¹Hôpital Saint Philibert, Pathologie Digestive, Lomme, France, ²Epimad Registry- Maison de la Recherche CHU Lille, Public Health- Epidemiology, Lille, France, ³CHU Rouen, Service d’Hépato-Gastroentérologie et Oncologie Digestive, Rouen, France, ⁴CHU Amiens, Service d’Hépato-Gastroentérologie, Amiens, France, ⁵Hôpital Huriez- CHU Lille, Maladies de l’Appareil Digestif, Lille, France

¹Centre of Molecular Inflammation Research, Norwegian University of Science and Technology NTNU, Trondheim, Norway, ²Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology NTNU,Trondheim, Norway, ³Department of Gastroenterology, St. Olav’s University Hospital, Trondheim, Norway

¹Clermont-Auvergne University, M2iSH Laboratory, Clermont-Ferrand, France, ²INRA, Plateforme d’Exploration du Métabolisme- Composante Protéomique PFEMcp, Saint-Genès-Champanelle, France, ³INRA, UMR Microbiologie Environnement Digestif Santé MEDiS, Saint-Genès-Champanelle, France, ⁴CHU, Gastro-entérologie, Clermont-Ferrand, France

¹Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK, ²Cancer, Aging and Somatic Mutations, Wellcome Trust Sanger Institute, Hinxton, UK, ³Department of Gastroenterology, Addenbrooke’s Hospital, Cambridge, UK, ⁴Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

Charité Universitätsmedizin Berlin – Campus Benjamin Franklin, Berlin, Germany

¹Hospital of the Ludwig Maximilian Universität, General Visceral und Transplantation Surgery, München, Germany, ⁵Hospital of the Ludwig Maximilian Universität, Department of Medicine II, München, Germany

Department of Gastroenterology and Hepatology, University Hospital Zurich, c/o University of Zurich, Zurich, Switzerland

¹Department of Chemistry, University of Cambridge, Cambridge, UK, ²Earlham Institute, Norwich, UK, ³Gut Microbes and Health Programme, Quadram Institute, Norwich, UK, ⁴Department of Gastroenterology, Norfolk and Norwich University Hospitals, Norwich, UK, ⁵Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium, ⁶Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium, ⁷Department of Genetics, Eötvös Loránd University, Budapest, Hungary

¹Department of Gastroenterology, Evangelismos Hospital, Athens, Greece, ²Department of Gastroenterology, St. Paul’s Hospital, Vancouver, Canada, ³Department of Gastroenterology, Sheba Medical Center, Tel Aviv, Israel, ⁴Evidera, Real-World Evidence, Montreal, Canada, ⁵Evidera, Real-World Evidence, San Francisco, USA, ⁶Department of Medical Affairs, Takeda Pharmaceuticals USA Inc., Deerfield, USA, ⁷Department of Medical Affairs, Takeda Canada Inc., Oakville, Canada, ⁸Department of Medical Affairs, Takeda Hellas S.A. Athens, Athens, Greece, ⁹Department of Global Medical Affairs, Takeda Pharmaceuticals International AG, Zurich, Switzerland, ¹⁰Evidence Generation and Publications, Takeda Pharmaceuticals International, Singapore, ¹¹Global Outcomes Research, Takeda Pharmaceuticals International, Boston, USA, ¹²Department of Gastroenterology, Medical College of Wisconsin, Milwaukee, USA

¹Department of Gastroenterology, University of California San Diego, La Jolla, USA, ²Department of Gastroenterology and Hepatology, Auckland City Hospital, Auckland, New Zealand, ³Department of Gastroenterology, Concord and Macquarie University Hospitals, Sydney, Australia, ⁴Strategic Market Access, Janssen Global Services- LLC, Malvern, USA, ⁵Department of Clinical Biostats, Janssen Research and Development- LLC, Spring House, USA, ⁶Department of Immunology, Janssen Research and Development- LLC, Spring House, USA, ⁷Department of Gastroenterology, Humanitas Research Hospital, Milan, Italy

¹Department of Gastroenterology and Liver Diseases, Tel Aviv Medical Center, Tel Aviv, Israel, ²Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ³The Edinburgh IBD Unit, Western General Hospital, Edinburgh, UK, ⁴Department of Gastroenterology and Liver Diseases, Sheba Medical Center, Ramat Gan, Israel, ⁵IBD Center, Division of Gastroenterology, Rabin Medical Center, Petah Tikvah, Israel, ⁶Digestive Diseases Institute, Shaare Zedek Medical Center, Jerusalem, Israel, ⁷Hadassah Medical School, Hebrew University of Jerusalem, Jerusalem, Israel, ⁸The University of Edinburgh, Western General Hospital Campus, Center for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK

¹Department of Gastroenterology and Hepatology, Radboudumc, Nijmegen, The Netherlands, ²Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands, ³Department of Gastroenterology and Hepatology, Amphia Hospital, Breda, The Netherlands, ⁴Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands, ⁵Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands, ⁶Department of Gastroenterology and Hepatology, Amsterdam University Medical Center- AMC, Amsterdam, The Netherlands, ⁷Department of Gastroenterology and Hepatology, Zuyderland Medical Center, Sittard, The Netherlands, ⁸Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands, ⁹Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, The Netherlands, ¹⁰Department of Gastroenterology and Hepatology, Haaglanden Medical Center, Den Haag, The Netherlands, ¹¹Department of Gastroenterology and Hepatology, Sint Franciscus Hospital, Rotterdam, The Netherlands, ¹²Department of Gastroenterology and Hepatology, Jeroen Bosch Hospital, ‘s-Hertogenbosch, The Netherlands, ¹³Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, The Netherlands, ¹⁴Department of Gastroenterology and Hepatology, OLVG Hospital, Amsterdam, The Netherlands, ¹⁵Department of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, The Netherlands

¹Icahn School of Medicine at Mount Sinai Hospital, New York, New York, USA, ²Penn Presbyterian Medical Center, Philadelphia, PA, USA, ³Clínica Las Condes, Santiago, Chile, ⁴Pfizer Inc., Collegeville, PA, USA, ⁵Medical University of Vienna, Vienna, Austria

¹Department of Gastrointestinal Immunopathology, Humanitas University, Milan, Italy, ²Gastroenterology and Hepatology Unit, Canberra Hospital, Canberra, Australia, ³University of the Free State, Department of Gastroenterology, Bloemfontein- Free State, South Africa, ⁴Department of Global Medical Affairs, Takeda Pharmaceuticals International AG, Zurich, Switzerland, ⁵Statistical and Quantitative Sciences, Data Sciences Institute, Takeda Pharmaceuticals International AG, Zurich, Switzerland, ⁶Chief Medical Office, Global Medical Research, Takeda Pharmaceuticals International AG, Zurich, Switzerland, ⁷Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium

¹Division of Gastroenterology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, USA, ²Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA, ³Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, Province of China, ⁴Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil, ⁵Pfizer Inc., Collegeville, PA, USA, ⁶University College London Hospitals NHS Foundation Trust, London, UK, UK

¹Surgery of the Alimentary Tract, Sant’Orsola Hospital, Alma Mater Studiorum University of Milan, Bologna, Italy, ²Inflammatory Bowel Disease Unit, Sant’Orsola Hospital, Alma Mater Studiorum University of Milan, Bologna, Italy

¹Department of Gastroenterology, IBD Center, Humanitas Research Hospital, Rozzano, Italy, ²Inserm U954, Nancy University Hospital, IBD Unit, Nancy, France

¹Department of Biology, Morphic Therapeutic, Waltham, USA, ²Department of Chemistry, Morphic Therapeutic, Waltham, USA, ³Department of Drug Metabolism and Pharmacokinetics, Morphic Therapeutic, Waltham, USA, ⁴Department of Structural Biology, Morphic Therapeutic, Waltham, USA, ⁵Department of Development, Morphic Therapeutic, Waltham, USA, ⁶Department of Translational Sciences, Morphic Therapeutic, Waltham, USA

¹Eli Lilly and Company, Lilly Biomedicines, Indianapolis IN, USA, ²Centre for Inflammation Biology and Cancer Immunology, King’s College London, London, UK, ³Lilly Biotechnology Center, Eli Lilly and Company, Sand Diego, CA, USA, ⁴Division of Gastroenterology, University California San Diego, La Jolla, CA, USA, ⁵Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

¹Humanitas Research Hospital, IBD Center, Milano, Italy, ²Icahn School of Medicine at Mount Sinai, Division of Pediatric Gastroenterology and The Mindich Child Health and Development Institute, New York, USA, ³Department of Pharmacy, University of Naple, Naple, Italy, ⁴Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, USA, ⁵The Leona M. and Harry B. Helmsley Charitable Trus, The Leona M. and Harry B. Helmsley Charitable Trust, New York, USA, ⁶Icahn School of Medicine at Mount Sinai, The Precision Immunology Institute, New York, USA