P0111: Patient reported outcome measures (PROM) in patients scheduled to undergo bowel resection for Crohn’s diseaseECCO'25Year: 2025
Authors: Schmitz, A.(1)*;Bercher, M.(1);Iesalnieks, I.(1);Hinrichs, N.(2);
(1)Evangelisches Krankenhaus Kalk, Abdominal Surgery, Cologne, Germany;(2)Charite Berlin, Medical Data Science- Dept. of Cardiothoracic Surgery- Charite, Berlin, Germany;
P0112: Cannabidiol (CBD) targeting of colorectal cancer cells is mutation-independent and via CB2 receptorECCO'25Year: 2025
Authors: Moniruzzaman, M.(1,2,3)*;Janjua, T.(1);Begun, J.(3);Popat, A.(1);
(1)School of Pharmacy- The University of Queensland, Faculty of Health and Behavioral Sciences, Brisbane, Australia;(2)Faculty of Medicine- The University of Queensland, Translational Research Institute, Brisbane, Australia;(3)Mater Research Institute - The University of Queensland, Faculty of Medicine, Brisbane, Australia;
P0113: Maintained microglial homeostasis and adult neurogenesis despite chronic ileocolitisECCO'25Year: 2025
Authors: Mundlos, H.(1)*;Masanetz, R.K.(1);Gauer, C.(1);Stolzer, I.(2);Günther, C.(2);Winkler, J.(1);Süß, P.(1);
(1)University Hospital Erlangen- Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Molecular Neurology, Erlangen, Germany;(2)University Hospital Erlangen- Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Medicine I, Erlangen, Germany;
(1) Masanetz RK, Winkler J, Winner B, Günther C, Süß P. The Gut-Immune-Brain Axis: An Important Route for Neuropsychiatric Morbidity in Inflammatory Bowel Disease. Int J Mol Sci. 2022;23(19):11111. Published 2022 Sep 21. doi:10.3390/ijms231911111
(2) Ekdahl CT, Claasen JH, Bonde S, Kokaia Z, Lindvall O. Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci U S A. 2003;100(23):13632-13637. doi:10.1073/pnas.2234031100
(3) Toda T, Parylak SL, Linker SB, Gage FH. The role of adult hippocampal neurogenesis in brain health and disease. Mol Psychiatry. 2019;24(1):67-87. doi:10.1038/s41380-018-0036-2
(4) Günther C, Martini E, Wittkopf N, et al. Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature. 2011;477(7364):335-339. Published 2011 Sep 14. doi:10.1038/nature10400
P0114: Tracking Crohn’s Disease Progression through Extracellular Matrix Remodeling: A Longitudinal Study of Pre- and Post-Resection SamplesECCO'25Year: 2025
Authors: Poulsen, A.(1)*;S. Alexdóttir, M.(2);Buhl Riis, L.(3,4);D. Ovesen, P.(5);Rasmussen, J.(6);D. Wewer, M.(7,8);Lin, V.(9);M.B. Lagström, R.(9);Al-Sheikh, M.(10);Dahl, E.(1); Ries, A.(11);Porsbjerg, L.(1);Katranara Tsapanou , T.(2);Pehrsson, M.(2);Gögenur, I.(9);Krarup, P.M.(10);Burisch, J.(4,7,8);H. Mortensen, J.(2);B. Seidelin, J.(1,4);
(1)University Hospital of Copenhagen- Rigshospitalet, Department of Digestive Diseases- Transplantation and General Surgery- Section for IBD, Copenhagen, Denmark;(2)Nordic Bioscience, Biomarkers and Research, Herlev, Denmark;(3)Copenhagen University Hospital - Herlev and Gentofte, Department of Pathology, Herlev, Denmark;(4)University of Copenhagen, Department of Clinical Medicine- Faculty of Health and Medical Sciences, Copenhagen, Denmark;(5)Copenhagen University Hospital - Herlev and Gentofte, Department of Gastroenterology and Hepatology, Herlev, Denmark;(6)Zealand University Hospital- Koege, Department of Medical Gastroenterology, Koege, Denmark;(7)Copenhagen University Hospital- Amager and Hvidovre, Gastrounit- Medical Section, Hvidovre, Denmark;(8)Copenhagen University Hospital- Amager and Hvidovre, Copenhagen Center for Inflammatory Bowel Disease in Children- Adolescents and Adults, Hvidovre, Denmark;(9)Zealand University Hospital- Koege, Center for Surgical Science, Koege, Denmark;(10)Copenhagen University Hospital- Bispebjerg and Frederiksberg, Digestive Disease Center, Copenhagen, Denmark;(11)Copenhagen University Hospital - Amager and Hvidovre, Department of Pathology, Hvidovre, Denmark;
