¹Asan Medical Center, Clinical Epidemiology and Biostatistics, Seoul, Republic of Korea, ²Asan Medical Center, Internal Medicine, Seoul, Republic of Korea, ³Asan Medical Center, University of Ulsan College of Medicine, Gastroenterology, Seoul, Republic of Korea

¹Asan Medical Center Children’s Hospital, Department of Pediatrics, Seoul, Republic of Korea, ²Seoul National University College of Engineering, Interdisciplinary Programme for Bioengineering, Seoul, Republic of Korea, ³Seoul National University College of Medicine, Department of Biomedical Engineering, Seoul, Republic of Korea, ⁴Chonnam National University Children’s Hospital, Department of Pediatric Surgery, Gwangju, Republic of Korea, ⁵Asan Medical Center, University of Ulsan College of Medicine Department of Gastroenterology

¹Virginia Mason Medical Center, Gastroenterology, Seattle, USA, ²Takeda Development Center Americas Inc, Gastroenterology, Cambridge, USA, ³Takeda Pharmaceuticals U.S.A- Inc, Gastroenterology, Deerfield, USA, ⁴Analysis Group- Inc., Gastroenterology, Montreal, Canada

¹University Hospital Fribourg, Gastroenterology, Fribourg, Switzerland, ²Institute of Social and Preventive Medicine, Public Health, Bern, Switzerland, ³CHUV - Centre Hospitalier Universitaire Vaudois, Gastroenterology and Hepatology, Lausanne, Switzerland

¹Medical Centre- Hungarian Defence Forces, Division of Gastroenterology, Budapest, Hungary, ²Semmelweis University, Department of Medicine I, Budapest, Hungary, ³McGill University, Division of Gastroenterology, Montreal, Canada

¹Lausanne University Hospital, Service of Internal Medicine, Lausanne, Switzerland, ²Crohn and Colitis Center, Clinique la Source, Lausanne, Switzerland, ³Lausanne University Hospital, Center for Investigation and Research in Sleep, Lausanne, Switzerland, ⁴Unisanté, Center for Primary Care and Public Health, Lausanne, Switzerland

Department of Internal Medicine, Korea University College of Medicine, Division of Gastroenterology and Hepatology- Seoul, Republic of Korea

¹Leiden University Medical Center, Department of Gastroenterology and Hepatology, Leiden, The Netherlands, ²Haga Teaching Hospital, Department of Gastroenterology and Hepatology, Den Haag, The Netherlands, ³Haaglanden Medical Centre, Department of Gastroenterology and Hepatology, Den Haag, The Netherlands, ⁴Maastricht University Medical Center, Department of Gastroenterology and Hepatology, Maastricht, The Netherlands, ⁵Leiden University Medical Center, Department of Gerontology and Geriatrics, Leiden, The Netherlands, ⁶Institute for Evidence-Based Medicine in Old Age IEMO, Institute for Evidence-Based Medicine in Old Age IEMO, Leiden, The Netherlands

Tel Aviv Sourasky Medical Center, Gastroenterology Unit, Tel Aviv, Israel

Gastroenterology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

Hospital Universitario San Cecilio, UGC Aparato Digestivo, Granada, Spain

¹University of Athens, Gastrenterology department- 3rd Internal Medicine clinic- University of Athens, Athens, Greece, ²Democritus University of Thrace, Laboratory of Pharmacology, Alexandroupoli, Greece

¹Kliniczny Szpital Wojewodzki Nr 2 im. Sw. Krolowej Jadwigi w Rzeszowie, Klinika Gastroenterologii i Centralna Pracownia Endoskopii, Rzeszow, Poland, ²Instytut Nauk o Zdrowiu- Kolegium Nauk Medycznych, Uniwersytet Rzeszowski, Rzeszów, Poland

¹Pusan National University School of Medicine & Pusan National University Hospital, Internal Medicine, Busan, Republic of Korea, ²Inje University Busan Paik Hospital, Internal Medicine, Busan, Republic of Korea, ³Pusan National University Yangsan Hospital, Internal Medicine, Yangsan, Republic of Korea, ⁴Ewha Womans University College of Medicine, Internal Medicine, Seoul, Republic of Korea, ⁵Yeungnam University College of Medicine, Internal Medicine, Daegu, Republic of Korea, ⁶Healthcare System Gangnam Center, Seoul National University Hospital, Internal Medicine, Seoul, Republic of Korea, ⁷Soonchunhyang University Bucheon Hospital, Gastroenterology and Hepatology, Bucheon, Republic of Korea, ⁸Hallym University Sacred Heart Hospital, Internal Medicine-, Anyang, Republic of Korea, ⁹The Catholic University of Korea, Internal Medicine, Seoul, Republic of Korea, ¹⁰Inje university Haeundae Paik Hospital, Internal Medicine, Busan, Republic of Korea

¹University of Szeged, First Department of Medicine, Szeged, Hungary, ²University of Semmelweis, First Department of Surgery, Budapest, Hungary, ³University of Pécs, First Department of Medicine, Pécs, Hungary, ⁴University of Pécs, Department of Psychiatry and Psychotherapy, Pécs, Hungary, ⁵University of Szeged, Department of Medical Physics and Informatics, Szeged, Hungary

¹Department of Gastroenterology, Galilee Medical Center, Bar Ilan University, Safed- Israel, Naharia, Israel, ²Hadassah Medical Organization, Department of Gastroenterology and liver disease, Jerusalem, Israel, ³EMMS Nazreth Hospital, Gastroenterology and Endoscopy Units, Nazareth, Israel

Lefkoşa State Hopital Education and Research Hospital, Gastroenterology, Lefkoşa/Turkish side, Cyprus

¹Department of Chronic Diseases- Metabolism and Ageing, KU Leuven, Leuven, Belgium, ²Department of Human Genetics, KU Leuven, Leuven, Belgium, ³University of Antwerp, Department of Biomedical sciences, Antwerp, Belgium, ⁴Radboud University Medical Center, Department of Human Genetics, Nijmegen, The Netherlands

¹London Health Sciences Centre, Medicine, London, Canada, ²Western University, Medicine, London, Canada

¹Tohoku University Graduate School of Medicine, Division of Gastroenterology, Sendai, Japan, ²Graduate School of Medical Sciences- Kyusyu University, Department of Medicine and Clinical Science, Fukuoka, Japan, ³National hospital organization NHO Nagasaki Medical Center, Clinical Research Center, Omura, Japan, ⁴Saga University, Department of Endoscopic Diagnostics and Therapeutics, Saga, Japan, ⁵Iwate Medical University, Division of Gastroenterology- Department of Internal Medicine- Faculty of Medicine, Morioka, Japan