P093: Creeping fat-derived long chain free fatty acids drive intestinal muscularis propria muscle cell proliferation via carnitine palmitoyltransferase 1 (CPT-1) – a relevant mechanism for stricturing Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Le, T.H.N.(1);Mao, R.(2);Liu, W.(1);Czarnecki, D.(1);Chandra, J.(1);Gordon, I.O.(3);Plesec, T.(3);Wang, J.(4);Lin, S.(2);Zhao, S.(1);Dejanovic, D.(1);Mukherjee, P.(1);West, G.(1);Fiocchi, C.(1);Brown, J.M.(5);Rieder, F.(6)*;
(1)Cleveland Clinic, Inflammation and Immunity, Cleveland, United States;(2)First Affiliated Hospital of Sun Yat-sen University, Gastroenterology, Guangzhou, China;(3)Cleveland Clinic, Pathology, Cleveland, United States;(4)Xinxiang Medical University, Henan Key Laboratory of Immunology and Targeted Drug, Cleveland, United States;(5)Cleveland Clinic, Cardiovascular and Metabolic Sciences, Cleveland, United States;(6)Cleveland Clinic, Gastroenterology- Hepatology and Nutrition, Cleveland, United States;
P094: Impacts of 5-aminosalicylic acid on the intestinal microbiota leading to the anti-inflammatory effectECCO’23 CopenhagenYear: 2023
Authors: Wada, H.(1)*;Miyoshi, J.(1);Kuronuma, S.(2);Hibi, N.(1);Nishinarita, Y.(1);Oguri, N.(1);Matsuura, M.(1);Takeuchi, O.(2);Kobayashi, T.(3);Akimoto, Y.(4);Hibi, T.(3);Hisamatsu, T.(1);
(1)Kyorin University School of Medicine, Department of Gastroenterology and Hepatology, Mitaka-shi, Japan;(2)Kitasato University Kitasato Institute Hospital, Department of Research- BioMedical Laboratory, Minato-ku, Japan;(3)Kitasato University Kitasato Institute Hospital, Center for Advanced IBD Research and Treatment, Minato-ku, Japan;(4)Kyorin University School of Medicine, Department of Anatomy, Mitaka-shi, Japan;
P095: Newly discovered gut matrikines from Crohn's disease intestinal tissue induce cell proliferation, activation and inflammatory response in intestinal myofibroblasts in vitroECCO’23 CopenhagenYear: 2023
Authors: Papatheodoridi, M.(1)*;Giuffrida , P.(1);Canetti, D.(2);Yutaka, Y.(3);Hodgetts, H.(1);Di Sabatino, A.(4);Johnston, H.(5);Verona, G.(6);Rendell, N.(6);Al-Akkad, W.(1);Frenguelli, L.(1);Hall, A.(1);Luong , T.(1);Sampietro, G.(7);Pinzani, M.(1);Rombouts, K.(1);Belloti, V.(6);Mazza, G.(1);
(1)University College London, Institute for Liver and Digestive Health, London, United Kingdom;(2)University College London, Centre for Amyloidosis and Acute Phase Protein, London, United Kingdom;(3)Institute for Liver and Digestive Health, University College London, London, United Kingdom;(4)University of Pavia- San Matteo Hospital Foundation, First Department of Internal Medicine, Pavia, Italy;(5)UCL EGA Institute for Women's Health, Cancer Proteomics- Women's cancer-, London, United Kingdom;(6)University College London, Centre for Amyloidosis and Acute Phase Proteins, London, United Kingdom;(7)Università degli Studi di Milano, ivision of General and HPB Surgery, Milan, Italy;
P096: Characterization of suppressive immune cell subsets in mouse models of colitis-associated colorectal cancerECCO’23 CopenhagenYear: 2023
Authors: Frigerio, S.(1)*;Saris, J.(1);Franco Fernandez, R.(1);Koelink, P.(1);van Roest, M.(1);Wildenberg, M.(1);D'Haens, G.(1);Grootjans, J.(1);
(1)Tytgat Institute for Liver and Intestinal Research- Amsterdam University Medical Centers- Location AMC- AGEM Amsterdam, Department of Gastroenterology and Hepatology- Amsterdam University Medical Centers- Location AMC, Amsterdam, The Netherlands;
P097: Various regulatory single nucleotide polymorphisms regulate similar biological pathways in Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Modos, D.(1,2);Poletti, M.(1,2);Brooks-Warburton, J.(3,4)*;Bohar, B.(2,5);Madgwick, M.(2);Verstockt, B.(6,7);Vermeire, S.(6,7);Carding, S.(1,8);Korcsmaros, T.(1,2,9);
(1)Quadram Institute Bioscience, Gut Microbes & Health, Norwich, United Kingdom;(2)Earlahm Institute, Organisms and Ecosystems, Norwich, United Kingdom;(3)Lister Hospital, Department of Gastroenterology-, Stevenage, United Kingdom;(4)University of Hertfordshire, Department of Clinical- Pharmaceutical and Biological Sciences, Hertford, United Kingdom;(5)Eötvös Loránd University, Department of Genetics, Budapest, Hungary;(6)KU Leuven, University Hospitals Leuven- Department of Gastroenterology and Hepatology, Leuven, Belgium;(7)KU Leuven, Department of Chronic diseases and Metabolism, Leuven, Belgium;(8)University of East Anglia, Norwich Medical School, Norwich, United Kingdom;(9)Imperial College London, Department of Metabolism- Digestion and Reproduction, London, United Kingdom;
P099: IL-33 activates CD73-expressing cells promoting tumorigenesis during colitis-associated colorectal cancerECCO’23 CopenhagenYear: 2023
Authors: Lopetuso, L.R.(1)*;Privitera, G.(2);Di Martino, L.(3);Scaldaferri, F.(1);Gasbarrini, A.(1);Cominelli, F.(3);De Salvo, C.(2);Pizarro, T.(2);
(1)Fondazione Policlinico Universitario "A. Gemelli" IRCCS- Università Cattolica del Sacro Cuore, IBD Unit- Centro Malattie dell'Apparato Digerente - CEMAD, Roma, Italy;(2)Case Western Reserve University, Pathology, Cleveland, United States;(3)Case Western Reserve University, Digestive Health Institute, Cleveland, United States;
P100: Atypical Anti-Neutrophil Cytoplasmatic Antibodies Are Antibodies Against Neutrophil Extracellular Traps: A Novel Pathophysiological Mechanism In Ulcerative ColitisECCO’23 CopenhagenYear: 2023
Authors: Mendieta Escalante, E.A.(1)*;Faber, K.N.(1);Hermoso Ramello, M.(1);Parada-Venegas, D.(1);Bourgonje, A.(2);Roozendaal, C.(3);Dijkstra, G.(1);
(1)University Medical Center of Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(2)University Medical Center Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(3)University Medical Center Groningen, Department of Laboratory Medicine, Groningen, The Netherlands;
P102: A small molecule selective integrin α4β7 inhibitor demonstrates efficacy in a chronic model of Inflammatory Bowel DiseaseECCO’23 CopenhagenYear: 2023
Authors: Redhu, N.S.(1)*;Rowe, M.(1);Lee, D.(2);Jain, D.(1);Sang, A.(1);Granata, D.(1);Harrison, B.(3);Cui, D.(2);Bursavich, M.(3);Ray, A.S.(1);Lippa, B.(3);Rogers, B.N.(3);Wong , J.(1);
(1)Morphic Therapeutic, Biology and Translation, Waltham, United States;(2)Morphic Therapeutic, Drug Metabolism and Pharmacokinetics, Waltham, United States;(3)Morphic Therapeutic, Chemistry, Waltham, United States;
P103: Colitis-associated faecal miRNAs are mediators of host-microbiota interactions and key regulators of intestinal permeability and inflammationECCO’23 CopenhagenYear: 2023
Authors: Casado-Bedmar, M.(1)*;Roy, M.(1);Hugot, J.P.(1);Le Gall, M.(1);Chassaing, B.(2);Viennois, E.(1);
(1)INSERM, Center of Research on Inflammation CRI, Paris, France;(2)INSERM, Mucosal microbiota in chronic inflammatory diseases CNRS UMR 8104, Paris, France;
P104: Exploring the transcriptomic miRNA signatures of Egyptian Inflammatory Bowel Disease patientsECCO’23 CopenhagenYear: 2023
Authors: Khaled, M.(1)*;Hamdy, K.(2);Abou-Aisha, K.(3);Mansour, M.(4);
(1)German University in Cairo, Microbiology and Immunology, Cairo, Egypt;(2)Ain Shams University, Internal Medicine, Cairo, Egypt;(3)German University in Cairo, Microbiology, Cairo, Egypt;(4)German University in Cairo, Pharmaceutical Biology, Cairo, Egypt;
P105: Epithelial microRNA signatures as potential biomarkers in Crohn's disease related to clinical and endoscopic activityECCO’23 CopenhagenYear: 2023
Authors: Moon, J.M.(1)*;Kim, K.U.(2);Shin, S.Y.(1);Joo, H.J.(1);Min, H.(2);Choi, C.H.(1);
(1)Chung-Ang University College of Medicine, Department of Internal Medicine, Seoul, Korea- Republic Of;(2)Chung-Ang University, College of Pharmacy, Seoul, Korea- Republic Of;
P106: Identification of urine and serum diagnostic biomarkers of inflammatory bowel disease using a proteomic approachECCO’23 CopenhagenYear: 2023
Authors: Baldan-Martin, M.(1)*;Azkargorta, M.(2);Lloro, I.(2);Soleto Fernández, I.(1);Orejudo, M.(1);Ramírez, C.(1);García, S.(1);Mercado, J.(1);Riestra, S.(3);Rivero, M.(4);Gutiérrez, A.(5);Rodríguez-Lago, I.(6);Fernández-Salazar, L.(7);Ceballos, D.(8);Benítez, J.M.(9);Aguas, M.(10);Bastón-Rey, I.(11);Bermejo, F.(12);Casanova, M.J.(1);Lorente, R.(13);Ber, Y.(14);Royo, V.(15);Esteve, M.(16);Elortza, F.(2);Gisbert, J.P.(1);Chaparro, M.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Unit, Madrid, Spain;(2)Proteomics Platform- CIC bioGUNE- BRTA Basque Research & Technology Alliance- CIBERehd- ProteoRed-ISCIII, Proteomics Platform, Derio, Spain;(3)Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias ISPA, Gastroenterology Unit, Oviedo, Spain;(4)Hospital Universitario Marqués de Valdecilla and IDIVAL, Gastroenterology Unit, Santander, Spain;(5)Hospital General Universitario de Alicante- ISABIAL and CIBERehd, Gastroenterology Unit, Alicante, Spain;(6)Hospital Galdakao-Usansolo, Gastroenterology Unit, Vizcaya, Spain;(7)Hospital Clínico Universitario de Valladolid, Gastroenterology Unit, Valladolid, Spain;(8)Hospital Universitario de Gran Canaria Dr. Negrín, Gastroenterology Unit, Las Palmas de Gran Canaria, Spain;(9)Hospital Universitario Reina Sofía and IMIBIC, Gastroenterology Unit, Córdoba, Spain;(10)Health Research Institute IISLaFe and Hospital Universitari i Politecnic La Fe, Gastroenterology Unit, Valencia, Spain;(11)Hospital Clínico Universitario de Santiago de Compostela, Gastroenterology Unit, Santiago de Compostela, Spain;(12)Hospital Universitario de Fuenlabrada and IDIPAZ, Gastroenterology Unit, Madrid, Spain;(13)Hospital General Universitario de Ciudad Real, Gastroenterology Unit, Ciudad Real, Spain;(14)Hospital San Jorge, Gastroenterology Unit, Huesca, Spain;(15)Hospital Universitari Son Espases, Gastroenterology Unit, Palma de Mallorca, Spain;(16)Hospital Universitari Mutua Terrasa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Unit, Terrasa, Spain;
P107: Decreased epithelial keratinization contributes to defective wound healing in Crohn's disease fistulaECCO’23 CopenhagenYear: 2023
Authors: Beckerdrs., M.(1)*;Koelink, P.(1);Bemelman, W.(2);D'Haens, G.(3);Buskens, C.(2);Wildenberg, M.(1);
(1)Tytgat Institute for Liver and Intestinal Research, Gastroenterology, Amsterdam, The Netherlands;(2)Amsterdam UMC, Surgery, Amsterdam, The Netherlands;(3)Amsterdam UMC, Gastroenterology, Amsterdam, The Netherlands;
P108: Development and evaluation of the i-Tracker Risankizumab and i-Tracker Anti-Risankizumab kits: rapid and innovative tests intended for monitoring patients treated with Risankizumab.ECCO’23 CopenhagenYear: 2023
Authors: Khater, G.(1)*;Noguier, G.(2);Daviere, S.(1);Montaillier, C.(2);Guilbert, V.(2);
(1)Theradiag, Theranostic, Croissy Beaubourg, France;(2)Theradiag, Research & Development, Croissy Beaubourg, France;
P109: Using baseline Peripheral blood mononuclear cell (PBMC) transcriptomics of Crohn Disease patients receiving Ustekinumab treatment as a tool to assess potential response at 1 yearECCO’23 CopenhagenYear: 2023
Authors: Granot, M.(1); Braun, T.(2); Efroni, G.(2); Fudim, E.(2);Yavzori, M.(2);Haj, O.(3); Ben-Horin, S.(3);Kopylov, U.(3);Haberman Ziv, Y.(1)*;
(1)The Edmond and Lily Safra Children's Hospital- Sheba Medical Center- Tel-Hashomer, Pediatric Gastroenterology and Nutrition Unit, Ramat Gan, Israel;(2)Sheba Medical Center- Tel-Hashomer, The Pediatric Gastroenterology Unit and Sheba Microbiome Center, Ramat Gan, Israel;(3)Sheba Medical Center- Tel-Hashomer, Department of Gastroenterology, Ramat Gan, Israel;
P110: Fibroblast activation protein is strongly expressed in intestinal fibrosis in inflammatory bowel disease patientsECCO’23 CopenhagenYear: 2023
Authors: Lartey, D.(1,2)*;van Roest, M.(1);Verhoeff, J.(1,3);Grootjans, J.(1,2);Buskens, C.(4);van der Bilt, J.(4,5);Wildenberg, M.(1);D'Haens, G.(2);Löwenberg, M.(2);
(1)Amsterdam UMC- University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(2)Amsterdam UMC- University of Amsterdam, Department of Gastroenterology & Hepatology, Amsterdam, The Netherlands;(3)Amsterdam UMC- University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism AGEM, Amsterdam, The Netherlands;(4)Amsterdam UMC- University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands;(5)Flevoziekenhuis, Department of Surgery, Almere, The Netherlands;
P111: Efficacy of a novel long-acting lipidated interleukin-22, alone and in combination with anti-TNF treatment, in a murine chronic DSS colitis modelECCO’23 CopenhagenYear: 2023
Authors: Van De Bunt, M.(1)*;D'Alessio, S.(2);Norrild, J.C.(3);Kjølbye, A.L.(1);Jorgensen, R.(1);
(1)Cytoki Pharma, Research & Development, Hellerup, Denmark;(2)PhoenixLAB srls, Research, Lodi, Italy;(3)Cytoki Pharma, CMC & Quality, Hellerup, Denmark;
P112: S1PR expression on circulating immune cells is not limited to lymphocytes in patients with inflammatory bowel diseaseECCO’23 CopenhagenYear: 2023
Authors: Verstockt., B.(1,2)*;Verstockt, S.(2);Cremer, J.(3);Sabino, J.(1,2);Ferrante, M.(1,2);Vermeire, S.(1,2);
(1)University Hospitals Leuven, Dpt. Gastroenterology and Hepatology, Leuven, Belgium;(2)KU Leuven, Dpt. Chronic Diseases and Metabolism, Leuven, Belgium;(3)KU Leuven, Department of Microbiology- Immunology and Transplantation- Allergy and Clinical Immunology, Leuven, Belgium;
