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P086: Mucosal microbiota modulate host intestinal immune signatures in Inflammatory Bowel DiseaseECCO'22
Year: 2022
Authors: Hu, S.(1,2);Bourgonje, A.R.(1);Gacesa, R.(1,2);Jansen, B.H.(1);Bangma, A.(1);Hidding, I.(1,2);Festen, E.A.M.(1);van Dullemen, H.M.(1);Visschedijk, M.C.(1);Dijkstra, G.(1);Harmsen, H.J.M.(3);Vich Vila, A.(1,2);Spekhorst, L.M.(1,4);Weersma, R.K.(1);
(1)University of Groningen- University Medical Center Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(2)University of Groningen- University Medical Center Groningen, Genetics, Groningen, The Netherlands;(3)University of Groningen- University Medical Center Groningen, Medical Microbiology, Groningen, The Netherlands;(4)Medisch Spectrum Twente, Gastroenterology and Hepatology, Enschede, The Netherlands;
P087: Communicating Needs and Features of IBD Experiences (CONFIDE) Survey: Impact of Ulcerative Colitis Symptoms on Daily LifeECCO'22
Year: 2022
Authors: Dubinsky, M.C.(1);Schreiber, S.(2);Potts Bleakman, A.(3);Kayhan, C.(3);Ellis, H.(4);Hunter Gibble, T.(3);Flynn, E.(3);Suldecki, G.(4);Travis, S.(5);
(1)Icahn School of Medicine, Mount Sinai, New York, United States;(2)University Hospital Schleswig-Holstein, Department of Internal Medicine, Kiel, Germany;(3)Eli Lilly and Company, Eli Lilly and Company, Indianapolis, United States;(4)Adelphi Real World, Bespoke, Bollington, United Kingdom;(5)University of Oxford, Gastroenterology, Oxford, United Kingdom;
P088: Metabolomic analysis reveals differences among UC and non-IBD human colonic resections: role of GPCRsECCO'22
Year: 2022
Authors: Bauset, C.(1);Carda-Diéguez, M.(2);Buetas, E.(2);Coll, S.(1);Lis-López, L.(1);Seco-Cervera, M.(3);Navarro, F.(4);Mira, Á.(2);Calatayud, S.(1);Barrachina, M.D.(1);Cosín-Roger, J.(3);
(1)Universidad de Valencia, Pharmacology, Valencia, Spain;(2)FISABIO, Genomics and Health Department, Valencia, Spain;(3)FISABIO, Unidad Mixta Facultad de Medicina-Hospital Dr. Peset, Valencia, Spain;(4)Hospital de Manises, Colorectal surgery, Valencia, Spain;
P089: Long ncRNA Landscape in the Rectum of Treatment Naïve Early Onset Ulcerative Colitis Highlights Association with Severity and Early and Late Disease Outcome, with Potential Role in Epithelial Metabolic FunctionsECCO'22
Year: 2022
Authors: Haberman Ziv, Y.(1);Braun, T.(1);Sosnovski , K.(1);Amir , A.(1);VanDussen , K.(2);Igor Ulitsky , I.U.(3);Griffiths , A.(4);Walters , T.(4);Mack , D.(5);Boyle, B.(6);Kugathasan, S.(7);Jegga, A.(8);Hyams , J.(9);Denson, L.(2);
(1)Tel-HaShomer Sheba Medical Center, Department of Pediatric Gastroenterology, Ramat Gan, Israel;(2)Cincinnati Children's Hospital Medical Center, Gastroenterology, Cincinnati, United States;(3)Weizmann Institute of Science, Biology, Rehovot, Israel;(4)Hospital For Sick Children, Pediatrics, Toronto, Canada;(5)Children's Hospital of East Ontario, Pediatrics, Ottawa, Canada;(6)Nationwide Children's Hospital, Pediatrics, Colombus, United States;(7)Emory University, Pediatirics, Atlanata, United States;(8)Cincinnati Children's Hospital Medical Center, Pediatirics, Cincinnati, United States;(9)Connecticut Children’s Medical Center, Pediatrics, Hartford, United States;PROTECT cohort
P090: Unraveling the rewiring of cytokine signalling in Inflammatory Bowel Disease using a novel network biology approachECCO'22
Year: 2022
Authors: Olbei, M.(1,2);Thomas, J.(1,2,3);Hautefort, I.(1);Treveil, A.(1,2);Bohar, B.(1,4);Madgwick, M.(1,2);Gul, L.(1);Csabai, L.(1,4);Modos, D.(1,2);Korcsmaros, T.(1,2,5);
(1)Earlham Institute, Organisms and Ecosystems, Norwich, United Kingdom;(2)Quadram Institute BioScience, Gut Microbes and Health, Norwich, United Kingdom;(3)Norfolk and Norwich University Hospital, Department of Gastroenterology, Norwich, United Kingdom;(4)Eotvos Lorand University, Department of Genetics, Budapest, Hungary;(5)Imperial College London, Faculty of Medicine- Department of Metabolism- Digestion and Reproduction, London, United Kingdom;
