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P420: Correlation between Infliximab trough levels and endoscopic activity in ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Bernardo*1, S. Fernandes1, A. R. Gonçalves1, C. Baldaia1, A. Valente1, P. Moura Santos1, L. Correia1, R. Marinho1

1Hospital Santa Maria, CHLN, Gastrenterology, Lisbon, Portugal

P421: Effects of combination therapy in inflammatory bowel disease: how long should we keep concomitant immunomodulators?

ECCO '19 Copenhagen

Year: 2019
Authors:

J. C. Silva*1, A. P. Silva1, A. Rodrigues1, C. Fernandes1, A. Ponte1, J. Rodrigues1, M. Sousa1, A. C. Gomes1, J. Carvalho1

1Centro Hospitalar Vila Nova de Gaia/Espinho, Gastroenterology, Vila Nova de Gaia, Portugal

P422: Immunogenicity of a proposed adalimumab biosimilar, FKB327, and the reference product in patients with rheumatoid arthritis

ECCO '19 Copenhagen

Year: 2019
Authors:

R. Alten*1, C. Markland2, K. Kawakami3, M. Boyce4, F. Casty5, R. Muniz5, M. C. Genovese6

1Schlosspark Klinik, University Medicine Berlin, Head of Department of Internal Medicine II, Rheumatology, Clinical Immunology, Osteology Director of Rheumatology Research Center, Berlin, Germany, 2NDA Group, Leatherhead, Surrey, UK, 3Fujifilm Kyowa Kirin Biologics Co., Ltd., Clinical Development Department, Tokyo, Japan, 4Hammersmith Medicines Research, London, UK, 5Mylan Inc., Global Medical Affairs, Canonsburg, USA, 6Stanford University School of Medicine, James W. Raitt Endowed Professor of Medicine Co-Chief Division of Immunology and Rheumatology, Palo Alto, USA

P423: Comparative efficacy of anti-tumour necrosis factor agents and vedolizumab in ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Subramanian*1, R. Davis1, P. MacParland1, S. Dodd2, D. Storey1, C. Probert1, P. Collins1, T. Skouras1, A. Steel1, E. Derbyshire1, M. Dibb1

1Royal Liverpool University Hospital, Liverpool, UK, 2Institute of Translational medicine, Department of Biostatistics, Liverpool, UK

P424: Is the switch to a second thiopurine a safe strategy in elderly patients with inflammatory bowel disease? A multi-centre cohort study of the ENEIDA registry

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Calafat*1, M. Mañosa1,2, E. Ricart2,3, E. Iglesias4, M. Calvo5, F. Rodríguez-Moranta6, C. Taxonera7, P. Nos2,8, F. Mesonero9, M. Martín-Arranz10, M. Mínguez11, J. P. Gisbert2,12, S. García-López13, R. de Francisco14, F. Gomollón2,15, X. Calvet2,16, E. García-Planella17, M. Rivero18, J. Martínez-Cadila19, F. Argüelles20, L. Arias21, M. Cimavilla22, Y. Zabana2,23, F. Cañete1,2, E. Cabré1,2, E. Domènech1,2, ENEIDA Registry of GETECCU1

1Hospital Universitari Germans Trias i Pujol, Gastroenterology Department, Badalona, Spain, 2CIBERehd, Madrid, Spain, 3Hospital Clínic, Barcelona, Spain, 4Hospital Reina Sofía, Córdoba, Spain, 5Hospital Puerta de Hierro, Majadahonda, Spain, 6Hospital de Bellvitge, L'Hospitalet del Llobregat, Spain, 7Hospital Clínico San Carlos, Madrid, Spain, 8Hospital La Fe de Valencia, Valencia, Spain, 9Hospital Ramón y Cajal, Madrid, Spain, 10Hospital La Paz, Madrid, Spain, 11Hospital Clínico de Valencia, Valencia, Spain, 12Hospital Universitario de La Princesa, Madrid, Spain, 13H.U. Miguel Servet, Zaragoza, Spain, 14H.U. Central de Asturias, Oviedo, Spain, 15H. Clínico Lozano Blesa, Zaragoza, Spain, 16H. Parc Taulí, Sabadell, Spain, 17H. Santa Creu i Sant Pau, Barcelona, Spain, 18H.U. Marqués de Valdecilla, Santander, Spain, 19Complexo H.U. de Vigo, Vigo, Spain, 20H. Virgen de la Macarena, Sevilla, Spain, 21H.U. Burgos, Burgos, Spain, 22H. Río Hortega, Valladolid, Spain, 23H. Mútua de Terrassa, Terrassa, Spain

