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P443 Magnetic resonance imaging after ligation of the intersphincteric fistula tract for high perianal fistulas in Crohn’s disease: a retrospective cohort study

ECCO'20 Vienna

Year: 2020
Authors:

E. Van Praag1, K. van Rijn2, M. Monraats2, J. Stoker2, C. Buskens1

1Amsterdam UMC, Surgery, Vleuten, The Netherlands, 2Amsterdam UMC, Radiology and Nuclear Medicine, Amsterdam, The Netherlands

P444 The impact of azathioprine on inflammatory bowel disease patients’ overall health-related quality of life: a single-centre retrospective cohort study

ECCO'20 Vienna

Year: 2020
Authors:

Y. ALRUTHIA1, W. Alsharif1, G. Almuaythir1, H. Alrasheed1, O. Alharbi2, N. Azzam2, M. Almadi2, M. Saeed2, B. HajkhderMullaissa2, A. Aljebreen2

1Clinical Pharmacy, King Saud University College of Pharmacy, Riyadh, Saudi Arabia, 2Gastroenterology Division- Department of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia

P445 Efficacy and safety of induction therapy with calcineurin inhibitors followed by maintenance therapy with vedolizumab in severe ulcerative colitis: a large patient cohort with long-term follow-up

ECCO'20 Vienna

Year: 2020
Authors:

J. OLLECH1, S. Dwadasi1, I. Normatov1, A. Israel1, V. Rai1, P. Sossenheimer1, B. Christensen2, S. Dalal1, J. Pekow1, A. Sakuraba1, R. Cohen1, D. Rubin1

1Gastroenterology, University of Chicago Medicine, Chicago, USA, 2Gastroenterology, The Royal Melbourne Hospital, Melbourne, Australia

P446 Transcriptional and microbial biomarkers of response to anti-TL1A therapy in ulcerative colitis: the Phase 2a TUSCANY study

ECCO'20 Vienna

Year: 2020
Authors:

M. Hassan-Zahraee1, Z. Ye1, L. Xi1, M.L. Baniecki1, X. Li1, W. Farin2, L. Tibaldi3, J.R. Allegretti4, J. Romatowski5, E.J. Scherl6, M. Klopocka7, C. Hyde1, S. Danese8, R. Longman6, K.E. Hung1

1Pfizer Inc., Cambridge, Massachusetts, USA, 2Enterome, Data Science Department, Paris, France, 3Enterome, Drug Discovery Department, Paris, France, 4Brigham and Women’s Hospital- Harvard Medical School, Division of Gastroenterology- Boston, Massachusetts, USA, 5J. Sniadecki’s Regional Hospital, Internal Medicine and Gastroenterology Department, Białystok, Poland, 6Jill Roberts Center for IBD- Weill Cornell Medicine, Division of Gastroenterology and Hepatology- New York, New York, USA, 7Department of Gastroenterology and Nutrition, Nicolaus Copernicus University in Toruń- Collegium Medicum, Bydgoszcz, Poland, 8Department of Gastroenterology, IBD Center- Humanitas Research Hospital, Milan, Italy

P447 No severe neonatal and maternal complications in inflammatory bowel diseases patients treated with ustekinumab or vedolizumab during pregnancy

ECCO'20 Vienna

Year: 2020
Authors:

P. Wils1, P. Seksik2, C. Stefanescu3, S. Nancey4, M. Allez5, D. Laharie6, G. Pineton De Chambrun7, R. Altwegg7, C. Gilletta8, L. Vuitton9, S. Viennot10, M. Serrero11, M. Fumery12, G. Savoye13, M. Collins14, F. Goutorbe15, H. Brixi16, G. Bouguen17, N. Tavernier18, M. Boualit19, A. Amiot20, V. Abitbol21, B. Pariente22

