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P040: The cytokine milieu in patients with inflammatory bowel disease impacts the phenotype of mesenchymal stromal cells

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Barnhoorn*1, K. Schepers2, H. Verspaget1, W. Fibbe2, L. Hawinkels1, M. van Pel2, A. van der Meulen - de Jong1

1Leiden University Medical Center, Gastroenterology and Hepatology, Leiden, The Netherlands, 2Leiden University Medical Center, Immunohematology and Blood Transfusion, Leiden, The Netherlands

P041: Differences in NOTCH signalling between stricturing and penetrating behaviour in Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Rodriguez-Antequera1, J. Cosin-Roger2,3, D. Macias-Ceja3, P. Salvador4, L. Gisbert-Ferrándiz4, S. Coll4, J. Manyé5, R. Alós6, F. Navarro-Vicente7, S. Calatayud2,4, M. D. Barrachina2,4, D. Ortiz-Masia1,2

1Universidad de Valencia, Medicine, Valencia, Spain, 2CIBERehd, Valencia, Spain, 3Fisabio, Valencia, Spain, 4Universidad de Valencia, Pharmacology, Valencia, Spain, 5CIBERehd, Badalona, Spain, 6Hospital de Sagunto, Sagunto, Spain, 7Hospital de Manises, Manises, Spain

P042: APL expression is down-regulated in an animal model of chronic colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

T. Nagaishi*1, Y. Kojima1, D. Yamada1, T. Watabe1, N. Tsugawa1, N. Jose1, M. Onizawa1, M. Watanabe1

1Tokyo Medical and Dental University, Gastroenterology, Tokyo, Japan

P043: Secretome modulation of Caco-2 cell line induced by a multi-strain probiotic

ECCO '19 Copenhagen

Year: 2019
Authors:

V. Petito*1, V. Greco2,3, L. Laterza4, C. Graziani4, L. Lopetuso1,4, F. Scaldaferri1,4, A. Urbani2,3, A. Gasbarrini1,4

1Universita' Cattolica del Sacro Cuore, Institute of Medical Pathology, Rome, Italy, 2Università cattolica del Sacro Cuore, Institute of Biochemistry and Clinical Biochemistry, Rome, Italy, 3Fondazione Policlinico A. Gemelli IRCCS, Department of Laboratory Diagnostic and Infectious Diseases, Rome, Italy, 4Fondazione Policlinico Universitario Gemelli IRCCS, Gastroenterological Area, Gastroenterological, Endocrino-Metabolical and Nefro-urological Sciences Department, Rome, Italy

P044: A novel porcine model of Crohn’s disease anastomotic stricture

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Lukas*1, M. Kolar1, O. Ryska2,3, S. Juhas3, J. Juhasova3, J. Kalvach3,4, J. Pazin3,4, J. Hadac3,4, I. Vitkova5, M. Bortlik1,6,7, M. Lukas1,8

1ISCARE I.V.F. a.s., IBD Clinical and Research Centre, Prague, Czech Republic, 2University Hospitals of Morecambe Bay NHS Foundation Trust, Royal Lancaster Infirmary, Lancaster, UK, 3Institute of Animal Physiology and Genetics, Czech Academy of Sciences, PIGMOD Centre, Laboratory of Cell Regeneration and Plasticity, Libechov, Czech Republic, 4Military University Hospital and 2nd Faculty of Medicine, Charles University, Department of Surgery, Prague, Czech Republic, 5Institute of Pathology of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic, 6Military University Hospital and First Faculty of Medicine, Charles University, Department of Internal Medicine, Prague, Czech Republic, 7Institute of Pharmacology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 8Institute of Medical Biochemistry and Laboratory Medicine, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic

P045: Local inflammation modulates vitamin D receptor protein levels in fibroblasts

ECCO '19 Copenhagen

Year: 2019
Authors:

L. Gisbert-Ferrándiz1, J. Cosin-Roger2, P. Salvador1, D. C. Macias-Ceja2, F. Navarro-Vicente3, R. Alos4, S. Calatayud1, M. D. Barrachina1

