P018: Myeloid diversity in inflammatory bowel disease revealed by single-cell transcriptomicsECCO'21 VirtualYear: 2021
Authors: Garrido Trigo, A.(1);Corraliza, A.M.(1);Melón-Ardanaz, E.(1);Veny, M.(1);Ordás, I.(2);Ricart, E.(2);Masamunt, M.C.(2);Panès, J.(2);Hemberg, M.(3);Mereu, E.(4);Heyn, H.(5);Azucena, S.(1);
(1)IDIBAPS, Inflammatory bowel disease group, Barcelona, Spain;(2)Hospital Clinic de Barcelona, Inflammatory Bowel Disease Unit, Barcelona, Spain;(3)Harvard Medical School, The Evergrande Center for Immunologic Diseases- Brigham and Women's Hospital, Boston- MA, United States;(4)Josep Carreras Research Institute, Cellular Systems Genomics Group, Barcelona, Spain;(5)National Centre for Genomic Analysis- Centre for Genomic Regulation, Single Cell Genomics Group, Barcelona, Spain
P019: Differential effects of first-line IFX and conventional treatment on inflammatory serum proteins of paediatric moderate- to-severe Crohn’s disease patients.ECCO'21 VirtualYear: 2021
Authors: JongsmaMSc, M.(1);Costes, L.M.M.(2);Tindemans, I.(2);Cozijnsen, M.A.(1);Raatgeep, R.H.C.(2);van Pieterson, M.(1);Li, Y.(3);Escher, J.C.(1);de Ridder, L.(1);Samsom, J.N.(2);
(1)Erasmus MC - Sophia Children's hospital, Department of Pediatric Gastroenterology, Rotterdam, The Netherlands;(2)Erasmus MC - Sophia Children's hospital, Laboratory of Paediatrics- division Gastroenterology and Nutrition, Rotterdam, The Netherlands;(3)Erasmus University Medical Centre/Erasmus MC Cancer Institute, Department of Pathology & Clinical Bioinformatics, Rotterdam, The Netherlands
P020: Mapping the changing intercellular communication and its downstream effect in Ulcerative ColitisECCO'21 VirtualYear: 2021
Authors: Potari-gul, L.(1);Modos, D.(1,2);Turei, D.(3);Valdeolivas, A.(3);Madgwick, M.(1,2);Saez-Rodriguez, J.(3,4);Korcsmaros, T.(1,2);
(1)Earlham Institute- Norwich Research Park, Organisms and Ecosystems, Norwich, United Kingdom;(2)Quadram Institute Bioscience- Norwich Research Park, Gut Microbes and Health Programme, Norwich, United Kingdom;(3)Heidelberg University, Faculty of Medicine and Heidelberg University Hospital- Institute of Computational Biomedicine- Bioquant, Heidelberg, Germany;(4)RWTH Aachen University, Faculty of Medicine- Joint Research Centre for Computational Biomedicine JRC-COMBINE, Aachen, Germany
P021: Circulating inflammatory protein and cellular profiles at time of diagnosis classify inflammatory bowel disease patients according to their underlying immune response and clinical disease courseECCO'21 VirtualYear: 2021
Authors: Heredia, M.(1);Charrout, M.(2);Klomberg, R.(3);Aardoom, M.(3);Jongsma, M.(3);Kemos, P.(4);van Haaften, D.(1);Tuk, B.(1);van Berkel, L.(1);Bley Folly, B.(1);Mahfouz, A.(2);Reinders, M.(2);Ruemmele, F.(5);Croft, N.(4);Escher, J.(3);de Ridder, L.(3);Samsom, J.(1);
(1)Erasmus University Medical Center-Sophia Children’s Hospital, Laboratory of Pediatrics- division Gastroenterology and Nutrition, Rotterdam, The Netherlands;(2)Delft University of Technology, Delft Bioinformatics Lab, Delft, The Netherlands;(3)Erasmus University Medical Center-Sophia Children’s Hospital, Pediatric Gastroenterology, Rotterdam, The Netherlands;(4)Blizard Institute- Queen Mary University of London, Centre for Immunobiology, London, United Kingdom;(5)Necker-Enfants Malades University Hospital- Institut Imagine- AP-HP- Université de Paris, Pediatric Gastroenterology, Paris, France
