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P063 B-cell receptor signalling in lymphoid tissues may be regulated by CEACAM1

ECCO'20 Vienna

Year: 2020
Authors:

T. Nagaishi, N. Tsugawa, D. Yamada, T. Watabe, M. Onizawa, M. Watanabe

Tokyo Medical and Dental University, Gastroenterology, Tokyo, Japan

P064 Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism

ECCO'20 Vienna

Year: 2020
Authors:

X.R. Wu1, P. Lan1, X.J. Wu1, X. Gao2

1The Sixth Affiliated Hospital of Sun Yat-sen University, Department of Colorectal Surgery, Guangzhou, China, 2The Sixth Affiliated Hospital of Sun Yat-sen University, Department of Gastroenterology, Guangdong, China

P065 Metabolic utilisation of propanediol by adherent-invasive E. coli regulates intestinal tissue immunity

ECCO'20 Vienna

Year: 2020
Authors:

M. Viladomiu1, M. Metz1, S. Lima1, C.J. Guo1, K. Simpson2, E. Scherl1, R. Longman1

1Weill Cornell Medicine, Medicine, New York, USA, 2Cornell University, Veterinary Medicine, Ithaca, USA

P066 Azathioprine linked with impaired intestinal epithelial regeneration in Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

K. Borycka-Kiciak1, A. Pietrzak2,3, K. Ferenc4, P. Pietrzak4,5, L. Janaszek1, W. Tarnowski1, R. Zabielski4

1Orlowski Hospital, CPME, Department of General, Oncological and Gastrointestinal Surgery, Warsaw, Poland, 2Centre of Postgraduate Medical Education, Department of Gastroenterology, Hepatology and Clinical Oncology, Warsaw, Poland, 3Institute of Oncology, Department of Oncological Gastroenterology, Warsaw, Poland, 4Warsaw University of Life Sciences, Department of Large Animal Diseases with the Clinic, Faculty of Veterinary Medicine, Warsaw, Poland, 5Warsaw Agricultural University, Department of Physiological Sciences, Warsaw, Poland

P067 Proteins citrullination and Crohn’s disease: PAD4 but not PAD2 is a strong marker of ileal inflammation

ECCO'20 Vienna

Year: 2020
Authors:

G. Dragoni1,2, B. Creyns2,3, G. De Hertogh4, B. Verstockt2,5, W.J. Wollants2, B.J. Ke2, L. Marcellis4, G. Matteoli2, A. D’Hoore6, A. Galli1, M. Ferrante2,5, S. Vermeire2,5

1University of Florence, Clinical Gastroenterology Unit- Department of Biomedical Clinical and Experimental Sciences ‘Mario Serio’, Firenze, Italy, 2KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders TARGID, Leuven, Belgium, 3KU Leuven, Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven, Belgium, 4KU Leuven, Department of Imaging and Pathology, Translational Cell and Tissue Research, Leuven, Belgium, 5University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, 6University Hospitals Leuven, Department of Abdominal Surgical Oncology, Leuven, Belgium

P068 Erythrocyte and reticulocyte parameters in children with inflammatory bowel diseases

ECCO'20 Vienna

Year: 2020
Authors:

E. Semikina1, A. Potapov2, V. Tsvetkova2, A. Anoushenko2, S. Akulova1

1National Medical Research Center for Children’s Health of the Ministry of Health of the Russian Federation, Central clinical laboratory, Moscow, Russian Federation, 2National Medical Research Center for Children’s Health of the Ministry of Health of the Russian Federation, Gastroenterology Department with Hepatology Group, Moscow, Russian Federation

P069 CD73 promotes colitis-associated tumourigenesis in mice

ECCO'20 Vienna

Year: 2020
Authors:

X. Wu, X. Liu, N. Lan, X. Zheng, Y. Chen, Z. Cai, P. Lan, X. Wu

The Sixth Affiliated Hospital, Sun Yat-sen University, Department of Colorectal Surgery, Guangzhou, China

P070 Machine learning approaches to identify IBD biomarkers from longitudinal microbiome data

ECCO'20 Vienna

Year: 2020
Authors:

