P0091: Faecal Urgency in Crohn’s Disease: Correlation with Disease Location, Activity, Quality of Life and Mental Health Status – A Cross-Sectional StudyECCO'25Year: 2025
Authors: Borges Chaves, C.(1)*;Azevedo Silva, I.(2);Feijó, D.(1);Temido, M.J.(1);Souto, P.(3);Ferreira, A.M.(3);Lopes, S.(3);Mendes, S.(3);Ferreira, M.(3);Narra Figueiredo, P.(1,4);Portela, F.(3,4);
(1)Local Health Unit of Coimbra, Gastroenterology Department, Coimbra, Portugal;(2)Local Health Unit of Alto Alentejo, Psychiatry Department, Portalegre, Portugal;(3)Local Health Unit of Coimbra, IBD Unit- Gastroenterology Department, Coimbra, Portugal;(4)University of Coimbra, Faculty of Medicine, Coimbra, Portugal;
1. Ha C, Naegeli AN, Lukanova R, Shan M, Wild R, Hennessy F, Jyothi Kommoju U, Potts Bleakman A, Hunter Gibble T. Rectal Urgency Among Patients With Ulcerative Colitis or Crohn's Disease: Analyses from a Global Survey. Crohns Colitis 360. 2023 Sep 25;5(4):otad052. doi: 10.1093/crocol/otad052. PMID: 37928613; PMCID: PMC10622170.
2. Dawwas GK, Jajeh H, Shan M, Naegeli AN, Hunter T, Lewis JD. Prevalence and Factors Associated With Fecal Urgency Among Patients With Ulcerative Colitis and Crohn's Disease in the Study of a Prospective Adult Research Cohort With Inflammatory Bowel Disease. Crohns Colitis 360. 2021 Jul 8;3(3):otab046. doi: 10.1093/crocol/otab046. PMID: 36776663; PMCID: PMC9902261.
3.Dubinsky MC, Clemow DB, Hunter Gibble T, Li X, Vermeire S, Hisamatsu T, Travis SPL. Clinical Effect of Mirikizumab Treatment on Bowel Urgency in Patients with Moderately to Severely Active Ulcerative Colitis and the Clinical Relevance of Bowel Urgency Improvement for Disease Remission. Crohns Colitis 360. 2022 Dec 13;5(1):otac044. doi: 10.1093/crocol/otac044. PMID: 36777368; PMCID: PMC9802448.
4. Caron B, Ghosh S, Danese S, Peyrin-Biroulet L. Identifying, Understanding, and Managing Fecal Urgency in Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2023 Jun;21(6):1403-1413.e27. doi: 10.1016/j.cgh.2023.02.029. Epub 2023 Mar 9. PMID: 36906079.
P0092: Advancing precision medicine in IBD: Systematic evaluation of single-cell transcriptomics protocols for intestinal biopsiesECCO'25Year: 2025
Authors: P. Bernardes, J.(1)*;Schulte-Schrepping, J.(2);Tran, F.(3);Lorant, A.(4);Soumyabrata, G.(4);Taubenheim, J.(5);Volk, V.(6);Yim, A.L.(7);Wang, X.(4);Aden, K.(8);Ellinghaus, D.(9);Feuerhake, F.(10);Häsler , R.(11);Kaleta, C.(5);Röcken, C.(12);Satagopam, V.(4);L. Schultze, J.(2);Vetrano, S.(13);Schreiber, S.(8);Rosenstiel, P.(1);
(1)Institute of Clinical Molecular Biology, Systems Immunology, Kiel, Germany;(2)Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Systems Medicine, Bonn, Germany;(3)Institute of Clinical Molecular Biology, Translational and Molecular Gastroenterology, Kiel, Germany;(4)Luxembourg Centre for Systems Biomedicine, Bioinformatics Core, Luxembourg, Luxembourg;(5)Institute for Experimental Medicine, Medical Systems Biology, Kiel, Germany;(6)Hannover Medical School, Department of Pathology, Kiel, Germany;(7)University of Amsterdam, Tytgat Institute for Liver and Intestinal Research-, Amsterdam, The Netherlands;(8)University Hospital Schleswig Holstein, I. Medical Department, Kiel, Germany;(9)Institute of Clinical Molecular Biology, Biomedical Informatics and Genetic Redefinition of Phenotypes, Kiel, Germany;(10)Hannover Medical School, Department of Pathology, Hannover, Germany;(11)University Hospital Schleswig Holstein, Clinic for Dermatology- Venerology und Allergology, Kiel, Germany;(12)University Hospital Schleswig Holstein, Department of Pathology, Kiel, Germany;(13)Humanitas University, Gastrointestinal Immunopathology Laboratory, Milan, Italy;