P425: Development of an enzyme-linked immunosorbent assay for therapeutic drug monitoring of ustekinumab

ECCO '19 Copenhagen

Year: 2019
Authors:

K. Farrag*1,2, M. Rohlfs3, J. Ruppert3, F-P. Armbruster3, J. Stein1,2

1Interdisciplinary Crohn Colitis Centre Rhein-Main, Frankfurt/Main, Germany, 2DGD Clinics Sachsenhausen, Frankfurt/Main, Germany, 3Immundiagnostik AG, Bensheim, Germany

P426: Lympocytosis in patients with inflammatory bowel disease treated with anti-TNFa agents: is it significant?

ECCO '19 Copenhagen

Year: 2019
Authors:

K. Soufleris*1, N. Kafalis1, M. Charalampidis1, K. Fasoulas1, I. Pilpilidis1, G. Lazaraki1, D. Tzilves1, D. Markala2

1Theagenion CHT, Gastroenterology Department, Thessaloniki, Greece, 2Theagenion CHT, Dir Haematology Lab, Thessaloniki, Greece

P427: Impact of curcuma longa on clinical activity and inflammatory markers in patients with active ulcerative colitis: a double-blind randomised placebo-controlled trial

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Kumar1, U. Dutta1, J. Shah*1, P. Singh1, C. Vaishnavi1, K. K. Prasad1, K. Singh1

1PGIMER, Gastroenterology, Chandigarh, India

P428: Long-term outcomes of endoscopic ballon dilation for small-bowl strictures using double balloon enteroscopy in patients with Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

T. Takeda*1, F. Hirai1, N. Takatsu1, M. Kishi2, T. Beppu2, K. Yao3, T. Ueki2

1Fukuoka University Chikushi Hospital, IBD Center, Fukuoka, Japan, 2Fukuoka University Chikushi Hospital, Department of Gastroenterology, Fukuoka, Japan, 3Fukuoka University Chikushi Hospital, Department of Endoscopy, Fukuoka, Japan

P429: Factors associated with weight gain in patients treated with anti-TNF-α for inflammatory bowel disease: a cohort study

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Haas1, V. Abitbol2, T. Paupard3, S. Chaussade2, S. Nahon*1

1GHI Le Raincy-Montfermeil, Gastroenterology, Montfermeil, France, 2Hopital Cochin, Paris, Gastroenterology, Paris, France, 3Hopital de Dunkerque, Gastroenterology, Dunkerque, France

P430: European clinician perspective on withdrawing immunosuppression

ECCO '19 Copenhagen

Year: 2019
Authors:

R. Boyapati1, S. R. Fehily*2, N. S. Ding3

1Monash Medical Centre, Gastroenterology, Melbourne, Australia, 2St Vincent's Hospital, Gastroenterology, Melbourne, Australia, 3St Vincent’s Hospital, Gastroenterology, Melbourne, Australia

P431: Validation of a therapeutic drug monitoring test to measure the adalimumab biosimilar SB5 in comparison with the reference adalimumab

ECCO '19 Copenhagen

Year: 2019
Authors:

M. B. Ruiz-Argüello*1, A. Maguregui1, A. Martínez1, D. Nagore1

1Progenika Biopharma-Grifols, Derio, Spain

P432: Barriers to prescribing anti-TNF therapy in inflammatory bowel disease (IBD) across newly industrialised emerging market countries: an analysis of the ‘EXPLORE’ study

ECCO '19 Copenhagen

Year: 2019
Authors:

B. D. Ye*1, J. K. Yamamoto Furusho2, M. Rana Qasim Khan3, O. Fadeeva3, D. Demuth4, J. Qian5, I. L. Khalif6, T. Chia-Hung7, M. Toruner8, A. H. Othman9, W. Chan10, E. Ponce de Leon11, M. Guennec12, C. Sison13, E. Uberti Foppa14, A. Armuzzi15

