¹Department of Surgery, Amsterdam UMC-location AMC, Amsterdam, The Netherlands, ²Department of Gastroenterology and Hepatology, Amsterdam UMC-location AMC, Amsterdam, The Netherlands

¹Exeter IBD Pharmacogenetics Research Group, University of Exeter, Exeter, UK, ²Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK, ³Translational Exchange @ Exeter- Living Systems Institute, University of Exeter, Exeter, UK, ⁴Department of Research and Development, AbbVie Inc., North Chicago, USA

¹Cedars Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA, ²Cedars Sinai Medical Center, Department of Surgery, Los Angeles, CA, USA

¹Massachusetts General Hospital, Division of Gastroenterology, Boston, USA, ²Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, USA, ³Department of Molecular Biology, Massachusetts General Hospital, Boston, USA

¹Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium, ²Laboratory for Complex Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, ³Department of Electrical Engineering ESAT, KU Leuven, Leuven, Belgium, ⁴Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium, ⁵Department of Gastroenterology, University Hospital of Ghent, Ghent, Belgium, ⁶Department of Gastroenterology, University Hospitals Brussels, Brussels, Belgium

Janssen Research and Development- LLC, Immunology, Spring House, USA

¹Hospital of the Ludwig Maximilian Universität, General, Visceral- und Transplantation Surgery, München, Germany, ²Hospital of the Ludwig Maximilian Universität, Institute of Laboratory Medicine, München, Germany, ³Hospital of the Ludwig Maximilian Universität, Department of Medicine II, München, Germany

¹Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Basic Sciences, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel, ³Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland, ⁴Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, ⁵Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel

¹APHP Saint Louis, Gastroenterology, Paris, France, ²INSERM, Unité U1160, Paris, France

¹Department of Gastroenterology, Center for Crohn’s and Colitis, Kyung Hee University College of Medicine, Seoul, Korea Republic of, ²Department of Biology, Kyung Hee University College of Sciences, Seoul, Korea Republic of

¹Department of Gastroenterology, Erasme University Hospital- ULB, Brussels, Belgium, ²Institut Jules Bordet, Department of Pathology, Brussels, Belgium, ³Department of Gastroenterology, University Hospital Ghent, Ghent, Belgium, ⁴Department of Gastroenterology, CHU UCL Namur, Yvoir, Belgium, ⁵Department of Gastroenterology, AZ Delta, Roeselare, Belgium, ⁶Department of Gastroenterology, University Hospital Antwerp, Edegem, Belgium, ⁷Department of Gastroenterology, University Hospital Liège, Liège, Belgium, ⁸Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium

¹Department of Gastroenterology, Hopital Erasme, Brussels, Belgium, ²Laboratory of Experimental Gastroenterology, ULB, Brussels, Belgium

¹Center for Advanced IBD Research and Treatment, Kitasato Institute Hospital, Kitasato University, Tokyo, Japan, ²IBD Center, Sapporo Kosei General Hospital, Sapporo, Japan, ³Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya, Japan, ⁴Yokkaichi Hazu Medical Centre, IBD Centre, Yokkaichi, Japan, ⁵Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan, ⁶Department of Endoscopy and Medicine, Hiroshima University, Hiroshima, Japan, ⁷Department of Gastroenterology and Hepatology, School of Medicine, Kyorin University, Mitaka, Japan, ⁸Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan, ⁹Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan, ¹⁰Department of Intestinal Inflammation Research, Hyogo College of Medicine, Nishinomiya, Japan, ¹¹Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan, ¹²Department of Pathology, Hirosaki Municipal Hospital, Morioka, Japan, ¹³Department of Data Science, Yokohama City University, Yokohama, Japan, ¹⁴IBD Center, Toho University Sakura Medical Center, Sakura, Japan

Center for Primary Care and Public Health, University of Lausanne, Epidemiology and Health Services, Lausanne, Switzerland

¹Wolfson Endoscopy Unit, St Mark’s Hospital, London, UK, ²Division of Surgery and Cancer, Imperial College London, London, UK, ³Barts Cancer Institute, Queen Mary University of London, London, UK, ⁴Inflammatory Bowel Diseases Unit, St Mark’s Hospital, London, UK, ⁵Gastroenterology Department, National University Hospital, Singapore, ⁶Translational Gastroenterology Unit, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK, ⁷Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, London, UK, ⁸Barts and the London School of Medicine and Dentistry, Centre for Immunobiology, Queen Mary University of London, London, UK, ⁹Endoscopy Unit, University College London Hospital, London, UK

¹Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, ²Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USA, ³Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark

Copenhagen University Hospital Hvidovre, The Gastrounit, Hvidovre, Denmark

¹Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands, ²Department of Health and Nursing Sciences, University of the Faroe Islands, Torshavn, Faroe Islands, ³Department of Occupational Medicine and Public Health, The Faroese Hospital System, Torshavn, Faroe Islands

¹Division of Gastroenterology, McGill University, Montreal, Canada, ²Department of Medicine I, Semmelweis University, Budapest, Hungary

¹Laboratory of Complex Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, ²Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Republic of, ³Department Chronic Diseases Metabolism and Ageing CHROMETA, Translational Research Center for Gastrointestinal Disorders TARGID, KU Leuven, Leuven, Belgium, ⁴Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium