¹Immunology, CHU Saint Etienne, Hospital Nord, Saint Priest en Jarez, France, ²Department of Gastroenterology and Hepatology, Inserm CIC1408, CHU Saint Etienne, Hospital Nord, Saint Priest en Jarez, France, ³CHU Lyon, Gastroenterology, Lyon, France, ⁴CHU Nancy, Gastroenterology, Nancy, France

¹Department of Gastroenterology, 401 General Military Hospital of Athens, Athens- Attica, Greece, ²Department of Gastroenterology, Agios Panteleimon General Hospital, Nikaia- Attica, Greece, ³Department of Gastroenterology and Hepatology, University of Zurich, Zurich, Switzerland, ⁴Faculty of Nursing- School of Public Health, National and Kapodistrian University of Athens, Athens- Attica, Greece, ⁵Department of Internal Medicine- Second Medical Clinic, Ippokration Hospital- Aristotle University of Thessaloniki, Thessaloniki- Macedonia, Greece

¹Department of Gastroenterology, Northern Care Alliance, Manchester, UK, ²Division of Diabetes- Endocrinology and Gastroenterology, University of Manchester, Manchester, UK

¹Gastroenterology, Alfred Hospital, Melbourne, Australia, ²Gastroenterology, Guys and St Thomas’ Trust, London, UK, ³Gastroenterology, CHU de St. Etienne, St. Etienne, France, ⁴Epidemiology and Preventative Medicine, Monash University, Melbourne, Australia

¹Department of Gastroenterology with IBD Unit, Clinical Hospital No.2- Rzeszow, Rzeszow, Poland, ²Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland, ³Institute of Health Sciences, Medical College of Rzeszow University, Rzeszow, Poland, ⁴Department of Conservative Dentistry with Endodontics, Medical University of Lublin, Lublin, Poland, ⁵Department of Internal Medicine- Endocrinology- Nephrology, Clinical Hospital No.2 Rzeszow, Rzeszow, Poland, ⁶Medical College of Rzeszow University

¹ErasmusMC, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands, ²Amsterdam UMC- location vumc, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands

Paediatric Gastroenterology and Nutrition Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine- Graduate School of Medical Science, Kyoto, Japan

¹Hospital Universitari de Bellvitge, Gastroenterology, Barcelona, Spain, ²Hospital Universitari de Bellvitge, Pharmacy, Barcelona, Spain, ³Hospital Universitari de Bellvitge, Clinical Genetics Laboratory, Barcelona, Spain

¹UNIFI Investigators, 1Janssen Research & Development- LLC, Immunology, Spring House, USA, ²Janssen Research & Development- LLC, Clinical Biostats, Spring House, USA, ³University of California San Diego, Gastroenterology, La Jolla, USA, ⁴Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, USA, ⁵Robarts Research Institute, Robarts Clinical Trials, London, Canada, ⁶University of Chicago Medicine, Gastroenterology, Chicago, USA, ⁷Nancy University Hospital- Université de Lorraine, Gastroneterology, Nancy, France, ⁸University Hospitals KU Leuven, Pathology, Leuven, Belgium

¹Department of Gastroenterology, The Royal London Hospital- Barts Health NHS Trust, London, UK, ²Gastroenterology Department, St Mark’s Hospital and Academic Institute-, London, UK, ³Department of Gastroenterology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK, ⁴Department of Gastroenterology, Mercy University Hospital, Cork, Ireland, ⁵Gastroenterology Department, Bristol Royal Infirmary- University Hospitals Bristol NHS Foundation Trust, Bristol, UK, ⁶Department of Gastroenterology, University Hospitals of Derby and Burton NHS Foundation Trust- Royal Derby Hospital, Derby, UK, ⁷Gastroenterology, The Edinburgh IBD Unit- Western General Hospital, Edinburgh, UK, ⁸Medical Department, Takeda UK Ltd, London, UK, ⁹Market Access, Takeda UK Ltd, London, UK

¹The SWIBREG SVEAH Study Group, 1Department of Gastroenterology, Faculty of Medicine and Health- Örebro University, Örebro, Sweden, ²Department of Gastroenterology, Linköping University, Linköping, Sweden, ³Clinical Epidemiology and Biostatistics, School of Medical Sciences- Örebro University, Örebro, Sweden, ⁴Department of Internal Medicine, Danderyd Hospital, Stockholm, Sweden, ⁵Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden, ⁶Department of Internal Medicine, St Göran Hospital, Stockholm, Sweden, ⁷IBD-Unit-Gastroenterology, Karolinska University Hospital, Stockholm, Sweden, ⁸Department of Gastroenterology, Skåne University Hospital, Lund, Sweden, ⁹Department of Internal Medicine, Kungälv Hospital, Kungälv, Sweden, ¹⁰Takeda Pharma AB, Takeda, Stockholm, Sweden, ¹¹Department of Gastroenterology, Ersta Hospital, Stockholm, Sweden, ¹²Department of Internal Medicine, Södra Älvs.borgs Hospital, Borås, Sweden, ¹³Department of Internal Medicine, Skaraborgs Hospital, Lidköping, Sweden, ¹⁴Department of Internal Medicine, Sunderby Hospital, Sunderbyn, Sweden