1. Martin JC, Chang C, Boschetti G, et al. Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy. Cell. 2019;178(6):1493-1508.e20. doi:10.1016/j.cell.2019.08.008
2. Smillie CS, Biton M, Ordovas-Montanes J, et al. Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis. Cell. 2019;178(3):714-730.e22. doi:10.1016/j.cell.2019.06.029
P0093: Identification of metabolic predictive biomarkers of response to Inflammatory Bowel Disease treatmentECCO'25Year: 2025
Authors: Martínez González, P.J.(1)*;Baldán-Martín , M.(1);Gil-Redondo, R.(2);Soleto, I.(1);Orejudo, M.(1);Ramírez, C.(1);Alfredo J, L.(3);Rodríguez, C.(4);Gutiérrez-Casbas , A.(5);Martín-Arranz , E.(6);Bujanda, L.(7);Rodríguez-Lago , I.(8);De Francisco , R.(9);Iglesias-Flores , E.(10);Bermejo , F.(11);Van Domselaar , M.(12);García, M.J.(13);Fernández-Salazar , L.(14);Jesús, B.(15);Calvet , X.(16);Torrealba, L.(17);Bastón-Rey , I.(18);Pallares Manrique , H.(19);Ber Nieto, Y.(20);Leo-Carnerero, E.(21);Casanova, M.J.(1);Millet, O.(2);Mato, J.M.(2);Chaparro*, M.(1);P. Gisbert*, J.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, Gastroenterology Department, Madrid, Spain;(2)CIC bioGUNE, Precision Medicine and Metabolism Lab, Derio, Spain;(3)Hospital General de Tomelloso- Instituto de Investigación Sanitaria de Castilla-La Mancha IDISCAM- CIBEREHD, Gastroenterology Department, Ciudad Real, Spain;(4)Hospital Universitario de Navarra and Instituto de Investigación de Navarra IdiSNA, Gastroenterology Department, Pamplona, Spain;(5)Hospital General Universitario de Alicante- CIBEREHD and Instituto Investigación Sanitaria y Biomédica de Alicante, Gastroenterology Department, Alicante, Spain;(6)Hospital Universitario La Paz and Instituto de Investigación Sanitaria La Paz IdiPaz, Gastroenterology Department, Madrid, Spain;(7)Hospital Universitario Donostia and Instituto Biodonostia and Universidad del País Vasco UPV/EHU, Gastroenterology Department, Donostia, Spain;(8)Hospital Universitario de Galdakao- Biocruces Bizkaia HRI, Gastroenterology Department, Vizcaya, Spain;(9)Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias ISPA, Gastroenterology Department, Oviedo, Spain;(10)Hospital Universitario Reina Sofía, Gastroenterology Department, Córdoba, Spain;(11)Hospital Universitario de Fuenlabrada and IDIPAZ, Gastroenterology Department, Madrid, Spain;(12)Hospital Universitario de Torrejón and Universidad Francisco de Vitoria, Gastroenterology Department, Madrid, Spain;(13)Hospital Universitario Marqués de Valdecilla- IDIVAL, Gastroenterology Department, Santander, Spain;(14)Hospital Clínico de Valladolid, Gastroenterology Department, Valladolid, Spain;(15)Hospital Universitario Río Hortega, Gastroenterology Department, Valladolid, Spain;(16)Servei d'Aparell Digestiu- Parc Taulí- Hospital Universitari- Institut d'Investigació i Innovació Parc Taulí- Departament de Medicina- Universitat Autònoma de Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD- Instituto de Salud Carlos III, Gastroenterology Department, Sabadell, Spain;(17)Hospital Universitario Dr. Josep Trueta, Gastroenterology Department, Girona, Spain;(18)Hospital Clínico Universitario de Santiago, Gastroenterology Department, Santiago de Compostela, Spain;(19)Hospital Juan Ramón Jiménez, Gastroenterology Department, Huelva, Spain;(20)Hospital San Jorge, Gastroenterology Department, Huesca, Spain;(21)Hospital Universitario Virgen del Rocío, Gastroenterology Department, Sevilla, Spain; *Authors share co-senior authorship.
