¹Hospital Parc Taulí, Aparell digestiu, Sabadell, Spain, ²Servei Català de la Salut, Unitat d’Informació i Coneixement., Barcelona, Spain, ³Servei Català de la Salut, Àrea del Medicament, Barcelona, Spain, ⁴Universitat Autònoma de Barcelona, Departament de Farmacologia- de Terapèutica i de Toxicologia, Bellaterra, Spain, ⁵Instituto de Salud Carlos III, CIBERehd, Madrid, Spain, ⁶Universitat Autònoma de Barcelona, Departament de Medicina, Bellaterra, Spain

¹Hospital Universitario de La Princesa- IIS-IP- Universidad Autónoma de Madrid and CIBEREHD, Gastroenterology Unit, Madrid, Spain, ²Complexo Hospitalario Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain, ³Hospital Universitario Reina Sofía and IMIBIC, Gastroenterology Unit, Córdoba, Spain, ⁴Hospital de Galdakao-Usansolo, Gastroenterology Unit, Vizcaya, Spain, ⁵Hospital Universitario de Gran Canaria Dr. Negrin, Gastroenterology Unit, Las Palmas, Spain, ⁶Hospital Universitari Mutua Terrasa and CIBERehd, Gastroenterology Unit, Tarrasa, Spain, ⁷Hospital San Pedro, Gastroenterology Unit, Logroño, Spain, ⁸Hospital Universitari Son Espases, Gastroenterology Unit, Palma de Mallorca, Spain, ⁹Hospital Clínico Universitario ‘Lozano Blesa’- IIS Aragón and CIBEREHD, Gastroenterology Unit, Zaragoza, Spain, ¹⁰Hospital General Universitario de Ciudad Real, Gastroenterology Unit, Ciudad Real, Spain, ¹¹Hospital Universitari i Politecnic La Fe and CIBEREHD, Gastroenterology Unit, Valencia, Spain, ¹²Hospital Universitario Central de Asturias and ISPA, Gastroenterology Unit, Oviedo, Spain, ¹³Hospital Universitario Marqués de Valdecilla, Gastroenterology Unit, Santander, Spain, ¹⁴Hospital Universitario San Pedro de Alcántara, Gastroenterology Unit, Cáceres, Spain, ¹⁵Complejo Hospitalario De Navarra, Gastroenterology Unit, Pamplona, Spain, ¹⁶Hospital Universitario de Burgos, Gastroenterology Unit, Burgos, Spain, ¹⁷Hospital General Universitario J.M. Morales Meseguer, Gastroenterology Unit, Murcia, Spain, ¹⁸Universidad Autónoma de Madrid/IdiPaz and CIBERESP, Preventive Medicine and Public Health, Madrid, Spain

¹Shaare Zedek Medical Center- The programmesity of Jerusalem- Israel., Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, Jerusalem, Israel, ²Maccabi Health Services- Tel-Aviv- Israel, Maccabi Health Services, Tel-Aviv, Israel, ³IBD Center- Department of Gastroenterology and Liver diseases and the Research Center for Digestive Diseases- Tel-Aviv Sourasky Medical Center- and the Sackler School of Medicine-, IBD Center- Department of Gastroenterology and Liver diseases, Tel-Aviv, Israel, ⁴Clalit Research Institute- Chief Physician’s Office- Clalit Health Services, Clalit Research Institute, Tel-Aviv, Israel, ⁵The Hebrew University, School of Computer Science and Engineering, Jerusalem, Israel, ⁶Ministry of health Israel, Ministry of health Israel, Jerusalem, Israel

¹H Germans Trias i Pujol Badalona, Gastroenterology, Badalona, Spain, ²H Germans Trias i Pujol Badalona & CIBEREHD, Gastroenterology, Badalona, Spain, ³H Gregorio Marañón, Gastroenterology, Madrid, Spain, ⁴H Universitario Ramón y Cajal, Gastroenterology, Madrid, Spain, ⁵H Donostia & CIBEREHD, Gastroetnerology, San Sebastián, Spain, ⁶H Clínic, Gastroenterology, Barcelona, Spain, ⁷H Puerta de Hierro, Gastroenterology, Madrid, Spain, ⁸H Universitario Central de Asturias and ISPA, Gastroenterology, Oviedo, Spain, ⁹H Rio Hortega, Gastroenterology, Valladolid, Spain, ¹⁰H Marqués de Valdecillas, Gastroenterology, Santander, Spain, ¹¹H Santa Creu i Sant Pau, Gastroenterology, Barcelona, Spain, ¹²H General Universitario, Gastroenterology, Valencia, Spain, ¹³H Politècnic La Fe & CIBEREHD, Gastroenterology, Valencia, Spain, ¹⁴H de León, Gastroenterology, León, Spain

