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P823 DNA methylation profiles accurately predict vedolizumab response and remain stable during induction and maintenance treatment in Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

V. Joustra1, I. Hageman2, A. Li Yim3, K. Gecse1, M. Lowenberg1, A. te Velde2, J. Satsangi4, W. de Jonge2, P. Henneman3, G. D’Haens1

1Amsterdam UMC location AMC, Gastroenterology and Hepatology, Amsterdam, The Netherlands, 2Tytgat Institute for Liver and Intestinal Research- Amsterdam UMC, Gastroenterology, Amsterdam, The Netherlands, 3Genome Diagnostics Laboratory- Amsterdam UMC location AMC, Clinical Genetics, Amsterdam, The Netherlands, 4John Radcliffe Hospital, Translational Gastroenterology Unit, Oxford, UK

P824 Molecular predictors of anti-TNF treatment response in patients with Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

M. WALCZAK1, L. Lykowska-Szuber2, M. Plucinska3, M. Michalak4, I. Krela-Kazmierczak2, O. Zakerska-Banaszak1, K. Stawczyk-Eder2, P. Eder2, A. Dobrowolska2, R. Slomski1, M. Skrzypczak-Zielinska1

1Institute of Human Genetics- Polish Academy of Sciences, Department of Nucleic Acid Function, Poznan, Poland, 2Poznan University of Medical Sciences, Department of Gastroenterology- Dietetics and Internal Diseases, Poznan, Poland, 3Institute of Molecular Biology and Biotechnology- Faculty of Biology- Adam Mickiewicz University, Department of Computational Biology, Poznan, Poland, 4Poznan University of Medical Sciences, Department of Computer Sciences and Statistics, Poznan, Poland

P825 The impact of a SNP-dose–response effect on course of inflammatory bowel disease: a numerical analysis of SNP distribution within the Swiss IBD Cohort Study

ECCO'20 Vienna

Year: 2020
Authors:

L. Biedermann1, L. Denoth1, J.B. Rossel2, M. Butter1, S. Vavricka3, B. Misselwitz4, T. Greuter1, P. Schreiner1, I. Cleynen5, G. Rogler1, M. Scharl1

1University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland, 2University of Lausanne, Center for Primary Care and Public Health Unisanté, Lausanne, Switzerland, 3Private Practice, Center for Gastroenterology and Hepatology, Zurich, Switzerland, 4Inselspital Bern, Gastroenterology and Hepatology, Bern, Switzerland, 5KU Leuven- Leuven- Belgium, Department of Human Genetics, Leuven, Belgium

P826 A predictive molecular classification developed in UC patients with active disease is observed consistently in a heterogeneous group of IBD patients

ECCO'20 Vienna

Year: 2020
Authors:

K. Kulmala1, O.E. Diaz1, S. Huber2, C. Hedin3, E.J. Villablanca1

1Division of Immunology and Allergy, Department of Medicine- Solna- Karolinska Institutet and University Hospital- 17176 Stockholm- Sweden. Center of Molecular Medicine- 17176, Stockholm, Sweden, 2Department of Medicine, University Medical Center, Hamburg-Eppendorf, Germany, 3Gastroenterology unit- Patient Area Gastroenterology- Dermatovenereology and Rheumatology- Karolinska University Hospital- Stockholm- Sweden, Department of Medicine- Solna- Karolinska Institutet- 17176, Solna, Sweden

P827 The clinical phenotype of collagenous colitis is associated with T-cell-related genetic variants

ECCO'20 Vienna

Year: 2020
Authors:

G. Roda1, D. Piovani2, J. Prantesh3, I. Gordon3, R. Asselta4, S. Duga4, S. Vetrano1, S. Bonovas2, N. Harpaz5, S. Danese1, I. Peter6, J.F. Colombel7, F. Rieder3

1Humanitas Research Hospital, IBD Center, Milano, Italy, 2Humanitas Research Hospital, IBD Center/Department of Biomedical Sciences, Milano, Italy, 3Cleveland Clinic, Department of Gastroenterology, Cleveland, USA, 4Humanitas Research Hospital, Dept. Biomed. Sciences, Milano, Italy, 5Icahn School of Medicine at Sinai, Department of Pathology, New York, USA, 6Icahn School of Medicine at Sinai, Division of Genetics and Genomic Sciences, New York, USA, 7Icahn School of Medicine at Sinai, The Henry D. Janowitz Division of Gastroenterology, New York, USA

P828 DNA methylation profile defines epigenetic characteristics and molecular targets of Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

T.O. Kim1, J. Yi2, S.H. Jung3, D.H. Baek4, H.S. Lee5

1Inje University Haeundae Paik Hospital, Department of Internal Medicine, Busan, Republic of Korea, 2Inje University College of Medicine, Department of Microbiology and Immunology, Busan, Republic of Korea, 3Eunpyeong St. Mary’s Hospital- College of Medicine- The Catholic University of Korea, Department of Internal Medicine-, Seoul, Republic of Korea, 4Pusan National University School of Medicine and Biomedical Research Institute- Pusan National University Hospital, Department of Internal Medicine, Busan, Republic of Korea, 5Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea, Department of Internal Medicine, Busan, Republic of Korea

