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P060: The protective effect of necrosis inhibition on acute murine colitis induced by dextran sulphate sodium

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Kim*1, J. S. Koo1, J. H. Park1, S. H. Hwang1, D. Lee1, J. W. Choe1, J. J. Hyun1, S. W. Jung1, Y. T. Jeen2, S. W. Lee1

1Korea University Ansan Hospital, Internal medicine, Ansan, South Korea, 2Korea University Anam Hospital, Internal medicine, Seoul, South Korea

P061: Succinate promotes EMT in intestinal epithelial cells through SUCNR1: Relevance in fistula development

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Cosin-Roger*1,2, D. Ortiz-Masia3, M. Aragón-Borrego1, L. Gisbert-Ferrándiz1, S. Calatayud1, M. D. Barrachina1

1University of Valencia, Pharmacology, Valencia, Spain, 2Hospital Dr Peset, Valencia, Spain, 3University of Valencia, Medicine, Valencia, Spain

P062: Differences in immune cell population subsets in inflammatory bowel disease patients under anti-TNF treatment

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Notararigo*1,2, J. E. Viñuela Roldán3, M. Abanades-Tercero4, J. E. Dominguez-Munoz1, M. Barreiro-de Acosta1

1University Hospital, Gastroenterology, Santiago de Compostela, Spain, 2Fundación Ramón Domínguez, Santiago, Spain, 3University Hospital, Immunology, Santiago, Spain, 4Hospital Virgen de la Salud, Gastroenterology, Toledo, Spain

P063: Representative and comprehensive analysis of colonic and ileac biopsies from IBD patients by gene expression profiling using the straightforward, fast, and affordable novel application Whole Transcriptome AmpliSeq on the Ion Torrent NGS platform

ECCO '19 Copenhagen

Year: 2019
Authors:

F. Raulf*1, L. Roth1, C. Delucis-Bronn1, A. Begrich1, G. Wieczorek1, D. Picard2, J. Rush1, C. Beglinger3, P. Hruz4

1Novartis Pharma AG / NIBR, Autoimmunity, Transplantation and Inflammation Disease Area, Basel, Switzerland, 2Novartis Pharma AG / NIBR, Translational Medicine, Basel, Switzerland, 3University Basel, Deaprtment of Biomedicine, Basel, Switzerland, 4University Hospital Basel, Gastroenterology and Hepatology, Basel, Switzerland

P064: The role of the vagal innervation in a DSS-induced colitis mouse model

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Lo Sasso*1, B. Phillips2, C. Foong2, M. Talikka1, A. Sewer1, A. Kondylis1, N. V. Ivanov3, J. Hoeng1

1Philip Morris International, PMI Science and Innovation, System Toxicology, Neuchatel, Switzerland, 2Philip Morris International Laboratories, PMI Science and Innovation, Pre-clinical Toxicology, Singapore, Singapore, 3Philip Morris International, PMI Science and Innovation, Biomarker and Biosensor Research, Neuchatel, Switzerland

P065: Olfactory receptor, OR51E2 is a marker for innate immune cells in ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

B. J. Lee*1, N. J. Kim1, S. B. Park1, J. S. Koo1, Y. T. Jeen1, J. J. Park1, M. K. Joo1

1Korea University, Seoul, South Korea

P066: Validation of assay for detection of free soluble mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in human serum and cerebrospinal fluid

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Fernandez Ocana1, J. Y. Zhang2, B. R. Jones3, S. W. Martin2, M. Goetsch*4, H. Neubert1

1Pfizer, Andover, MA, USA, 2Pfizer, Cambridge, MA, USA, 3Q2 Solutions, Ithaca, NY, USA, 4Shire, Zug, Switzerland

P067: Human colonic subepithelial myofibroblasts from IBD patients demonstrate a differential expression of Th-related cytokine receptors compared with healthy controls

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Bamias4, E. Filidou1, V. Valatas2, I. Drygiannakis2, K. Arvanitidis1, S. Vradelis3, G. Kouklakis*3, G. Kolios1

1Democritus University of Thrace, Laboratory of Pharmacology, Faculty of Medicine, Alexandroupolis, Greece, 2University of Crete, Laboratory of Gastroenterology, Faculty of Medicine, Heraklion, Greece, 3Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece, 4GI Unit, 3rd Academic Department of Internal Medicine, National and Kapodistrian University of Athens Sotiria Hospital, Athens, Greece

P068: Aberrant brain function in active-stage ulcerative colitis patients: a resting-state functional MRI study

ECCO '19 Copenhagen

Year: 2019
Authors:

W. Fan*1, S. Zhang1, J. Hu1, B. Liu1, L. Wen1, M. Gong1, G. Wang1, L. Yang2, Y. Chen2, H. Chen2, H. Guo2, D. Zhang1

1新桥医院, Radiology Department, Chongqing, China, 2新桥医院, Gastroenterology Department, Chongqing, China

P069: New methylation biomarker panel of inflammatory Mucosa in Korean Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

S. M. Lee1, T. O. Kim*2

1Dongnam Institute of Radiological and Medical Sciences (DIRAMS), Busan, South Korea, 2Inje University Haeundae Paik Hospital, Busan, South Korea

P070: The level of nuclear factor kappa B (NF-kB) translocation during infliximab therapy in children with IBD

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Petrichuk1, T. Radigina1, D. Gerasimova1, A. Illarionov2,3, A. Anushenko2, T. Erlikh-Fox4, A. Potapov*2

