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OP37: Efficacy and safety of ustekinumab as maintenance therapy in ulcerative colitis: Week 44 results from UNIFI

ECCO '19 Copenhagen

Year: 2019
Authors:

W. J. Sandborn*1, B. E. Sands2, R. Panaccione3, C. D. O’Brien4, H. Zhang4, J. Johanns4, L. Peyrin-Biroulet5, G. Van Assche6, S. Danese7, S. R. Targan8, M. T. Abreu9, T. Hisamatsu10, P. Szapary4, C. Marano4

1University of California San Diego, La Jolla, USA, 2Icahn School of Medicine at Mount Sinai, New York, USA, 3University of Calgary, Calgary, Canada, 4Janssen Research and Development, LLC, Spring House, USA, 5Nancy University Hospital, Université de Lorraine, Nancy, France, 6University of Leuven, Leuven, Belgium, 7Humanitas Research Hospital, Milan, Italy, 8Cedars-Sinai Medical Center, Los Angeles, USA, 9University of Miami Miller School of Medicine, Miami, USA, 10Kyorin University, Tokyo, Japan

OP38: Maintenance treatment with mirikizumab, a p19-directed IL-23 antibody: 52-week results in patients with moderately-to-severely active ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Geert. R. D’Haens*1, W. J. Sandborn2, M. Ferrante3, B. R. Bhandari4, E. Berliba5, T. Hibi6, J. Tuttle7, J. B. Canavan8, S. Friedrich8, M. Durante8, V. Arora8, B. Feagan9

1Amsterdam University Medical Centers, Amsterdam, The Netherlands, 2University California San Diego, La Jolla, California, USA, 3UZ Leuven, KU Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, 4Delta Research Partners, LLC, Bastrop, LA, USA, 5Nicolae Testemițanu State University of Medicine and Pharmacy, Chisinau, Moldova, Republic of, 6Kitasato Institute Hospital Center for Advanced IBD Research and Treatment, Minato-ku, Tokyo, Japan, 7Eli Lilly and Company, Lilly Biotechnology Center, San Diego, California, USA, 8Eli Lilly and Company, Indianapolis, Indiana, USA, 9Western University, Robarts Clinical Trials Inc., London, Ontario, Canada

P001: Multi-omic data integration assisted identification of molecular features contributing to disease heterogeneity in Crohn's disease

ECCO '19 Copenhagen

Year: 2019
Authors:

P. Sudhakar*1,2,3, B. Verstockt1,4, B. Creyns5, J. Cremer5, G. van Assche1,4, T. Korcsmaros2,3, M. Ferrante1,4, S. Vermeire1,4

1KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, 2Earlham Institute, Norwich, UK, 3Quadram Institute, Norwich, UK, 4University Hospitals Leuven, Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium, 5KU Leuven Department of Microbiology and Immunology, Laboratory of Clinical Immunology, Leuven, Belgium

P002: Endoscopic placement of a drug-eluting platform with monoclonal antibodies in an animal model of experimental colitis by TNBS: effect on disease outcome and anti-drug antibodies (ADA’s) formation

ECCO '19 Copenhagen

Year: 2019
Authors:

I. Bon-Romero1,2, R. Bartolí1,2,3, N. De la Ossa4, V. Moreno de Vega2, I. Marín2, E. Domènech1,2,3, V. Lorenzo-Zúñiga1,2,3

1Health Research Institute Germans Trias i Pujol, Digestive System, Badalona, Spain, 2Germans Trias i Pujol Hospital, Endoscopy Unit, Badalona, Spain, 3CIBERehd, Madrid, Spain, 4Germans Trias i Pujol Hospital, Pathology Service, Badalona, Spain

P003: C86/CD16 macrophages may act as a source of WNT2b in intestinal tissue from B3 Crohn’s disease patients

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Ortiz-Masia1,2, J. Cosin-Roger2,3, M. Rodriguez-Antequera1, D. Macias-Ceja3, S. Coll4, P. Salvador4, L. Gisbert-Ferrándiz4, R. Alós5, J. Manyé6, F. Navarro-Vicente7, S. Calatayud2,4, M. D. Barrachina2,4

1Universidad de Valencia, Medicine, Valencia, Spain, 2CIBERehd, Valencia, Spain, 3Fisabio, Valencia, Spain, 4Universidad de Valencia, Pharmacology, Valencia, Spain, 5Hospital de Sagunto, Sagunto, Spain, 6CIBERehd, Badalona, Spain, 7Hospital de Manises, Manises, Spain

P004: IL-22 affects barrier function and cell polarity by MAPK/PI3 kinase signal transduction

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Delbue da Silva*1, L. Lebenheim1, C. Heldt1, B. Siegmund1, M. Schumann1

1Charité Universitätsmedizin, Department of Gastroenterology, Berlin, Germany

P005: Persistent transcriptional reprogramming in the choroid plexus during chronic colitis: towards understanding persistent fatigue in patients with quiescent inflammatory bowel disease?

