P898: Uncovering of tissue-associated risk factors that lead to different genetic risk profiles across Inflammatory Bowel Disease patientsECCO’23 CopenhagenYear: 2023
Authors: Gaite, A.(1)*;Sánchez-Mayor, M.(1);Bujanda, L.(2);M. Marigorta, U.(1);
(1)CIC bioGUNE, Integrative Genomics, Derio, Spain;(2)Biodonostia, Gastrointestinal Disease Group, San Sebastián, Spain;
P899: Analysis of IL-23 receptor genetic variants associations with gut microbiome composition and barrier function in a cohort of healthy first-degree relatives of subjects with Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Leibovitzh, H.(1)*;Neustaeter, A.(1);Lee, S.H.(1);Xue, M.(1);Espin-Garcia, O.(2);Olivera, P.A.(1);Mbareche, H.(1);Huynh, H.Q.(3);Griffiths, A.M.(4);Turner, D.(5);Madsen, K.L.(6);Silverberg, M.S.(1);Steinhart, A.H.(1);Mack, D.R.(7);Jacobson, K.(8);Moayyedi, P.(9);Aumais, G.(10);Bernstein, C.N.(11);Marshall, J.K.(9);Panaccione, R.(12);Xu, W.(2);Turpin, W.(1);Croitoru, K.(1);
(1)Zane Cohen Centre for Digestive Diseases- Mount Sinai Hospital, Division of Gastroenterology & Hepatology- Temerty Faculty of Medicine- University of Toronto, Toronto, Canada;(2)Dalla Lana School of Public Health- University of Toronto- Toronto- Ontario- Canada, Division of Biostatistics, Toronto, Canada;(3)Faculty of Medicine and Dentistry- University of Alberta- Edmonton- Alberta- Canada, Division of Gastroenterology and Nutrition- Department of Pediatrics, Edmonton, Canada;(4)Faculty of Medicine- University of Toronto- Toronto- Ontario- Canada, IBD Center- The Hospital for Sick Children- Department of Paediatrics, Toronto, Canada;(5)Shaare Zedek Medical Center- The Hebrew University of Jerusalem- Jerusalem- Israel, The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Jerusalem, Israel;(6)University of Alberta, Department of Medicine- Division of Gastroenterology- Edmonton- Alberta- Canada, Edmonton, Canada;(7)Children's Hospital of Eastern Ontario and University of Ottawa- Ottawa- Ontario- Canada, Division of Gastroenterology- Hepatology & Nutrition, Ottawa, Canada;(8)British Columbia Children's Hospital Research Institute- University of British Columbia- Vancouver- British Columbia- Canada, Canadian Gastro-Intestinal Epidemiology Consortium- Canada- British Columbia Children's Hospital, Vancouver, Canada;(9)Farncombe Family Digestive Health Research Institute- Hamilton- Ontario- Canada, Department of Medicine- McMaster University, Hamilton, Canada;(10)Montreal University- Montreal- Quebec- Canada, Hôpital Maisonneuve-Rosemont- Department of Medicine, Montreal, Canada;(11)Rady Faculty of Health sciences- University of Manitoba- Winnipeg- MB- Canada, University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre and Department of Internal Medicine- Max Rady College of Medicine, Manitoba, Canada;(12)University of Calgary- Calgary- Alberta- Canada, Inflammatory Bowel Disease Clinic- Division of Gastroenterology and Hepatology of Gastroenterology, Calgary, Canada;The Genetics Environment Microbial Project (CCC-GEM) cohort
P900: Studying causality association of ustekinumab with cardiovascular disease outcomes using Mendelian randomizationECCO’23 CopenhagenYear: 2023
