¹Icahn School at Mount Sinai, Department of Population, Health Science and Policy, New York, USA, ²University College of London, London, UK, ³Icahn School at Mount Sinai, Department of Genetics and Genomic Science, New York, USA, ⁴Icahn School at Mount Sinai, Department of Medicine, Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center, New York City, USA, ⁵Janssen Research and Development, Janssen Biotech, Johnson and Johnson, Spring House, USA

¹Schneider Children’s Hospital, Gastroenterology, Nutrition and Liver Diseases, Petach Tikva, Israel, ²Schneider Children’s medical Center, Gastroenterology, Nutrition and Liver Diseases, Petach Tikva, Israel, ³Shaare Zedek Medical Center, Gastroenterology, Nutrition and Liver Diseases, Jerusalem, Israel, ⁴Assaf Harofeh, Pediatric Gastroenterology, Zerifin, Israel, ⁵Sheba Medical Center, Pediatric Gastroenterology, Ramat Gan, Israel, ⁶Shaare Zedek Medical Center, Pediatric Gastroenterology, Nutrition and Liver Diseases, Jerusalem, Israel, ⁷Tel Aviv Medical Center, Pediatric Gastroenterology, Tel-Aviv, Israel, ⁸Kaplan Medical Center, Pediatric Gastroenterology, Rehovot, Israel, ⁹Rambam Medical center, Pediatric Gastroenterology, Haifa, Israel, ¹⁰Soroka Medical Center, Pediatric Gastroenterology, Beer Sheva, Israel

¹Sheba Medical Center, Tel Hashomer, Israel, ²Cincinnati Children Hospital Medical Center, Cincinnati, USA, ³Broad Institute of MIT and Harvard University, Cambridge, USA, ⁴Georgia Institute of Technology, Atlanta, USA, ⁵University of North Carolina, Chapel Hill, USA, ⁶Emory University, Atlanta, USA, ⁷Hospital For Sick Children, Toronto, Canada, ⁸Harvard School of Public Health, Boston, USA, ⁹Broad Institute of MIT and Harvard University, Boston, USA, ¹⁰Connecticut Children’s Medical Center, Hartford, USA

¹Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Genomics and Child Health, London, UK, ²Centre for Digestive Diseases, Queens Medical Centre, Nottingham, UK, ³Department of Gastroenterology, Hôpital Saint Louis, APHP, INSERM UMRS 1160, Paris Diderot, Sorbonne Paris-Cité Unversity, Paris, France, ⁴Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK, ⁵Department of Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland, ⁶Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Immunobiology, London, UK

¹University Hospitals Leuven, Leuven, Belgium, ²CHU Nice Hopital Archet 2, Nice, France, ³Piotr Napora Centrum Badań Klinicznych Lekarze Sp.p., Wroclaw, Poland, ⁴SANTA FAMILIA, Centrum Badań, Profilaktyki i Leczenia, Lodz, Poland, ⁵Vasútegészségügyi Nonprofit Közhasznú Kft, Debrecen, Hungary, ⁶CHU Nantes Hotel Dieu, Nantes, France, ⁷KO-Med, Lublin, Poland, ⁸Abivax, Paris, France

¹Leiden University Medical Center, Gastroenterology and Hepatology, Leiden, The Netherlands, ²Leiden University Medical Center, Cell and Chemical Biology, Leiden, The Netherlands

¹Research Institute, Chong Kun Dang Pharmaceutical Corporation, Yongin, South Korea, ²Hallym University, Department of Biomedical Science, Chuncheon, South Korea, ³Inje University College of Medicine, Department of Microbiology and Immunology, Gimhae, South Korea, ⁴Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, South Korea, ⁵Seoul National University Hospital Healthcare System Gangnam Center, Department of Internal Medicine and Healthcare Research Institute, Seoul, South Korea

