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P463 Induction of endoscopic response: a network meta-analysis of induction studies comparing ontamalimab with other treatments for moderate-to-severe ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

A. Vickers1, A. Nag2, B. Devine3, B.E. Sands4, R. Panaccione5, L. Peyrin-Biroulet6, S. Danese7, S. Vermeire8, K.J. Gorelick9, M. Goetsch10, L. Hartley1

1RTI Health Solutions, Data Analytics and Design Strategy, Manchester, UK, 2Shire- a Takeda company, Health Economics- Outcomes Research and Epidemiology, Lexington, USA, 3School of Pharmacy, University of Washington, Seattle, USA, 4Icahn School of Medicine at Mount Sinai Medical Center, Dr Henry D. Janowitz Division of Gastroenterology, New York, USA, 5Division of Gastroenterology, University of Calgary, Calgary, Canada, 6Department of Gastroenterology, University Hospital of Nancy-Brabois, Vandœuvre-lès-Nancy, France, 7IBD Center, Humanitas University, Milan, Italy, 8Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium, 9Zymo Consulting Group, Clinical Development, Newtown Square, USA, 10Shire- a Takeda Company, Clinical Development, Zug, Switzerland

P464 Vedolizumab concentrations in colonic mucosal tissue of ulcerative colitis patients inversely correlate with the severity of inflammation

ECCO'20 Vienna

Year: 2020
Authors:

N. Van den Berghe1, B. Verstockt2,3, A. Gils1, M. Ferrante2,3, S. Vermeire2,3, D. Thomas1

1Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium, 2Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium, 3Department of Chronic Diseases- Metabolism and Ageing, KU Leuven, Leuven, Belgium

P465 Therapeutic drug monitoring in Crohn’s disease patients, a comparison between homogeneous mobility shift assay and point of care method

ECCO'20 Vienna

Year: 2020
Authors:

G. Bodini1, M.G. Demarzo1, A. Djahandideh1, I. Baldissarro1, E. Savarino2, V. Savarino3, A. Jain4, P.M. Risso3, E.G. Giannini3

1Gastroenterology Unit- Department of Internal Medicine, University of Genoa, Genoa, Italy, 2Department of Surgery- Oncology and Gastroenterology, University of Padua, Padua, Italy, 3Department of Internal Medicine, University of Genoa, Genoa, Italy, 4Department of Research and Development, Prometheus Laboratories Inc., San Diego, USA

P466 Is it possible avoid colectomy with rescue dual therapy with vedolizumab plus tacrolimus in ulcerative colitis that losing response to anti-tumour necrosis factor?

ECCO'20 Vienna

Year: 2020
Authors:

L. Sanchis1, J.R. Molés1, J. Borrás2, J. Rodriguez1, X. Cortés1

1Department of Digestive Disease, Hospital of Sagunto, Sagunto, Spain, 2Department of Pharmacology, Hospital of Sagunto, Sagunto, Spain

P467 Can induction and maintenance serum vedolizumab levels predict long-term clinical outcome in inflammatory bowel disease (IBD)?

ECCO'20 Vienna

Year: 2020
Authors:

C. Miller1, H. Morgan2, A. Steel3, M. Wahed4

1Chelsea and Westminister Hospital Department of Gastroenterology, 1Gastroenterology, University College Hospital, London, UK, 2Gastroenterology, Chelsea and Westminister Hospital, London, UK, 3Gastroenterology, The Royal Liverpool University and Broadgreen University Hospitals NHS Trust, Liverpool, UK, 4Gastroenterology, Cheslsea and Westminister Hospital, London, UK

P468 Switching from adalimumab originator to ABP 501 biosimilar: a multicentre North Italian study

ECCO'20 Vienna

Year: 2020
Authors:

B. Barberio1, P. Melatti1, F. Zingone1, L. Bertani2, A. Ferronato3, A. GUBBIOTTI1, D. Massimi4, R. D’Incà1, E.V. Savarino5

1Department of Surgery Oncology Gastroenterology, University of Padua, Padua, Italy, 2Department of Gastroenterology, University of Padua, Pisa, Italy, 3Gastroenterology Unit, Santorso Hospital, Santorso, Italy, 4Department of Surgery- Oncology- Gastroenterology, Univeristy of Padua, Padua, Italy, 5Department of Surgery- Oncology- Gastroenterology, University of Padua, Padua, Italy

P469 Stay in class or switch out of class after anti-TNF failure in inflammatory bowel disease (IBD). Real-world data from a large district general hospital