P0094: The Role Of Sdf2l1 On Intestinal Physiology And Inflammatory Bowel DiseaseECCO'25Year: 2025
Authors: Thies, M.(1)*;Schuran, F.A.(1);Mishra, N.(1);Pimenta Bernardes, J.(1);Hinrichsen, F.(1);Rosenstiel, P.(1);
(1)University Hospital Schleswig-Holstein UKSH, Institute of Clinical Molecular Biology IKMB, Kiel, Germany;
1. Eugene SP, Reddy VS, Trinath J. Endoplasmic Reticulum Stress and Intestinal Inflammation: A Perilous Union. Front Immunol. 2020 Nov 25;11:543022. doi: 10.3389/fimmu.2020.543022. PMID: 33324392; PMCID: PMC7723926.
2. Kim J-S, Mochida K, Shinozaki K. ER Stress and the Unfolded Protein Response: Homeostatic Regulation Coordinate Plant Survival and Growth. Plants. 2022; 11(23):3197. https://doi.org/10.3390/plants11233197
3. Sasako, T., Ohsugi, M., Kubota, N. et al. Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism. Nat Commun 10, 947 (2019). https://doi.org/10.1038/s41467-019-08591-6
P0095: Human multi-lineage gut-on-chip to study near-physiological epithelial barrier function and directed secretionECCO'25Year: 2025
Authors: Hensel, I.V.(1,2)*;Steinhauer, M.(2);Éliás, S.(2);Neurath, M.F.(1);Günther, C.(1);Resnik-Docampo, M.(2);
(1)University Hospital Erlangen- Friedrich-Alexander-University Erlangen-Nürnberg, Department of Medicine 1, Erlangen, Germany;(2)BioMed X Institute, Immunology, Heidelberg, Germany;
P0097: STING pathway drives cellular tryptophan degradation and pro-inflammatory responses in intestinal fibroblastsECCO'25Year: 2025
Authors: Wu, Q.(1)*;Yang, G.(1);Xiang, H.(1);Shima, K.(2);Springer, E.(1);Bornhäuser, J.(1);Welz, L.(1);Aden, K.(3);
(1)Kiel University, Institute of Clinical Molecular Biology IKMB, Kiel, Germany;(2)University of Lübeck, Department of Infectious Diseases and Microbiology, Lübeck, Germany;(3)University Hospital Schleswig-Holstein, Department of Internal Medicine I, Kiel, Germany; AG Aden
P0098: Effect of the dietary emulsifier κ-carrageenan on the inflammatory state and permeability of intestinal epithelial cells from patients with Crohn’s diseaseECCO'25Year: 2025
Authors: Vissers, E.(1)*;Wellens, J.(1,2);Giorio, L.(1);Zadora, W.(3);Verstockt, B.(1,2);Ferrante, M.(1,2);Vermeire, S.(1,2);Matthys, C.(4,5);Arnauts, K.(1);Sabino, J.(1,2);
(1)KU Leuven, Department of Chronic Diseases and Metabolism CHROMETA- Translational Research Center for Gastrointestinal Disorders TARGID, Leuven, Belgium;(2)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(3)KU Leuven, Department of Microbiology- Immunology and Transplantation- Nephrology and Renal Transplantation Research Group, Leuven, Belgium;(4)University Hospitals Leuven, Department of Endocrinology, Leuven, Belgium;(5)KU Leuven, Department of Chronic Diseases and Metabolism CHROMETA- Clinical and Experimental Endocrinology, Leuven, Belgium;
1. Narula N, Wong ECL, Dehghan M, et al. Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study. BMJ. Jul 14 2021;374:n1554. doi:10.1136/bmj.n1554
2. Wellens J, Debrauwere M, Hoekx S, et al. Total emulsifier intake, but not ultra-processed food consumption is higher in patients with inflammatory bowel disease compared to healthy controls. Abstract submitted to ECCO 2025.