P829 Methylation patterns in dysplasia in inflammatory bowel disease patients

ECCO'20 Vienna

Year: 2020
Authors:

I.A. da Luz Rosa1, P. Silva2, S. Mata3, F. Magro4, F. Carneiro5, A. Peixoto4, M. Silva4, H. Sousa6, J. Roseira6, J. Parra7, R. Barosa8, A. Vieira8, M.J. Brito9, P. Lago10, A. Coelho11, J. Moleiro1, J. Silva1, R. Fonseca3, C. Albuquerque2, A.D. Pereira1

1Grupo de Estudos em Doença Inflamatória Intestinal, 1Instituto Português de Oncologia de Lisboa, Gastroenterology, Lisbon, Portugal, 2Instituto Português de Oncologia de Lisboa, Molecular Pathobiology Investigation Unit, Lisbon, Portugal, 3Instituto Português de Oncologia de Lisboa, Pathology, Lisbon, Portugal, 4Centro Hospitalar de São João, Gastroenterology, Porto, Portugal, 5Centro Hospitalar de São João, Pathology, Porto, Portugal, 6Centro Hospitalar Universitário do Algarve- Unidade de Portimão, Gastroenterology, Portimão, Portugal, 7Centro Hospitalar Universitário do Algarve- Unidade de Portimão, Pathology, Portimão, Portugal, 8Hospital Garcia de Orta, Gastroenterology, Almada, Portugal, 9Hospital Garcia de Orta, Pathology, Almada, Portugal, 10Centro Hospitalar do Porto- EPE–Hospital de Santo António, Gastroenterology, Porto, Portugal, 11Centro Hospitalar do Porto- EPE–Hospital de Santo António, Pathology, Porto, Portugal

P830 Genotype-based treatment with thiopurine reduces incidence of myelosuppression in patients with inflammatory bowel diseases

ECCO'20 Vienna

Year: 2020
Authors:

J.Y. Chang1, S.J. Park2, E.S. Jung3, S.A. Jung4, C.M. Moon5, J. Chun2, J.J. Park2, E.S. Kim6, Y. Park2, T.I. Kim2, W.H. Kim2, J.H. Cheon2

1College of Medicine- Ewha Womans University, Health Promotion Center, Seoul, Republic of Korea, 2Yonsei University College of Medicine, Internal Medicine, Seoul, Republic of Korea, 3Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea, 4Internal Medicine, College of Medicine- Ewha Womans University, Seoul, Republic of Korea, 5College of Medicine- Ewha Womans University, Internal Medicine, Seoul, Republic of Korea, 6Korea University College of Medicine, Internal Medicine, Seoul, Republic of Korea

P831 The role of adherent-invasive E. coli in pediatric Crohn’s disease: cause or effect?

ECCO'20 Vienna

Year: 2020
Authors:

N. Faqerah, Michael. Logan, Richard. Russell, Konstantinos. Gerasimidis, Daniel. Walker

University of Glasgow, Bacteriology, Glasgow, UK

P832 Gastrointestinal infections are associated with unique gut microbiome signatures in patients with inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

J. Axelrad1, A. Hine2, J. Devlin2, P. Loke2, K. Cadwell2

1New York University School of Medicine, Gastroenterology, New York, USA, 2New York University School of Medicine, Microbiology, New York, USA

P833 Bacterial mucosa-associated microbiome in inflamed and proximal non-inflamed ileum of patients with Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

M. Olaisen1,2, A. Flatberg1, A. van Beelen Granlund1,3, E.S. Røyset1,4, T.C. Martinsen1,2, A.K. Sandvik1,2,3, R. Fossmark1,2

1Department of Clinical and Molecular Medicine- Faculty of Medicine and Health Science, NTNU - Norwegian University of Sciences and Technology, Trondheim, Norway, 2Department of Gastroenterology, St. Olav’s Hospital- Trondheim University Hospital, Trondheim, Norway, 3Centre of Molecular Inflammation Research, NTNU - Norwegian University of Sciences and Technology, Trondheim, Norway, 4Department of Pathology, St. Olav’s Hospital- Trondheim University Hospital, Trondheim, Norway

P834 Effects of short-chain fatty acids supplementation on gut inflammation in DSS-induced murine colitis model

ECCO'20 Vienna

Year: 2020
Authors:

C.S. Eun, D.S. Han, J.G. Lee, C.H. Park

Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Republic of Korea

P835 Correlation between microbial markers and faecal calprotectin in IBD patients

ECCO'20 Vienna

Year: 2020
Authors:

J. Amoedo Cibeira1,2, S. Ramió-Pujol1, M. Serra-Pagès3, A. Bahí4, C. Puig-Amiel4, L. Oliver1, P. Gilabert5, A. Clos6, M. Mañosa6, F. Cañete6, J.O. Miquel-Cusachs7, L. Torrealba7, D. Busquets7, M. Sàbat8, E. Domènech6, J. Guardiola5, J. Garcia-Gil1,2, X. Aldeguer1,4,7

1GoodGut SL, IBD Department, Girona, Spain, 2University of Girona, Department of Biology, Girona, Spain, 3GoodGut SL, Chief Executive Officer, Girona, Spain, 4Institut d’Investigació Biomèdica de Girona, Digestiu, Girona, Spain, 5Hospital Universitari de Bellvitge, Aparell Digestiu, Hospitalet de Llobregat, Spain, 6Hospital Universitari Germans Trias i Pujol de Badalona, Aparell Digestiu, Badalona, Spain, 7Hospital Universitari Doctor Josep Trueta de Girona, Aparell Digestiu, Girona, Spain, 8Hospital de Santa Caterina, Aparell Digestiu, Salt, Spain

P836 Biomarkers response to anti-TNF treatment in Crohn’s disease through the intestinal microbiota

ECCO'20 Vienna

Year: 2020
Authors:

L. Sanchis1, S. Manresa1, J.F. Martínez2, M. Valls3, M. Iborra4, J.M. Paredes5, M. Boscá6, J.M. Huguet7, R. Gil8, N. Maroto9, J. Rodriguez1, X. Cortés1

1Hospital of Sagunto, Department of Digestive Disease, Sagunto, Spain, 2Lifesequencing–ADM Nutrition, Genomics Laboratory, Paterna, Spain, 3Hospital General de Castellón, Department of Digestive Disease, Castellón, Spain, 4Hospital La Fe, Department of Digestive Disease, Valencia, Spain, 5Hospital Doctor Peset, Department of Digestive Disease, Valencia, Spain, 6Hospital Clínico de Valencia, Department of Digestive Disease, Valencia, Spain, 7Hospital General de Valencia, Department of Digestive Disease, Valencia, Spain, 8Hospital LLuís Alcanyís, Department of Digestive Disease, Xàtiva, Spain, 9Hospital Manises, Department of Digestive Disease, Manises, Spain

P837 Changes in the intestinal microbiota of patients with inflammatory bowel disease during an 8-week infliximab infusion cycle

ECCO'20 Vienna

Year: 2020
Authors:

G. Seong, J.H. Song, J. Shin, S.M. Kong, E.R. Kim, D.K. Chang, S.N. Hong, Y.H. Kim

Samsung Medical Center, Gastroenterology, Seoul, Republic of Korea

P838 Characteristics of mucosal microbial composition of patients with inflammatory bowel disease susceptibility HLA genotype

ECCO'20 Vienna

Year: 2020
Authors:

A. Hirano, J. Umeno, T. Torisu

Kyushu University, Department of Medicine and Clinical Science, Fukuoka, Japan

P839 Analysis of mucosa-associated microbiota and serum cytokines levels in Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

S. Fukushima1, A. Shiotani1, H. Matsumoto1, R. Inoue2, Y. Naito3

1Kawasaki Medical School Department of Internal Medicine- Division of Gastroenterology, 1Kawasaki Medical School, Department of Internal Medicine- Division of Gastroenterology, Okayama, Japan, 2Kyoto Prefectural University, Laboratory of Animal Science as a lecturer, Kyoto, Japan, 3Kyoto Prefectural University of Medicine, Division of Gastroenterology and Hepatology, Kyoto, Japan

P840 Immunomodulatory effects of two different postbiotics on primary human cell culture

ECCO'20 Vienna

Year: 2020
Authors:

A. Mayorgas

Microbiology, 1IDIBAPS, Intestinal Bowel Disease, Barcelona, Spain

P841 Evaluation of gut microbiota composition in NAFLD with UC pancolitis in clinical remission: a pilot study

ECCO'20 Vienna

Year: 2020
Authors:

S. Cocciolillo1, G. De Palma2, T. Chen1, M.P. Ghali3, M. Deschenes1, P. Wong1, G. Wild1, W. Afif1, P.L. Lakatos1, A. Bitton1, G. Sebastiani1, P. Bercik2, T. Bessissow1

1Division of Gastroenterology and Hepatology- McGill University Health Centre, Medicine, Montreal, Canada, 2Farncombe Family Digestive Health Research Institute- McMaster University, Medicine, Hamilton, Canada, 3Division Gastroenterology- College of Medicine- Jacksonville- University of Florida, Medicine, Jacksonville, USA

P842 Analysis of fungal microbiota dysbiosis in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

L. Zeng, Y. Wang, M. Zhuo

Gastroenterology, West China Hospital- Sichuan University, Chengdu, China