ECCO'20 Vienna

Year: 2020
Authors:

H. Johnson, S. Vythilingam, S. McLaughlin

Department of Gastroenterology, Royal Bournemouth Hospital, Bournemouth, UK

P470 The concept of illness identity in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

L.L. Knödler1, A. Thomann2, M.P. Ebert2, S. Lis3, W. Reindl2

1Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 2Department of Medicine II, Medical Faculty Mannheim- Heidelberg University, Mannheim, Germany, 3Institute of Psychiatric and Psychosomatic Psychotherapy- Central Institute of Mental Health, Medical Faculty Mannheim- Heidelberg University-, Mannheim, Germany

P471 What is the appropriate cut-off value of CRP to predict endoscopic remission in ulcerative colitis patients with clinical remission?

ECCO'20 Vienna

Year: 2020
Authors:

J. Shin, G. Seong, J.H. Song, S.M. Kong, T.J. Kim, E.R. Kim, S.N. Hong, D.K. Chang, Y.H. Kim

Samsung Medical Center, Internal Medicine Gastroenterology and Hepatology, Seoul, Republic of Korea

P472 Optimising the development of apps for the management of inflammatory bowel disease and participation in clinical trials

ECCO'20 Vienna

Year: 2020
Authors:

F. Hussain1, M. DeLegge2, M. Copeman3, M.B. Gallagher2, T. Stewart2, G. Georgiev4

1Iqvia, Therapeutic Science and Strategy Unit, Reading, UK, 2Iqvia, Therapeutic Science and Strategy Unit, Raleigh, USA, 3Iqvia, Project Leadership, Reading, UK, 4Iqvia Bulgaria, Therapeutic Science and Strategy Unit, Sofia, Bulgaria

P473 Long-term follow-up of switching from original adalimumab to adalimumab biosimilar: real-world data in IBD

ECCO'20 Vienna

Year: 2020
Authors:

C. Padilla Suarez, K. Webb, N. Persad, J. Sercombe, E. Tyler, K. Klimova

Gastroenterology, University Hospitals Plymouth NHS Trust, Plymouth, UK

P474 Efficacy and safety of GCAP therapy for UC with PSC

ECCO'20 Vienna

Year: 2020
Authors:

A. Ito, S. Murasugi, T. Omori, M. Yonezawa, K. Tokushige

Department of Gastroenterology- Department of Medicine, Tokyo Women’s Medical University Hospital, Tokyo, Japan

P475 Association between disease duration and degree of endoscopic improvement in patients with ulcerative colitis treated with tofacitinib

ECCO'20 Vienna

Year: 2020
Authors:

W.J. Sandborn1, J.P. Gisbert2, I. Modesto3, C. Su4, D. Quirk4, R. Mundayat3, X. Guo4, M. Chiorean5, W. Reinisch6

1Division of Gastroenterology- University of California, San Diego, La Jolla- California, USA, 2Gastroenterology Unit, Hospital Universitario de La Princesa- IIS-IP and CIBERehd, Madrid, Spain, 3Pfizer Inc., New York, New York, USA, 4Pfizer Inc., Collegeville, Pennsylvania, USA, 5Virginia Mason Medical Center, Seattle, Washington, USA, 6Medical University of Vienna, Vienna, Austria, Austria

P476 Efficacy and safety of 2 vedolizumab IV regimens in patients with perianal fistulising Crohn’s disease: results of the ENTERPRISE study

ECCO'20 Vienna

Year: 2020
Authors:

D. Schwartz1, L. Peyrin-Biroulet2, K. Lasch3, S. Adsul4, S. Danese5

1Inflammatory Bowel Disease Center, Vanderbilt University Medical Center, Nashville, USA, 2Department of Gastroenterology, Nancy University Hospital, Nancy, France, 3Medical Affairs, Takeda Pharmaceuticals USA, Deerfield, USA, 4Takeda Pharmaceuticals International AG, Chief Medical Office- Global Medical Affairs, Zurich, Switzerland, 5Department of Gastrointestinal Immunopathology, Humanitas University, Milan, Italy

P477 Italian real-life study evaluating the long-term effectiveness of vedolizumab for the treatment of inflammatory bowel disease: the elderly cohort

ECCO'20 Vienna

Year: 2020
Authors:

D. Pugliese, G. Privitera, A. Armuzzi, LIVE IG-IBD study group (Ambrogio Orlando and Federica Crispino – AZ.Osp. Ospedali Riuniti ‘Villa Sofia-Cervello’ Palermo Nicolò Mezzina and Alessandro Massari – ASST Fatebenefratelli Sacco Department of Biochemical and Clinical Sciences University of Milan Milan Lucienne Pellegrini and Fabiana Castiglione – AOU ‘Federico II’ Napoli Lucrezia Laterza and Franco Scaldaferri – CEMAD Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Anna Viola and Walter Fries – Policlinico Messina Pietro Soru and Flavio Caprioli – Fondazione IRCCS Cà Granda Ospedale Policlinico Milan Maria Cappello and Barbara Scrivo – Universita’ di Palermo Policlinico Paolo Giaccone Palermo Brigida Barberio and Edoardo Savarino – University of Padua - Azienza Ospedaliera di Padova Padova Chiara Ricci – Università degli Studi di Brescia Ospedali Civili Brescia Brescia Dario Pluchino – AOU Policlinico Vittorio Emanuele Catania Maria Lia Scribano – San Camillo-Forlanini Rome Lorenzo Bertani Azienda Ospedaliera Universitaria Pisana Pisa Renato Sablich – Azienda per l’Assistenza Sanitaria n. 5 ‘Friuli Occidentale’ Pordenone Luca Pastorelli – University of Milan IRCCS Policlinico San Donato Milan Francesco Manguso – AORN A. Cardarelli Napoli Angela Variola – IRCCS Sacro Cuore Don Calabria Negrar di Valpolicella (VR) Antonio Di Sario – Università Politecnica delle Marche Ospedali Riuniti - University Hospital Ancona Laurino Grossi – G d’Annunzio University Ospedale Spirito Santo Pescara Davide Giuseppe Ribaldone – University of Turin Turin Giuseppe Biscaglia – IRCCS Ospedale Casa Sollievo della Sofferenza San Giovanni Rotondo (FG) Pierenrico Lecis – Ospedale S.Maria del Prato - ULSS 1 Dolomiti Belluno Paola Balestrieri – Unviersità Campus Biomedico Roma Gianmarco Mocci – AOU G Brotzu Cagliari Angelo Viscido – University of L’Aquila L’Aquila Maria Carla Di Paolo Azienda Ospedaliera San Giovanni Addolorata Roma Sara Onali – University of Rome Tor Vergata Rome Stefano Rodinò – Azienda Ospedaliera ‘Pugliese-Ciaccio’ Catanzaro Marina Coletta – ASST Santi Paolo e Carlo-Ospedale San Paolo Polo Universitario Milano Mariabeatrice Principi – Azienda Ospedaliera Universitaria Policlinico di Bari Bari Agnese Miranda – Università della Campania Luigi Vanvitelli II Policlinico di Napoli Napoli Arnaldo Amato – Valduce hospital Como Cristina Bezzio – Rho Hospital ASST Rhodense Rho Carlo Petruzzellis – Istituto Ospedaliero Fondazione Poliambulanza Brescia Silvia Mazzuoli – Osp San Nicola Pellegrino ASL BT Trani Stefano Festa – San Filippo Neri Hospital Rome Alessandro Sartini – Azienda Ospedaliero-Universitaria Policlinico di Modena Modena Libera Frangiulo – Ospedale SS. Annunziata di Taranto Taranto Sara Gallina – Ospedale Belcolle Viterbo Giorgia Bodini – University of Genoa Genoa)

Fondazione Policlinico Universitario A Gemelli IRCCS- Università Cattolica del Sacro Cuore, IBD Unit Presidio Columbus, Rome, Italy

P478 Thiopurines’ metabolites levels and drug toxicity: a systematic review and meta-analysis

ECCO'20 Vienna

Year: 2020
Authors:

P.C. Sousa1, M. Estevinho2, C.C. Dias3, D. Martins1, E. Cancela1, F. Pires1, C. Carvalho1, P. Ministro1, F. Magro2

1Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal, 2Department of Biomedicine, University of Porto, Oporto, Portugal, 3Faculty of Medicine of University of Porto, Unit of Pharmacology and Therapeutics, Oporto, Portugal

P479 The effect of adalimumab on linear growth in children with Crohn’s disease: a post hoc analysis of the PAILOT randomised control trial

ECCO'20 Vienna

Year: 2020
Authors:

M. Matar1, R. Shamir2, D. Turner3, E. Broide4, B. Weiss5, O. Ledder6, A. Guz-Mark2, F. Rinawi2, S. Cohen7, C. Topf-Olivestone8, R. Shaoul9, B. Yerushalmi10, S. Ben-Horin11, A. Assa2