1Universitat de Valencia and CIBERehd, Pharmacology, Valencia, Spain, 2Fisabio, Hospital Dr. Peset, Valencia, Spain, 3Hospital Manises, Valencia, Spain, 4Hospital La Fe, Valencia, Spain

P046: Iron mobilisation into the intestinal epithelium prevents hypoxia-associated autophagy and reduces inflammation through the inhibition of NF-κB

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Simmen1, J. Cosin-Roger1, H. Melhem1, N. Maliachovas1, M. Maane1, K. Baebler1, B. Weder1, C. Maeyashiki1, K. Spanaus1, M. Scharl1, C. de Vallière1, J. Zeitz1, S. R. Vavricka1, M. Hausmann1, G. Rogler1, P. A. Ruiz-Castro1

1University of Zurich / University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland

P047: Neuroendocrine cells densities alterations in colonic mucosa of patients with inflammatory bowel disease

ECCO '19 Copenhagen

Year: 2019
Authors:

C. Meianu*1, G. Becheanu1, C-M. Preda1, D. Istratescu1, C-A. Ciora1, M. Manuc1, L. Tugui1, A-C. Andrei1, M. Diculescu1

1Clinic Fundeni Institute- Gastroenterology and Hepatology, Bucuresti, Romania

P048: Exploring mucosal function as a clinical endpoint in ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Kjaergaard*1,2, M. M. B. Damm1, J. Chang3, L. B. Riis4, R. Hytting-Andreasen5, S. Krug6, J. D. Schulzke6, N. Bindslev2, M. B. Hansen1

1Bispebjerg Hospital, Digestive Disease Center, Copenhagen, Denmark, 2Faculty of Health and Medical Sciences, Department of Biomedical Sciences, Copenhagen, Denmark, 3University of Manchester, Wellcome Trust Centre for Cell-Matrix Research, Manchester, UK, 4Herlev Hospital, Department of Pathology, Copenhagen, Denmark, 5NNF Center of Basic Metabolic Research, University of Copenhagen, Department of Biomedical Sciences, Copenhagen, Denmark, 6Institute of Clinical Physiology, Charité, Berlin, Germany

P049: Dietary walnus to prevent indomethacin-induced intestinal damages

ECCO '19 Copenhagen

Year: 2019
Authors:

K. B. Hahm*1, Y. W. Shin2

1CHA University, Gastroenterology, Seongnam, South Korea, 2Inha University Hospital, Incheon, South Korea

P050: Serum adropin levels in patients with Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

P. M. Zivkovic*1, I. Tadin Hadjina1, D. Rusic2, M. Vilovic3, D. Supe-Domic4, D. Martinovic3, Z. Puljiz1, A. Tonkic1, J. Bozic3

1University Hospital of Split, Department of Gastroenterology and Hepatology, Split, Croatia, 2University of Split School of Medicine, Department of Pharmacy, Split, Croatia, 3University of Split School of Medicine, Department of Pathophysiology, Split, Croatia, 4University Hospital of Split, Department of Laboratory Diagnostics, Split, Croatia

P051: DNA methylation signatures associated with pathogenesis Crohn's disease-related genes

ECCO '19 Copenhagen

Year: 2019
Authors:

I. Moret Tatay1,2, E. Cerrillo1,3, E. Sáez-González1,3, D. Hervás4, M. Iborra1,2,3, J. Sandoval5, E. Busó6, L. Tortosa1,2, P. Nos1,2,3, B. Beltrán1,2,3

1IIS Hospital La Fe, Gastroenterology, Valencia, Spain, 2Networked Biomedical Research Centre for Hepatic and Digestive Diseases (CIBEREHD), Madrid, Spain, 3Hospital Universitari i Politècnic La Fe, Inflammatory Bowel Disease Unit, Gastroenterology Department, Valencia, Spain, 4IIS Hospital La Fe, Biostatistics, Valencia, Spain, 5IIS Hospital La Fe, Biomarkers and Precision Medicine, Valencia, Spain, 6University of Valencia, Central Unit for Research in Medicine (UCIM), Valencia, Spain

P052: Heat shock protein GP96 is essential for maintaining intestinal epithelial architecture by supporting its self-renewal capacity