¹Amiens University Hospital, Gastroenterology, AMIENS (80000), France, ²Nancy University Hospital, Gastroenterology, Nancy, France, ³Lyon University Hospital, Lyon, France, ⁴Montpellier University Hospital, Gastroenterology, Montpellier, France, ⁵Saint Etienne University Hospital, Gastroenterology, Saint Etienne, France, ⁶Rennes University Hospital, Gastroenterology, Rennes, France, ⁷Caen University Hospital, Gastroenterology, Caen, France, ⁸Bordeaux University Hospital, Gastroenterology, Bordeaux, France, ⁹Nice University Hospital, Gastroenterology, Nice, France, ¹⁰Clermont-Ferrand, Gastroenterology, Clermont-Ferrand, France, ¹¹Hopital Beaujon, Gastroenterology, Clichy, France, ¹²Toulouse University Hospital, Gastroenterology, Toulouse, France, ¹³Amiens University Hospital, Gastroenterology, Amiens, France, ¹⁴Lyon University Hospital, Gastroenterology, Lyon, France, ¹⁵Saint Etienne University Hospital, Gastroenterology, Saint-Etienne, France

¹University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium, ²AZ Delta, Department of Gastroenterology, Roeselare, Belgium, ³Hôpital Haut-Lévêque, Service d’Hépato-gastroentérologie et Oncologie Digestive, Bordeaux, France, ⁴Imelda General Hospital, IBD Clinic, Bonheiden, Belgium, ⁵Beaujon Hospital, APHP, Paris Diderot University, Department of Gastroenterology, Clichy, France, ⁶Estaing University Hospital, Department of Gastroenterology, Clermont-Ferrand, France, ⁷AZ Damiaan, Department of Gastroenterology, Oostende, Belgium, ⁸Liège University Hospital, Department of Gastroenterology, Liège, Belgium, ⁹University Medical Centre, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands, ¹⁰Huriez Hospital, Lille 2 University, Department of Gastroenterology and Hepatology, Lille, France, ¹¹University Medical Centre, Department of Gastroenterology and Hepatology, Maastricht, The Netherlands, ¹²Erasmus Medical Centre, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands, ¹³Academic Medical Centre, Department of Gastroenterology, Amsterdam, The Netherlands, ¹⁴University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, ¹⁵University of Leuven, Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium

¹University Hospitals Leuven, Leuven, Belgium, ²Icahn School of Medicine at Mount Sinai, New York, USA, ³Western University, London, Canada, ⁴University of California San Diego, La Jolla, USA, ⁵Humanitas University, Milan, Italy, ⁶Academic Medical Centre, Amsterdam, The Netherlands, ⁷University of Calgary, Calgary, Canada, ⁸University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, USA, ⁹Shafran Gastroenterology Research Center, Winter Park, USA, ¹⁰Takeda Pharmaceuticals, Cambridge, USA, ¹¹Mayo Clinic College of Medicine, Rochester, USA

¹Leiden University Medical Center, Department of Immunohematology and Blood Transfusion, Leiden, The Netherlands, ²Delft University of Technology, Delft Bioinformatics Lab, Delft, The Netherlands, ³Leiden University Medical Center, Leiden Computational Biology Center, Leiden, The Netherlands, ⁴Leiden University Medical Center, Department of Gastroenterology, Leiden, The Netherlands, ⁶Delft University of Technology, Computer Graphics and Visualization, Delft, The Netherlands, ⁷Leiden University Medical Center, Department of Paediatrics, Leiden, The Netherlands, ⁸Alrijne Hospital, Department of Gastroenterology, Leiderdorp, The Netherlands, ⁹Erasmus University Medical Center, Department of Paediatric Gastroenterology, Rotterdam, The Netherlands, ¹⁰Delft University of Technology, Pattern Recognition and Bioinformatics Group, Delft, The Netherlands, ¹¹Leiden University Medical Center, Department of LKEB Radiology, Leiden, The Netherlands

¹Translational Gastroenterology Unit, University of Oxford, Oxford, UK, ²Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK

¹Fondazione Policlinico Universitario A. Gemelli IRCCS – Università Cattolica del Sacro Cuore, UOC Internal Medicine, Gastroenterology and Hepatology Gastroenterological and Oncological Area, Gastroenterological and Endocrino-Metabolical Sciences Department, Roma, Italy, ²Case Western Reserve University, Cleveland, USA

¹KU Leuven, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, ²University Hospitals Leuven, Department of gastroenterology and hepatology, Leuven, Belgium, ³University Hospitals Leuven, Abdominal surgery, Leuven, Belgium

¹Tokyo Medical and Dental Universityl and Dental Universityl and, Tokyo, Japan

¹King’s College London, Peter Gorer Department of Immunobiology, London, UK, ²Francis Crick Institute, Immunosurveillance Lab, London, UK, ³Guy’s and St Thomas Hospital, Department of Gastroenterology, London, UK

¹Humanitas University, Pieve Emanuele, Italy, ²Humanitas Research Hospital, Rozzano, Italy

¹University-Hospital Schleswig-Holstein, Kiel, Germany, ²Nancy University Hospital, Nancy, France, ³Mayo Clinic College of Medicine, Rochester, MN, USA, ⁴Humanitas University, Milan, Italy, ⁵Icahn School of Medicine at Mount Sinai, NY, USA, ⁶Formerly Takeda Development Centre Europe Ltd, London, UK, ⁷Takeda Development Center Americas, Inc., Cambridge, MA, USA

¹Amiens University Hospital, Amiens, France, ²Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, USA, ³IBD Clinic, Department of Gastroenterology, Imelda General Hospital, Bonheiden, Belgium, ⁴AZ Delta Roeselare, Roeselare, Belgium, ⁵2nd Department of Internal Medicine, University Hospital Hradec Králové, Hradec Králové, Czech Republic, ⁶Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands, ⁷Cumming School of Medicine, University of Calgary, Calgary, Canada, ⁸Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria, ⁹Presidio Columbus Fondazione Policlinico A. Gemelli IRCCS – Università Cattolica del Sacro Cuore, Rome, Italy, ¹⁰Medical Clinical Investigational Center of Medical Center Health Clinic LLC, Vinnytsia, Ukraine, ¹¹Universitatea de Medicina si Farmacie, Timisoara, Romania, ¹²Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK, ¹³Gastro-Entérologie and Nutrition Clinique, Hopital de l’Archet 2, Nice, France, ¹⁴University Hospitals Leuven, Leuven, Belgium, ¹⁵Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland, ¹⁶Humanitas University, Istituto Clinico Humanitas, Milan, Italy, ¹⁷Central Clinical Hospital of the Ministry of Interior in Warsaw, Warsaw, Poland, ¹⁸Claude Huriez Hospital, Lille University, Lille, France, ¹⁹Skane University Hospital, Lund, Sweden, ²⁰Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania, ²¹Hepato-Gastroenterology Department, North Hospital, University of Mediterranean, Marseille, France, ²²University of Medicine and Pharmacy ‘Carol Davila’, Bucharest, Romania, ²³Hépato Gastro-Entérologie, Hôpital de Brabois, Nancy, France, ²⁴Hépato-gastroentérologie et d’Oncologie Digestive, Hôpital Haut-Lévêque, Pessac, France, ²⁵Kingsbury Hospital, Cape Town, South Africa, ²⁶Hospital Clínico de Zaragoza, IIS Aragón, Zaragoza, Spain, ²⁷Military Medical Academy Named After S.M.Kirov, Saint-Petersburg, Russian Federation, ²⁸Department of Internal Medicine I, Kiel University, Kiel, Germany, ²⁹IBD Center, Sapporo Kosei General Hospital, Sapporo, Japan, ³⁰Uppsala University Hospital, Uppsala, Sweden, ³¹Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

¹Janssen Research and Development, LLC, Spring House, USA, ²Janssen Pharmaceutical K.K., Tokyo, Japan