Authors: Miguel González, J.A.(1)*;Sánchez Mayor, M.(1);Cervera Seco, L.M.(1);Gaite Reguero, A.(1);Pavlidis, P.(2);Martínez Marigorta, U.(1);
(1)CIC bioGUNE, Integrative Genomics, Bilbao, Spain;(2)King's College London, Immunology, London, United Kingdom;
P901: A genetic analysis of familial aggregation in Inflammatory Bowel Disease multiplex familiesECCO’23 CopenhagenYear: 2023
Authors: Jans, D.(1)*;Lee, H.S.(2);Ferrante, M.(3,4);Vermeire, S.(3,4);Cleynen, I.(1);
(1)KU Leuven, Department of Human Genetics- Laboratory for Complex Genetics, Leuven, Belgium;(2)University of Ulsan College of Medicine, Department of Biochemistry and Molecular Biology, Seoul, Korea- Republic Of;(3)KU Leuven, Department of Chronic Diseases- Metabolism and Ageing CHROMETA, Leuven, Belgium;(4)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;
P902: Native American Mapuche ancestry is related to higher IBD risk in ChileansECCO’23 CopenhagenYear: 2023
Authors: Pérez, T.(1,2)*;Bustamante, M.L.(3);Magne, F.(3);Travisany, D.(4);Alvarez-Lobos, M.(1);Hernandez-Rocha, C.(1);Azocar, L.(1);Aguilar, N.(1);Espino, A.(1);Estela, R.(2);Escobar, S.(2);Zazueta, A.(3);Baez, P.(5);Silva, V.(2);Arriagada, E.(2);Barahona, C.(6);Zollner, L.(6);Miquel , J.F.(1);Lorenzo-Bermejo, J.(6);
(1)Pontificia Universidad Católica de Chile, Department of Gastroenterology, Santiago, Chile;(2)Hospital San Borja Arriarán, Department of Gastroenterology, Santiago, Chile;(3)University of Chile, Faculty of Medicine- ICBM, Santiago, Chile;(4)Universidad de la Americas, NIDS- Núcleo de Investigación en Data Science- Facultad de Ingeniería y Negocios, Santiago, Chile;(5)University of Chile, Center for Mathematical Modeling - University of Chile ..., Santiago, Chile;(6)University of Heidelberg, Statistical Genetics Research Group- Institute of Medical Biometry and Informatics, Heidelberg, Germany;
P903: Lactase non-persistence and Inflammatory Bowel Disease in a Basque cohortECCO’23 CopenhagenYear: 2023
Authors: Garcia-Etxebarria, K.(1,2)*;Merino, O.(3);Ezcurra, A.(4);Segues, N.(4);Arzallus, T.(4);Marigorta, U.M.(5);Vignau, R.(4);Bujanda, L.(2,4);
(1)Biodonostia HRI, Gastrointestinal Genetics Group, Donostia-San Sebastián, Spain;(2)Centro de Investigación Biomédica en Red, Enfermedades Hepáticas y Digestivas, Barcelona, Spain;(3)Hospital Universitario Cruces, Gastroenterology Department, Barakaldo, Spain;(4)Biodonostia HRI, Gastrointestinal Disease Group, Donostia - San Sebastián, Spain;(5)Center for Cooperative Research in Biosciences CIC bioGUNE, Integrative Genomics Lab, Derio, Spain;
P904: Genetic Variants in IBD Chilean Patients are related to clinical outcomes.ECCO’23 CopenhagenYear: 2023
Authors: Pérez, T.(1,2)*;Bustamante, M.L.(3);Travisany, D.(4);Magne, F.(3);Hernandez-Rocha, C.(1);Alvarez-Lobos, M.(1);Orellana, M.(5);Ascui, G.(6);Azocar, L.(1);Espino, A.(1);Aguilar, N.(1);Baez, P.(7);Zazueta, A.(3);Estela, R.(2);Silva, V.(2);Escobar, S.(2);De la Vega, A.(2);Arriagada, E.(2);Miquel, J.F.(1);Alvares, D.(8);