3. VanDussen KL, Marinshaw JM, Shaikh N, et al. Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Gut. Jun 2015;64(6):911-20. doi:10.1136/gutjnl-2013-306651
4. Arnauts K, Verstockt B, Ramalho AS, Vermeire S, Verfaillie C, Ferrante M. Ex Vivo Mimicking of Inflammation in Organoids Derived From Patients With Ulcerative Colitis. Gastroenterology. Oct 2020;159(4):1564-1567. doi:10.1053/j.gastro.2020.05.064
P0099: Histone H4 lysine 12 lactylation in CD4+ T cells promotes the progression of Ulcerative Colitis through PKM2/glycolysis loop and PKM2/STAT3 signaling pathwayECCO'25Year: 2025
Authors: Xu, S.(1)*;Ye, L.(2);Wu, J.(1);Tao, H.(1);Li, L.(1);Lu, H.(1);Wang, F.(1);
(1)Jinling Hospital- Affiliated Hospital of Medical School- Nanjing University, Department of Gastroenterology and Hepatology, Nanjing, China;(2)Ruijin Hospital- Shanghai Jiao Tong University School of Medicine, Department of Gastroenterology, Shanghai, China;
P0100: Intestinal adaptation in a mouse model of Crohn’s- like ileitis under short bowel conditionsECCO'25Year: 2025
Authors: Jadzewski, E.(1)*;Reiner, J.(2);Lamprecht, G.(2);Witte, M.(3);Berlin, P.(1);
(1)University Medical Center Rostock, Gastroenterology, Rostock, Germany;(2)University Medical Center Rostock- Clinic for internal medicine, Gastroenterology, Rostock, Germany;(3)University Medical Center Rostock, General- Visceral- Thoracic- Vascular and Transplant Surgery, Rostock, Germany;
P0101: Phenotyping of human UC colonic tissue reveals inflammatory pathway gene expression in PD-1+ conventional and regulatory T cells which overlap with those regulated by rosnilimab in a mouse model of colitisECCO'25Year: 2025
Authors: Linggi, B.(1)*;Haines, C.(2);Ren, Y.(1);Parmley, S.(2);Dahl, M.(2);Kwon, J.(3);Soroosh, P.(2);Lizzul, P.(4);Sibley, C.(1);
(1)AnaptysBio, Translational Medicine, San Diego, United States;(2)AnaptysBio, Research, San Diego, United States;(3)AnaptysBio, Clinical Development, San Diego, United States;(4)AnaptysBio, Medical, San Diego, United States;
- Long Y, et al. Immunol Letters 2021;233:2-10.
2. Parmley S, et al. United European Gastroenterol J 2024;12:482 (Abstract MP448).
3. Gupta T, et al. Cancer Cell 2024;42:797–814.
4. Schubert M, et al. Nat Commun 2018;9:20.
5. Linggi B, et al. Sci Rep 2021;11:18243.
P0102: Isatin: An indole alkaloid with intestinal anti-inflammatory activity in the trinitrobenzene sulfonic acid colitis modelECCO'25Year: 2025
Authors: Socca, E.A.R.(1);de Almeida, A.C.A.(2);Dunder, R.J.(1);Manzo, L.P.(1);de-Faria, F.M.(3);Souza-Brito, A.R.M.(1);Luiz-Ferreira, A.(4)*;
(1)Faculty of Medical Sciences, Department of Pharmacology, Campinas, Brazil;(2)Federal Institute of Education Science and Technology of Mato Grosso, Campus Confresa, Confresa, Brazil;(3)Faculty of Medicine and Health Sciences, Department of Biomedical and Clinical Sciences, Linköping, Sweden;(4)Federal University of Catalão, Department of Biological Sciences - IBD Research Laboratory, Catalão, Brazil;