1GETAID group, 1Gastroenterology Department, CHRU Lille, Lille, France, 2Gastroenterology, Saint Antoine Hospital, Paris, France, 3Gastroenterology, Beaujon Hospital, Paris, France, 4Gastroenterology, Lyon Sud Hospital, Lyon, France, 5Gastroenterology, Saint Louis Hospital, Paris, France, 6Gastroenterology, Haut-Leveque Hospital, Bordeaux, France, 7Montpellier, Gastroenterology, Montpellier, France, 8Toulouse, Gastroenterology, Toulouse, France, 9Besancon, Gastroenterology, Besancon, France, 10Caen Hospital, Gastroenterology, Caen, France, 11North Hospital of Marseille, Gastroenterology, Marseille, France, 12CHU Amiens Nord, Gastroenterology, Amiens, France, 13Rouen, Gastroenterology, Rouen, France, 14Kremlin-Bicêtre Hospital, Gastroenterology, Paris, France, 15Bayonne, Gastroenterology, Bayonne, France, 16Robert Debré University Hospital, Gastroenterology, Reims, France, 17University Hospital of Rennes, Gatsroenterology, Rennes, France, 18Gastroenterology, Tourcoing, Tourcoing, France, 19Gastroenterology, Valenciennes, Valenciennes, France, 20Gastroenterology, Henri Mondor Hospital, Paris, France, 21Gastroenterology, Cochin Hospital, Paris, France, 22Gastroenterology, University of Lille- CHRU Lille, Lille, France

P448 Dose adjustment in patients with moderate-to-severe ulcerative colitis: results from the UNIFI maintenance study long-term extension

ECCO'20 Vienna

Year: 2020
Authors:

S. Danese1, R. Panaccione2, L. Peyrin-Biroulet3, C. Marano4, C.D. O’Brien4, H. Zhang5, Y. Zhou5, J. Johanns5, E. Scherl6, R.W.L. Leong7, D.S. Rowbotham8, R.P. Arasaradnam9, B.E. Sands10

1UNIFI Investigators, 1Humanitas Research Hospital, Inflammatory Bowel Diseases Center, Milan, Italy, 2Department of Medicine, University of Calgary, Calgary, Canada, 3Gastroenterology, Nancy University Hospital, Nancy, France, 4Janssen Research and Development- LLC, Immunology, Spring House, USA, 5Janssen Research and Development- LLC, Clinical Biostats, Spring House, USA, 6Weill Cornell Medicine, Jill Roberts Center for Inflammatory Bowel Disease, New York, USA, 7Gastroenterology, Concord and Macquarie University Hospitals, Sydney, Australia, 8Gastroenterology and Hepatology, Auckland City Hospital, Auckland, New Zealand, 9Gastroenterology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK, 10Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USA

P449 Systematic review with meta-analysis: risk of lymphoma associated with anti-tumour necrosis factor (TNF) agents in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

A. CHUPIN1, V. Perduca2, C. Bellanger1, F. Carbonnel1, C. Dong1

1Gastroenterology Department, Kremlin Bicetre Hospital- AP-HP- University Paris Sud, Paris, France, 22 MAP5 laboratory UMR CNRS 8145, Paris Descartes University, Paris, France

P450 Thioguanine and low dose thiopurines and allopurinol are both safe options after failure of conventional thiopurines: a comparative analysis of two multicentre cohorts

ECCO'20 Vienna

Year: 2020
Authors:

V. Biemans Drs1, E. Savelkoul2, G. Dijkstra3, M. Simsek4, R. Gabriels5, M. Pierik6, R. West7, N. de Boer8, F. Hoentjen2

1Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre- Maastricht University Medical Centre, Nijmegen, The Netherlands, 2Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 3Gastroenterology and Hepatology, University Medical Centre Groningen- Groningen University, Groningen, The Netherlands, 4Gastroenterology and Hepatology, Amsterdam University Medical Centre- Vrije Universiteit, Amsterdam, The Netherlands, 5Gastroenterology and Hepatology, University Medical Centre Groningen, Groningen, The Netherlands, 6Gastroenterology and Hepatology, Maastricht University Medical Centre, Maastricht, The Netherlands, 7Gastroenterology and Hepatology, Franciscus Gasthuis and Vlietland, Rotterdam, The Netherlands, 8Gastroenterology and Hepatology, Amsterdam University Medical Centre- Vrije Universiteit- Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam, The Netherlands

P451 Short-and long-term effectiveness of ustekinumab in patients with Crohn’s disease: real-world data from a German IBD cohort