(1)Pontificia Universidad Católica de Chile, Department of Gastroenterology, Santiago, Chile;(2)Hospital San Borja Arriarán, Department of Gastroenterology, Santiago, Chile;(3)University of Chile, Faculty of Medicine- ICBM, Santiago, Chile;(4)Universidad de las Americas, NIDS- Núcleo de Investigación en Data Science- Facultad de Ingeniería y Negocios-, Santiago, Chile;(5)University of Chile, Department of Computer Science- Faculty of Physical Sciences and Mathematics., Santiago, Chile;(6)La Jolla Institute for Immunology, Immunology, San Diego, Chile;(7)University of Chile, Center for Mathematical Modeling, Santiago, Chile;(8)University of Cambridge, MRC Biostatistics Unit, Cambridge, United Kingdom;
P905: Predictive pharmacogenetic risk of pancreatitis in Inflammatory Bowel Disease patients treated with thiopurines: a case-control study from the ENEIDA registry.ECCO’23 CopenhagenYear: 2023
Authors: Guerra Marina, I.(1)*;Barros, F.(2);Chaparro, M.(3,4);Benítez, J.M.(5);Martín Arranz, M.D.(6);de Francisco, R.(7);Piqueras, M.(8);de Castro, L.(9);Carbajo, A.Y.(10);Bermejo, F.(1);Mínguez, M.(11);Gutiérrez, A.(4,12);Mesonero, F.(13);Cañete, F.(4,14);González-Muñoza, C.(15);Calvo, M.(16);Sicilia, B.(17);Alfambra, E.(4,18);Tardillo, C.A.(19);Rivero, M.(20);Lucendo, A.J.(4,21);Bujanda, L.(4,22);Van Domselaar, M.(23);Almela, P.(24);Ramos, L.(25);Fernández Sánchez, M.(26);Hinojosa, E.(27);Verdejo, C.(28);Gimenez, A.(29);Rodríguez-Lago, I.(30);Manceñido, N.(31);Pérez Calle, J.L.(32);Moreno, M.D.P.(33);Delgado-Guillena, P.G.(34);Antolín, B.(35);Ramírez de la Piscina, P.(36);Casanova, M.J.(3,4);Carracedo, Á.(2);Domènech, E.(4,14);Gisbert, J.P.(3,4);
(1)Hospital Universitario de Fuenlabrada, Gastroenterology, Fuenlabrada, Spain;(2)Fundación Pública Galega de Medicina Xenómica - Sergas, Unidad de Medicina Molecular, Santiago de Compostela, Spain;(3)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- UAM, Gastroenterology, Madrid, Spain;(4)Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, Gastroenterology, Spain, Spain;(5)Hospital Universitario Reina Sofía e Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC, Gastroenterology, Córdoba, Spain;(6)Hospital Universitario La Paz, Gastroenterology, Madrid, Spain;(7)Hospital Universitario Central de Asturias- Instituto de Investigación Sanitaria del Principado de Asturias ISPA, Gastroenterology, Oviedo, Spain;(8)Consorci Sanitari Terrasa, Gastroenterology, Terrasa, Spain;(9)Hospital Alvaro Cunqueiro-Complexo Hospitalario Universitario de Vigo- Instituto de Investigación Biomédica Galicia Sur, Gastroenterology, Vigo, Spain;(10)Hospital Universitario Rio Hortega, Gastroenterology, Valladolid, Spain;(11)Hospital Clínico Universitario de Valencia, Gastroenterology, Valencia, Spain;(12)Hospital General Universitario Dr Balmis de Alicante. ISABIAL, Gastroenterology, Alicante, Spain;(13)Hospital Universitario Ramón y Cajal, Gastroenterology, Madrid, Spain;(14)Hospital Universitari Germans Trias i Pujol, Gastroenterology, Badalona, Spain;(15)Hospital de la Santa Creu i Sant Pau, Gastroenterology, Barcelona, Spain;(16)Hospital Universitario Puerta de Hierro-Majadahonda, Gastroenterology, Madrid, Spain;(17)Hospital Universitario de Burgos, Gastroenterology, Burgos, Spain;(18)Hospital Clínico Universitario “Lozano Blesa” e Instituto de Investigación Sanitaria de Aragón IIS Aragón, Gastroenterology, Zaragoza, Spain;(19)Hospital Universitario Nuestra Señora Candelaria, Gastroenterology, Santa Cruz de Tenerife, Spain;(20)Hospital Universitario Marqués de Valdecilla e IDIVAL, Gastroenterology, Santander, Spain;(21)Hospital General de Tomelloso, Gastroenterology, Ciudad Real, Spain;(22)Hospital Donostia/Instituto Biodonostia- Universidad del País Vasco UPV/EHU, Gastroenterology, Donostia/San Sebastian, Spain;(23)Hospital Universitario de Torrejón y Universidad Francisco de Vitoria, Gastroenterology, Madrid, Spain;(24)Hospital General Universitari de Castelló, Gastroenterology, Castelló, Spain;(25)Hospital Universitario de Canarias, Gastroenterology, Santa Cruz de Tenerife, Spain;(26)Hospital General Universitario de Elche, Gastroenterology, Alicante, Spain;(27)Hospital de Manises, Gastroenterology, Valencia, Spain;(28)Hospital General Universitario de Ciudad Real, Gastroenterology, Ciudad Real, Spain;(29)Hospital Sant Joan de Déu-Althaia, Gastroenterology, Manresa, Spain;(30)Hospital de Galdakao, Gastroenterology, Galdakao, Spain;(31)Hospital Universitario Infanta Sofía, Gastroenterology, San Sebastián de los Reyes, Spain;(32)Hospital Universitario Fundación Alcorcón, Gastroenterology, Madrid, Spain;(33)Hospital General La Mancha Centro, Gastroenterology, Alcázar de San Juan- Ciudad Real, Spain;(34)Hospital General de Granollers, Gastroenterology, Granollers, Spain;(35)Hospital Clínico Universitario de Valladolid, Gastroenterology, Valladolid, Spain;(36)Hospital Universitario de Áraba, Gastroenterology, Vitoria, Spain;On behalf of the ENEIDA project of GETECCU.
P906: Prevalence and CARD9 IBD risk variant rs4077515 in a Chilean IBD Cohort.ECCO’23 CopenhagenYear: 2023
Authors: Pérez, T.(1,2)*;Bustamante, M.L.(3);Magne, F.(3);Alvares, D.(4);Álvarez-Lobos, M.(1);Hernandez-Rocha, C.(1);Aguliar, N.(1);Azocar, L.(1);Baez, P.(5);Zazueta, A.(3);Estela, R.(2);Escobar, S.(2);Silva, V.(2);De la Vega, A.(2);Arriagada, E.(2);Espino, A.(1);Miquel, J.F.(1);Travisany, D.(6);
(1)Pontificia Universidad Católica de Chile, Department of Gastroenterology, Santiago, Chile;(2)Hospital San Borja Arriarán, Department of Gastroenterology, Santiago, Chile;(3)University of Chile, Faculty of Medicine- ICBM, Santiago, Chile;(4)University of Cambridge, MRC Biostatistics Unit, Cambridge, United Kingdom;(5)University of Chile, Center for Mathematical Modeling, Santiago, Chile;(6)Universidad de las Americas, NIDS- Núcleo de Investigación en Data Science- Facultad de Ingeniería y Negocios, Santiago, Chile;
P907: NOD2 mutations are associated with the development of inflammatory and progressive digestive tract damage in Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Behnisch, S.(1)*;Reiner, J.(1);Witte, M.(2);Holle, A.(1);Schäffler, H.(1);Huth, A.(1);Jaster, R.(1);Lamprecht, G.(1);