1. Luiz-Ferreira A, Stolfi C. Pharmaceuticals. 2023;17:59. doi: 10.3390/ph17010059.
2. Jauregui-Amezaga A, Smet A. J Clin Med. 2024;13:4622. doi: 10.3390/jcm13164622.
3. de Almeida, de-Faria FM, Dunder RJ, et al. Evid Based Complement Alternat Med. 2017;2017:8528210. doi: 10.1155/2017/8528210.
P0103: Systems biology analysis of cytokine signalling in IBD highlights the importance of TYK2-dependent pathwaysECCO'25Year: 2025
Authors: Desch, N.(1)*;Petrakis, I.(1);Singh, N.(1);Tang, J.(1);Sirota-Madi, A.(2);Schuster, R.(2);Davidzohn, N.(2);Wyrobnik, I.(2);Shen-Orr, S.S.(2,3);Chowers, Y.(2);Panchal, P.(1);Wennbo, H.(1);Thakker, P.(1);Arunachalam, V.(1);
(1)Takeda Development Center Americas- Inc., Gastroenterology, Cambridge, United States;(2)CytoReason, Science Operations, Tel Aviv, Israel;(3)Technion – Israel Institute of Technology, Faculty of Medicine, Haifa, Israel;
1. Barbie DA, Tamayo P, Boehm JS, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. Nov 5 2009;462(7269):108-12. doi:10.1038/nature08460
2. Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. Oct 25 2005;102(43):15545-50. doi:10.1073/pnas.0506580102
P0104: Decoding cytokine networks in ulcerative colitis to identify pathogenic mechanisms and therapeutic targetsECCO'25Year: 2025
Authors: Olbei, M.(1)*;Hautefort, I.(1,2,3,4);Thomas, J.P.(1,5);Csabai, L.(6);Bohar, B.(1);Ibraheim, H.(1);Saifuddin, A.(1);Modos, D.(1,3);Powell, N.(1);Korcsmaros, T.(1,2,3,4);
(1)Imperial College London, Metabolism- Digestion and Reproduction, London, United Kingdom;(2)Imperial College London, NIHR Imperial BRC Organoid Facility, London, United Kingdom;(3)Quadram Institute, Quadram Institute, Norwich, United Kingdom;(4)Earlham Institute, Earlham Institute, Norwich, United Kingdom;(5)Hammersmith Hospital Campus, UKRI MRC Laboratory of Medical Sciences, London, United Kingdom;(6)Eotvos Lorand University, Department of Genetics, Budapest, Hungary;
[1]: Nie H, Lin P, Zhang Y, Wan Y, Li J, Yin C, Zhang L. Single-cell meta-analysis of inflammatory bowel disease with scIBD. Nature Computational Science. 2023 Jun;3(6):522-531. doi: 10.1038/s43588-023-00464-9. Epub 2023 Jun 15. PMID: 38177426.
[2]: Hassan-Zahraee M, Ye Z, Xi L, Baniecki ML, Li X, Hyde CL, Zhang J, Raha N, Karlsson F, Quan J, Ziemek D, Neelakantan S, Lepsy C, Allegretti JR, Romatowski J, Scherl EJ, Klopocka M, Danese S, Chandra DE, Schoenbeck U, Vincent MS, Longman R, Hung KE. Antitumor Necrosis Factor-like Ligand 1A Therapy Targets Tissue Inflammation and Fibrosis Pathways and Reduces Gut Pathobionts in Ulcerative Colitis. Inflammatory Bowel Diseases. 2022 Mar 2;28(3):434-446. doi: 10.1093/ibd/izab193. PMID: 34427649; PMCID: PMC8889296.