P091: A single-cell RNAseq approach to understand and predict the efficacy of tofacitinib in Ulcerative ColitisECCO'22
Year: 2022
Authors: Melon, E.(1);Corraliza, A.M.(1);Garrido, A.(1);Veny, M.(1);Masamunt, M.C.(1);Giner, A.(1);Ordás, I.(1);Fernández, A.(1);Ricart, E.(1);Panés, J.(1);Salas, A.(1);
(1)Institut d'Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Hospital Clinic of Barcelona - Inflammatory Bowel Disease Unit, Barcelona, Spain;
P092: Humoral and T cell responses to COVID-19 vaccination in IBDECCO'22
Year: 2022
Authors: Zhang, E.(1);Bond, K.(2);Nguyen, O.(3);Allen, L.(3);Kedzierski , L.(3);Kedzierka, K.(3);Christensen, B.(1);
(1)Royal Melbourne Hospital, Gastroenterology, Melbourne, Australia;(2)Royal Melbourne Hospital, Microbiology, Victoria, Australia;(3)University of Melbourne, Microbiology and Immunology, Victoria, Australia;
P093: Probiotic strains Lactobacillus plantarum and Saccharomyces boulardii influence the fibrotic responses of human intestinal subepithelial myofibroblasts.ECCO'22
Year: 2022
Authors: Tarapatzi, G.(1);Filidou, E.(1);Kandilogiannakis, L.(1);Spathakis, M.(1);Arvanitidis, K.(1);Kotzampassi , K.(2);Kolios, G.(1);Vradelis, S.(3);
(1)Laboratory of Pharmacology- Faculty of Medicine, Democritus University of Thrace- Alexandroupolis, Alexandroupolis, Greece;(2)Department of Surgery, Aristotle University of Thessaloniki- AHEPA Hospital, Thessaloniki, Greece;(3)University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece;
P094: Transcriptomic and small RNA sequencing profile in ileal resections from complicated Crohn´s Disease patientsECCO'22
Year: 2022
Authors: Seco-Cervera, M.(1);Bauset, C.(2);Santana-Plata, C.(2);Civera-Barrachina, M.(2);Ortiz-Masià, D.(2);Calatayud, S.(2);Barrachina, M.D.(2);
(1)Hospital Dr Peset- FISABIO, Pharmacology, Valencia, Spain;(2)Faculty of Medicine - University of Valencia, Pharmacology, Valencia, Spain;
P095: Anti-inflammatory effect of high acetate concentration on organoid-derived epithelial monolayer from patients with Ulcerative ColitisECCO'22
Year: 2022
Authors: Deleu, S.(1);Arnauts, K.(1,2);Machiels, K.(1);Huys, G.R.B.(3,4);Thevelein, J.(5,6);Raes, J.(3,4);Vermeire, S.(1,7);
(1)KU Leuven, Chrometa Targid, Leuven, Belgium;(2)KU Leuven, Development and Regeneration- Stem Cell Institute Leuven, Leuven, Belgium;(3)KU Leuven, Microbiology and Immunology- Rega Institute, Leuven, Belgium;(4)VIB, Center for Microbiology, Leuven, Belgium;(5)Erasmus High School, NovelYeast bv- Open Bio-Incubator, Brussels, Belgium;(6)KU Leuven, Molecular Cell Biology- Institute of Botany and Microbiology, Leuven, Belgium;(7)University Hospitals Leuven- KU Leuven, Gastroenterology and Hepatology, Leuven, Belgium;MIMOSA
P096: Store-Operated Calcium Entry Controls Innate and Adaptive Immune Cell Function in Inflammatory Bowel DiseaseECCO'22
Year: 2022
Authors: Letizia, M.(1);Kaufmann, U.(2);Wang, Y.H.(2);Gerbeth, L.(1);Sand, A.(1);Brunkhorst, M.(1);Böttcher, C.(3);Schlickeiser, S.(4);Fernández-Zapata, C.(3);Kunkel, D.(4);Siegmund, B.(1);Feske, S.(2);Weidinger, C.(1);
(1)Charité Universitätsmedizin Berlin, Medical Department- Division of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)New York University Grossman School of Medicine, Department of Pathology, New York, United States;(3)Charité and MDC, Experimental and Clinical Research Center, Berlin, Germany;(4)Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Flow & Mass Cytometry Core Facility, Berlin, Germany;IBDome researchers TRR 241 Research Initiative
P098: Mucosal Microbiota Composition Predicts Infliximab Response in Inflammatory Bowel DiseasesECCO'22
Year: 2022
Authors: Gazouli, M.(1);Dovrolis , N.(2); Kolios, G.(2);