P0115: Selective immune responses to Lachnospiraceae flagellins discriminate therapy-naive pediatric Crohn’s disease patients with distinct host-microbial interactionECCO'25Year: 2025
Authors: Barendregt, D.(1)*;Joosse, M.E.(1);Hulleman-van Haaften, D.H.(1);Costes, L.M.M.(1);Gacesa, R.(2);Plomp, N.(3);Duck, L.W.(4);Klomberg, R.C.W.(5);Vuijk, S.A.(5);Doukas, M.(6);Escher, J.C.(5);Harmsen, H.J.M.(3);Elson, C.O.(4);de Ridder, L.(5);Samsom, J.N.(1);
(1)Erasmus University Medical Center-Sophia Children’s Hospital, Laboratory of Pediatrics, Rotterdam, The Netherlands;(2)University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands;(3)University Medical Center Groningen, Department of Medical Microbiology and Infection Prevention, Groningen, The Netherlands;(4)University of Alabama at Birmingham, Department of Medicine- division of Gastroenterology and Hepatology, Birmingham- AL, United States;(5)Erasmus University Medical Center-Sophia Children’s Hospital, Department of Pediatric Gastroenterology, Rotterdam, The Netherlands;(6)Erasmus University Medical Center, Department of Pathology, Rotterdam, The Netherlands;
P0116: The Protective Role of PYY in Intestinal Mucosal Defects Induced by SATB2 Deficiency in Inflammatory Bowel DiseaseECCO'25Year: 2025
Authors: Liu, Y.(1)*;Wu, L.(2);Li, X.(3);Chen, R.(4);Sun, Q.(5);Tang, W.(6);
(1)Nanjing Drum Tower Hospital- the Affiliated Hospital of Nanjing University Medical School, Department of Pathology, Nanjing, China;(2)Soochow University, Department of Pathology, Suzhou, China;(3)Soochow University, Department of Pathology, Department of Pathology, China;(4)the Second Affiliated Hospital of Soochow University, Department of Gastroenterology, Department of Gastroenterology, China;(5)Nanjing Drum Tower Hospital- the Affiliated Hospital of Nanjing University Medical School, Nanjing Drum Tower Hospital- the Affiliated Hospital of Nanjing University Medical School, Nanjing, China;(6)the Second Affiliated Hospital of Soochow University, Department of Gastroenterology, Suzhou, China;
1 Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 2017;390:2769-78.2 Andreyev J. Gastrointestinal complications of pelvic radiotherapy: are they of any importance? Gut 2005;54:1051-4.3 Abayomi J, Kirwan J, Hackett A. The prevalence of chronic radiation enteritis following radiotherapy for cervical or endometrial cancer and its impact on quality of life. Eur J Oncol Nurs 2009;13:262-7.4 Tsutsui KM, Sano K, Tsutsui K. Dynamic view of the nuclear matrix. Acta Med Okayama 2005;59:113-20.5 Gu W, Wang H, Huang X, Kraiczy J, Singh PNP, Ng C, et al. SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell Stem Cell 2022;29:101-15 e10.6 Ni H, Chen Y, Xia W, Wang C, Hu C, Sun L, et al. SATB2 Defect Promotes Colitis and Colitis-associated Colorectal Cancer by Impairing Cl-/HCO3- Exchange and Homeostasis of Gut Microbiota. J Crohns Colitis 2021;15:2088-102.7 Metcalfe C, Kljavin NM, Ybarra R, de Sauvage FJ. Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell 2014;14:149-59.8 Parikh K, Antanaviciute A, Fawkner-Corbett D, Jagielowicz M, Aulicino A, Lagerholm C, et al. Colonic epithelial cell diversity in health and inflammatory bowel disease. Nature 2019;567:49-55.9 Middelhoff M, Nienhuser H, Valenti G, Maurer HC, Hayakawa Y, Takahashi R, et al. Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche. Nat Commun 2020;11:111.10 Haegebarth A, Clevers H. Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol 2009;174:715-21.11 Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, et al. Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol 2009;296:G23-35.12 Xie Z, Zhou G, Zhang M, Han J, Wang Y, Li X, et al. Recent developments on BMPs and their antagonists in inflammatory bowel diseases. Cell Death Discov 2023;9:210.13 Chen Q, Zheng L, Zhang Y, Huang X, Wang F, Li S, et al. Special AT-rich sequence-binding protein 2 (Satb2) synergizes with Bmp9 and is essential for osteo/odontogenic differentiation of mouse incisor mesenchymal stem cells. Cell Prolif 2021;54:e13016.14 Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, et al. Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism. Science 2023;381:502-8.15 Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002;418:650-4.16 Berger J, Moller DE. The mechanisms of action of PPARs. Annu Rev Med 2002;53:409-35.17 Mastrofrancesco A, Kovacs D, Sarra M, Bastonini E, Cardinali G, Aspite N, et al. Preclinical studies of a specific PPARgamma modulator in the control of skin inflammation. J Invest Dermatol 2014;134:1001-11.18 Koch TR, Roddy DR, Go VL. Abnormalities of fasting serum concentrations of peptide YY in the idiopathic inflammatory bowel diseases. Am J Gastroenterol 1987;82:321-6.19 El-Salhy M, Mazzawi T, Gundersen D, Hatlebakk JG, Hausken T. The role of peptide YY in gastrointestinal diseases and disorders (review). Int J Mol Med 2013;31:275-82.20 Villumsen M, Schelde AB, Jimenez-Solem E, Jess T, Allin KH. GLP-1 based therapies and disease course of inflammatory bowel disease. EClinicalMedicine 2021;37:100979.21 Jing F, Liu G, Zhang R, Xue W, Lin J, Zhu H, et al. PYY modulates the tumorigenesis and progression of colorectal cancer unveiled by proteomics. Am J Cancer Res 2022;12:5500-15.22 Grise KR, Rongione AJ, Laird EC, McFadden DW. Peptide YY inhibits growth of human breast cancer in vitro and in vivo. J Surg Res 1999;82:151-5.23 Gu J, Chen YZ, Zhang ZX, Yang ZX, Duan GX, Qin LQ, et al. At What Dose Can Total Body and Whole Abdominal Irradiation Cause Lethal Intestinal Injury Among C57BL/6J Mice? Dose Response 2020;18:1559325820956783.24 Ni H, Chen L, Song L, Sun L, Cui H, Zhou Q, et al. ErbB4 acts as a suppressor in colitis and its associated carcinoma by negatively regulating cholesterol metabolism. Carcinogenesis 2019;40:680-6.
P0118: A novel subset of TNIP3+ OLR1+ AQP9+ inflammatory monocytes drives resistance to multiple biologics in ulcerative colitisECCO'25Year: 2025
Authors: Saifuddin, A.(1)*;Cozzetto, D.(2);Olbei, M.(2);Korcsmaros, T.(2);Hart, A.(3);Powell, N.(2);
(1)Imperial College London, Department of Metabolism- Digestion and Reproduction, Beckenham, United Kingdom;(2)Imperial College London, Department of Metabolism- Digestion and Reproduction, London, United Kingdom;(3)St Mark's Academic Institute, Department of Gasteroenterology, London, United Kingdom;
[1] Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, Herbst RH, Rogel N, Slyper M, Waldman J, Sud M, Andrews E, Velonias G, Haber AL, Jagadeesh K, Vickovic S, Yao J, Stevens C, Dionne D, Nguyen LT, Villani AC, Hofree M, Creasey EA, Huang H, Rozenblatt-Rosen O, Garber JJ, Khalili H, Desch AN, Daly MJ, Ananthakrishnan AN, Shalek AK, Xavier RJ, Regev A. Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis. Cell. 2019 Jul 25;178(3):714-730.e22. doi: 10.1016/j.cell.2019.06.029.