1University of Ulsan College of Medicine, Asan Medical Center, Department of Gastroenterology and Inflammatory Bowel Disease Center, Seoul, South Korea, 2National Institute of Medical Sciences and Nutrition, Department of Gastroenterolgy, Mexico city, Mexico, 3Takeda Pharmaceutical International AG Singapore branch, Singapore, Singapore, 4Takeda International - UK Branch, London, UK, 5Peking Union Medical College Hospital, Beijing, China, 6Federal State Budgetary Institution ‘State Scientific Center of Coloproctology n.a. A.N. Rizhikh’ of the Ministry of Public Health of Russian Federation, Inflammatory and Functional Bowel Diseases Research Unit, Moscow, Russian Federation, 7National Taiwan University, Taipei, Taiwan, 8Ankara University School of Medicine, Department of Gastroenterology, Ankara, Turkey, 9King Khalid University Hospital , King Saud University, Department of Medicine, Riyadh, Saudi Arabia, 10Singapore General Hospital, Department of Gastroenterology and Hepatology, Singapore, Singapore, 11Fundación CardioInfantil, Instituto de Cardiología, Bogota, Colombia, 12IQVIA, Saint Ouen, France, 13IQVIA, Makati City, Philippines, 14PRA Health Sciences, Global Medical Affairs – Research, Europe Development Centre, Takeda International – UK Branch, London, UK, 15Presidio Columbus Fondazione Policlinico A. Gemelli IRCCS – Università Cattolica del Sacro Cuore, Rome, Italy

P433: Aetiologies of iron deficiency-related anaemia in German patients with inflammatory bowel disease

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Aksan*1,2, E. Leventi1,3, K. Farrag1,3, I. Mavrommataki1,3, A. Dignass4, J. Stein1,3

1Interdisciplinary Crohn Colitis Centre Rhein-Main, Frankfurt/Main, Germany, 2Hacettepe University, Ankara, Turkey, 3DGD Clinics Sachsenhausen, Frankfurt/Main, Germany, 4Agaplesion Markuskrankenhaus, Frankfurt/Main, Germany

P434: Surgery management of Crohn's disease in children: our experience

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Pujol Muncunill*1, J. González Pérez1, L. Saura García2, A. I. Pascual Pérez1, V. Vila Miravet1, X. Tarrado Castellarnau2, J. Martin de Carpi1

1Hospital Sant Joan de Déu, Unit for Comprehensive Care of Pediatric Inflammatory Bowel Disease, Pediatric Gasatroneterology, Hepatology and Nutrition Unit, Barcelona, Spain, 2Hospital Sant Joan de Déu, Unit for the Comprehensive Care of Pediatric Inflammatory Bowel Disease, Department of Pediatric Surgery, Barcelona, Spain

P435: Rapidity of symptomatic and inflammatory biomarker improvements following upadacitinib induction treatment: data from the U-ACHIEVE study

ECCO '19 Copenhagen

Year: 2019
Authors:

G. D’Haens*1, E. V. Loftus Jr2, P. D. R. Higgins3, J. Panes4, R. Panaccione5, W. Zhou6, F. Cataldi6, W-J. Lee6, B. Huang6, W. Xie6, S. Vermeire7

1Amsterdam University Medical Centers, Amsterdam, The Netherlands, 2Mayo Clinic, Rochester, USA, 3University of Michigan, Ann Arbor, USA, 4Hospital Clínic Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain, 5University of Calgary, Calgary, Canada, 6AbbVie Inc., North Chicago, USA, 7University Hospital Leuven, Leuven, Belgium

P436: Darvadstrocel treatment outcomes in Crohn’s disease patients with complex perianal fistulas: the role of TNFi co-treatment in ADMIRE CD

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Panés*1, D. García-Olmo2, D. Lindner3, I. Tagarro García4, C. Agboton3

1Hospital Clínic de Barcelona, Gastroenterology Department, Barcelona, Spain, 2‘Fundación Jiménez Díaz’ University Hospital, Autonomous University of Madrid, Department of Surgery, Madrid, Spain, 3Takeda Pharmaceuticals International AG, Zurich, Switzerland, 4Takeda Spain, Madrid, Spain

P437: Risk of immunomediated adverse events or secondary loss of response to infliximab in elderly patients with inflammatory bowel disease: a cohort study of the ENEIDA registry