Humanitas Research Hospital, IBD Center, Milano, Italy

¹First Department of Medicine, University of Szeged, Szeged, Hungary, ²Department of Paediatrics, University of Szeged, Szeged, Hungary

¹National Institute of Medical Science and Nutrition Salvador Zubiran, Department of Gastroenterology, Mexico City, Mexico, ²IBD Clinic- Department of Gastroenterology- Instituto Nacional de Ciencias Medicas y Nutricion, Gastroenterology, Mexico, Mexico, ³Grupo Colombiano de Interés en EII, Gastroenterology, Bogota, Colombia, ⁴Hospital universitario Universidad Autonoma de Nuevo Leon, Gastroenterology, Monterrey, Mexico, ⁵Hospital Vargas de Caracas, Gastroenterology, Caracas, Venezuela- Bolivarian Republic, ⁶Universidad de Puerto Rico, Gastroenterology, San Juan, Puerto Rico, ⁷Centro Nacional de Cirugía de Mínimo Acceso, Gastroenterology, La Habana, Cuba, ⁸CEDIMAT Centro de Gastroenterología, Gastroenterology, Santo Domingo, Dominican Republic, ⁹IBD Hospital Moscoso Puello, Gastroenterology, Santo domingo, Dominican Republic, ¹⁰Consultorio Privado, Gastroenterology, Lima, Peru, ¹¹Casmu Cosem, Gastroenterology, Montevideo, Uruguay

¹Seoul National University Hospital Healthcare System Gangnam Center, Department of Internal Medicine, Seoul, Republic of Korea, ²Seoul National University Hospital and liver research institute, Department of Internal Medicine, Seoul, Republic of Korea

¹Universitätsklinikum Heidelberg, Department of Gastroenterology and Hepatology, Heidelberg, Germany, ²Universitätsklinikum Heidelberg, Department of Medical Biometry, Heidelberg, Germany

¹Graduate School of Medical Sciences, Kyushu University, Department of Medicine and Clinical Science, Fukuoka, Japan, ²Saga University Hospital, Department of Endoscopic Diagnostics and Therapeutics-, Saga, Japan, ³Iwate Medical University, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine-, Morioka, Japan, ⁴Fujita Health University School of Medicine, Department of Gastroenterology, Toyoake, Japan, ⁵Kyorin University School of Medicine, Department of Gastroenterology and Hepatology, Mitaka, Japan, ⁶Hyogo College of Medicine, Department of Intestinal Inflammation Research, Nishinomiya, Japan, ⁷Keio University School of Medicine, Center for Diagnostic and Therapeutic Endoscopy, Tokyo, Japan, ⁸Fukuoka University Faculty of Medicine, Department of Gastroenterology, Fukuoka, Japan, ⁹Fukuoka University Chikushi Hospital, Department of Gastroenterology, Chikushino, Japan, ¹⁰Sada Hospital, Gastroenterology, Fukuoka, Japan

¹Shaare Zedek Medical Center- The Hebrew University of Jerusalem- Israel., Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, Jerusalem, Israel, ²Schneider Children’s Medical Center, Institute of Gastroenterology- Nutrition- and Liver Diseases., Petah Tikva, Israel, ³Maccabi Health Services, Maccabi Health Services, Tel-Aviv, Israel, ⁴Meuhedet Sick Fund- Medical Division, Meuhedet Sick Fund- Medical Division, Tel-Aviv, Israel, ⁵Leumit Health Fund, Leumit Health Fund, Tel Aviv, Israel, ⁶Sourasky Medical Center- and the Sackler School of Medicine- Tel-Aviv- Israel, IBD Center- Department of Gastroenterology and Liver diseases and the Research Center for Digestive Diseases, Tel-Aviv, Israel