[2] Stankey CT, Bourges C, Haag LM, Turner-Stokes T, Piedade AP, Palmer-Jones C, Papa I, Silva Dos Santos M, Zhang Q, Cameron AJ, Legrini A, Zhang T, Wood CS, New FN, Randzavola LO, Speidel L, Brown AC, Hall A, Saffioti F, Parkes EC, Edwards W, Direskeneli H, Grayson PC, Jiang L, Merkel PA, Saruhan-Direskeneli G, Sawalha AH, Tombetti E, Quaglia A, Thorburn D, Knight JC, Rochford AP, Murray CD, Divakar P, Green M, Nye E, MacRae JI, Jamieson NB, Skoglund P, Cader MZ, Wallace C, Thomas DC, Lee JC. A disease-associated gene desert directs macrophage inflammation through ETS2. Nature. 2024 Jun;630(8016):447-456. doi: 10.1038/s41586-024-07501-1
P0119: Elevated Circulating Succinate in Crohn's Disease Correlates with Gut Microbiota Alterations and Inflammatory ActivityECCO'25Year: 2025
Authors: Boronat-Toscano, A.(1)*;Menacho, M.(2);Monfort-Ferré, D.(1);Valldosera, G.(2);Clua-Ferré, L.(3);Plaza-Andrade, I.(4);Arángena-Martín, L.(4);Astiarraga , B.(1);Abadia, C.(2);Cabrinety, L.(2);Moliné, A.(2);Vañó, I.(1);Caro, A.(5);Castellano-Castillo, D.(4);Suau, R.(3);Fernández-Veledo, S.(1);Vendrell, J.(1);Manyé, J.(3);Queipo-Ortuño, M.(4);Serena, C.(1);
(1)Health Institute Pere Virgili IISPV, University Hospital Joan XXIII, Tarragona, Spain;(2)University Hospital Joan XXIII, Digestive Department, Tarragona, Spain;(3)Health Institute Germans Trias i Pujol IGTP, Inflammatory Bowel Diseases, Badalona, Spain;(4)Hospital Virgen de la Victoria, UGC Intercentro de Oncología Médica. Facultad de Medicina., Málaga, Spain;(5)University Hospital Joan XXIII, Surgery Department, Tarragona, Spain;
1. Serena C et al. Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota. ISME J 2018 Jun;12(7):1642-1657
2. Connors J et al. The Role of Succinate in the Regulation of Intestinal Inflammation. Nutrients 2019 Jan 11(1): 256.
3. Macias-Ceja DC et al. Succinate receptor mediates intestinal inflammation and fibrosis. Mucosal Immunol 2019. Jan;12(1):178-187.
P0120: Study of the Implication of the Epithelium in the Development and Progression of Fibrosis in Ulcerative ColitisECCO'25Year: 2025
Authors: Stepniak, M.(1)*;Adam, P.(1);Salée, C.(1);Massot, C.(1);Loly, J.P.(2);Vieujean, S.(1,2,3);Reenaers, C.(2);Coimbra Garcia Marques, C.(4);Decker, E.(4);Delvenne, P.(5);Blétard, N.(6);Speca, S.(7);Beq, S.(8);Louis, E.(1,2);Meuwis, M.A.(1,2);
(1)GIGA Institute, Translational Gastroenterology Research, Liège, Belgium;(2)CHU of Liège, Hepato-gastroenterology and digestive oncology, Liège, Belgium;(3)INFINY Institute- INSERM NGERE - CHRU, Department of Gastroenterology, Nancy, France;(4)CHU of Liège, Abdominal surgery, Liège, Belgium;(5)CHU of Liège, Pathological anatomy, Liège, Belgium;(6)CHC MontLégia, Anatomo-pathology, Liège, Belgium;(7)INSERM University of Lille, INFINITE Unit, Lille, France;(8)Thabor Therapeutics, RnD, Paris, France;
1) Co, J. Y., et al. (2021). Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases. In Nature Protocols. https://doi.org/10.1038/s41596-021-00607-0
2) Gordon, I. O., et al. (2018). Fibrosis in ulcerative colitis is directly linked to severity and chronicity of mucosal inflammation. Alimentary Pharmacology and Therapeutics. https://doi.org/10.1111/apt.14526
3) Vieujean, S., et al. (2021). Potential Role of Epithelial Endoplasmic Reticulum Stress and Anterior Gradient Protein 2 Homologue in Crohn’s Disease Fibrosis. Journal of Crohn’s and Colitis. https://doi.org/10.1093/ecco-jcc/jjab061
4) F. C. EDWARDS and S. C. TRUELOVE, "the Course and Prognosis of Ulcerative Colitis. Iii. Complications.," Gut, vol. 5, pp. 1–22, 1964
P0121: Molecular features of extracellular matrix activity persist in patients who achieve mucosal healing with ustekinumab inductionECCO'25Year: 2025
Authors: Saifuddin, A.(1)*;Cozzetto, D.(2);Powell, N.(2);
(1)Imperial College London, Metabolism- Digestion and Reproduction, Beckenham, United Kingdom;(2)Imperial College London, Department of Metabolism- Digestion and Reproduction, London, United Kingdom;
[1] Arijs I, De Hertogh G, Lemmens B, Van Lommel L, de Bruyn M, Vanhove W, Cleynen I, Machiels K, Ferrante M, Schuit F, Van Assche G, Rutgeerts P, Vermeire S. Effect of vedolizumab (anti-α4β7-integrin) therapy on histological healing and mucosal gene expression in patients with UC. Gut. 2018 Jan;67(1):43-52.