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Calafat*1, M. Mañosa1,2, J. Panes2,3, P. Nos2,4, E. Iglesias5, I. Vera6, A. López-Sanromán7, J. Guardiola8, C. Taxonera9, M. Mínguez10, M. D. Martín11, L. de Castro12, S. Riestra13, M. Rivero14, E. García-Planella15, X. Calvet2,16, S. García-López17, M. Andreu18, F. Gomollón19, J. Barrio20, M. Esteve2,21, A. Rodríguez22, J. P. Gisbert2,23, A. Gutierrez24, J. Hinojosa25, F. Argüelles26, D. Busquets27, L. Bujanda28, J. Lázaro29, B. Sicilia30, O. Merino31, P. Martínez32, F. Bermejo33, R. Lorente34, M. Barreiro-de-Acosta35, C. Rodríguez36, M. Fe37, M. Piqueras38, P. Romero39, E. Rodríguez40, Ó. Roncero41, J. Llaó42, G. Alcaín43, J. Riera44, M. Sierra45, L. I. Fdez. Salazar46, V. Jair47, M. Navarro48, M. A. Montoro49, C. Muñoz, A. J. Lucendo, M. Van Domselaar, I. Moraleja, J. M. Huguet, L. Ramos, P. Ramírez, P. Almeda, R. Pajares, S. Khorrami, R. E. Madrigal, E. Sesé, A. M. Trapero, J. Legido, Á. Abad, F. Cañete1,2, E. Cabré1,2, E. Domènech1,2

1Hospital Universitari Germans Trias i Pujol, Gastroenterology Department, Badalona, Spain, 2CIBERehd, Madrid, Spain, 3Hospital Clínic, Barcelona, Spain, 4Hospital La Fe de Valencia, Valencia, Spain, 5Hospital Reina Sofía, Córdoba, Spain, 6Hospital Puerta de Hierro, Majadahonda, Spain, 7Hospital Ramón y Cajal, Madrid, Spain, 8Hospital de Bellvitge, L'Hospitalet del Llobregat, Spain, 9Hospital Clínico San Carlos, Madrid, Spain, 10Hospital Clínico de Valencia, Valencia, Spain, 11Hospital La Paz, Madrid, Spain, 12Complexo H. Universitario de Vigo, Vigo, Spain, 13H.U. Central de Asturias, Oviedo, Spain, 14H.U. Marqués de Valdecilla, Santander, Spain, 15H. Santa Creu i Sant Pau, Barcelona, Spain, 16H. Parc Taulí, Sabadell, Spain, 17H.U. Miguel Servet, Zaragoza, Spain, 18Hospital del Mar, Barcelona, Spain, 19H. Clínico Lozano Blesa, Zaragoza, Spain, 20H. Río Hortega, Valladolid, Spain, 21H. Mútua de Terrassa, Terrassa, Spain, 22H.U. Salamanca, Salamanca, Spain, 23Hospital Universitario de La Princesa, Madrid, Spain, 24H.G.U. Alicante, Alicante, Spain, 25H. Manises, Manises, Valencia, Spain, 26H. Virgen de la Macarena, Sevilla, Spain, 27H. Dr. Josep Trueta, Girona, Spain, 28H. Donostia, Donostia, Spain, 29H.U. Fundación de Alcorcón, Alcorcón, Spain, 30Complejo Hosp. Burgos, Burgos, Spain, 31H. de Cruces, Cruces-Barakaldo, Spain, 32H. 12 de Octubre, Madrid, Spain, 33H.U. Fuenlabrada, Fuenlabrada, Spain, 34H. General de Ciudad Real, Ciudad Real, Spain, 35H. Clínico Santiago, Santiago, Spain, 36Complejo Hospitalario de Navarra, Pamplona, Spain, 37H.G.U. Elche, Elche, Spain, 38Consorci Sanitari de Terrassa, Terrassa, Spain, 39H. Santa Lucía Cartagena, Cartagena, Spain, 40H. Nuestra Sra. de la Candelaria, Santa Cruz de Tenerife, Spain, 41H. Mancha Centro, Alcázar de San Juan, Spain, 42H. Sant Joan de Déu – Althaia, Manresa, Spain, 43H. Clínico de Málaga, Virgen de la Victoria, Spain, 44Hospital Son Llàtzer, Palma De Mallorca, Spain, 45Complejo Hospitalario de León, León, Spain, 46H. Clínico Univ. Valladolid, Valladolid, Spain, 47H. General de Granollers, Granollers, Spain, 48H. Moisès Broggi, St Joan Despí, Spain, 49H. San Jorge, Huesca, Spain, H. Basurto, Bilbao, Spain, H. General de Tomelloso, Ciudad Real, Spain, H. Torrejón, Madrid, Spain, H. de Galdakao, Vizcaya, Spain, H.G.U. de Valencia, Valencia, Spain, H.U. Canarias, La Laguna, Spain, H.U. Áraba, Vitoria, Spain, H. General de Castelló, Castelló, Spain, H. Infanta Sofía, San Sebastián de los Reyes, Spain, H. Son Espases, Mallorca, Spain, Complejo Hospitalario de Palencia, Palencia, Spain, H.U. Arnau de Vilanova, LLeida, Spain, Complejo Hospitalario de Jaén, Jaén, Spain, H. General de Segovia, Segovia, Spain, H. Viladecans, Viladecans, Spain

