P019: GS-1069518 is a potent and selective small molecule α4β7 inhibitorECCO'22Year: 2022
Authors: Wang, Y.(1);Zhou, J.(2);Chang, C.(3);Roedder, S.(3);Bonne-Annee, S.(1);Marchand, B.(4);Hung, K.(4);Currie, K.(5);Clarke, A.(1);
(1)Gilead Sciences- Inc., Inflammation Biology, Seattle, United States;(2)Gilead Sciences- Inc., Oncology Biology, Seattle, United States;(3)Gilead Sciences- Inc., Biomarkers, Foster City, United States;(4)Gilead Sciences- Inc., Discovery Sciences, Foster City, United States;(5)Gilead Sciences- Inc., Medicinal Chemistry, Seattle, United States;
P020: Differential expression of miR-424-5p and miR-378c in stenotic and penetrating lessions of Crohn’s Disease associates with altered transcription of genes involved in vascular regulationECCO'22Year: 2022
Authors: Coll, S.(1);Seco, M.(1);Bauset, C.(1);Lis, L.(1);Cosín-Roger, J.(2);Ortiz-Masia, D.(3);Gisbert-Ferrandiz, L.(1);Barrachina, D.(1);Calatayud, S.(1);
(1)Faculty of Medicine - University of Valencia, Pharmacology, Valencia, Spain;(2)FISABIO, Unidad Mixta Facultad de Medicina-Hospital Dr Peset, Valencia, Spain;(3)Faculty of Medicine - University of Valencia, Medicine, Valencia, Spain;
P021: Vitamin D receptor-dependent protective effect of moderate hypoxia in a mouse colitis model Running title: Hypoxia prevents mouse colitis through VDRECCO'22Year: 2022
Authors: Wang, Z.(1);Hong, Y.(2);Hong, L.(3);Changzhi, H.(4);Jiaming, Q.(3);
(1)Peking Union Medical College Hospital, Gastroenterology, Beijing- China, China;(2)Peking Union Medical College Hospital, Gastroenterology, Beijng, China;(3)Peking Union Medical College Hospital, Gastroenterology, Beijing, China;(4)Cancer Hospital- CAMS and PUMC, State Key Laboratory of Molecular Oncology, Beijing, China;
P022: Transcriptional biomarkers for vedolizumab therapy response in patients with moderate to severe Ulcerative Colitis.ECCO'22Year: 2022
Authors: Arosa García, L.(1);Camba-Gómez, M.(1);Calviño-Suárez, C.(2);Bastón-Rey, I.(2);Ferreiro-Iglesias, R.(2);Porto , M.(2);Nieto-García , L.(2);Domínguez-Muñoz, J.E.(2);Barreiro-de Acosta , M.(2);Conde-Aranda, J.(1);
(1)Health Research Institute of Santiago de Compostela IDIS, Molecular and Cellular Gastroenterology, Santiago de Compostela, Spain;(2)University Hospital of Santiago de Compostela, Department of Gastroenterology and Hepatology, Santiago de Compostela, Spain;Molecular and Cellular Gastroenterology
P024: CD40 and key CD40/CD154 pathway members are significantly upregulated in inflamed lesional IBD biopsies as shown by whole transcriptome AmpliSeq gene expression profiling and corresponding immunohistochemistry.ECCO'22Year: 2022
Authors: Raulf, F.(1);Delucis-Bronn, C.(1);Angevaare, E.(1);Caesar, N.(1);Marcantonio, A.(1);Ceci, M.(1);Regnier, C.(1);Bonal, C.(2);Siegel, R.(2);Niess, J.H.(3);Wieczorek, G.(1);Hrúz, P.(3);
(1)Novartis Pharma AG / Novartis Institutes for BioMedical Research, Autoimmunity- Transplantation and Inflammation Disease Area, Basel, Switzerland;(2)Novartis Pharma AG / Novartis Institutes for BioMedical Research, Translational Medicine, Basel, Switzerland;(3)Clarunis AG, University Center for Gastrointestinal and Liver Diseases, Basel, Switzerland;
P026: Inflammatory bowel disease does not preclude the presence of environmental enteropathy in Zambian adultsECCO'22Year: 2022
Authors: Hodges, P.(1);Mulenga, C.(2);Banda, R.(2);Kelly, P.(1);
(1)Queen Mary University of London, Blizard Institute- Barts and the London School of Medicine and Dentistry, London, United Kingdom;(2)University of Zambia School of Medicine, Tropical Gastroenterology and Nutrition Group, Lusaka, Zambia;
P027: Effects of anti-TNF and anti-α4β7 drugs on circulating monocytes migratory capacity in inflammatory bowel diseaseECCO'22Year: 2022
