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P080: Thioguanine nucleotide cut-off levels to predict leucopoenia should be considered differently based on NUDT15 R139C genotypes in Chinese Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

X. Zhu1, K. Chao2, H. Zheng1, P. Hu2, M. Huang1, X. Gao*2, X. Wang1

1Sun Yat-sen University, Guangzhou, China, 2The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

P081: Effect of bile acid on lymphocyte migration in the small intestine

ECCO '19 Copenhagen

Year: 2019
Authors:

N. Shibuya*1, M. Higashiyama1, S. Nishii1, A. Mizoguchi1, K. Inaba1, N. Sugihara1, Y. Hanawa1, A. Wada1, K. Horiuchi1, H. Furuhashi1, C. Kurihara1, H. Hozumi1, Y. Okada1, C. Watanabe1, S. Komoto1, K. Tomita1, S. Nagao1, M. Saruta2, R. Hokari1

1National Defense Medical College, Internal Medicine, Tokorozawa, Japan, 2Jikei University School of Medicine, Internal Medicine, Tokyo, Japan

P082: Xenobiotic nuclear receptors: linking bile acid signalling to alterations in CYP3A4 metabolism in Crohn's disease

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Wilson*1, A. Almousa2, R. Rose3, W. Teft2, R. Kim1

1Western University, Medicine, London, Canada, 2Western University, Physiology and Pharmacology, London, Canada, 3Western University, Epidemiology and Biostatistics, London, Canada

P083: The transcriptomic signature of IL-23-treated lamina propria mononuclear cells is significantly enriched for genes in the Th17 pathway and is enriched in active UC

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Digby-Bell1, P. Pavlidis1, U. Niazi2, Z. Kassam1, N. Prescott3, E. Perucha1, M. Saqi2, N. Powell1

1King's College London, Centre for Inflammation and Cancer Immunology (CIBCI), London, UK, 2King's College London, NIHR Biomedical Research Center, London, UK, 3King's College London, Department of Medical and Molecular Genetics, London, UK

P084: Clinical response to Ustekinumab in Crohn’s disease is linked to a dose-dependent reduction of T follicular helper cells

ECCO '19 Copenhagen

Year: 2019
Authors:

A-M. Globig*1,2, N. P. Sommer1, A. K. Thomann3, W. Reindl3, R. Schreiner4, M. Hofmann1, C. Schempp5, R. Thimme1, P. Hasselblatt1

1Medical Center – University of Freiburg, Department of Medicine II, Freiburg, Germany, 2Faculty of Medicine, University of Freiburg, Berta-Ottenstein-Programme, Freiburg, Germany, 3Medical Faculty Mannheim, Heidelberg University, Department of Medicine II, Mannheim, Germany, 4Limbach Group, Heidelberg, Germany, 5Medical Center – University of Freiburg, Department of Dermatology, Freiburg, Germany

P085: Crohn’s disease patients under combined therapy with Azathioprine and Infliximab present persistent inflammation together with a counter regulatory response during clinical disease remission

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Duarte-Silva1,2, R. S. Parra*3, M. R. Feitosa3, O. Féres3, J. J. Ribeiro da Rocha3, C. R. d1, B. Cardoso1

1School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil, Department of Clinical Analysis, Toxicology and Food Science, Ribeirão Preto, SP, Brazil, 2Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil, Department of Immunology and Biochemistry, Ribeirão Preto, Brazil, 3Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil, Surgery and Anatomy, Ribeirão Preto, SP, Brazil

P086: Eukaryotic microbial dysbiosis in treatment-naïve patients with newly diagnosed Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

I. Goren*1,2, L. Reshef3, L. Godny1, K. Rabinowitz1, I. Dotan1,2, H. Yanai1,2