DOP06: Histologic activity in Ulcerative Colitis patients achieving endoscopic healing is associated with higher rate of relapse and a distinct mucosal microbial and transcriptional profileECCO'21 VirtualYear: 2021
Authors: Hernandez-Rocha, C.(1);Turpin, W.(2);Nayeri, S.(3);Borowski, K.(3);Stempak, J.(3);Conner, J.(4);Silverberg, M.S.(1)
(1)Zane Cohen Centre for Digestive Diseases- Lunenfeld-Tanenbaum Research Institute- Sinai Health System, Division of Gastroenterology- Mount Sinai Hospital- University of Toronto, Toronto- ON, Canada;(2)Zane Cohen Centre for Digestive Diseases- Lunenfeld-Tanenbaum Research Institute- Sinai Health System, Department of Medicine- University of Toronto, Toronto- ON, Canada;(3)Zane Cohen Centre for Digestive Diseases- Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto- ON, Canada;(4)Department of Pathology & Laboratory Medicine, Mount Sinai Hospital, Toronto- ON, Canada
DOP07: Ulcerative Colitis associated single nucleotide polymorphisms found in transcription factor binding sites effect key pathogenesis pathways and facilitate patient stratificationECCO'21 VirtualYear: 2021
Authors: Modos, D.(1,2,3);Brooks-Warburton, J.(1,3,4,5,6,7);Sudhakar, P.(1,3,8);Madgwick, M.(1,3);Fazekas, D.(3,9);Szalay-Beko, M.(3);Thomas, J.P.(3,7);Verstockt, B.(8,10);Watson, A.(6,7);Tremelling, M.(7);Parkes, M.(11);Vermeire, S.(8,10);Bender, A.(2);Carding, S.R.(1,6);Korcsmaros, T.(1,3)
(1)Quadram Institute Bioscience, Gut Microbes and Health Programme, Norwich, United Kingdom;(2)University of Cambridge, Department of Chemistry, Cambridge, United Kingdom;(3)Earlahm Institute, Earlahm Institute, Norwich, United Kingdom;(4)University of Hertfordshire-, Department of Clinical- Pharmaceutical and Biological Sciences, Hertford, United Kingdom;(5)Lister Hospital, Department of Gastroenterology, Stevenage, United Kingdom;(6)University of East Anglia, Norwich Medical School, Norwich, United Kingdom;(7)Norfolk and Norwich University Hospitals, Department of Gastroenterology, Norwich, United Kingdom;(8)KU Leuven, Department of Chronic diseases- Metabolism and Ageing, Leuven, Belgium;(9)Eotvos Lorand University, Department of Genetics, Budapest, Hungary;(10)KU Leuven, University Hospitals Leuven- Department of Gastroenterology and Hepatology, Leuven, Belgium;(11)University of Cambridge, Inflammatory Bowel Disease Research Group- Addenbrooke's Hospital, Cambridge, United Kingdom
DOP08: Serum proteomics predict endoscopic remission in patients with Crohn’s DiseaseECCO'21 VirtualYear: 2021
Authors: Alsoud, D.(1);Sudhakar, P.(1);Sabino, J.(1,2);Ferrante , M.(1,2);Verstockt , B.(1,2);Vermeire, S.(1,2)
(1)KU Leuven, Translational Research Center for GastroIntestinal Disorders- Department of Chronic Diseases- Metabolism and Ageing, Leuven, Belgium;(2)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium
DOP09: Mirikizumab-induced transcriptome changes in patient biopsies at Week 12 are maintained through Week 52 in patients with Ulcerative ColitisECCO'21 VirtualYear: 2021
Authors: Johnson, T.(1);Steere, B.(2);Zhang, P.(1);Zang, Y.(1);Higgs, R.(2);Gottlieb, K.(2);Reinisch, W.(3);Panés, J.(4);Krishnan, G.(2)
(1)Indiana University School of Medicine, IU Clinical and Translational Sciences Institute, Indianapolis, United States;(2)Eli Lilly and Company, Biomedicines, Indianapolis, United States;(3)Medical University Vienna, Internal Medicine, Vienna, Austria;(4)Hospital Clinic of Barcelona, Gastroenterology, Barcelona, Spain
DOP10: Persistent sonographic Inflammation as a predictor of clinical complications in patients with Crohn’s DiseaseECCO'21 VirtualYear: 2021
Authors: Vaughan, R.(1);Tjandra, D.(1);Patwardhan, A.(1);Mingos, N.(1);Gibson, R.(2);Boussioutas, A.(1);Christensen, B.(1)