Authors: Soleto, I.(1);Fernández-Tomé, S.(2);Mora-Gutiérrez, I.(3);Baldan-Martin, M.(1);Ramirez, C.(1);Santander, C.(1);Moreno-Monteagudo, J.A.(1);Casanova, M.J.(1);Casals, F.(1);Casabona, S.(1);Becerro, I.(1);Chaparro, M.(1);Bernardo, D.(4);Gisbert, J.P.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria IIS-IP and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Unidad de Enfermedad Inflamatoria Intestinal, Madrid, Spain;(2)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria IIS-IP and Departamento de Nutrición y Ciencia de los Alimentos- Facultad de Farmacia- Universidad Complutense de Madrid, Unidad de Enfermedad Inflamatoria Intestinal, Madrid, Spain;(3)Biobanco del sistema de salud de Aragón, Biobanco, Zaragoza, Spain;(4)Mucosal Immunology Lab- Instituto de Biología y Genética Molecular IBGM- Universidad de Valladolid-CISC, Mucosal Immunology, Valladolid, Spain;
P028: Inhibition of stromal glycolysis by targeting PFKFB3 decreases experimental colitisECCO'22Year: 2022
Authors: Zhou, Z.(1);Plug, L.G.(1);de Jonge-Muller, E.S.M.(1);Abou Elmagd , A.(1);van der Meulen-de Jong, A.E.(1);Barnhoorn , M.C.(1);Hawinkels, L.J.A.C.(1);
(1)Leiden University Medical Center, Department of Gastroenterology and Hepatology, Leiden, The Netherlands;
P029: Expression of miR-21 in mucosal biopsies give clues to anti-TNF treatment non-response in IBD children and adultsECCO'22Year: 2022
Authors: Pallikkunnath James, J.(1);Schnack Nielsen, B.(2);Langholz, E.(3,4);Mikkel , M.(5,6,7);Estrid , H.(1);Buhl Riis, L.(8);
(1)Herlev University Hospital, Department of Pathology, 2730- Herlev, Denmark;(2)Bioneer A/S, Molecular histology and detection, 2970 Hørsholm, Denmark;(3)Herlev University Hospital, Gastroenheden D, 2730 Herlev, Denmark;(4)University of Copenhagen, Institute for Clinical Medicine, 2200 Copenhagen, Denmark;(5)Hvidovre Hospital- Universty of Copenhagen, The Pediatric Department, 2650 Hvidovre, Denmark;(6)Hvidovre Hospital- University of Copenhagen, Copenhagen Center for Inflammatory Bowel Disease in Children- Adolescents and Adults, 2650 Hvidovre, Denmark;(7)Holbæk Sygehus, The Pediatric Department, 4300 Holbæk, Denmark;(8)Herlev University Hospital, Department of Pathology-, 2730- Herlev, Denmark;
P030: Distinct molecular profiles between idiopathic cryptoglandular and Crohn-related perianal fistulasECCO'22Year: 2022
Authors: Verstockt., B.(1,2);Verstockt, S.(2);Bislenghi, G.(3);Sabino, J.(1,2);Ferrante, M.(1,2);D'Hoore, A.(3);Vermeire, S.(1,2);
(1)University Hospitals Leuven, Dpt. Gastroenterology and Hepatology, Leuven, Belgium;(2)KU Leuven, Dpt. Chronic Diseases and Metabolism, Leuven, Belgium;(3)University Hospitals Leuven, Dpt. Abdominal Surgery, Leuven, Belgium;
P031: Intestinal lymphoepithelial interactions in Crohn's disease: modeling alphaE-beta7 and NKG2D blockadeECCO'22Year: 2022
Authors: Hammoudi, N.(1);Hamoudi, S.(2);Bonnereau, J.(2);Bottois, H.(2);Perez, K.(2);Bezault, M.(2);Hassid, D.(1);Chardiny, V.(2);Celine, G.(2);Gergaud, B.(2);Bonnet, J.(1);Chedouba, L.(1);Tran Minh, M.L.(1);Gornet, J.M.(1);Baudry, C.(1);Corte, H.(3);Maggiori, L.(3);Toubert, A.(2);McBride, J.(4);Brochier, C.(5);Neighbors, M.(4);Le Bourhis, L.(2);Allez, M.(1);
(1)APHP Saint Louis, Gastroenterology, Paris, France;(2)Inserm, Unit 1160, Paris, France;(3)APHP Saint Louis, Digestive Surgery, Paris, France;(4)Genentech, OMNI Biomarker Development, San Francisco, United States;(5)Roche, Roche, Boulogne-Billancourt, France;
P032: Host transcriptome signatures in human fecal-washes predict histological remission in IBD patientsECCO'22Year: 2022
Authors: Ungar, B.(1);Yavzori, M.(1);Fudim, E.(1);Picard, O.(1);Kopylov, U.(1);Eliakim, R.(1);Shouval, D.(2);Levin, Y.(3);Savidor, A.(3);Ben-Moshe, S.(4);Manco, R.(4);Dan, S.(4);Egozi, A.(4);Bahar Halpern, K.(4);Mayer, C.(5);Barshak, I.(5);Ben-Horin, S.(1);Itzkovitz, S.(4);
