Department of Clinical Epidemiology and Biostatistics, Seoul, South Korea

¹Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, South Korea, ²College of Medicine, The Catholic University of Korea, Department of Biostatistics, Seoul, South Korea

¹Institut Universitari Parc Taulí, Digestive Unit, Sabadell, Spain, ²Complejo Hospitalario de Pontevedra, Gastroenterology Unit, Pontevedra, Spain, ³Hospital Clínico Universitario, Unidad de Gastroenterología, Valencia, Spain, ⁴Hospital Universitario Puerta de Hierro, Servicio de Gastroenterologia, Madrid, Spain, ⁵Hospital Universitari Germans Trias i Pujol, Gastroenterology Unit, Badalona, Spain, ⁶Spanish Association of patients with Crohn′s disease and Ulcerative colitis, Madrid, Spain, ⁷Medical Department, MSD, Madrid, Spain, ⁸Hospital Vall d′Hebron, Gastroenterology Department, Barcelona, Spain