P022: Pathologic involvement of the farnesoid X receptor/fibroblast growth factor 19 axis to the Crohn’s disease early postsurgical recurrence.ECCO'21 VirtualYear: 2021
Authors: Suau, R.(1);Garcia-Jaraquemada, A.(2);Lorén, V.(1);Torres, P.(2);Jou, E.(2);Llaves, M.(2);Aterido, A.(3);Julià, T.(3);Zabana, Y.(4);Lozano, J.J.(5);Domènech, E.(6);Mañosa, M.(6);Manyé, J.(1);
(1)CIBER-'Germans Trias i Pujol' Research Institute, IBD Research Group, Badalona, Spain;(2)'Germans Trias i Pujol' Research Institute, IBD Research Group, Badalona, Spain;(3)Vall d'Hebron Research Institute, Rheumatology Research Group, Barcelona, Spain;(4)Hospital Mutua de Terrassa, Gastroenterology Department, Terrassa, Spain;(5)CIBER in Liver and Gastroenterology, Bioinformatics Unit, Barcelona, Spain;(6)'Germans Trias i Pujol' University Hospital CIBER, Gastroenterology Department, Badalona, Spain
P023: SZN-1326, a Wnt agonist, improved epithelial healing and ameliorated colitis in a chronic DSS model, in stark contrast to anti-TNF and anti-IL-12/23p40 antibodiesECCO'21 VirtualYear: 2021
Authors: Xie, L.(1);Handa, P.(1);Tun, C.(1);Liu, A.(1);Lu, C.(2);Baribault, H.(1);Newman, M.(3);Le, L.(3);Shah, D.(2);Deshmukh, S.(2);Mutha, D.(1);Le, T.(1);Fletcher, R.(2);Chen, H.(4);Ye, J.(4);Tibbitts, J.(3);Srinivasan, U.(3);Li, Y.(4);Vanhove, G.(3);Yeh, W.C.(1);
(1)Surrozen. INC, In vivo pharmacology, South San Francisco, United States;(2)Surrozen. INC, Discovery biology, South San Francisco, United States;(3)Surrozen. INC, Pre-Clinical, South San Francisco, United States;(4)Surrozen. INC, Protein science, South San Francisco, United States
P024: Development of a treatment for short bowel syndrome using small intestinal organoidsECCO'21 VirtualYear: 2021
Authors: Sugimoto, S.(1);Kobayashi, E.(2);Fujii, M.(3);Ohta, Y.(3);Ishikawa, K.(1);Nanki, K.(1);Hakamata, Y.(4);Kanai, T.(5);Sato, T.(1);
(1)Keio University School of Medicine, Department of Organoid Medicine- Department of Gastroenterology, Tokyo, Japan;(2)Keio University School of Medicine, Department of Organ Fabrication, Tokyo, Japan;(3)Keio University School of Medicine, Department of Organoid Medicine, Tokyo, Japan;(4)Nippon Veterinary and Life Science University, School of Veterinary Nursing and Technology, Tokyo, Japan;(5)Keio University School of Medicine, Department of Gastroenterology, Tokyo, Japan
P025: Identification and validation of predictors for tofacitinib through supervised and unbiased approaches in Inflammatory Bowel DiseaseECCO'21 VirtualYear: 2021
Authors: Liu, B.(1);Spalinger, M.(2);Perez , L.G.(1);Machicote, A.(1);Gagliani, N.(1);Scharl, M.(2);Huber, S.(1);
(1)University Medical Center Hamburg-Eppendorf, I. Department of Medicine, Hamburg, Germany;(2)University Hospital Zurich, Department for Gastroenterology and Hepatology, Zurich, Switzerland
P026: Microbial Diversity is affected by Cognitive Behavioral and Mindfulness-Based Stress Reduction and accompanied by an Inflammatory Response in Patients with Crohn’s DiseaseECCO'21 VirtualYear: 2021
Authors: Ilan, K.(1);Motro, Y.(2);Nemirovsky, A.(2);Lerner, L.(3);Schwartz, D.(4);Goren, G.(5);Sergienko, R.(6);Greenberg, D.(7);Slonim-Nevo , V.(5);Sarid, O.(5);Friger, M.(6);Regev, S.(5);Odes, S..(8);Moran-Gilad , J.(9);Monsonego, A.(10);