ECCO'20 Vienna

Year: 2020
Authors:

A. Kubesch1, L. Rueter1, K. Farrag2, T. Krause3, K. Stienecker4, J. Hausmann1, N. Filmann5, A. Dignass6, J. Stein2, I. Blumenstein1

1Department of Internal Medicine 1, University Hospital Frankfurt, Frankfurt a. M., Germany, 2Crohn- und Colitis Zentrum, Rhein-Main, Frankfurt a. M., Germany, 3R. Rautenkranz- T. Krause, Gastroenterologie Opernstraße- CED-Schwerpunktpraxis, Kassel, Germany, 4Dr. Stienecker, CED Schwerpunktpraxis, Fulda, Germany, 5Institute of Biostatistics and Mathematical Modeling, University Hospital Frankfurt, Frankfurt a. M, Germany, 6Department of Internal Medicine I, Agaplesion Markus Krankenhaus, Frankfurt a. M., Germany

P452 Biologic use patterns and predictors for non-persistence and switching of biologics in patients with inflammatory bowel disease: a nationwide population-based study

ECCO'20 Vienna

Year: 2020
Authors:

Y.S. Jung Prof. Dr.1, M. Han2, S. Park3, J.H. Cheon4

1Department of Internal Medicine, Kangbuk Samsung Hospital, Seoul, Republic of Korea, 2Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea, 3Department of Biostatistics, Yonsei University, Seoul, Republic of Korea, 4Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

P453 Comparison of therapeutic effects between groups of thiopurine alone and combination of thiopurine with 5-ASA after remission introduced by oral tacrolimus for patients with severe ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

T. Sato1, K. Kojima2, R. Koshiba2, K. Fujimoto2, M. Kawai2, K. Kamikoduru2, Y. Yokoyama2, T. Miyazaki2, K. Watanabe1, N. Hida2, S. Nakamura2

1Department of Intestinal Inflammation Research, Hyogo College of Medicine, Nishinomiya, Japan, 2Department of Inflammatory Bowel Disease- Division of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

P454 Serum oncostatin M predicts mucosal healing in Crohn’s disease patients treated with infliximab

ECCO'20 Vienna

Year: 2020
Authors:

L. Bertani1, L. Antonioli2, M. Fornili2, M. Fornai2, G. Tapete1, E. Albano1, G. Baiano Svizzero1, L. Ceccarelli3, M.G. Mumolo3, L. Baglietto2, S. Marchi1, C. Blandizzi2, F. Costa3

1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy, 2Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 3Department of General Surgery and Gastroenterology - IBD Unit, Pisa University Hospital, Pisa, Italy

P455 Adherence to enteral nutrition therapy by adults with active Crohn’s disease is associated with conscientiousness personality trait

ECCO'20 Vienna

Year: 2020
Authors:

C. Wall1, A. McCombie2, R. Mulder3, A. Day4, R. Gearry1

1Department of Medicine, University of Otago, Christchurch, New Zealand, 2Department of General Surgery, Canterbury District Health Board, Christchurch, New Zealand, 3Department of Psychological Medicine, University of Otago, Christchurch, New Zealand, 4Department of Paediatrics, University of Otago, Christchurch, New Zealand

P456 Longer-term outcomes in acute severe colitis

ECCO'20 Vienna

Year: 2020
Authors:

R. CAMPBELL, R. Haddock, K. Parman, J. MacDonald, J.P. Seenan

Gastroenterology, Queen Elizabeth University Hospital, Glasgow, UK

P457 IBD couples and their offspring: a European survey

ECCO'20 Vienna

Year: 2020
Authors:

A. Oliveira1, M.P. Costa-Santos1, C. Frias Gomes1, J. Sabino2, A. Sampaio3, L. Avedano4, S. Leone4, J.F. Colombel5, J. Torres1

1Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal, 2Gastroenterology, University Hospital of Leuven, Leuven, Belgium, 3Portuguese Association of Inflammatory Bowel Disease, Portuguese Association of Inflammatory Bowel Disease, Lisbon, Portugal, 4European Federation of Crohn’s and Ulcerative Colitis Associations EFCCA, European Federation of Crohn’s and Ulcerative Colitis Associations EFCCA, Brussels, Belgium, 5Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, USA