P438: Lupus-like reactions in patients with inflammatory bowel disease treated with anti-TNFs are rare but insidious adverse events: data from a large single-centre cohort

ECCO '19 Copenhagen

Year: 2019
Authors:

F. S. Macaluso*1, C. Sapienza1, M. Ventimiglia1, M. Cottone1, A. Orlando1

1IBD Unit, ‘Villa Sofia-Cervello’ Hospital, Palermo, Italy

P439: Effectiveness and safety of the sequential use of a second and third anti-TNF agent in patients with inflammatory bowel disease: results from the ENEIDA registry

ECCO '19 Copenhagen

Year: 2019
Authors:

M. J. Casanova*1, M. Chaparro1, M. Mínguez2, E. Ricart3, C. Taxonera4, S. García-López5, J. Guardiola6, A. López-San Román7, E. Iglesias8, B. Beltrán9, B. Sicilia10, M. I. Vera11, J. Hinojosa12, S. Riestra13, E. Domènech14, X. Calvet15, J. L. Pérez-Calle16, M. D. Martín-Arranz17, X. Aldeguer18, M. Rivero19, D. Monfort20, J. Barrio21, M. Esteve22, L. Márquez23, R. Lorente24, E. García-Planella25, L. de Castro26, F. Bermejo27, O. Merino28, A. Rodríguez-Pérez29, P. Martínez-Montiel30, M. Van Domselaar31, G. Alcaín32, M. Domínguez-Cajal33, C. Muñoz34, F. Gomollón35, L. Fernández-Salazar36, M. F. García-Sepulcre37, I. Rodríguez-Lago38, A. Gutiérrez39, F. Argüelles-Arias40, C. Rodriguez41, G. E. Rodríguez42, L. Bujanda43, J. Llaó44, P. Varela45, L. Ramos46, J. M. Huguet47, P. Almela48, P. Romero49, M. Navarro-Llavat, Á. Abad, P. Ramírez-de la Piscina, A. J. Lucendo, E. Sesé, R. E. Madrigal, M. Charro, A. García-Herola, R. Pajares, S. Khorrami, J. P. Gisbert1