[3]: Olbei M, Hautefort I, Thomas JP, Csabai L, Bohar B, Ibraheim H, Saifuddin A, Modos D, Powell N, Korcsmaros T. Decoding Cytokine Networks in Ulcerative Colitis to Identify Pathogenic Mechanisms and Therapeutic Targets. bioRxiv 2024.09.12.612623; doi: https://doi.org/10.1101/2024.09.12.612623
P0105: Evaluation of Stimuli Driving Oncostatin M Expression in Bone Marrow-Derived MacrophagesECCO'25Year: 2025
Authors: Velasco Blázquez, L.(1,2)*;Cancino, C.(1,2);Luo, Y.(1,2);Konopka, A.(1,2);Hegazy, A.N.(1,2);
(1)Charité-Universitätsmedizin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;(2)Deutsches Rheumaforschungszentrum DRFZ, Leibniz Association, Berlin, Germany;
P0106: Profiling inflammation-associated T helper subsets in Inflammatory Bowel DiseaseECCO'25Year: 2025
Authors: Jiang, Q.(1)*;Lindelauf, C.(1);Ouboter, L.F.(2);Koning, F.(1);van der Meulen-de Jong, A.E.(2);van Unen, V.(1);Pascutti, M.F.(3);
(1)Leiden University Medical Center, Department of Immunology, Leiden, The Netherlands;(2)Leiden University Medical Center, Department of Gastroenterology and Hepatology, Leiden, The Netherlands;(3)Erasmus Medical Center, Laboratory of Pediatrics, Rotterdam, The Netherlands;
1.van Unen V, Ouboter LF, Li N, et al. Identification of a Disease-Associated Network of Intestinal Immune Cells in Treatment-Naive Inflammatory Bowel Disease. Front Immunol. 2022;13:893803. doi:10.3389/fimmu.2022.893803
P0107: Conceptualising avoidable inflammatory bowel disease admissions from the perspective of clinicians: An international mixed methods studyECCO'25Year: 2025
Authors: Hawkins, R.(1)*;Hind, D.(1);Matthew, L.(2);Lobo, A.(3);
(1)The University of Sheffield, Sheffield Centre for Health and Related Research SCHARR, Sheffield, United Kingdom;(2)Sheffield Teaching Hospitals NHS Foundation Trust, School of Medicine and Population Health, Sheffield, United Kingdom;(3)Sheffield Teaching Hospitals NHS Foundation Trust, Gastroenterology and Liver Unit- Royal Hallamshire Hospital, Sheffield, United Kingdom;
1- Hawkins RL, Zia M, Hind D, Lobo AJ. Inequalities in Healthcare Access, Experience and Outcomes in Adults With Inflammatory Bowel Disease: A Scoping Review. Inflamm Bowel Dis. Published online April 11, 2024:izae077. doi:10.1093/ibd/izae077
2 - Booker M, Purdy S. Towards new definitions of avoidable hospital admissions. Br J Gen Pract. 2022;72(723):464. doi:10.3399/bjgp22X720725
P0108: Exploring Microbiota-Immune Interactions in Short Bowel Syndrome and Crohn’s Disease in a model of human microbiota associated miceECCO'25Year: 2025
Authors: Masi , L.(1);Petito , V.(1);Troisi , S.(1,2);Emoli , V.(1);Deleu , S.(1,3,4);Becherucci , G.(1);Migliore , G.(1);Pane , C.(1,2)*;Carlà , A.S.(1);Foscarini , E.(1);Profeta , F.(1);Chieppa , M.(5);Mocci , G.(6);Lopetuso , L.R.(2,7,8);Gasbarrini , A.(1,3,7);Papa , A.(3,7);Scaldaferri , F.(1,3,7);
(1)Fondazione Policlinico Universitario “A. Gemelli”- IRCCS, CeMAD Translational Research Laboratories- Digestive Disease center- Department of Medical and Surgical Sciences, Rome, Italy;(2)University of Chieti-Pescara, Center for Advanced Studies and Technology CAST- ‘G. D’Annunzio’, Chieti, Italy;(3)Catholic University of the Sacred Heart, Department of Translational Medicine and Surgery, Rome, Italy;(4)KU Leuven, Department of Chronic Diseases & Metabolism CHROMETA, Leuven, Belgium;(5)University of Salento Centro Ecotekne, Department of Experimental Medicine, Lecce, Italy;(6)ARNAS G. Brotzu, Department of Medicine SC Gastroenterology, Cagliari, Italy;(7)Fondazione Policlinico Universitario “A. Gemelli” IRCCS, IBD unit- Digestive Disease center- Department of Medical and Surgical Sciences, Rome, Italy;(8)University of Chieti-Pescara, Department of Medicine and Ageing Sciences- ‘G. D’Annunzio’, Chieti, Italy;
Fundings: 2.1 "Rafforzamento e potenziamento della ricerca biomedica del SSN", finanziato dall’Unione europea – NextGenerationEU, CUP C53C22001140007. 2022 PNRR Project "Changing the future of intestinal failure in intestinal chronic inflammation: towards innovative predictive factors and therapeutic targets" code: PNRR-MAD-2022-12376791.