Hospital Italiano de Buenos Aires, Gastroenterology, Buenos Aires, Argentina

¹ASST Papa Giovanni XXIII, Pediatric Hepatology- Gastroenterology and Transplantation, Bergamo, Italy, ²University ‘Federico II’, Translational Medical Science–Pediatric Section, Napoli, Italy, ³Hospices Civils de Lyon- Hôpital Femme Mère Enfant, Paediatric Gastroenterology Hepatology and Nutrition, Bron, France, ⁴University Hospital Liège, Division of Gastroenterology- Hepatology and Nutrition- Department of Pediatrics, Liège, Belgium, ⁵Great Ormond Street Hospital for sick children, Pediatric Gastroenterology Hepatology and Nutrition, London, UK, ⁶Royal Hospital for Children, Pediatric Gastroenterology Hepatology and Nutrition, Glasgow, UK, ⁷University of Oxford, Translational Gastroenterology Unit and Department of Paediatrics, Oxford, UK, ⁸Dr. von Hauner Children’s Hospital- LMU Munich Medical Center, Division of Gastroenterology and Hepatology, Munich, Germany, ⁹CHR Citadelle, Department of Gastroenterology, Liege, Belgium, ¹⁰Medical University of Warsaw, Department of Paediatrics- Gastroenterology and Nutrition, Warsaw, Poland, ¹¹Medical University of Innsbruck, Pediatric I, Innsbruck, Austria, ¹²Children’s Hospital- University of Helsinki, Department of Paediatric Gastroenterology, Helsinki, Finland, ¹³Necker Children Hospital, Pediatric Gastroenterology Hepatology and Nutrition, Paris, France

Midlands Regional Hospital Tullamore, Department of Gastroenterology, Tullamore, Ireland

¹QEII Health Sciences Centre, Digestive Care & Endoscopy, Halifax, Canada, ²University of Toronto, Factor-Inwentash Faculty of Social Work, Toronto, Canada, ³Dalhousie University, Research Methods Unit, Halifax, Canada, ⁴Patient-Research Partner, Patient-Research Partner, 100 Mile House, Canada, ⁵University of Alberta, Medicine, Edmonton, Canada, ⁶University of Toronto, Medicine, Toronto, Canada, ⁷University of Ottawa, Medicine, Ottawa, Canada, ⁸Dalhousie University, Medicine, Fredericton, Canada, ⁹McGill University, Medicine, Montreal, Canada, ¹⁰University of Saskatchewan, Medicine, Saskatoon, Canada, ¹¹University of Victoria, Medicine, Victoria, Canada, ¹²Dalhousie University, Medicine, Halifax, Canada

¹Mount Sinai Hospital, Department of Surgery, Toronto, Canada, ²Zane Cohen Centre for Digestive Diseases, Inflammatory Bowel Diseases, Toronto, Canada, ³University of Toronto, Department of Surgery, Toronto, Canada, ⁴Linkoping University Hospital, Department of Surgery, Linkoping, Sweden, ⁵Linkoping University, Department of Experimental Medicine, Linkoping, Sweden

¹Department of Gastroenterology and Hepatology, Clinical Hospital Centre Zagreb, Zagreb, Croatia, ²Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia

¹St. Olavs. Hospital, Department of Gastroenterology and Hepatalogy, Trondheim, Norway, ²Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Trondheim, Norway, ³University of Oslo, Department of Health Management and Health Economics, Oslo, Norway

Department of Medicine- King Abdulaziz University- Jeddah- Saudi Arabia, Department of Medicine-, Jeddah, Saudi Arabia

¹Hospital das Clinicas da Faculdade de Medicina da USP, Inflammatory Bowel Disease Department, São Paulo, Brazil, ²Hospital das Clinicas da Faculdade de Medicina da USP, HPV Institute, São Paulo, Brazil, ³Instituto de Infectologia Emilio Ribas, Coloproctology department, São Paulo, Brazil, ⁴Hospital das Clinicas da Faculdade de Medicina da USP, Pathology department, São Paulo, Brazil