¹University of California San Diego, La Jolla, USA, ²Icahn School of Medicine at Mount Sinai, New York, USA, ³University of Calgary, Calgary, Canada, ⁴Janssen Research and Development, LLC, Spring House, USA, ⁵Nancy University Hospital, Université de Lorraine, Nancy, France, ⁶University of Leuven, Leuven, Belgium, ⁷Humanitas Research Hospital, Milan, Italy, ⁸Cedars-Sinai Medical Center, Los Angeles, USA, ⁹University of Miami Miller School of Medicine, Miami, USA, ¹⁰Kyorin University, Tokyo, Japan

¹Amsterdam University Medical Centers, Amsterdam, The Netherlands, ²University California San Diego, La Jolla, California, USA, ³UZ Leuven, KU Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, ⁴Delta Research Partners, LLC, Bastrop, LA, USA, ⁵Nicolae Testemițanu State University of Medicine and Pharmacy, Chisinau, Moldova, Republic of, ⁶Kitasato Institute Hospital Center for Advanced IBD Research and Treatment, Minato-ku, Tokyo, Japan, ⁷Eli Lilly and Company, Lilly Biotechnology Center, San Diego, California, USA, ⁸Eli Lilly and Company, Indianapolis, Indiana, USA, ⁹Western University, Robarts Clinical Trials Inc., London, Ontario, Canada

¹KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, ²Earlham Institute, Norwich, UK, ³Quadram Institute, Norwich, UK, ⁴University Hospitals Leuven, Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium, ⁵KU Leuven Department of Microbiology and Immunology, Laboratory of Clinical Immunology, Leuven, Belgium

¹Health Research Institute Germans Trias i Pujol, Digestive System, Badalona, Spain, ²Germans Trias i Pujol Hospital, Endoscopy Unit, Badalona, Spain, ³CIBERehd, Madrid, Spain, ⁴Germans Trias i Pujol Hospital, Pathology Service, Badalona, Spain

¹Universidad de Valencia, Medicine, Valencia, Spain, ²CIBERehd, Valencia, Spain, ³Fisabio, Valencia, Spain, ⁴Universidad de Valencia, Pharmacology, Valencia, Spain, ⁵Hospital de Sagunto, Sagunto, Spain, ⁶CIBERehd, Badalona, Spain, ⁷Hospital de Manises, Manises, Spain

¹Charité Universitätsmedizin, Department of Gastroenterology, Berlin, Germany

¹Vlaams Instituut voor Biotechnologie, Center for Inflammation Research, Zwijnaarde, Belgium, ²Department of Biomedical Molecular Biology, Ghent University, Gent, Belgium, ³Department of Gastroenterology, Ghent University Hospital, Gent, Belgium, ⁴Ghent Gut Inflammation Group (GGIG), Ghent University, Gent, Belgium

¹University Hospital Zurich/ University of Zurich, Gastroenterology and Hepatology, Zurich, Switzerland, ²Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland

¹Tel Aviv medical Center, The Research Center for Digestive Tract and Liver Diseases, Tel Aviv, Israel, ²Tel-Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel, ³Tel Aviv medical Center, Department of Gastroenterology and Liver Diseases, Tel Aviv, Israel, ⁴Tel Aviv medical Center, IBD center, Tel Aviv, Israel, ⁶Tel Aviv medical Center, Division of Surgery Colorectal Unit, Tel Aviv, Israel, ⁷Rabin Medical Center, Division of Gastroenterology, Petah Tikva, Israel, ⁸Tel Aviv Medical Center, IBD Center, Tel Aviv, Israel, ⁹Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel

¹IMIBIC/Hospital Universitario Reina Sofia/Córdoba University, CÓRDOBA, Spain

¹Josephs-Hospital Warendorf, Department of Medicine I, Warendorf, Germany, ²University Hospital Münster, Department of Medicine B, Gastroenterology and Hepatology, Münster, Germany, ³University Hospital Münster, Institute of Palliative Care, Münster, Germany, ⁴University Hospital Münster, Translational Research Imaging Center, Department of Clinical Radiology, Münster, Germany

¹Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan, ²Department of Comprehensive Pathology, Tokyo Medical and Dental University, Tokyo, Japan, ³Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Tokyo Medical and Dental University, Department of Advanced Therapeutics in GI Diseases, Tokyo, Japan

¹University of Cambridge, Chemistry, Cambridge, UK, ²The Quadram Institute Bioscience, Gut Microbes and Health Programme, Norwich, UK, ³Norfolk and Norwich University Hospitals, Norwich Medical School, Norwich, UK, ⁴Earlham Institute, Norwich, UK, ⁵University Hospitals, Department of Gastroenterology Norfolk and Norwich, Norwich, UK, ⁶KU Leuven, Department of Chronic Diseases, Leuven, The Netherlands, ⁷University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, The Netherlands, ⁸Eötvös Loránd University, Department of Genetics, Budapest, Hungary

¹Blizard Institute, QMUL, Immunobiology, London, UK, ²Royal London Hospital, Barts Health NHS Trust, London, UK

¹Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain, ²Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM, CEI UAM+CSIC), Madrid, Spain, ³Universidad Autónoma de Madrid, Madrid, Spain

¹Charité Universitätsmedizin, Department of Gastroenterology, Berlin, Germany

¹Rijnstate Crohn and Colitis Centre, Gastroenterology and Hepatology, Arnhem, The Netherlands, ²Rijnstate Hospital, Department of Pathology, Arnhem, The Netherlands, ³Rijnstate Hospital, Department of Microbiology and Immunology, Arnhem, The Netherlands

¹QMUL, Blizard Institute, London, UK

¹St.Vincent's University Hospital, Center for Colorectal Disease, Dublin, Ireland, ²University College Dublin, Conway Institute, Dublin, Ireland, ³University College Dublin, School of Medicine and Medical Science, Dublin, Ireland, ⁴University of Groningen, Graduate School of Medical Sciences, Groningen, The Netherlands

¹Peking University First Hospital, Gastroenterology, Beijing, China