¹Institute of Pediatric Gastroenterology, The Hebrew University of Jerusalem, Jerusalem, Israel, ²Schneider Children’s Hospital, Petach Tikva, Israel, ³Soroka University Medical Center and Faculty of Pediatric Gastroenetrology Unit, Health Sciences, Beer-Sheva, Israel, ⁴Pediatric Gastroenterology Institute, Ruth Children’s Hospital, Rambam Medical Center, Haifa, Israel, ⁵Pediatric Gastroenterology Unit, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Ramat gan, Israel, ⁶Digestive diseases institute, Shaare Zedek Medical Center, Jerusalem, Israel, ⁷Division of Gastroenterology, Rabin Medical Center, Sackler Faculty of Medicine, Petach Tikva, Israel, ⁸Health Division, Maccabi Healthcare Services, Jerusalem, Israel

¹Kyorin University School of Medicine, The Third Department of Internal Medicine, Tokyo, Japan, ²Saitama Medical Centre, Saitama Medical University, Department of Gastroenterology and Hepatology, Saitama, Japan, ³Yokohama City University Medical Center, Inflammatory Bowel Disease Centre, Kanagawa, Japan, ⁴Graduate School of Medicine, Kyoto University, Department of Gastroenterology and Hepatology, Kyoto, Japan, ⁵Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Tokyo, Japan, ⁶Sapporo Kosei General Hospital, Inflammatory Bowel Disease Center, Sapporo, Japan, ⁷Graduate School of Medical Sciences, Kyushu University, Department of Medicine and Clinical Science, Fukuoka, Japan, ⁸Kansai Medical University, Third Department of Internal Medicine, Osaka, Japan, ⁹Kobe City Medical Center General Hospital, Departments of Gastroenterology, Hyogo, Japan, ¹⁰Japan Red Cross Ashikaga Hospital, Department of Internal Medicine, Tochigi, Japan, Japan, ¹¹Hirosaki University Graduate School of Medicine, Department of Gastroenterology and Hematology, Hirosaki, Japan, ¹²Fukuoka University Chikushi Hospital, Department of Gastroenterology, Chikushino, Japan, ¹³Osaka City General Hospital, Division of Gastroenterology, Osaka, Japan, ¹⁴Hyogo College of Medicine, Department of Intestinal Inflammation Research, Nishinomiya, Japan, ¹⁵Keio University, Department of Internal Medicine, School of Medicine, Tokyo, Japan, ¹⁶Sapporo Medical University School of Medicine, Department of Gastroenterology and Hepatology, Sapporo, Japan, ¹⁷Toho University Sakura Medical Center, Department of Internal Medicine, Sakura, Japan, ¹⁸Kitasato University, Kitasato Institute Hospital, Center for Advanced IBD Research and Treatment, Tokyo, Japan, ¹⁹Institute of Medical Science Hospital, University of Tokyo, Center for Translational Research, Tokyo, Japan, ²⁰Iwate Medical University, Division of Gastroenterology, Department of Medicine, Morioka, Japan

¹Hopital Erasme – ULB, Department of Gastroenterology, Brussels, Belgium, ²University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, ³KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium, ⁴Centre Hospitalier Universitaire Sart-Tilman – ULG, Department of Gastroenterology, Liège, Belgium, ⁵Universiteit ziekenhuis Antwerpen – UZA, Department of Gastroenterology, Antwerpen, Belgium, ⁶Universitair ziekenhuis Gent, Department of Gastroenterology, Gent, Belgium, ⁷AZ Groeninge, Department of Gastroenterology, Kortrijk, Belgium, ⁸Centre Hospitalier Universitaire Mont-Godinne – UCL, Department of Gastroenterology, Yvoir, Belgium, ⁹Imeldaziekenhuis, Department of Gastroenterology, Bonheiden, Belgium, ¹⁰Ziekenhuis Netwerk Antwerpen, Department of Gastroenterology, Antwerpen, Belgium, ¹¹Ziekenhuis Oost-Limburg – Campus Sint-Jan, Department of Gastroenterology, Genk, Belgium, ¹²GZA Sint-Vincentius ziekenhuis, Department of Gastroenterology, Antwerpen, Belgium, ¹³Algemeen Ziekenhuis Sint-Lucas, Department of Gastroenterology, Gent, Belgium, ¹⁴Algemeen Ziekenhuis Sint-Lucas, Department of Gastroenterology, Brugge, Belgium, ¹⁵AZ Delta, Department of Gastroenterology, Roeselare-Menen, Belgium