M. Madgwick1,2, P. Sudhakar1,2,3, N.S. Tabib3, P. Norvaisas4, P. Creed4, B. Verstockt3,5, S. Vermeire3,5, T. Korcsmáros1,2

1Earlham Institute, Organisms and Ecosystems, Norwich, UK, 2Quadram Institute, Gut Microbes and Health, Norwich, UK, 3KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders TARGID, Leuven, Belgium, 4BenevolentAI, Precision Medicine Team, London, UK, 5University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium

P071 Studying the effects of the probiotic bifidobacteria on gut health and intestinal epithelial cells function

ECCO'20 Vienna

Year: 2020
Authors:

M. Poletti1, I. Hautefort1, A. Treveil1,2, A. Demeter1, E. Rodriguez1, A. Brion2, A. Goldson2, D. Divekar3, Z. Schofield2, I. O’Neill2, A. Lister1, J. Lipscombe1, A. Watson3,4, I. Macaulay1, L. Hall2, T. Korcsmaros1,2

1Earlham Institute, Organisms and Ecosystems, Norwich, UK, 2Quadram Institute Biosciences, Gut microbes and Health, Norwich, UK, 3University of East Anglia, Norwich Medical School, Norwich, UK, 4University of East Anglia, School of Biological Sciences, Norwich, UK

P072 Evaluation of dosing strategies of anti-TNFα monoclonal antibodies using pharmacokinetic modelling and simulation

ECCO'20 Vienna

Year: 2020
Authors:

A. Démaris1,2, A.M. Grišić1,2, W. Huisinga3, R. Walter4, C. Kloft1

1Freie Universität Berlin, Department of Clinical Pharmacy and Biochemistry, Berlin, Germany, 2PharMetrx, Graduate Research Training Program, Berlin, Germany, 3Universität Potsdam, Institute of Mathematics, Potsdam, Germany, 4Medical University of Vienna, Department for Gastroenterology and Hepatology, Vienna, Austria

P073 Compartmentalised human gut immunity: studies of innate and adaptive lymphocyte distribution in the epithelium, lamina propria and GALT of healthy gut mucosa by flow cytometry

ECCO'20 Vienna

Year: 2020
Authors:

A. Carrasco Garcia1,2, A. Rao1, E. Kokkinou1, S. Haapaniemi2,3, U. Lindforss4, M.E. Winberg2, M. Casado-Bedmar2, T. Fenton5, P. Jørgensen5, C. Nordenvall4, W. Agace5, Å.V. Keita2, J.D. Söderholm2,6, J. Mjösberg1,2

1Karolinska Institutet, Center for Infectious Medicine, Stockholm, Sweden, 2Linköping University, Department of Clinical and Experimental Medicine, Linköping, Sweden, 3Linköping University, Department of Surgery, Norrköping, Sweden, 4Karolinska Institutet and Karolinska University Hospital, Department of Molecular Medicine and Surgery, Stockholm, Sweden, 5Technical University of Denmark, Department of Health Technology, Lyngby, Denmark, 6Linköping University, Department of Surgery, Linköping, Sweden

P074 Histopathologic evaluation and lymphocyte subpopulations of the upper digestive tract of Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

A. Martin Cardona1,2, A. Carrasco García1,2, E. Tristán Lopez3, Y. Zabana Abdo1,2, M. Aceituno Quintanilla1,2, C. Ferrer Cassadó4, D. Horta Sangenis1, L. Ruiz-Campos1, C. Loras Alastruey1,2, X. Andujar Murcia1,2, O. Benítez Leiva1, F. Fernández-Bañares1,2, M. Esteve Comas1,2

1Hospital Universitari Mútua Terrassa, Digestive Diseases Department, Terrassa, Spain, 2Centro de Investigación biomédica en red de enfermedades hepáticas y digestivas CIBERehd, Terrassa, Barcelona, Spain, 3Hospital Universitari Mútua Terrassa, Laboratori de Recerca. Fundació Mútua de Terrassa, Terrassa, Spain, 4Hospital Universitari Mútua Terrassa, Department of Pathology, Terrassa, Spain

P075 Muc5ac expression protects the colonic barrier in experimental colitis

ECCO'20 Vienna

Year: 2020
Authors:

L. O’Connell1, K. Olli2, C. Rapp2, C. Collins1, E. McNamee3, O. Jensen2, P. Jedlicka4, K. Allison2, M. Goldberg5, M. Gerich5, C. Evans6, C. AHERNE1,2

1University College Dublin, School of Medicine, Dublin 4, Ireland, 2University of Colorado Denver, Anesthesiology, Aurora, USA, 3Maynooth University, Biology, Maynooth, Ireland, 4University of Colorado Denver, Pathology, Aurora, USA, 5University of Colorado Denver, Gastroenterology, Aurora, USA, 6University of Colorado Denver, Pulmonary medicine and critical care, Aurora, USA

P076 Role of gut microbiota in mediating the effects of thiopurines

ECCO'20 Vienna

Year: 2020
Authors:

M. Franzin1, M. Lucafò2, C. Lagatolla3, G. Stocco3, G. Decorti4

1PhD Course in Reproductive and Developmental Sciences, University of Trieste, Department of Medical, Surgical and Health Sciences, Trieste, Italy, 2IRCCS Burlo Garofolo, Advanced Translational Diagnostics Laboratory, Trieste, Italy, 3University of Trieste, Department of Life Sciences, Trieste, Italy, 4University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy

P077 Metabonomic profiling distinguishes Crohn’s perianal fistulas and idiopathic idiopathic (cryptoglandular) perianal fistulas: possible clues to underlying pathogenesis?

ECCO'20 Vienna

Year: 2020
Authors:

S. Adegbola1, M. Sarafian2, K. Sahnan1, P. Tozer1, N. Ding3, O. Faiz1, J. Warusavitarne1, R. Phillips1, E. Holmes2, A. Hart3

1St. Mark’s Hospital, Department of Colorectal Surgery, Harrow, UK, 2Imperial College London, Computational Systems Division, London, UK, 3St. Mark’s Hospital, Inflammatory Bowel Diseases Unit, Harrow, UK

P078 Efficiency of evaluating the expression of Toll-like receptors 2, 4, 6 and proteins proteomic profiling as integral indicators for predicting the risk of early relapse of ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

G. Tarasova, A. Volkov, A. Iakovlev, T. Ghazudin, I. Shcherbakova

Rostov State Medical University, Gastroenterology, Rostov-on-Don, Russian Federation

P079 High-dimensional mass cytometry after local MSC treatment in patients with refractory proctitis shows an effect on the myeloid compartment: preliminary data

ECCO'20 Vienna

Year: 2020
Authors:

L. Ouboter Drs.1,2, M.C. Barnhoorn1, L.J.A.C. Hawinkels1, M. van Pel2, J.J. Zwaginga2, H.W. Verspaget1, F. Koning2, M.F. Pascutti2, A.E. van der Meulen-de Jong1

1Leiden University Medical Center, Gastroenterology and Hepatology, Leiden, The Netherlands, 2Leiden University Medical Center, Immunohematology and Blood Transfusion, Leiden, The Netherlands

P080 Therapeutical effect of urine-derived stem cells on DSS-induced chronic model of mice

ECCO'20 Vienna

Year: 2020
Authors:

X.R. Wu, C. Zhou, H.S. Liu, L. Xuan-hui, T. Hu, X.B. Zheng, Z.X. Liang, X.J. Wu, X. Gao, X.S. He, J. Ke, Y.F. Chen, X.W. He, J.C. Hu, Y. Zou, P. Lan

The Sixth Affiliated Hospital, Sun Yat-Sen University South Campus, Department of Colorectal Surgery, Guangzhou, China

P081 The structure of the proteomic profile and gut microbiota in patients with primary immunodeficiency, common variable immunodeficiency and inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

A.A. Iakovlev, A. Volkov, O. Bashtovaya, I. Shcherbakova, T. Ghazudin, G. Leonova, G. Tarasova

Rostov State Medical University, Department of Gastroenterology, Rostov-on-Don, Russian Federation

P082 Spicy food is a vital trigger for relapse in patient with inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

Y. Chen, C. Ma, Y. Dang, K. Chen, S. Shen, M. Jiang, Z. Zeng, H. Zhang

West China Hospital, Gastroenterology, Chengdu, China