(1)School of Medicine- National and Kapodistrian University of Athens, Basic Medical Sciences, Athens, Greece;(2)Faculty of Medicine- Democritus University of Thrace, Laboratory of Pharmacology, Alexandroupolis, Greece;
P099: Serum proteomic analysis reveals novel biomarkers associated with disease activity in pediatric patients with Crohn’s diseaseECCO'22
Year: 2022
Authors: Werner, L.(1);Weiss, B.(2);Matar, M.(1);Shamir, R.(1);Shouval, D.(1);
(1)Schneider Children's Medical Center of Israel, Institute of Gastroenterology- Nutrition and Liver Diseases, Petah Tiqwa, Israel;(2)Edmond and Lliy Safra Children's Hospital, Pediatric Gastroenterology Unit, Ramat Gan, Israel;
P100: Serum inflammatory protein profiling to corroborate selection of therapy naïve moderate-to-severe pediatric Crohn’s disease patients eligible for first-line infliximab treatmentECCO'22
Year: 2022
Authors: Jongsma , M.M.E.(1);Costes , L.M.M.(2);Tindemans , I.(2);Cozijnsen , M.A.(1);Raatgreep , R.H.C.(2);van Pieterson , M.(1);Li , Y.(3);Escher , J.C.(1);de Ridder , L.(1);Samsom , J.N.(2);
(1)Erasmus University Medical Center/Sophia Children's Hospital, Department of Pediatric Gastroenterology, Rotterdam, The Netherlands;(2)Erasmus University Medical Center, Laboratory of Paediatrics- Division of Gastroenterology and Nutrition, Rotterdam, The Netherlands;(3)Erasmus University Medical Center- Erasmus MC Cancer Institute, Department of Pathology & Clinical Bioinformatics, Rotterdam, The Netherlands;
P101: Isosteviol Attenuates Dextran Sulfate Sodium-Induced Colitis by Maintaining the Intestinal Barrier Through PDK1/AKT/NF-κB SignalingECCO'22
Year: 2022
Authors: Yao, L.(1);Cao, Q.(1);
(1)Sir Run Run Shaw Hospital- College of Medicine Zhejiang University, Department of Gastroenterology, Hangzhou, China;
P102: Changes in serum immune protein profiles following vedolizumab therapy in Inflammatory Bowel Disease.ECCO'22
Year: 2022
Authors: O'Connell, J.(1,2);O'Connell, F.(2);O'Sullivan, J.(2);Kevans, D.(1,2,3);
(1)St James's Hospital, Gastroenterology, Dublin, Ireland;(2)Dublin University- Trinity College, Trinity Translational Medicine Institute, Dublin, Ireland;(3)Dublin University- Trinity College, School of Medicine, Dublin, Ireland;
P103: Identifying CES-1 positive myeloid cells with mass cytometry as a potential therapeutic target for Crohn’s diseaseECCO'22
Year: 2022
Authors: HagemanMD, I.(1);Elfiky, A.(2);Becker, M.(2);Joustra, V.(1);Buskens, C.(3);Li Yim, A.(2);Hakvoort, T.(2);Verhoeff, J.(4);Garcia Vallejo, J.(4);D'Haens, G.(1);Wildenberg, M.(2);De Jonge, W.(2);
(1)Academic Medical Center AMC University of Amsterdam, Department of Gastroenterology & Hepatology, Amsterdam, The Netherlands;(2)Academic Medical Center AMC University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(3)Academic Medical Center AMC University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands;(4)Academic Medical Center AMC University of Amsterdam, Department of Molecular Cell Biology & Immunology- Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam, The Netherlands;
P104: Icariin Attenuates Intestinal Inflammation through Inhibition of the Nuclear Factor-ĸB signalingECCO'22
Year: 2022
Authors: Soh, H.(1);Park, S.(2);Lee, H.J.(1);Koh, S.J.(1);Im, J.P.(1);Kim, J.S.(1);
(1)Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea- Republic Of;(2)Incheon Sejong Hospital, Department of Internal Medicine, Incheon, Korea- Republic Of;
P105: Treatment of the lower gastrointestinal tract Klebsiella infections by recombinant bacteriocin KvarIaECCO'22
Year: 2022
Authors: Karaliute, I.(1);Ramonaite, R.(1);Kupcinskas, J.(2);Misiunas, A.(3);Denkovskiene, E.(3);Gleba, Y.(4);Razanskiene, A.(3);Skieceviciene, J.(1);
(1)Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania;(2)Lithuanian University of Health Sciences, Department of Gastroenterology, Kaunas, Lithuania;(3)UAB Nomads, Nomad Bioscience Gmbh, Vilnius, Lithuania;(4)NOMAD Bioscience GmbH, NOMAD Bioscience GmbH, Halle, Germany;