1Hospital Universitario de La Princesa, IIS-IP , Universidad Autónoma de Madrid and CIBEREHD, Gastroenterology Unit, Madrid, Spain, 2Hospital Clínico Universitario de Valencia, Gastroenterology Unit, Valencia, Spain, 3Hospital Clínic i Provincial, CIBEREHD and IDIBAPS, Gastroenterology Unit, Barcelona, Spain, 4Hospital Universitario Clínico San Carlos, Gastroenterology Unit, Madrid, Spain, 5Hospital Universitario Miguel Servet and CIBEREHD, Gastroenterology Unit, Zaragoza, Spain, 6Hospital Universitario de Bellvitge, Gastroenterology Unit, Barcelona, Spain, 7Hospital Universitario Ramón y Cajal, Gastroenterology Unit, Madrid, Spain, 8Hospital Universitario Reina Sofía, Gastroenterology Unit, Córdoba, Spain, 9Hospital Universitario y Politécnico La Fe and CIBEREHD, Gastroenterology Unit, Valencia, Spain, 10Hospital Universitario de Burgos, Gastroenterology Unit, Burgos, Spain, 11Hospital Universitario Puerta de Hierro Majadahonda, Gastroenterology Unit, Madrid, Spain, 12Hospital de Manises, Gastroenterology Unit, Valencia, Spain, 13Hospital Universitario Central de Asturias, Gastroenterology Unit, Oviedo, Spain, 14Hospital Universitario Germans Trias i Pujol and CIBEREHD, Gastroenterology Unit, Badalona, Spain, 15Hospital de Sabadell. Corporació Sanitària Universitària Parc Taulí and CIBEREHD, Gastroenterology Unit, Sabadell, Spain, 16Hospital Universitario Fundación de Alcorcón, Gastroenterology Unit, Madrid, Spain, 17Hospital Universitario La Paz and Instituto de Investigación de La Paz (IdiPaz), Gastroenterology Unit, Madrid, Spain, 18Hospital Universitari de Girona Dr. Josep Trueta, Gastroenterology Unit, Gerona, Spain, 19Hospital Universitario Marqués de Valdecilla and IDIVAL, Gastroenterology, Santander, Spain, 20Consorci Sanitari Terrassa, Gastroenterology, Tarrasa, Spain, 21Hospital Universitario Río Hortega, Gastroenterology, Valladolid, Spain, 22Hospital Universitario Mutua Terrasa, Gastroenterology Unit, Tarrasa, Spain, 23Hospital del Mar, Gastroenterology Unit, Barcelona, Spain, 24Hospital General Universitario de Ciudad Real and CIBEREHD, Gastroenterology Unit, Ciudad Real, Spain, 25Hospital de la Santa Creu i Sant Pau, Gastroenterology Unit, Barcelona, Spain, 26Complejo Hospitalario Universitario de Vigo, Gastroenterology Unit, Vigo, Spain, 27Hospital Universitario de Fuenlabrada and Instituto de Investigación de La Paz (IdiPaz), Gastroenterology Unit, Madrid, Spain, 28Hospital Universitario Cruces, Baracaldo, Spain, 29Hospital Clínico Universitario de Salamanca, Gastroenterology Unit, Salamanca, Spain, 30Hospital Universitario Doce de Octubre, Gastroenterology Unit, Madrid, Spain, 31Hospital de Torrejón, Gastroenterology Unit, Madrid, Spain, 32Hospital Universitario Virgen de la Victoria, Gastroenterology Unit, Málaga, Spain, 33Hospital General San Jorge, Gastroenterology Unit, Huesca, Spain, 34Hospital de Basurto, Gastroenterology Unit, Bilbao, Spain, 35Hospital Clínico Universitario Lozano Blesa, Gastroenteroogy Unit, Zaragoza, Spain, 36Hospital Clínico Universitario de Valladolid, Gastroenterology Unit, Valladolid, Spain, 37Hospital General Universitario de Elche, Gastroenterology Unit, Elche, Spain, 38Hospital de Galdakao-Usansolo, Gastroenterology Unit, Galdakao, Spain, 39Hospital General Universitario de Alicante and CIBEREHD, Gastroenterology Unit, Alicante, Spain, 40Hospital Universitario Virgen Macarena, Gastroenterology Unit, Sevilla, Spain, 41Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Gastroenterology Unit, Pamplona, Spain, 42Hospital Universitario Nuestra Señora de la Candelaria, Gastroenterology Unit, Santa Cruz de Tenerife, Spain, 43Hospital Universitario de Donostia, Instituto Biodonostia, Universidad del País Vasco (UPV/EHU) and CIBEREHD, Gastroenterology Unit, San Sebastián, Spain, 44ALTHAIA Xarxa Assistencial Universitària de Manresa, Gastroenterology Unit, Manresa, Spain, 45Hospital Universitario de Cabueñes, Gastroenterology Unit, Gijón, Spain, 46Hospital Universitario de Canarias, Gastroenterology Unit, La Laguna, Spain, 47Consorcio Hospital General Universitario de Valencia, Gastroenterology Unit, Valencia, Spain, 48Hospital General Universitario de Castellón, Gastroenterology Unit, Castellón, Spain, 49Hospital General Universitario de Santa Lucía, Gastroenterology Unit, Murcia, Spain, Hospital de Sant Joan Despí Moisès Broggi, Gastroenterology Unit, Sant Joan Despí, Spain, Hospital de Viladecans, Gastroenterology Unit, Barcelona, Spain, Hospital Universitario de Álava, Gastroenterology Unit, Vitoria, Spain, Hospital General de Tomelloso, Gastroenterology Unit, Ciudad Real, Spain, Hospital Universitario Arnau de Vilanova, Gastroenterology Unit, Lérida, Spain, Complejo Asistencial Universitario de Palencia, Gastroenterology Unit, Palencia, Spain, Hospital Royo Villanova, Gastroenterology Unit, Zaragoza, Spain, Hospital Marina Baixa, Gastroenterology Unit, Alicante, Spain, Hospital Universitario Infanta Sofía, Gastroenterology Unit, Madrid, Spain, Hospital Universitario Son Espases, Gastroenterology Unit, Palma de Mallorca, Spain