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Bruggeman1,2, C. Vandendriessche1,2, M. De Vos3,4, R. Vandenbroucke1,2, D. Laukens*3,4

1Vlaams Instituut voor Biotechnologie, Center for Inflammation Research, Zwijnaarde, Belgium, 2Department of Biomedical Molecular Biology, Ghent University, Gent, Belgium, 3Department of Gastroenterology, Ghent University Hospital, Gent, Belgium, 4Ghent Gut Inflammation Group (GGIG), Ghent University, Gent, Belgium

P006: Loss of protein tyrosine phosphatase non-receptor type 23 (PTPN23) in intestinal epithelial cells induces inflammation and epithelial hyperproliferation

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Montalban-Arques1, C. Gottier1, I. Olivares-Rivas1, M. Scharl1,2, M. Spalinger1

1University Hospital Zurich/ University of Zurich, Gastroenterology and Hepatology, Zurich, Switzerland, 2Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland

P007: Faecal protease activity as a predictor marker of disease recurrence in patients with Crohn's disease following ileocecectomy

ECCO '19 Copenhagen

Year: 2019
Authors:

R. Golovey*1,2, S. Hoffman1,2, E. Scapa2,3, N. Fliss4,3, H. Tulchinski2,6, I. Dotan2,7, N. Maharshak1,3,8,9

1Tel Aviv medical Center, The Research Center for Digestive Tract and Liver Diseases, Tel Aviv, Israel, 2Tel-Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel, 3Tel Aviv medical Center, Department of Gastroenterology and Liver Diseases, Tel Aviv, Israel, 4Tel Aviv medical Center, IBD center, Tel Aviv, Israel, 6Tel Aviv medical Center, Division of Surgery Colorectal Unit, Tel Aviv, Israel, 7Rabin Medical Center, Division of Gastroenterology, Petah Tikva, Israel, 8Tel Aviv Medical Center, IBD Center, Tel Aviv, Israel, 9Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel

P008: Proteomic markers of response to anti-TNF drugs in patients with Crohn's disease

ECCO '19 Copenhagen

Year: 2019
Authors:

R. Medina-Medina1, E. Iglesias-Flores1, J. M. Benítez1, S. Marín-Pedrosa1, I. Salgueiro1, G. Ferrín1, C. I. Linares1, S. González-Rubio1, P. Soto1, B. Gros1, C. Moral1, F. Alvarez1, M. Rodríguez-Perálvarez1, E. Chicano-Gálvez1, I. Ortea1, V. García-Sánchez1, P. Aguilar-Melero1

1IMIBIC/Hospital Universitario Reina Sofia/Córdoba University, CÓRDOBA, Spain

P009: Fluorescence mediated tomography detects and quantifies early intestinal neutrophil infiltration in experimental colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

T. M. Nowacki*1,2, P. Lenz3, D. Bettenworth2, M. Brückner2, P. Tepasse2, A. Becker4, M. Wildgruber4, M. Eisenblätter4

1Josephs-Hospital Warendorf, Department of Medicine I, Warendorf, Germany, 2University Hospital Münster, Department of Medicine B, Gastroenterology and Hepatology, Münster, Germany, 3University Hospital Münster, Institute of Palliative Care, Münster, Germany, 4University Hospital Münster, Translational Research Imaging Center, Department of Clinical Radiology, Münster, Germany

P010: Synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Kawamoto*1, S. Nagata1, S. Anzai1, J. Takahashi1, M. Kawai1, M. Hama1, D. Nogawa2, K. Yamamoto2, R. Kuno1, K. Suzuki1, H. Shimizu1, Y. Hiraguri1, S. Yui3, S. Oshima1, K. Tsuchiya1, T. Nakamura1,4, K. Ohtsuka1, M. Kitagawa2, R. Okamoto1,3, M. Watanabe1

1Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan, 2Department of Comprehensive Pathology, Tokyo Medical and Dental University, Tokyo, Japan, 3Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan, 4Tokyo Medical and Dental University, Department of Advanced Therapeutics in GI Diseases, Tokyo, Japan

P011: Signalling and transcriptional network propagation uncovers novel ulcerative colitis pathogenetic pathways from single-nucleotide polymorphisms

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Modos*1, J. Brooks2,3,4,5, P. Sudhakar2,4,6, B. Verstockt6,7, B. Alexander-Dann1, A. Zoufir1, D. Fazekas4,8, S. Vermeire6,7, T. Korcsmaros2,4, A. Bender1

1University of Cambridge, Chemistry, Cambridge, UK, 2The Quadram Institute Bioscience, Gut Microbes and Health Programme, Norwich, UK, 3Norfolk and Norwich University Hospitals, Norwich Medical School, Norwich, UK, 4Earlham Institute, Norwich, UK, 5University Hospitals, Department of Gastroenterology Norfolk and Norwich, Norwich, UK, 6KU Leuven, Department of Chronic Diseases, Leuven, The Netherlands, 7University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, The Netherlands, 8Eötvös Loránd University, Department of Genetics, Budapest, Hungary

P012: IL22 expression in intestinal immune cells is not augmented by AHR activation in health or Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

P. Harrow*1,2, R. Datta1, A. Stagg1, J. O. Lindsay1,2

1Blizard Institute, QMUL, Immunobiology, London, UK, 2Royal London Hospital, Barts Health NHS Trust, London, UK

P013: Novel immunomodulatory role of food bioactive peptide lunasin in the healthy human intestinal mucosa

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Fernández-Tomé1, L. Pérez-Rodríguez2, A. C. Marin1, P. Indiano-Romacho2, L. Ortega-Moreno1,3, M. J. Casanova1, J. A. Moreno-Monteagudo1, C. Santander1, M. Chaparro1, J. P. Gisbert1, B. Hernández-Ledesma2, D. Bernardo1

1Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain, 2Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM, CEI UAM+CSIC), Madrid, Spain, 3Universidad Autónoma de Madrid, Madrid, Spain

P014: Disruption of epithelial barrier function by coeliac peripheral blood mononuclear cells

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Delbue da Silva1, A. Itzlinger1, B. Jessen1, H. Pfeiffert1, C. Heldt1, F. Branchi1, D. Lissner1, W. Dieterich1, B. Siegmund1, M. Schumann1

1Charité Universitätsmedizin, Department of Gastroenterology, Berlin, Germany

P015: PNAd+ and MAdCAM+ high endothelial venules correlate with disease activity in ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

B. Roosenboom*1, P. Wahab1, J. Meijer2, C. Smids1, M. Groenen1, E. Van Lochem3, C. Horjus Talabur Horje1

1Rijnstate Crohn and Colitis Centre, Gastroenterology and Hepatology, Arnhem, The Netherlands, 2Rijnstate Hospital, Department of Pathology, Arnhem, The Netherlands, 3Rijnstate Hospital, Department of Microbiology and Immunology, Arnhem, The Netherlands

P016: Constitutive activity of the cation channel TRPM8 regulates monocyte to macrophage transition in humans to control intestinal inflammation

ECCO '19 Copenhagen

Year: 2019
Authors:

E. Hornsby*1, M. Peiris1, M. Peiris1, H. W. King1, E. S. Wing1, J. O. Lindsay1, L. A. Blackshaw1, A. J. Stagg1

1QMUL, Blizard Institute, London, UK

P017: Transcriptional reprogramming of the HIF pathway is associated with inflammation and mucosal hypoxia in ulcerative colitis patients

ECCO '19 Copenhagen

Year: 2019
Authors:

C. R. Rowan*1, E. Brown2,3, M. J. Strowitzki2,3, R. R. Fagundes2,3,4, A. Guntsch2,3, D. N. Halligan2,3, G. A. Doherty1,3, C. T. Taylor2,3

1St.Vincent's University Hospital, Center for Colorectal Disease, Dublin, Ireland, 2University College Dublin, Conway Institute, Dublin, Ireland, 3University College Dublin, School of Medicine and Medical Science, Dublin, Ireland, 4University of Groningen, Graduate School of Medical Sciences, Groningen, The Netherlands

P018: Macrophage targeting contributes to the inhibitory effects of dihydroartemisinin on DSS-induced colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Teng*1, W. Ting1, W. Huahong1

1Peking University First Hospital, Gastroenterology, Beijing, China