(1)Rostock University Medical Center, Division of Gastroenterology- Department of Medicine II, Rostock, Germany;(2)Rostock University Medical Center, Department of General- Visceral- Thoracic- Vascular and Transplant Surgery, Rostock, Germany;
P908: Faecal Microbiota Transplantation refurbishes the crypt-associated microbiota in Ulcerative colitisECCO’23 CopenhagenYear: 2023
Authors: Markandey, M.(1)*;Bajaj, A.(1);Verma, M.(1);Virmani, S.(1);Singh, M.(1);Gaur, P.(2);Das, P.(3);Srikanth, C.(2);Makharia, G.(1);Kedia, S.(1);Ahuja, V.(1);
(1)All India Institute of Medical Sciences, Department of Gastroenterology, New Delhi, India;(2)Regional Centre for Biotechnology, 3rd milestone Gurugram-Faridabad Expressway, Faridabad, India;(3)All India Institute of Medical Sciences, Department of Pathology, New Delhi, India;
P909: Microbiome dynamics leading up to and during pregnancy in a matched IBD-control cohortECCO’23 CopenhagenYear: 2023
Authors: Binyamin, D.(1); Turjeman, S.(1);Koren, O.(1);Ben Ya'acov, A.(2);Gold, G.(2);Goldenberg, R.(2);Bar-Gil Shitrit, A.(2)*;
(1)Bar-Ilan University, Azrieli Faculty of Medicine, Safed, Israel;(2)Shaare Zedek Medical Center, Digestive Diseases Institute, Jerusalem, Israel;
P910: Emerging role of IL-33/ST2 and Gut Microbiota axis in the inflammatory process of ulcerative colitis patients with ileal pouch-anal anastomosis.ECCO’23 CopenhagenYear: 2023
Authors: Lopetuso, L.R.(1)*;Vetrone, L.(1);Petito, V.(1);Pugliese, D.(1);Parisio, L.(1);Laterza, L.(1);Gasbarrini, A.(1);Scaldaferri, F.(1);Papa, A.(1);
(1)Fondazione Policlinico Universitario "A. Gemelli" IRCCS- Università Cattolica del Sacro Cuore, IBD Unit- Centro Malattie dell'Apparato Digerente - CEMAD, Roma, Italy;
P911: The changes in the faecal microbiome and metabolome in Crohn's disease after treatment with anti-TNFα antibodies are of secondary originECCO’23 CopenhagenYear: 2023
Authors: Hurych, J.(1,2)*;Mascellani Bergo, A.(3);Lerchová, T.(2);Hlináková, L.(1);Kubát , M.(2);Malcová, H.(4);Cebecauerová, D.(4);Schwarz, J.(5);Karásková, E.(6);Hecht, T.(7);Vyhnánek, R.(7);Ťoukálková, L.(8);Dotlačil, V.(9);Kobrová, K.(10);Čížková, A.(11);Horváth, R.(4);Bronsky, J.(2);Havlík, J.(3);Hradský, O.(2);Cinek, O.(2);
(1)Charles University- Second Faculty of Medicine, Department of Medical Microbiology, Prague, Czech Republic;(2)Charles University- Second Faculty of Medicine, Department of Paediatrics, Prague, Czech Republic;(3)Czech Univesity of Life Sciences-Faculty of Agrobiology- Food and Natural Resources, Department of Food Science, Prague, Czech Republic;(4)Motol University Hospital, Department of Pediatric and Adult Rheumatology, Prague, Czech Republic;(5)Charles University- Faculty of Medicine in Pilsen, Department of Paediatrics, Pilsen, Czech Republic;(6)Palacky University Olomouc- Faculty of Medicine-, Department of Paediatrics, Olomouc, Czech Republic;(7)Charles University- First Faculty of Medicine, Department of Paediatrics, Prague, Czech Republic;(8)Tomas Bata Hospital, Department of Paediatrics, Zlin, Czech Republic;(9)Charles University- Second Faculty of Medicine, Department of Paediatric Surgery, Prague, Czech Republic;(10)Masaryk Hospital, Department of Paediatrics, Usti nad Labem, Czech Republic;(11)Synlab Czech- Inc, Sampling station Prague 7, Prague, Czech Republic;