1National Medical Research Center for Children's Health, Laboratory of Experimental Immunology and Virology, Moscow, Russian Federation, 2National Medical Research Center for Children's Health, Gastroenterology and Hepatology, Moscow, Russian Federation, 3Sechenov First Moscow State Medical University, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation, 4National Medical Research Center for Children's Health, Cytochemical Research Center, Moscow, Russian Federation

P071: Supporting extrapolation of indications for ABP 501, the first adalimumab biosimilar: focus on Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Halder*1, W. Khan1, X. Wang1, S. Kuhns2, H. Sweet2, W. Reinisch1, H. McBride2

1McMaster, Ontario, Canada, 2Amgen, Thousand Oaks, USA

P072: Quantitative phase imaging for the characterisation of Crohn’s disease-derived intestinal strictures

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Bokemeyer*1, P. Tepasse1, L. Quill1, P. Lenz2, E. Rijcken3, M. Vieth4, S. Ketelhut5, F. Rieder6, B. Kemper7, D. Bettenworth1

1University Hospital Münster, Department of Medicine B for Gastroenterology and Hepatology, Münster, Germany, 2University Hospital Münster, Institute of Palliative Care, Münster, Germany, 3University Hospital Münster, Department of General and Visceral Surgery, Münster, Germany, 4Klinikum Bayreuth, Institute of Pathology, Bayreuth, Germany, 5University of Münster, Biomedical Technology Center, Münster, Germany, 6Cleveland Clinic, Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland, USA, 7University of Muenster, Biomedical Technology Center, Münster, Germany

P073: Evaluation of DPPH free radical scavenging activity by HPLC technique: a screening method for drugs and nutrients used in inflammatory bowel disease

ECCO '19 Copenhagen

Year: 2019
Authors:

M-L. Jelicic1, E. Brusac1, D. Amidzic Klaric1, B. Nigovic1, N. Turk*2, Z. Krznaric2, A. Mornar1

1Faculty of Pharmacy and Biochemistry, University of Zagreb, Department of Pharmaceutical Analysis, Zagreb, Croatia, 2University Hospital Center, Department of Gastroenterology and Hepatology, Zagreb, Croatia

P074: Autoimmunity against type IV collagen in ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Abdulganieva*1, D. Mukhametova1, O. Zinkevich2, N. Safina2, M. Koporulina2, A. Odintsova3

1Kazan State Medical University, Hospital therapy, Kazan, Russian Federation, 2Kazan State Medical Academy, Kazan, Russian Federation, 3Republican Clinical Hospital, Kazan, Russian Federation

P075: Adaptive defensive response is critical to determine dextran sulphate sodium-induced colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

K. B. Hahm*1, D. W. Kim1, K. J. Kim2

1CHA University, Gastroenterology, Seongnam, South Korea, 2Univ of Ulsan, Gastroenterology, Seoul, South Korea

P076: Conserved inflammatory profile between mice and humans allow unsupervised patient stratification and temporal allocation of IBD-risk genes

ECCO '19 Copenhagen

Year: 2019
Authors:

P. Czarnewski1, M. Parigi1, O. Diaz1, S. Das1, C. Sorini1, N. Gagliani1, E. J. Villablanca*1

1Karolinska Institute, Medicine, Stockholm, Sweden

P077: SMAD7 shows a biphasic expression pattern during progression of ulcerative colitis-associated colorectal cancer

ECCO '19 Copenhagen

Year: 2019
Authors:

P. Chandrasinghe*1,2,3, B. Cereser2, M. Moorghen4, P. Spaggiari5, A. Maroli5, L. Del Bel Belluz2, A. Hart6, A. Spinelli5,7, J. Stebbing2, J. Warusavitarne1

1St Mark's Hospital, Department of Colorectal Surgery, London, UK, 2Imperial College London, Department of Surgery and Cancer, London, UK, 3University of Kelaniya, Department of Surgery, Kelaniya, Sri Lanka, 4St Mark's Hospital, Department of Pathology, London, UK, 5Humanitas Clinical and Research Center, Division of Colon and Rectal Surgery, Milan, Italy, 6St Mark's Hospital, Department of Gastroenterology, London, UK, 7Humanitas University, Department of Biomedical Sciences, Milan, Italy

P078: Mucosal tissue short chain fatty acids contribute to prediction of pouchitis in restorative proctocolectomy

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Segal*1, M. Sarafian2, J. I. Serrano Contreras2, A. Pechlivanis2, L. Braz1,2, Y. Siaw3, S. Clark1,2, E. Holmes2, A. Hart1,2

1St Marks Hospital, Gastroenterology, Harrow, UK, 2Imperial College London, London, UK, 3Hillingdon Hospital, Gastroenterology, Hillingdon, UK

P079: Increased faecal proteolytic activity in pouchitis patients mediates epithelial barrier disruption through activation of protease-activated receptor-2

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Hoffman*1, I. M. Carrol2, H. Tulchinski3,4, I. Borovok5, I. Dotan6

1Tel Aviv medical Center, Digestive and liver Disease Research Center, Tel Aviv, Israel, 2University of North Carolina, Center for Gastrointestinal Biology and Disease, School of Medicine, Chapel Hill, USA, 3Tel Aviv Medical Center, Division of Surgery Colorectal Unit, Tel Aviv, Israel, 4Tel-Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel, 5Tel-Aviv University, Department of Molecular and Microbiology and Biotechnology, Tel Aviv, Israel, 6Rabin Medical Center, Division of Gastroenterology, Petah Tikva, Israel