¹Sapienza University of Rome, Department of Pediatrics, Pediatric Gastroenterology Unit, Rome, Italy, ²Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy, ³Ospedale Papa Giovanni XXIII, Pediatric Gastroenterology Hepatology and Nutrition, Bergamo, Italy, ⁴Istituto Giannina Gaslini, Department of Gastroenterology and Endoscopy, Genoa, Italy, ⁵Sapienza University of Rome, Department of Pediatric Gastroenterology, Rome, Italy, ⁶University of Naples ‘Federico II’, Department of Translational Medical Science, Section of Pediatrics, Naples, Italy, ⁷University of Messina, Department of Pediatric Gastroenterology and Endoscopy, Messina, Italy, ⁸San Gerardo Hospital, Monza, Italy, ⁹Maggiore Hospital, Bologna, Italy

¹Mayo Clinic, Gastroenterology and Hepatology, Rochester, USA, ²Icahn School of Medicine, Genetics and Genomic Sciences, New York, USA, ³Icahn School of Medicine at Mount Sinai, New York, USA, ⁴Hospital Beatriz Ângelo, Lisbon, Portugal, ⁵Janssen R&D, Spring House, USA, ⁶Prometheus Laboratories Inc., San Diego, USA, ⁷Naval Medical Research Center, Silver Spring, USA

¹Sheba Medical Center, Tel Hashomer, Israel, ²Cincinnati Children Hospital Medical Center, Cincinnati, USA

¹University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, ²KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium

¹Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium, ²KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, ³KU Leuven, Department of Human genetics, Laboratory for Complex Genetics, Leuven, Belgium, ⁴Earlham Institute, Norwich, UK, ⁵Quadram Institute, Norwich, Belgium, ⁶Department of Oncology, Laboratory of Lipid Metabolism and Cancer, Leuven, Belgium

¹Western University, Department of Medicine, Division of Gastroenterology, London, Ontario, Canada, ²King Fahad Specialist Hospital, Department of Medicine, Division of Gastroenterology, Dammam, Saudi Arabia, ³University of Calgary, Division of Gastroenterology and Hepatology, Calgary, Alberta, Canada, ⁴King Abdulaziz University, Department of Medicine, Rabigh, Saudi Arabia, ⁵Western University, Department of Epidemiology and Biostatistics, London, Ontario, Canada

¹Caisse Nationale Assurance Maladie, Paris, France, ²Caisse Nationale de l’Assurance Maladie, Paris, France, ³Hopital Bicetre, Le Kremlin Bicetre, France

¹Virginia Mason Medical Center, Seattle, WA, USA, ²Pfizer Inc., Collegeville, PA, USA, ³Toho University Sakura Medical Center, Sakura, Chiba, Japan, ⁴University of Palermo, IBD Unit, Palermo, Italy, ⁵Pfizer Inc., New York, NY, USA, ⁶University of Chicago Medicine, Chicago, IL, USA

¹Wolfson Medical Center, Pediatric Gastroenterology, Holon, Israel, ²Tel Aviv University, Tel Aviv, Israel, ³Dalhousie University, Halifax, Canada, ⁴Schneider Hospital, Petach Tikva, Israel, ⁵Meyer Hospital, Haifa, Israel, ⁶University of Alberta, Edmonton, Canada, ⁷Hadassah Hospital, Jerusalem, Israel, ⁸Tel Aviv Medical Center, Tel Aviv, Israel, ⁹Kaplan Hospital, Rehovot, Israel, ¹⁰HaEmek Hospital, Afula, Israel, ¹¹Poriah hospital, Tiberias, Israel, ¹²French Hospital, Nazareth, Israel

¹University of Chicago Medicine, Inflammatory Bowel Disease Center, Chicago, IL, USA, ²Icahn School of Medicine at Mount Sinai Hospital, Department of Pediatrics and Medicine, New York, NY, USA, ³Charles University, Prague, Czech Republic, ⁴Pfizer Inc., Collegeville, PA, USA