P912: Increased Primary Bile Acids with Ileocolonic Resection Impact Ileal Inflammation and Gut Microbiota in Inflammatory Bowel DiseaseECCO’23 CopenhagenYear: 2023
Authors: Battat, R.(1)*;Scherl, E.(2);Lukin, D.(2);Charilaou, P.(3);Mahtani, P.(4);Gerber, J.(2);Gandara, J.(5);Dündar, F.(6);Zumbo , P.(6);Betel , D.(6);Guo , C.J.(7);Longman, R.(2);
(1)University of Montreal, Gastroenterology and Hepatology, Montreal, Canada;(2)Weill Cornell Medicine, Gastroenterology, New York, United States;(3)Atrium Health, Gastroenterology and Hepatology, Charlotte, United States;(4)Weill Cornell Medicine, Gastroenterology and Hepatology, New York, United States;(5)Weill Cornell Medicine, Microbiome Core, New York, United States;(6)Weill Cornell Medicine, Applied Bioinformatics Core, New York, United States;(7)Weill Cornell Medicine, Medicine, New York, United States;Jill Roberts Institute Live Cell Bank
P915: Uncovering the role of Archaea in the pathogenesis of Inflammatory bowel diseaseECCO’23 CopenhagenYear: 2023
Authors: Singh, P.(1);Murugesan, S.(1); Kumar, M.(1); Saadaoui, M.(1);Elhag, D.A.(1);Hendaus, M.A.(2); Ibrahim, N.(3); Al-Mudhaka, F.(3); AbuHazima, K.(3); Akobeng, A.(3);Elawad , M.(3);Al Khodor, S.(1)*;
(1)Sidra Medicine, Research, Doha, Qatar;(2)Sidra Medicine, Pediatrics, Doha, Qatar;(3)Sidra Medicine, Pediatrics Gastroenterology- Hepatology and Nutrition, Doha, Qatar;
P916: Small bowel permeability improvement is associated with microbial changes seen in mild to moderate active paediatric Crohn's disease patients on nutritional therapyECCO’23 CopenhagenYear: 2023
Authors: VerburgtMD, C.(1,2)*;Dunn, K.(3);Sigall Boneh, R.(4);Wine, E.(5);Benninga, M.(1);de Jonge, W.(2,6);Van Limbergen, J.(1,2);
(1)Emma Children's Hospital- Amsterdam University Medical Centers, Dpt of Paediatric Gastroenterology and Nutrition, Amsterdam, The Netherlands;(2)Amsterdam Gastroenterology Endocrinology Metabolism- University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(3)Dalhousie University, Dpt of Biology, Halifax, Canada;(4)Sackler Faculty of Medicine- Tel Aviv University, Wolfson Medical Center, Tel Aviv, Israel;(5)Stollery Children's Hospital- University of Alberta, Division of Paediatric Gastroenterology, Edmonton, Canada;(6)University of Bonn, Dpt of Surgery, Bonn, Germany;
P917: Intestinal complement interacts with commensal microbiota and provides pattern recognition in Inflammatory Bowel DiseaseECCO’23 CopenhagenYear: 2023
Authors: Reider, S.(1)*;Posch, W.(2);Koch, R.(3);Orth-Höller, D.(4);Würzner, R.(2);Wilflingseder, D.(2);Tilg, H.(3);Moschen, A.(1);
(1)Johannes Kepler University and Kepler University Hospital, Department of Internal Medicine 2 - Gastroenterology and Hepatology, Linz, Austria;(2)Medical University Innsbruck, Department for Hygiene- Microbiology and Public Health, Innsbruck, Austria;(3)Medical University Innsbruck, Department of Internal Medicine I, Innsbruck, Austria;(4)MB-LAB, Mikrobiologisches Labor, Innsbruck, Austria;