1. Massironi S, Cavalcoli F, Rausa E, Invernizzi P, Braga M, Vecchi M. Understanding short bowel syndrome: current status and future perspectives. Dig Liver Dis.2020;52(3):253-261. doi:10.1016/j.dld.2019.11.013
2. Aksan A, Farrag K, Blumenstein I, Schröder O, Dignass AU, Stein J. Chronic intestinal failure and short bowel syndrome in Crohn's disease. World J Gastroenterol. 2021;27(24):3440-3465. doi: 10.3748/wjg.v27.i24.3440.
3. Staley C, Kaiser T, Beura LK, Hamilton MJ, Weingarden AR, Bobr A, Kang J, Masopust D, Sadowsky MJ, Khoruts A. Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning. Microbiome. 2017;5(1):87. doi: 10.1186/s40168-017-0306-2.
4. Zhu Z, Kaiser T, Staley C. Antibiotic Conditioning and Single Gavage Allows Stable Engraftment of Human Microbiota in Mice. Methods Mol Biol. 2021;2327:281-291. doi: 10.1007/978-1-0716-1518-8_17.
P0109: SEMA3B is related to anti-TNF therapy response in Ulcerative Colitis patients but shows no relevant outcomes in modulating intestinal inflammation in vivo.ECCO'25Year: 2025
Authors: Arosa García, L.(1)*;Malvar-Fernández, B.(2);García, S.(2);Conde-Aranda, J.(1);
(1)Health Research Institute of Santiago de Compostela, Molecular and Cellular Gastroenterology Group, Santiago de Compostela, Spain;(2)Galicia Sur Health Research Institute, Rheumatology and Immune-mediated Diseases Group, Vigo, Spain; Molecular and Cellular Gastroenterology Group
P0110: Effect of Tofacitinib on Hemostasis in Patients with Ulcerative Colitis: a Comparative Ex Vivo StudyECCO'25Year: 2025
Authors: Baldan-Martin, M.(1)*;Sanchez Sanchez, C.(1);Suarez Trujillo, F.(1);Ramírez, C.(1);Soleto, I.(1);Mercado, J.(1);Orejudo , M.(1);Martínez, P.J.(1);Rubio Collado, C.(2);Orts, M.(3);Rubio Franco, M.J.(2);Planas, A.(3);Acedo, N.(2);Butta, N.(4);Chaparro*, M.(1);Gisbert*, J.P.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD- Madrid. Spain, Gastroenterology Department, Madrid, Spain;(2)Servicio de Hematología. Hospital Universitario de La Princesa- Madrid- Spain., Hematología, Madrid, Spain;(3)Servicio de Anestesiología y Reanimación. Hospital Universitario de La Princesa- Madrid- Spain, Anestesiología y Reanimación, Madrid, Spain;(4)Servicio de Hematología y Hemoterapia. Hospital Universitario de La Paz- Madrid- Spain, Hematología y Hemoterapia, Madrid, Spain; *Authors share co-senior authorship