1Institute of Gastroenterology- Nutrition and Liver Diseases, Shneider Children’s Medical Center, Petach Tikva, Israel, 2The Institute of Gastroenterology- Nutrition and Liver Diseases, Schneider Children’s Hospital, Petach-Tikva, Israel, 3The Juliet Keidan Institute of Pediatric Gastroenterology, Shaare Zedek Medical Center, Jerusalem, Israel, 4Pediatric Gastroenterology Unit, Shamir Assaf Harofeh Medical Center, Zerifin, Israel, 5Pediatric Gastroenterology Unit, Sheba Medical Center- Edmond and Lily Safra Children’s Hospital-Tel-Hashomer, Ramat-Gan, Israel, 6The Juliet Keidan Institute of Pediatric Gastroenterology, Shaare Zedek Medical Center-, Jerusalem, Israel, 7Pediatric Gastroenterology Unit, ‘Dana-Dwek’ Children’s Hospital- Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, 8Pediatric Gastroenterology Unit, Kaplan Medical Center, Rehovot, Israel, 9Pediatric Gastroenterology Unit, Rambam Medical Center, Haifa, Israel, 10Pediatric Gastroenterology Unit, Saban Pediatric Medical Center- Soroka University Hospital and Faculty of Health Sciences, Beer-Sheva, Israel, 11Department of Gastroenterology, Sheba Medical Center- Tel-Hashomer, Ramat-Gan, Israel

P480 Efficiency and safety of endoscopic balloon dilatation of ileocolonic anastomotic strictures in patients with Crohn’s disease: A multicentric retrospective study

ECCO'20 Vienna

Year: 2020
Authors:

M. Lukáš1, M. Kolar1, M. Vasatko1, P. Klvana2, V. Leksa3, J. Dyntr4, L. Baca5, B. Pipek5, B. Bahnikova6, S. Summerova7

1ISCARE I.V.F. a.s., IBD Clinical and Research Centre, Prague, Czech Republic, 2Hospital Frydek-Mistek, Beskydy Gastroenterology Center- Department of Internal Medicine, Frydek-Mistek, Czech Republic, 3Pardubice Hospital, Endoscopy- Internal Department, Pardubice, Czech Republic, 4Krajska zdravotni- a.s.- Masaryk Hospital Usti nad Labem, Gastroenterology, Usti nad Labem, Czech Republic, 5Vitkovice Hospital, Digestive Diseases Center, Ostrava, Czech Republic, 6Regional Hospital Liberec, Gastroenterology and Hepatology, Liberec, Czech Republic, 7Thomayer Hospital and Third Faculty of Medicine- Charles University, Department of Internal Medicine, Prague, Czech Republic

P481 Repeated surgery for recurrent ileocolonic Crohn’s disease: does the outcome keep worsening operation after operation? A comparative study of 1224 consecutive procedures

ECCO'20 Vienna

Year: 2020
Authors:

F. Colombo1, A. Frontali1, C. Baldi1, G.M.B. Lamperti1, G. Maconi2, S. Ardizzone2, D. Foschi2, G. Sampietro1

1General Surgery, L.Sacco University Hospital, Milan, Italy, 2Gastroenterology Unit, L.Sacco University Hospital, Milan, Italy

P482 Patient and physician perspectives on the management of inflammatory bowel disease: Disease remission and durability of treatment

ECCO'20 Vienna

Year: 2020
Authors:

A. Afzali1, A. Armuzzi2, Y. Bouhnik3, B. Bressler4, A. Hart5, D. Rubin6, M. Sans7, B. Siegmund8, C. Sninsky9

1*All authors are IBD Global Assessment of Patient Unmet Needs Survey (GAPPS) Steering Committee members (listed αbetically), 1The Ohio State University Wexner Medical Center, Inflammatory Bowel Disease Center, Columbus, USA, 2Fondazione Policlinico A. Gemelli IRCCS - Universita’ Cattolica, Inflammatory Bowel Disease, Rome, Italy, 3Inserm et Université Paris, Gastroenterology, Paris, France, 4Gastroenterology, Univeristy of British Columbia, Vancouver BC, Canada, 5Gastroenterology, St. Mark’s Hospital, London, UK, 6Gastroenterology Hepatology and Nutrition, University of Chicago, Chicago, USA, 7Gastroenterology, Centro Médico Teknon, Barcelona, Spain, 8Gastroenterology- Infectiology and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 9Gastroenterology, Digestive Disease Associates, Gainesville, USA