¹Department of Public Health and Clinical Medicine- Umeå University, Medicine, Umeå, Sweden, ²Region Västernorrland, Medicine, Sundsvall, Sweden, ³Department of Public Health and Clinical medicine- Umeå University, Reumatology and Medicine, Umeå, Sweden

Samsung Medical Center, Internal Medicine Gastroenterology and Hepatology, Seoul, Republic of Korea

¹Inflammatory Bowel Disease Unit, Department of Clinical and Experimental Medicine, University of Messina, A.O.U. Policlinico ‘G. Martino’, Messina, Italy, ²Department of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, Italy, ³A.O.O.R. ‘Villa Sofia-Cervello’, Inflammatory Bowel Disease Unit, Palermo, Italy, ⁴Gastroenterology and Hepatology Unit, A.O.U. Policlinico ‘G. Giaccone’,, University of Palermo, , Palermo, Italy, ⁵A.O Cannizzaro, Inflammatory Bowel Disease Unit, Catania, Italy, ⁶A.O. ‘Santa Marta e S. Venera’, Gastroenterology Unit, Acireale, Italy, ⁷A.O.O.R. ‘S. Elia- M. Raimondi’, Gastroenterology Unit, Caltanissetta, Italy

¹The Schneider Children’s Hospital, Petach-Tikva, Israel, The institute of Gastroenterology- Nutrition and Liver diseases, Petach Tikva, Israel, ²Shaare Zedek Medical Center- The Hebrew University, Jerusalem, Israel, The Juliet Keidan institute of Pediatric Gastroenterology, Jerusalem, Israel, ³Shamir Assaf Harofeh Medical Center, Pediatric Gastroenterology Unit, Zerifin, Israel, ⁴Edmond and Lily Safra Children’s Hospital, Pediatric Gastroenterology Unit, Ranat Gan, Israel, ⁵Dana-Dwek Children’s Hospital, Tel Aviv Sourasky Medical Center, Pediatric Gastroenterology Unit, Tel Aviv, Israel, ⁶Kaplan Medical Center, Pediatric Gastroenterology Unit, Rehovot, Israel, ⁷Rambam Medical Center, Pediatric Gastroenterology Unit, Haifa, Israel, ⁸Sheba Medical Center, Department of Gastroenterology, Ramat Gan, Israel

¹Gastroenterology, Henri Mondor Hospital, Creteil, France, ²Gastroenterology, Cochin Hospital, Paris, France, ³Gastroenterology, Nice University Hospital, Nice, France, ⁴Gastroenterology, Reims University Hospital, Reims, France, ⁵Gastroenterology, Bordeaux University Hospital, Bordeaux, France, ⁶Gastroenterology, Marseille University Hospital, Marseille, France, ⁷Gastroenterology, Montpellier University Hospital, Montpellier, France, ⁸Gastroenterology, Beaujon Hospital, Clichy, France, ⁹Gastroenterology, Nancy University Hospital, Nancy, France, ¹⁰Gastroenterology, Toulouse University Hospital, Toulouse, France, ¹¹Gastroenterology, St Etienne, St Etienne, France, ¹²Gastroenterology, Besancon University Hospital, Besancon, France, ¹³Gastroenterology, St Antoine Hospital, Paris, France, ¹⁴Gastroenterology, Lyon University Hospital, Lyon, France, ¹⁵Gastroenterology, St Louis Hospital, Paris, France, ¹⁶Gastroenterology, Montfermeil Hospital, Montfermeil, France, ¹⁷Gastroenterology, Rennes University Hospital, Rennes, France, ¹⁸Gastroenterology, Caen University Hospital, Caen, France, ¹⁹Gastroenterology, Lille, Lille, France, ²⁰Department of Gastroenterology and Hepatology, Amiens University Hospital, Amiens Cedex 1, France

¹Beaujon Hospital, Colorectal Surgery, Clichy, France, ²Ospedale Policlinico di Sant’Orsola-Malpighi, Digestive Surgery, Bologna, Italy, ³APHP Beaujon, Department of Colorectal Surgery, Clichy, France

¹Department of Gastroenterology, St James’s Hospital, Dublin, Ireland, ²Gastroenterology, Tallaght University Hospital, Dublin, Ireland, ³Gastroenterology, St Vincent’s University Hospital, Dublin, Ireland, ⁴Department of Biochemistry, St James’s Hospital, Dublin, Ireland

¹Department of Gastroenterology and Hepatology- C2-112- Inflammatory Bowel Disease Center, Academic Medical Center AMC University of Amsterdam, Amsterdam, The Netherlands, ²Université de Nice-Sophia Antipolis- Hôpital de l’Archet, Faculté de Médecine, Nice, France, ³Department of Medicine- Division of Gastroenterology, University of Michigan, Ann Arbor, USA, ⁴Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, USA, ⁵AbbVie Inc., Global Pharmaceutical Research and Development, North Chicago, USA, ⁶AbbVie Inc., Data and Statistical Sciences, North Chicago, USA, ⁷Humanitas Clinico Research Centre, IBD Centre, Milan, Italy