¹Hospital de Galdakao, Gastroenterology, Galdakao, Spain, ²Hospital Clinic, Gastroenterology, Barcelona, Spain, ³Hospital Universitario Ramón y Cajal, Gastroenterology, Madrid, Spain, ⁴Hospital del March, Gastroenterology, Barcelona, Spain, ⁵Hospital Universitario Germans Trias i Pujol, Gastroenterology, Badalona, Spain, ⁶Complejo Hospitalario de Navarra, Gastroenterology, Pamplona, Spain, ⁷Hospital de Cruces, Gastroenterology, Bilbao, Spain, ⁸Hospital Universitario Puerta de Hierro, Gastroenterology, Majadahonda, Spain, ⁹Hospital de la Santa Creu i Sant Pau, Gastroenterology, Barcelona, Spain, ¹⁰Hospital Universitario Miguel Servet, Gastroenterology, Zaragoza, Spain, ¹¹Hospital Universitario de La Princesa, Gastroenterology, Madrid, Spain, ¹²Instituto de Investigación Sanitaria Princesa (IIS-IP) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain, ¹³Hospital Clínico Universitario de Santiago de Compostela, Gastroenterology, Santiago de Compostela, Spain, ¹⁴Hospital Montecelo, Gastroenterology, Pontevedra, Spain, ¹⁵Hospital Universitario Reina Sofía, Gastroenterology, Córdoba, Spain, ¹⁶IMIBIC, Córdoba, Spain, ¹⁷Hospital Clínico San Carlos, Gastroenterology, Madrid, Spain, ¹⁸Hospital Marqués de Valdecilla, Gastroenterology, Santander, Spain, ¹⁹Hospital Universitario La Paz, Gastroenterology, Madrid, Spain, ²⁰Hospital Son Llàtzer, Gastroenterology, Palma, Spain, ²¹Hospital Universitari Mutua Terrassa, Gastroenterology, Terrassa, Spain, ²²Centro de Investigación biomédica en red de enfermedades hepáticas y digestivas (CIBERehd), Terrassa, Spain, ²³Hospital de Salamanca, Gastroenterology, Salamanca, Spain, ²⁴Hospital Universitario de Girona, Gastroenterology, Girona, Spain, ²⁵Hospital Arnau de Vilanova, Gastroenterology, Lérida, Spain

¹University of California San Diego, Department of Medicine, La Jolla, USA, ²Robarts Clinical Trials, Inc., London, Canada, ³Beth-Israel Deaconess Medical Center, Harvard Medical School, Center for Inflammatory Bowel Diseases, Division of Gastroenterology, Boston, USA, ⁴University of Pennsylvania, Department of Medicine, Perelman School of Medicine, Philadelphia, USA

¹University California San Diego, La Jolla, California, USA, ²UZ Leuven, KU Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, ³Delta Research Partners, LLC, Bastrop, LA, USA, ⁴Nicolae Testemițanu State University of Medicine and Pharmacy, Chisinau, Moldova, Republic of, ⁵Kitasato Institute Hospital Center for Advanced IBD Research and Treatment, Minato-ku, Tokyo, Japan, ⁶Amsterdam University Medical Centers, Amsterdam, The Netherlands, ⁷Eli Lilly and Company, Lilly Biotechnology Center, San Diego, California, USA, ⁸Eli Lilly and Company, Indianapolis, Indiana, USA, ⁹Western University, Robarts Clinical Trials Inc., London, Ontario, Canada

¹University of Leuven, Leuven, Belgium, ²Cedars-Sinai Medical Center, Los Angeles, USA, ³Janssen Research and Development, Spring House, USA, ⁴Concord Hospital, Sydney, Australia, ⁵Macquarie University Hospital, Sydney, Australia, ⁶Auckland City Hospital, Auckland, New Zealand, ⁷University of Auckland, Auckland, New Zealand, ⁸Kyorin University, Tokyo, Japan, ⁹Humanitas Research Hospital, Milan, Italy, ¹⁰Icahn School of Medicine at Mount Sinai, New York, USA, ¹¹Nancy University Hospital, Vandœuvre-lès-Nancy, France

¹Academic Medical Centre, Amsterdam, The Netherlands, ²Humanitas Research Hospital, Gastroenterology, Milano, Italy, ³Mitsubishi Tanabe Europe Ltd., London, UK, ⁴Tokyo Medical and Dental University, Gastroenterology, Tokyo, Japan, ⁵University Kitasato Hospital, Gastroenterology, Tokyo, Japan

¹Medical University of Vienna, Vienna, Austria, ²University of California San Diego, La Jolla, CA, USA, ³Humanitas University, Milan, Italy, ⁴University of Nice Sophia Antipolis, Hospital l’Archet, Nice, France, ⁵Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland, ⁶Clinic of Gastroenterology and Hepatology, Military Medical Academy, Belgrade, Serbia, ⁷Charles University Hospital, Hradec Králové, Czech Republic, ⁸Gastroenterology Center, Nitra, Slovakia, ⁹Nature Coast Clinical Research, Inverness, FL, USA, ¹⁰Seoul National University College of Medicine, Seoul, South Korea, ¹¹Alfred Hospital, Melbourne, VIC, Australia, ¹²Zymo Consulting Group, Newtown Square, PA, USA, ¹³Shire, Zug, Switzerland, ¹⁴Shire, Lexington, MA, USA, ¹⁵Cytel Inc., Cambridge, MA, USA, ¹⁶University Hospitals Leuven, Leuven, Belgium

¹University of Lorraine, Nancy, France, ²Istituto Clinico Humanitas, Milan, Italy, ³CHU de Liège et Université de Liège, Liège, Belgium, ⁴University of Michigan, Ann Arbor, USA, ⁵Icahn School of Medicine at Mount Sinai, New York, USA, ⁶AbbVie Inc., North Chicago, USA