(1)Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- Faculty of Health Sciences, Beer Sheva, Israel;(2)Faculty of Health Sciences- Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics, Beer Sheva, Israel;(3)Faculty of Health Sciences- Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- and The National Institute of Biotechnology in the Negev- Zlotowski Neuroscience Center- and Regenerative Medicine and Stem Cell Research Center, Beer Sheva, Israel;(4)Faculty of Health Sciences- Ben-Gurion University of the Negev- and Soroka Medical Center, Gastroenterology & Hepatology, Beer Sheva, Israel;(5)Ben-Gurion University of the Negev, Spitzer Department of Social Work, Beer Sheva, Israel;(6)Faculty of Health Sciences- Ben-Gurion University of the Negev, Department of Public Health, Beer Sheva, Israel;(7)Faculty of Health Sciences- Ben-Gurion University of the Negev, Department of Health Systems Management- School of Public Health- Guilford Glazer Faculty of Business and Management, Beer Sheva, Israel;(8)Faculty of Health Sciences- Ben-Gurion University of the Negev, Gastroenterology & Hepatology, Metar, Israel;(9)Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- Faculty of Health Sciences- and The National Institute of Biotechnology in the Negev, Beer Sheva, Israel;(10)Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- Faculty of Health Sciences- and The National Institute of Biotechnology in the Negev- Zlotowski Neuroscience Center- and Regenerative Medicine and Stem Cell Research Center, Beer Sheva, Israel
P027: Epithelial cells of patients with ulcerative colitis do not show an increased sensitivity after microbiota stimulation compared to non-IBD controlsECCO'21 VirtualYear: 2021
Authors: Arnauts, K.(1,2);Lapierre, C.(1);Verstockt, B.(1,3);Verstockt, S.(1);Sudhakar, P.(1);Vermeire, S.(1,3);Verfaillie, C.(2);Sabino, J.(1,3);Ferrante, M.(1,3);
(1)KU Leuven, TARGID- Department of Chronic Diseases- Metabolism & Ageing, Leuven, Belgium;(2)KU Leuven, Stem Cell Institute Leuven- Department of Development and Regeneration, Leuven, Belgium;(3)KU Leuven, Department of Gastroenterology and Hepatology- University Hospitals Leuven, Leuven, Belgium
P028: The Apa I polymorphism in the Vitamin D receptor gene is associated with a stricturing behaviour in Crohn´s disease patientsECCO'21 VirtualYear: 2021
Authors: Gisbert-Ferrandiz, L.(1);Llau, J.(1);Cosin-Roger, J.(2);Coll, S.(1);Bauset, C.(1);Ortiz-Masia, D.(3);Hinojosa, J.(4);Calatayud, S.(1);Barrachina, M.D.(1);
(1)Universitat de València, Pharmacology, Valencia, Spain;(2)Unidad Mixta-Facultad de Medicina - Hospital Dr Peset, FISABIO Pharmacology, Valencia, Spain;(3)CIBERehd-Universitat València, Medicina, Valencia, Spain;(4)Hospital Manises, Gastroenterology, Valencia, Spain
P029: Activation of FXR restores expression of genes dysregulated in human IBD and suppresses TNFa and IL-6 signaling pathways in adoptive transfer colitis modelECCO'21 VirtualYear: 2021
Authors: Liu, X.(1);Milik, A.(1);O'Connell, R.(2);White, J.(2);Wagner, B.(1);
(1)Metacrine, Biology, San Diego, United States;(2)Bolder Biopath, Biology, Boulder, United States
P030: SUCNR1 mediates inflammasome activation: Relevance in Ulcerative ColitisECCO'21 VirtualYear: 2021
Authors: Bauset, C.(1);Lis-López, L.(1);Ortiz-Masia, D.(1);Gisbert-Ferrándiz, L.(1);Coll, S.(1);Calatayud, S.(1);Barrachina, M.D.(1);Cosín-Roger, J.(2);