(1)The Royal Melbourne Hospital, Gastroenterology, Melbourne, Australia;(2)The Royal Melbourne Hospital, Radiology, Melbourne, Australia
DOP11: Fibrosis and MAGNIFI-CD activity-index at MRI to predict treatment outcome in perianal fistulising Crohn’s Disease patientsECCO'21 VirtualYear: 2021
Authors: Van Rijn, K.(1);Meima-van Praag, E.(2);Bossuyt, P.(3);D'Haens, G.(4);Horsthuis, K.(5);Snijder, H.(2);Tielbeek, J.(1);Buskens, C.(2);Stoker, J.(1)
(1)Amsterdam UMC- University of Amsterdam, Radiology and Nuclear Medicine, Amsterdam, The Netherlands;(2)Amsterdam UMC- University of Amsterdam, Surgery, Amsterdam, The Netherlands;(3)Amsterdam UMC- University of Amsterdam, Epidemiology and Data Science, Amsterdam, The Netherlands;(4)Amsterdam UMC- University of Amsterdam, Gastroenterology and Hepatology, Amsterdam, The Netherlands;(5)Amsterdam UMC- Vrije Universiteit, Radiology and Nuclear Medicine, Amsterdam, The Netherlands
DOP12: Validation of a modified simple ultrasound activity Score for children with Crohn’s DiseaseECCO'21 VirtualYear: 2021
Authors: Ma, H.(1);Isaac, D.M.(1);Petrova, A.(1);Almeida, P.(1);Parsons, D.(1);Kuc, A.(1);Carroll, M.W.(1);Wine, E.(1);HuynhDr, H.(2)
(1)University of Alberta, Department of Paediatrics- Gastroenterology and Nutrition, Edmonton, Canada;(2)University of Alberta, Department of Paediatrics- Division of Gastroenterology and Nutrition, Edmonton, Canada
DOP13: Artificial Intelligence (AI) in endoscopy - Deep learning for detection and scoring of Ulcerative Colitis (UC) disease activity under multiple scoring systemsECCO'21 VirtualYear: 2021
Authors: Byrne, M.(1);East, J.(2);Iacucci, M.(3);Panaccione, R.(4);Kalapala, R.(5);Duvvur, N.(5);Rughwani, H.(5);Singh, A.(5);Henkel, M.(6);Canaran, L.(7);Laage, G.(7);St-Denis, L.(7);Nikfal, S.(7);Asselin, J.(7);Monsurate, R.(8);Cremonese, E.(7);Soudan, F.(7);Travis, S.(9)
(1)Vancouver General Hospital, Division of Gastroenterology, Vancouver, Canada;(2)John Radcliffe Hospital, Gastroenterology, Oxford- Oxfordshire, United Kingdom;(3)Institute of Translational of Medicine Immunology & Immunotherapy, Gastroenterology, Birmingham, United Kingdom;(4)University of Calgary, Gastroenterology, Calgary- AB, Canada;(5)Asian Institute of Gastroenterology, Gastroenterology, Hyderabad- Telangana, India;(6)University of Buenos Aires, Gastroenterology, Buenos Aires, Argentina;(7)Ivado Labs, Artificial Intelligence, Montreal- QC, Canada;(8)University of British Columbia, Business Administration, Vancouver- BC, Canada;(9)University of Oxford, Medical Sciences Division, Oxford- Oxfordshire, United Kingdom
DOP14: Ultra-high magnification endocytoscopy and molecular markers for defining endoscopic and histologic remission in Ulcerative ColitisECCO'21 VirtualYear: 2021
Authors: Iacucci, M.(1,2,3);Nardone, O.M.(1);Jeffery, L.(1);Acharjee, A.(4);Zardo, D.(5);Smith, S.C.(1);Bazarova, A.(6);Cannatelli, R.(1);Shivaji, U.N.(1);Williams, J.(4);Georgios, G.(4);Ghosh, S.(1,2,3)
(1)University of Birmingham, Institute of Immunology and Immunotherapy, Birmingham, United Kingdom;(2)University of Birmingham, NIHR Biomedical Research Centre, Birmingham, United Kingdom;(3)University Hospitals Birmingham NHS Trust, NIHR Wellcome Trust Clinical Research Facilities, Birmingham, United Kingdom;(4)University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, United Kingdom;(5)University Hospitals Birmingham NHS Trust, Department of Pathology, Birmingham, United Kingdom;(6)University of Cologne, Institute for Biological Physics, Cologne, Germany
DOP15: Clinical relevance of endoscopic peri-appendiceal red patch in Ulcerative Colitis patientsECCO'21 VirtualYear: 2021
Authors: Reijntjes, M.(1);Heuthorst, L.(1);Gecse, K.(2);Mookhoek, A.(3);Bemelman, W.(1);Buskens, C.(1)