P458 Association between adalimumab serum levels and level of remission in Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

S. Hambli1, S. Rogeau2, N. Duveau3, M. Nachury1, J. Branche1, R. Gérard1, P. Wils1, C. Lauriot Dit Prevost1, T. Lambin1, P. Desreumaux1, M. Labalette2, B. Pariente1

1CHRU Lille, Service des Maladies de l’Appareil Digestif et Nutrition, Lille, France, 2CHRU Lille, Institut d’immunologie, Lille, France, 3Service d’Hépato-Gastro-entérologie, Centre Hospitalier de Roubaix, Roubaix, France

P459 The impact of latent cytomegalovirus infection on the disease behaviour in patients with ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

P. Långvall1, C. Shi1, P. Karling2

1Department of Public Health and Clinical Medicine- Umeå University, Medicine, Umeå, Sweden, 2Department of Public Health and Clinical Medicine- Umeå University, Norrlands University Hospital NUS Umeå, Umeå, Sweden

P460 Evaluation of potential mechanisms underlying the safety observations of filgotinib in clinical studies in rheumatoid arthritis

ECCO'20 Vienna

Year: 2020
Authors:

A. Clarke, J. Di Paolo, B. Downie, A. Meng, N. Mollova, Y. Yu, P. Han

Clinical Development, Gilead Sciences Inc., Foster City- CA, USA

P461 Intolerance to 5-aminosalicylate is a risk of poor prognosis in ulcerative colitis patients

ECCO'20 Vienna

Year: 2020
Authors:

T. Fujii1, S. Hibiya1, C. Maeyashiki2, E. Saito1, K. Takenaka1, M. Motobayashi1, H. Shimizu1, M. Nagahori1, K. Ohtsuka1, M. Kurosaki2, T. Yauchi3, M. Watanabe1

1Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan, 2Gastroenterology, Musashino Red Cross Hospital, Tokyo, Japan, 3Gastroenterology, Soka Municipal Hospital, Soka, Japan

P462 Efficacy of ustekinumab for the prevention of postoperative recurrence in crohn’s disease. Data from clinical practice from the eneida registry

ECCO'20 Vienna

Year: 2020
Authors:

M. Mañosa Ciria1, A. Fernandez-Clotet2, A. Hernández-Camba3, R. Muñoz Pérez4, M. Iborra5, M. Sierra6, L. Márquez7, P. Delgado-Guillena8, D. Busquets9, M. Van Domselaar10, E. Girona11, E. Sánchez-Rodríguez12, M.D. Martín-Arranz13, R. Lorente14, D. Casas-Deza15, M. Boscá16, F. Cañete1, M. Calafat1, E. Domènech1

1Department of Gastroenterology CIBERehd- IBD Unit, Hospital Universitari Germans Trias I Pujol, Badalona, Spain, 2Gastroenterology, Hospital Clinic Barcelona, Barcelona, Spain, 3Gastroenterology, Hospital Nuestra Señora de la Candelaria, Tenerife, Spain, 4Gastroenterology, Hospital General Universitario de Alicante, Alicante, Spain, 5Gastroenterology, Hospital La Fe, Valencia, Spain, 6Gastroenterology, Hospital Universitario de Leon, Leon, Spain, 7Gastroenterology, Hospital del mar, Barcelona, Spain, 8Gastroenterology, Hospital General de Granollers, Granollers, Spain, 9Gastroenterology, Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain, 10Gastroenterology, Hospital de Torrejon, Torrejon, Spain, 11Gastroenterology, Hospital General Universitario de Elche, Elche, Spain, 12Gastroenterology, Hospital Ramon y Cajal, Madrid, Spain, 13Gastroenterology, Hospital la Paz, Madrid, Spain, 14Gastroenterology, Hospital de Ciudad Real, Ciudad Real, Spain, 15Gastroenetrology, Hospital Miguel Servet, Zaragoza, Spain, 16, Gastroenterology, Hospital Universitario Clínico de Valencia, Valencia, Spain