P0122: The Potential Role of Circulating Cytokines and Chemokines To Predict Intestinal Failure in Patients Affected by Short Bowel SyndromeECCO'25Year: 2025
Authors: Di Mattia, M.(1)*;Pane, C.(1);Petito, V.(2);Profeta , F.(2);Foscarini, E.(2);Lamolinara, A.(3);Iezzi, M.(3);Troisi, S.(1,2);Masi, L.(2);Emoli, V.(2);Becherucci, G.(2);Turchini, L.(2);Gasbarrini, A.(2,4,5);Papa, A.(4,5);Scaldaferri , F.(2,4,5);Lopetuso, L.R.(1,2);
(1)Center for Advanced Studies and Technnology CAST- G. d'Annunzio University of Chieti Pescara- Chieti- Italy., Department of Medicine and Ageing Science, Chieti, Italy;(2)CeMAD Translational Research Laboratories- Digestive Disease Center CeMAD- Fondazione Policlinico Universitario “A. Gemelli” IRCCS- Rome- Italy., Department of Medical and Surgical Sciences, Rome, Italy;(3)Center for Advanced Studies and Technnology CAST- G. d'Annunzio University of Chieti Pescara- Chieti- Italy., Department Neurosciences- Imaging and Clinical Sciences, Chieti, Italy;(4)Catholic University of the Sacred Heart- Rome- Italy., Department of Translational Medicine and Surgery, Rome, Italy;(5)IBD Unit- Digestive Disease Center CeMAD- Fondazione Policlinico Universitario “A. Gemelli” IRCCS- Rome- Italy., Department of Medical and Surgical Sciences, Rome, Italy;
1. Friedrich M, Pohin M, Powrie F. Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. Immunity. 2019;50(4):992-1006. doi:10.1016/j.immuni.2019.03.017
2. Singh UP, Singh NP, Murphy EA, et al. Chemokine and cytokine levels in inflammatory bowel disease patients. Cytokine. 2016;77:44-49. doi:10.1016/j.cyto.2015.10.008
3. Mello JDC, Gomes LEM, Silva JF, et al. The role of chemokines and adipokines as biomarkers of Crohn’s disease activity: a systematic review of the literature. Am J Transl Res. 2021;13(8):8561-8574.
4. Ansari N, Abdulla J, Zayyani N, Brahmi U, Taha S, Satir AA. Comparison of RANTES expression in Crohn’s disease and ulcerative colitis: an aid in the differential diagnosis? J Clin Pathol. 2006;59(10):1066-1072. doi:10.1136/jcp.2005.034983
P0123: The immune system of patients with immune-mediated diseases perceives dysbiotic intestinal microbial species, and IgG reactivity uncovers shared and non-shared responses across diseasesECCO'25Year: 2025
Authors: Barendregt, D.(1)*;Gacesa, R.(2);Plomp, N.(3);Calado, B.(1);Bourgonje, A.R.(2);van Heck, J.I.P.(4);van Mourik, A.G.(5);van der Woude, D.(5);Weersma, R.K.(2);Joosten, L.A.B.(4);Lubberts, E.(6);Rizopoulos, D.(7);Chandler, F.(8);Sikkema, R.S.(8);Harmsen, H.J.M.(3);de Ridder, L.(9);Samsom, J.N.(1);
(1)Erasmus University Medical Center-Sophia Children’s Hospital, Laboratory of Pediatrics, Rotterdam, The Netherlands;(2)University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands;(3)University Medical Center Groningen, Department of Medical Microbiology and Infection Prevention, Groningen, The Netherlands;(4)Radboud University Medical Center, Department of Internal Medicine and Radboud Institute of Molecular Life Sciences, Nijmegen, The Netherlands;(5)Leiden University Medical Center, Department of Rheumatology, Leiden, The Netherlands;(6)Erasmus University Medical Center, Department of Rheumatology, Rotterdam, The Netherlands;(7)Erasmus University Medical Center, Department of Biostatistics, Rotterdam, The Netherlands;(8)Erasmus University Medical Center, Department of Viroscience, Rotterdam, The Netherlands;(9)Erasmus University Medical Center-Sophia Children’s Hospital, Department of Pediatric Gastroenterology, Rotterdam, The Netherlands;