(1)Amsterdam UMC- location AMC, Surgery, Amsterdam, The Netherlands;(2)Amsterdam UMC- location AMC, Gastro-enterology, Amsterdam, The Netherlands;(3)Amsterdam UMC- location AMC, Pathology, Amsterdam, The Netherlands
DOP16: The ratio of submucosa thickness to the total bowel wall thickness can be a sonographic parameter to estimate endoscopic remission in Ulcerative ColitisECCO'21 VirtualYear: 2021
Authors: Miyoshi, J.(1);Ozaki, R.(1);Yonezawa, H.(1);Mori, H.(1);Kawamura, N.(1);Matsuura, M.(1);Hisamatsu, T.(1)
(1)Kyorin University School of Medicine, Department of Gastroenterology and Hepatology, Mitaka-shi, Japan
DOP17: In high-risk Crohn’s Disease patients, anastomosis configuration types have similar rates of endoscopic recurrenceECCO'21 VirtualYear: 2021
Authors: Bachour, S.(1);Shah, R.(1);Lyu, R.(2);Rieder, F.(1);Cohen, B.(1);Qazi, T.(1);Lashner, B.(1);Lipman, J.(3);Regueiro, M.(1);Lightner, A.(3);Holubar, S.(3);Click, B.(1)
(1)Cleveland Clinic Foundation, Department of Gastroenterology and Hepatology, Cleveland, United States;(2)Cleveland Clinic Foundation, Department of Quantitative Health Sciences, Cleveland, United States;(3)Cleveland Clinic Foundation, Department of Colorectal Surgery, Cleveland, United States
DOP18: UCEIS is associated with PRO2, partial Mayo and SCCAI remission in UC: Final results from a prospective studyECCO'21 VirtualYear: 2021
Authors: Golovics, P.(1);Gonczi, L.(2);Reinglas, J.(3);Verdon, C.(3);Pundir, S.(3);Afif, W.(3);Wild, G.(3);Bitton, A.(3);Bessissow, T.(3);Lakatos, P.L.(3)
(1)HDF Medical Centre, Division of Gastroenterology, Budapest, Hungary;(2)Semmelweis University, 1st Department of Medicine, Budapest, Hungary;(3)McGill University Health Centre, Division of Gastroenterology, Montreal, Canada
DOP19: Urinary metabolome in newly diagnosed treatment-naïve Crohn’s Disease patients: Results from the IBDomics studyECCO'21 VirtualYear: 2021
Authors: Aldars-García, L.(1);Gil-Redondo, R.(2);Embade, N.(2);Riestra, S.(3);Rivero, M.(4);Gutiérrez, A.(5);Rodríguez, I.(6);Fernández, L.(7);Ceballos, D.(8);Benítez, J.M.(9);Aguas, M.(10);Bastón-Rey, I.(11);Algaba, A.(12);Casanova, M.J.(1);Lorente, R.(13);Ber, Y.(14);Royo, V.(15);Esteve, M.(16);Millet, O.(2);Gisbert, J.P.(1);Chaparro, M.(1);
(1)Hospital Universitario de La Princesa IIS-P and CIBERehd, Gastroenterology, Madrid, Spain;(2)CIC bioGUNE, Precision Medicine and Metabolism Lab, Derio, Spain;(3)Hospital Universitario Central de Asturias, Gastroenterology, Asturias, Spain;(4)Hospital Universitario Marqués de Valdecilla and IDIVAL, Gastroenterology, Santander, Spain;(5)Hospital General Universitario de Alicante- CIBERehd and Instituto de Investigación Sanitaria y Biomédica de Alicante ISABIAL, Gastroenterology, Alicante, Spain;(6)Hospital Galdakao-Usansolo, Gastroenterology, Vizcaya, Spain;(7)Hospital Clínico Universitario de Valladolid, Gastroenterology, Valladolid, Spain;(8)Universitario de Gran Canaria Dr. Negrín, Gastroenterlogy, Las Palmas de Gran Canaria, Spain;(9)Hospital Universitario Reina Sofía and IMIBIC, Gastroenterology, Córdoba, Spain;(10)Hospital Universitari i Politecnic La Fe and CIBERehd, Gastroenterology, Valencia, Spain;(11)Complexo Hospitalario Universitario de Santiago, Gastroenterology, Santiago de Compostela, Spain;(12)Hospital Universitario de Fuenlabrada e Instituto de Investigación Hospital Universitario La Paz IdiPAZ, Gastroenterology, Madrid, Spain;(13)Hospital General Universitario de Ciudad Real, Gastroenterology, Ciudad Real, Spain;(14)Hospital San Jorge, Gastroenterology, Huesca, Spain;(15)Hospital Universitari Son Espases, Gastroenterology, Palma de Mallorca, Spain;(16)Hospital Universitari Mutua Terrasa, Gastroenterology, Terrasa, Spain
DOP20: Genetic of vitamin D as predictor of response to adalimumab in Crohn’s DiseaseECCO'21 VirtualYear: 2021
Authors: Cusato, J.(1);Ribaldone, D.G.(1);Bertani, L.(2);Antonucci, M.(1);Tomasello, C.(3);Caviglia, G.P.(1);Dibetto, S.(1);Mangia, M.(1);Astegiano, M.(4);D'Avolio, A.(1)
(1)University of Turin, Department of Medical Sciences, Turin, Italy;(2)University of Pisa, Department of Translational Research and New Technologies in Medicine and Surgery, Pisa, Italy;(3)Ospedale Maria Vittoria, S.C. Farmacie Ospedaliere, Turin, Italy;(4)Molinette hospital, Unit of Gastroenterology, Turin, Italy
DOP21: Role of P2X7 in intestinal fibrosis and inflammasome activation: Relevance in Crohn´s DiseaseECCO'21 VirtualYear: 2021
Authors: Lis-López, L.(1);Bauset, C.(1);Ortiz-Masia, D.(1);Gisbert-Ferrándiz, L.(1);Coll, S.(1);Calatayud, S.(1);Barrachina, M.D.(1);Cosín-Roger, J.(2)
(1)Faculty of Medicine- University of Valencia, Department of Pharmacology, Valencia, Spain;(2)Hospital Dr. Peset, Department of Endocrinology and Metabolism, Valencia, Spain
DOP22: Integrative -omic analysis reveals microbiota mediated molecular mechanisms influencing host mucosal gene expression in Crohn’s DiseaseECCO'21 VirtualYear: 2021
Authors: Sudhakar, P.(1);Andrighetti, T.(2);Verstockt, S.(1);Caenepeel, C.(1,3);Ferrante, M.(1,3);Sabino, J.(1,3);Verstockt., B.(1,3);Vermeire, S.(1,3)
(1)KU Leuven, Dpt. Chronic Diseases- Metabolism and Ageing- TARGID- IBD, Leuven, Belgium;(2)São Paulo University UNESP, Institute of Biosciences, Botucatu- Soa Paola, Brazil;(3)University Hospitals Leuven, Dpt. Gastroenterology and Hepatology, Leuven, Belgium
DOP23: Single-cell RNA sequencing identifies an important role for class I histone-deacetylase enzymes in intestinal myofibroblasts from patients with Crohn’s Disease stricturesECCO'21 VirtualYear: 2021
Authors: Lewis, A.(1);Pan-Castillo, B.(2);Berti, G.(2);Felice, C.(1);Gordon, H.(3);Gadhok, R.(3);Minicozzi, A.(4);Chinaleong , J.(5);Feakins, R.(6);Lindsay, J.(3);Silver, A.(1)
(1)Blizard Institute- Barts and The London School of Medicine and Dentistry, Centre of Genomics and Child Health, London, United Kingdom;(2)Blizard Institute- Barts and The London School of Medicine and Dentistry, Centre for Genomics and Child Health, London, United Kingdom;(3)Blizard Institute- Barts and The London School of Medicine and Dentistry, Centre for Immunobiology, London, United Kingdom;(4)The Royal London Hospital, Department of Colorectal Surgery- Division of Surgery & Perioperative Care, London, United Kingdom;(5)The Royal London Hospital, Department of Histopathology, London, United Kingdom;(6)Royal Free London NHS Foundation Trust, Department of Cellular Pathology, London, United Kingdom
DOP24: Crohn’s Disease fistula show skewed lymphoid/myeloid balance, altered myeloid cell profiles and high TNF-α expressionECCO'21 VirtualYear: 2021
Authors: Beckerdrs., M.(1);de Krijger, M.(1);Bemelman, W.(2);de Jonge, W.(1);Buskens, C.(2);Wildenberg, M.(1)
(1)Tytgat Institute for Liver and Intestinal Research, Gastroenterology, Amsterdam, The Netherlands;(2)Amsterdam UMC, Surgery, Amsterdam, The Netherlands; DigeST
DOP25: Association of Enterobacteriaceae with Crohn’s Disease subtypes during remissionECCO'21 VirtualYear: 2021
Authors: Pisani, A.(1);Rausch, P.(2);Ellul, S.(3);Bang, C.(2);Tabone, T.(1);Marantidis Cordina, C.(4);Zahra, G.(5);Ellul, P.(1);Franke, A.(2)
(1)Mater Dei Hospital, Department of Gastroenterology, Msida, Malta;(2)Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany;(3)Mater Dei Hospital, Division of Paediatric Surgery- Department of Surgery, Msida, Malta;(4)Mater Dei Hospital, Department of Microbiology, Msida, Malta;(5)Mater Dei Hospital, Molecular Diagnostics- Department of Pathology, Msida, Malta