(1)Faculty of Medicine- University of Valencia, Department of Pharmacology, Valencia, Spain;(2)Hospital Dr. Peset, Department of Endocrinology and Metabolism, Valencia, Spain
P031: Class A1 scavenger receptor mediates macrophage polarization and apoptotic progression in a murine dextran sulfate sodium-induced colitisECCO'21 VirtualYear: 2021
Authors: Su, J.(1);Xie, C.(1);Hu, Y.(1);Huang, Q.(1);Shi, H.(1);Wang, L.(1);Ren, J.(1);
(1)Affliated Zhongshan Hospital of Xiamen University, Department of Gastroenterology, Xiamen- Fujian Province, China
P032: MiR-511 deficiency aggravates T cell transfer colitis in miceECCO'21 VirtualYear: 2021
Authors: Rahman, S.(1);Elfiky, A.(1);H.P. van Hamersveld, P.(1);Verseijden, C.(1);Welting, O.(1);L Meijer, S.(2);B.M. Hakvoort, T.(1);J. de Jonge, W.(1);E.M. Heinsbroek, S.(1);
(1)Amsterdam UMC- University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(2)Amsterdam UMC- University of Amsterdam, Department of Pathology, Amsterdam, The Netherlands
P033: Dendritic cells from patients with active IBD imprint pro-inflammatory α4β7+CLA+ T cells with potential for gut and skin homingECCO'21 VirtualYear: 2021
Authors: Gordon, H.(1);Rodger, B.(1);Hoti, I.(1);Lindsay, J.O.(2);Stagg, A.(1);
(1)The Blizard Institute, Department of Immunobiology, London, United Kingdom;(2)Royal London Hospital, Gastroenterology, London, United Kingdom
P034: Human primary 2D culture as a tool to explore JAK1 pathway inhibition in the intestinal epithelium using siRNA technologyECCO'21 VirtualYear: 2021
Authors: Dotti, I.(1);Sulpice, E.(2);Nougarède, A.(3);Jary, D.(3);Clément, F.(2);Gidrol, X.(2);Navarro, F.(3);Salas, A.(1);
(1)IDIBAPS, Department of Gastroenterology, Barcelona, Spain;(2)CEA-INSERM, Biomics, Grenoble, France;(3)CEA-Leti, Division for biology and healthcare technologies, Grenoble, France
P035: Potential biomarkers for diagnosis through proteomics, in patients with Inflammatory Bowel DiseaseECCO'21 VirtualYear: 2021
Authors: Muñoz-Villafranca, C.(1);Aresti Goiriena, U.(2);Ispizua, N.(1);Irigoyen Muñoz, M.(3);Rivera Garcia, N.A.(2);Ortiz de Zárate, J.(1);Arreba Gonzalez , P.(1);Calderón García, Á.J.(1);
(1)Hospital Universitario de Basurto, Gastroenterology, Bilbao, Spain;(2)Hospital Universitario de Basurto, Research, Bilbao, Spain;(3)Hospital Universitario Príncipe de Asturias, Internal Medicine, Alcala de Henares, Spain
P036: MicroRNA composition of colon crypt-top and crypt-bottom epithelial cells in Ulcerative ColitisECCO'21 VirtualYear: 2021
Authors: Inčiūraitė, R.(1);Juzėnas, S.(1,2);Ramonaitė, R.(1);Skiecevičienė, J.(1);
(1)Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania;(2)Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany
P037: Nonclinical pharmacokinetics and absorption, distribution, metabolism, and excretion properties of MORF-057 support its clinical development as an oral selective α4β7 integrin inhibitorECCO'21 VirtualYear: 2021
Authors: Jones, J.(1);Lee, D.(1);Smukste, I.(1);Cui, D.(1);Bursavich, M.G.(2);Troast, D.(2);Zhong, C.(2);Wong , J.E.(3);Mangada, M.M.(3);Bain, G.(3);Lippa, B.(2);Ray, A.S.(3);Rogers, B.N.(4);
(1)Morphic Therapeutic, Dmpk, Waltham, United States;(2)Morphic Therapeutic, Molecular Discovery, Waltham, United States;(3)Morphic Therapeutic, Biology and Translation, Waltham, United States;(4)Morphic Therapeutic, Research, Waltham, United States