P0124: Therapeutic Potential of Adipose-Derived Extracellular Vesicles for Inflammation Modulation and Mucosal Healing in Crohn’s DiseaseECCO'25Year: 2025
Authors: Clua, L.(1)*;Suau, R.(1);Monfort-Ferré, D.(2);Boronat-Toscano, A.(2);Menacho, M.(2);Caro, A.(2);Mañas, M.J.(3);Mañosa, M.(4);Domènech, E.(4);Manyé, J.(5);Serena, C.(2);
(1)Germans Trias i Pujol Research Institute IGTP, Inflammatory Bowel Diseases, Badalona, Spain;(2)Joan XXIII University Hospital of Tarragona- Pere Virgili Health Research Institute, Inflammatory Bowel Diseases, Tarragona, Spain;(3)Sant Pau i Santa Tecla Hospital of Tarragona, Surgery Service, Tarragona, Spain;(4)Germans Trias i Pujol University Hospital. Centre for Biomedical Research in Network Hepatic and Digestive Diseases CIBEREHD, Digestive System Service, Badalona, Spain;(5)Germans Trias i Pujol Research Institute IGTP. Centre for Biomedical Research in Network Hepatic and Digestive Diseases CIBEREHD, Inflammatory Bowel Diseases, Badalona, Spain;
1.Golovics PA, Mandel MD, Lovasz BD, Lakatos PL. Inflammatory bowel disease course in Crohn’s disease: Is the natural history changing? World J Gastroenterol. 2014;20(12):3198-3207.
2.Zhou Y, Yamamoto Y, Xiao Z, Ochiya T. The immunomodulatory functions of mesenchymal stromal/stem cells mediated via paracrine activity. J Clin Med. 2019;8(1)
P0125: Crohn’s-associated invariant T Cells are associated with disease severity and location and are not affected by medication intakeECCO'25Year: 2025
Authors: Mahdy, A.(1)*;ElAbd, H.(1);Kriukova, V.(1);Olbjørn, C.(2);Perminow, G.(3);Bengtson, M.B.(4);Ricanek, P.(5);Andersen, S.(6);Detlie, T.(7);Kristensen, V.(8);Hov, J.(9);Høivik, M.(8);Franke, A.(1);
(1)University of Kiel and University Hospital Schleswig-Holstein, Institute of Clinical Molecular Biology, Kiel, Germany;(2)Akershus University Hospital, Department of Paediatric and Adolescent Medicine, Oslo, Norway;(3)Oslo University Hospital, Department of pediatrics, Oslo, Norway;(4)Vestfold Hospital Trust, Department of Gastroenterology, Tonsberg, Norway;(5)Lovisenberg Diaconal Hospital, Department of Gastroenterology, Oslo, Norway;(6)Vestfold Hospital Trust, Department of Paediatrics, Tonsberg, Norway;(7)Akershus University Hospital, Department of Gastroenterology, Lørenskog, Norway;(8)Oslo University Hospital, Department of Gastroenterology, Oslo, Norway;(9)Faculty of Medicine, Institute of Clinical Medicine, Oslo, Norway;
1. Rosati E., Martini GR., Pogorelyy M V., Minervina AA., Degenhardt F., Wendorff M., et al. A novel unconventional T cell population enriched in Crohn’s disease. Gut 2022;71(11):2194 LP – 2204. Doi: 10.1136/gutjnl-2021-325373.
2. Minervina AA., Pogorelyy M V., Paysen S., Luening U., Degenhardt F., Franke A., et al. Crohn’s-associated invariant T cells (CAITs) recognise small sulfonate molecules on CD1d. Gut 2022:gutjnl-2022-328684. Doi: 10.1136/gutjnl-2022-328684.
3. Kristensen VA., Opheim R., Perminow G., Huppertz-Hauss G., Detlie TE., Lund C., et al. Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway. Scand J Gastroenterol 2021;56(8):899–905. Doi: 10.1080/00365521.2021.1922746.