(1)Tel-HaShomer Sheba Medical Center, Department of Gastroenterology, Ramat Gan, Israel;(2)Schneider Children’s Medical Center, Gastroentreology- Nutrition and Liver Diseases, Petah Tikva, Israel;(3)The Nancy and Stephen Grand Israel National Center for Personalized Medicine, The De Botton Institute for Protein Profiling, Rehovot, Israel;(4)Weizmann Institute of Science- Rehovot- Israel, Molecular Cell Biology, Rehovot, Israel;(5)Sheba Medical Center Tel Hashomer, Pathology Institute, Ramat Gan, Israel;
P033: Single-cell analysis of gut mucosal- and peripheral blood cells in ulcerative colitis patients undergoing vedolizumab treatmentECCO'22Year: 2022
Authors: Karmi, N.(1);Sun, S.(1);de Jong, S.(1);Bangma, A.(1);Teunis, J.(2);Paraskevopoulou, M.(3);Juarez, J.(3);Bleck, B.(3);Farahmand, S.(3);Weersma, R.(1);Bigaeva, E.(1);Festen, E.(1);
(1)University Medical Center Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(2)University Medical Center Groningen, Flow Cytometry Unit, Groningen, The Netherlands;(3)Takeda Pharmaceuticals, GI Drug Discovery Unit, Cambridge MA, United States;
P034: DISRUPTive liquid biopsies in Inflammatory Bowel Disease (DISRUPT-IBD): Release of exosomal and molecular tissue signals by transabdominal ultrasound?ECCO'22Year: 2022
Authors: Tran, F.(1,2);Scharmacher, A.(1);Mishra, N.(1);Barann, N.(1);Sievers, L.K.(1,2);Juzenas, S.(1);Bernardes, J.P.(1);Lessing, M.(2);Lassen, A.(2);Rosenstiel, P.(1);Schreiber, S.(1,2);
(1)University Medical Center- Schleswig-Holstein- Kiel Campus, Institute of Clinical Molecular Biology, Kiel, Germany;(2)University Medical Center- Schleswig-Holstein- Kiel Campus, Department of Internal Medicine I, Kiel, Germany;
P035: An examination of resting state functional connectivity in patients with active Crohn’s diseaseECCO'22Year: 2022
Authors: Thapaliya, G.(1);Eldeghaidy, S.(2);Radford, S.(3);Francis, S.(2);Moran, G.(3);
(1)Johns Hopkins- School of Medicine, Department of Psychiatry, Baltimore, United States;(2)University of Nottingham, Sir Peter Mansfield Imaging Centre- School of Physics and Astronomy, Nottingham, United Kingdom;(3)University of Nottingham, NIHR Nottingham Biomedical Research Centre- Nottingham University Hospitals NHS Trust and School of Medicine, Nottingham, United Kingdom;
P036: Identification and functional analysis of stromal subsets in experimental IBD mouse modelsECCO'22Year: 2022
Authors: Zhou, Z.(1);Plug, L.G.(1);de Jonge-Muller, E.S.M.(1);van de Beek, L.M.(1);Brands, L.(1);van der Meulen-de Jong, A.E.(1);Hawinkels, L.J.A.C.(1);Barnhoorn, M.C.(1);
(1)Leiden University Medical Center, Department of Gastroenterology and Hepatology, Leiden, The Netherlands;
P037: MicroRNA-31 and microRNA-200 family reflect disease activity in Crohn’s disease: results from the BIOMIR studyECCO'22Year: 2022
Authors: Cristina, T.(1);Mateescu, B.(2);Mitroi, A.(3);Cozaru, G.(3);Brinzan, C.(3);State, M.(2);Dumitru, A.(1);Rafti, R.(1);Dina, E.(1);Alexandrescu, L.(1);Dumitru, E.(1);
(1)County Clinical Emergency Hospital of Constanta, Gastroenterology, Constanta, Romania;(2)Colentina Hospital Bucharest, Gastroenterology, Bucharest, Romania;(3)County Clinical Emergency Hospital of Constanta, Genetics, Constanta, Romania;
P038: Targeting the hepcidin-ferroportin axis with Nrf2 agonists to treat iron deficiency anaemia in Inflammatory Bowel DiseaseECCO'22Year: 2022
Authors: Martin, J.(1,2);Aksan, A.(1,2,3);Steinhilber, D.(2);Ulrich-Rückert, S.(1,2);Stein, J.M.(1,2,4);
(1)Interdisciplinary Crohn-Colitis Centre Rhein-Main, Clinical Research, Frankfurt am Main, Germany;(2)Goethe University Frankfurt, Institute of Pharmaceutical Chemistry, Frankfurt am Main, Germany;(3)Justus-Liebig University Giessen, Institute of Nutritional Science, Giessen, Germany;(4)DGD Clinics Sachsenhausen, Department of Gastroenterology and Clinical Nutrition, Frankfurt am Main, Germany;