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Häfliger1, M. Schwarzfischer1, M. Van de Sande1, R. Manzini1, C. Stanzel1, K. Atrott1, S. Lang1, M. Scharl1, M. Spalinger1

1University Hospital Zurich, University of Zurich, Department of Gastroenterology and Hepatology, Zurich, Switzerland

P053: Adipose-derived stem cells ameliorate colitis by suppression of inflammasome formation and regulation of M1-macrophage population through prostaglandin E2

ECCO '19 Copenhagen

Year: 2019
Authors:

H-S. Kim*1, H. Park1, Y. Eom1

1Wonju College of Medicine, Yonsei University, Wonju, South Korea

P054: CD103+SIRPα+ DC are specifically decreased in the inflamed colon from patients with ulcerative colitis but not with Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Bernardo*1, S. Fernandez-Tome1, A. C. Marin1, L. Ortega-Moreno1, A. Montalban-Arques1, I. Mora-Gutierrez1, A. Fiz-Lopez1, F. Casals1, J. A. Moreno-Monteagudo1, T. Alvarez-Male1, V. Martin1, I. Becerro1, M. J. Casanova1, C. Santander1, M. Chaparro1, J. P. Gisbert1

1Insittuto Investigación Princesa, Madrid, Spain

P055: Transcriptional profiling of ulcerative colitis in remission

ECCO '19 Copenhagen

Year: 2019
Authors:

C. Fenton1, H. Taman2, J. Florholmen3, R. H. Paulssen*4

1UiT-The Arctic University of Norway, Clinical Medcine, Tromsø, Norway, 2UiT-The Arctic University of Norway, Clinical Medicine, Tromsø, Norway, 3University Hospital of North Norway, Gastroenterology and Nutrition, Tromsø, Norway, 4UiT – The Arctic University of Norway, Clinical Medicine, Tromsø, Norway

P056: Transcriptional profiling of intestinal epithelial organoids derived from paediatric Crohn’s disease patients

ECCO '19 Copenhagen

Year: 2019
Authors:

I. Dotti*1, E. Ferrer-Picón1, N. Planell1, J. Martín de Carpi2, G. Pujol2, M. Masamunt1, M. Esteller1, A. Carrasco3, L. Alvarez2, E. Tristán3, I. Ordás1, M. Esteve3, E. Ricart1, A. Salas1

1IDIBAPS, Hospital Clínic, CIBERehd, Department of Gastroenterology, Barcelona, Spain, 2Hospital Sant Joan de Deu, Department of Gastroenterology, Hepatology and Pediatric Nutrition, Barcelona, Spain, 3Hospital Universitari Mutua Terrassa, Department of Gastroenterology, Terrassa, Barcelona, Spain

P057: Gut microbiome diversity in acute severe colitis is distinct from mild-to-moderate ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Kedia*1, T. S. Ghosh2, B. Das2, S. Jain1, S. Bopanna1, G. Makharia1, S. Travis3, V. Ahuja1

1All India Institute of Medical Sciences, New Delhi, India, 2Translational Health Science and Technology Institute, Faridabad, India, 3John Radcliffe Hospital, Translational Gastroenterology Unit, Oxford, UK

P058: Do circulating exosomes interfere with vedolizumab efficacy in IBD patients?

ECCO '19 Copenhagen

Year: 2019
Authors:

R. Domenis1, A. Cifu'1, M. Fabris1,2, G. Scardino3, M. Zilli3, M. Marino*3, F. Curcio1,2

1University Hospital of Udine, Dipartimento di Area Medica, Udine, Italy, 2University Hospital of Udine, Istituto di Patologia Clinica, Udine, Italy, 3University Hospital of Udine, Gastroenterology, Udine, Italy

P059: The metformin inhibits MDSC and M2 macrophage via AMPK-induced inhibition of HMG-CoA reductase in tumour microenvironment of colitic cancer

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Y. Kang1, Y. H. Park1, S. J. Park1, J. H. Cheon1, W. H. Kim1, T. I. Kim*1

1Yonsei University College of Medicine, Internal Medicine, Seoul, South Korea