4. Satsangi J., Silverberg MS., Vermeire S., Colombel J-F. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006;55(6):749. Doi: 10.1136/gut.2005.082909.
P0126: Single-cell analysis reveals enrichment of mucosal Th17-polarized T cells in Acute Severe Ulcerative ColitisECCO'25Year: 2025
Authors: Bourgonje, A.R.(1,2)*;Meringer, H.(1,2,3);Roudko, V.(4);Jha, D.(1,2);Canales-Herrerias, P.(1,2);Livanos, A.E.(1,2);Cossarini, F.(5);Tankelevich, M.(1,2);D'Souza, D.(4);Nie, K.(4);Kim-Schulze, S.(4);Petralia, F.(6);Kayal, M.(1);Colombel, J.F.(1);Mehandru, S.(1,2);
(1)Icahn School of Medicine at Mount Sinai, The Henry D. Janowitz Division of Gastroenterology- Department of Medicine, New York, United States;(2)Icahn School of Medicine at Mount Sinai, Precision Immunology Institute, New York, United States;(3)Assuta Ashdod Medical Center, Gastroenterology and Liver Diseases, Ashdod, Israel;(4)Icahn School of Medicine at Mount Sinai, Human Immune Monitoring Center, New York, United States;(5)Icahn School of Medicine at Mount Sinai, Department of Infectious Diseases, New York, United States;(6)Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York, United States;
P0127: Fistula-derived fibroblasts express genes associated with a dysfunctional wound healing processECCO'25Year: 2025
Authors: Van Os, B.(1)*;Su, J.(1);Bruckner, R.(1);Zhou, Z.(1);van der Meulen-de Jong, A.(1);Hawinkels, L.(1);Barnhoorn, M.(1);
(1)LUMC, Gastroenterology, Leiden, The Netherlands;
P0128: IL-27 signalling, but not IL-1B, is functionally relevant in the pathophysiology of immune checkpoint inhibitor induced colitisECCO'25Year: 2025
Authors: Ibraheim, H.(1)*;Cozzetto, D.(1);Goldin, R.(2);Kudo, H.(2);Zhou, X.(1);Lo, J.W.(1);Powell, N.(1);
(1)Imperial College London, Department of Metabolism- Digestion and Reproduction, London, United Kingdom;(2)St Mary's Hospital, Histopathology, London, United Kingdom;
P0129: Distinct involvement of plasma cells and monocytes/macrophages in ileal and colonic ulcer formation in patients with Crohn's diseaseECCO'25Year: 2025
Authors: PierreDr., N.(1)*;Jacobs, N.(2);Fernández-Verdejo, R.(3);Louis, E.(1);Vieujean, S.(1);
(1)University of Liège, Laboratory of Translational Gastroenterology- GIGA-institute, Liège, Belgium;(2)University of Liège, Cellular and Molecular Immunology- GIGA-institute, Liège, Belgium;(3)Universidad Finis Terrae, Laboratorio de Fisiología del Ejercicio y Metabolismo LABFEM, Santiago, Chile;
- Pierre N, Salée C, Massot C, Blétard N, Mazzucchelli G, Smargiasso N, et al. Proteomics Highlights Common and Distinct Pathophysiological Processes Associated with Ileal and Colonic Ulcers in Crohn’s Disease. J Crohns Colitis 2020;14(2):205–15.
P0130: Assessment of macrophage types in the intestinal tissue of treatment naïve Inflammatory Bowel Disease patients in relation to their disease and activation of the CCL2/CCR2 pathwayECCO'25Year: 2025
Authors: Begum, J.(1)*;Fatima, A.(1);Rimmer, P.(2);Iqbal, T.(3);Stoica, V.(2);Owusu, M.(2);Lelios, I.(4);McGettrick, H.(5);Welford, R.(4);Iqbal, A.(1);
(1)University of Birmingham, Department of Cardiovascular Sciences, Birmingham, United Kingdom;(2)Queen Elizabeth Hospital Birmingham NHS Foundation Trust, Department of Gastroenterology, Birmingham, United Kingdom;(3)University of Birmingham, Department of Immunology and Immunotherapy, Birmingham, United Kingdom;(4)F Hoffmann-La Roche, Roche Pharma Research and Early Development, Basel, Switzerland;(5)University of Birmingham, Department of Inflammation and Ageing, Birmingham, United Kingdom;
